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Pancreatits after endoscopic retrograde cholangio-pancreatography

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World Journal of Gastroenterology 2007年第19期13卷 2655-2668页

作者： Ayman M Abdel Aziz Glen A lehman Division of Gastroenterology and Hepatology Indiana University Medical Center United States

Pancreatitis is the most common complication after endoscopic retrograde cholangio-pancreatography (ERCP); the reported incidence of this complication varies from less than 1% to 40%, but a rate of 4%-8% is reported in most prospective studies involving non-selected patients. Differences in criteria for defining pancreatitis, methods of data collection, and patient populations (i.e. number of high-risk patients included in the published series) are factors that are likely to affect the varying rates of post-ERCP pancreatitis. The severity of post-ERCP pancreatitis (PEP) can range from a minor inconvenience with one or two days of added hospitalization with full recovery to a devastating illness with pancreatic necrosis, multiorgan failure, permanent disability, and even death. Although, most episodes of PEP are mild (about 90%), a small percentage of patients (about 10%) develop moderate or severe pancreatitis. In the past, PEP was often viewed as an unpredictable and unavoidable complication, with no realistic strategy for its avoidance. New data have aided in stratifi cation of patients into PEP risk categories and new measures have been introduced to decrease the risk of PEP. As most ERCPs are performed on an outpatient basis, the majority of patients will not develop PEP and can be discharged. Alternatively, early detection of those patients who will go on to develop PEP can guide decisions regarding hospital admission and aggressive management. In the last decade, great efforts have been addressed toward prevention of this complication. Points of emphasis have included technical measures, pharmacological prophylaxis, and patient selection. This review provides a comprehensive, evidence-based assessment of published data on PEP and current suggestions for its avoidance.

关键词： Endoscopic retrograde cholangiopancreatography Post-ERCP pancreatitis

The Discovery and Development of a Potent Antiviral Drug, Entecavir, for the Treatment of Chronic Hepatitis B

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Journal of Clinical and Translational Hepatology 2013年第1期1卷 51-58页

作者： Hong Tang Jamie Griffin Steven Innaimo Lois lehman-McKeeman Cyril Llamoso Bristol-Myers Squibb Princeton NJ USA Bristol-Myers Squibb Paris France Bristol-Myers Squibb Wallingford NJ USA

Since the first approval of interferon for the treatment of chronic hepatitis B virus (HBV) infection in 1992, six additional antivirals have been developed: pegylated interferon-alfa2a, and the oral antivirals lamivudine, adefovir, telbivudine, entecavir and tenofovir. The availability of animal models for HBV infection and hepatocyte cell culture led to the discovery and development of oral antivirals targeted at HBV polymerase and reverse transcriptase, which inhibit viral replication. The discovery and development of entecavir, the first oral anti-HBV drug with both potent antiviral activity and a high genetic barrier to resistance, took more than 10 years before it was first approved in the USA. Since then, multiple real-life studies have provided data consistent with the findings of the registration trials and the long-term rollover study in terms of efficacy, resistance, and safety. Data from the long-term follow-up of patients enrolled in the registra-tion studies showed that treatment with entecavir can lead to significant improvements in liver histopathology, and recent cohort studies have demonstrated that treatment with entecavir may reduce disease progression and the develop-ment of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B. In addition, real-life studies suggest that entecavir may reduce HCC recurrence and increase survival rates in patients with HBV-related HCC post-surgical resection.

关键词： Entecavir Chronic hepatitis B Hepatitis B Virus HBV DNA Resistance Discovery Development

Options therapy for childhood SLE in the 21st century:How do we get the best outcome?

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Options therapy for childhood SLE in the 21st century:How do...

Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis

The 8th International Congress on SLE

作者： Thomas lehman MD Division of Pediatric Rheumatology Hospital for Special SurgeryNew YorkNYUSA

＜正＞The etiology of SLE remains *** dysregulation with polyclonal B cell activation appears to drive the production of self-reactive *** production of auto-antibodies seems to be the sentinel event in the pathogenes...

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World Journal of Gastroenterology 2016年第16期22卷 4160-4167页

作者： Mohamad Mokadem Lama Noureddine Thomas Howard Lee Mc Henry Stuart Sherman Evan L Fogel James L Watkins Glen A lehman Division of Gastroenterology and Hepatology Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Division of Nephrology and Hypertension Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Community Health Network Indianapolis IN 46219 United States Division of Gastroenterology and Hepatology Indiana University Medical Center Indianapolis IN 46202 United States

AIM: To evaluate pain control in chronic pancreatitis patients who underwent total pancreatectomy with islet cell transplantation or intrathecal narcotic pump ***: We recognized 13 patients who underwent intrathecal narcotic pump(ITNP) infusion and 57 patients who underwent total pancreatectomy with autologous islet cell transplantation(TP + ICT) for chronic pancreatitis(CP) pain control between 1998 and 2008 at Indiana University Hospital. All patients had already failed multiple other modalities for pain control and the decision to proceed with either intervention was made at the discretion of the patients and their treating physicians. All patients were evaluated retrospectively using a questionnaire inquiring about their pain control(using a 0-10 pain scale), daily narcotic dose usage, and hospital admission days for pain control before each intervention and during their last follow-up. RESULTS: All 13 ITNP patients and 30 available TP + ICT patients were evaluated. The mean age was approximately 40 years in both groups. The median duration of pain before intervention was 6 years and 7 years in the ITNP and TP + ICT groups, respectively. The median pain score dropped from 8 to 2.5(on a scale of 0-10) in both groups on their last follow up. The median daily dose of narcotics also decreased from 393 mg equivalent of morphine sulfate to 8 mg in the ITNP group and from 300 mg to 40 mg in the TP + ICT group. No patient had diabetes mellitus(DM) before either procedure whereas 85% of those who underwent pancreatectomy were insulin dependent on their last evaluation despite ICT. CONCLUSION: ITNP and TP + ICT are comparable for pain control in patients with CP however with high incidence of DM among those who underwent TP + ICT. Prospective comparative studies and longer follow up are needed to better define treatment outcomes.

关键词： Chronic pancreatitis Intractable pain Total pancreatectomy Islet cell transplantation Intrathecal narcotic pump infusion

Remarks at the Banquet of Beijing Forum 2006

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Remarks at the Banquet of Beijing Forum 2006

The Development of Cross-Cultural Talent

文明的和谐与共同繁荣：对人类文明方式的思考——北京论坛（2006）

作者： Jeffrey S.lehman the Joint Center for China-U.S.Law & Policy Studies

Good evening I am honored to have been invited to offer a few words of welcome to this extraordinarily distinguished community of participants in the 2006 Beijing *** in its third year,the Beijing Forum has emerged as one of the great international focal points for discussion of the important questions facing our world.I know that I speak for everyone here when I

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国际人才交流 2014年第6期 66-67页

作者： Jeffrey S.lehman NYU Shanghai

I believe that there are many different elements to an outstanding education *** the element that may be the most new,the most different from what constituted an outstanding education in the past,is the need to help t... 详细信息

关键词：跨文化人才人才培养中国教育行业

Modeling Relative Humidity Effects on Power Electronic Performance

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Journal of Energy and Power Engineering 2011年第7期5卷 632-640页

作者： R. Ciprian B. lehman SLAC National Accelerator Laboratory Power Conversion Department Developmental Group Menlo Park CA 94025 USA Department of Electrical and Computer Engineering Northeastern University Boston MA 02115 USA

Variations in the behavior of power supplies caused electrical behavior dependence with environmental conditions. by environmental conditions require accurate characterization of the This paper introduces models to help predict relative humidity （Rtt） and other environmental factors influence on sensitive circuitry in power electronic systems. The resistivity and permittivity of an insulator have been modeled using different water contents i.e. RH, such model also included the mechanical properties of the design. An application example of a high power density, high voltage DC-DC converter is used to verify the results.

关键词： Power electronics insulator resistivity relative humidity insulator permittivity modeling.

The Potential for Excess Correlation (Entanglement) between Flow States in Pairs of Gamers Sharing Specific Circumcerebral Rotating Magnetic Fields

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Journal of Signal and Information Processing 2016年第3期7卷 115-122页

作者： Brendan S. lehman Michael A. Persinger Behavioural Neuroscience Program and Department of Biology Laurentian University Sudbury Canada

Excess correlation between the activity or properties of two particles separated by non-local distances has been demonstrated for photons, shifts in relative proton and hydroxyl ratios in spring water, and the distribution of values from random number generators if both loci shared a specific type of rotational magnetic field. Previous experiments had shown that specific responses from pairs of people who shared circumcerebral magnetic fields with changing angular velocities revealed significant excess correlation. The most significant differences occurred during the component of the field exposure that has previously been associated with “excess correlation”. In the present experiments, we found evidence of excess correlation of performance (serial in-game scores) occurred between pairs (separated by 10 m) of experienced gamers during the relative measures for the central portion of the protocol but was diminished when the “excess correlation” electromagnetic fields were activated, suggesting a similar competing mechanism. The results are consistent with the interpretation that shared video systems and activities may enhance excess correlation of responses. This can be simulated in novice players by experimentally inducing excess correlation through appropriate application of changing, circumcerebral angular velocity magnetic fields that were similar in magnitude to those associated with computer systems and time frames that define human consciousness.

关键词： Excess Correlation Entanglement Digital Games Learning Magnetic Fields Consciousness

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紫花苜蓿对根结线虫病的抗病性评价

中国草地 1992年第1期14卷 46-49页

作者：王根来 W.F.lehman 江苏省农科院粮食作物研究所 210014 美国加利福尼亚大学戴维斯分校

本试验主要探讨了紫花苜蓿根结线虫病(Meloidogyne arenaria Chituood)的发病温度及从接种到病情调查所需的培养时间等,并对9个紫花苜蓿品种进行了抗病性评价。结果表明,***(?)ia在紫花苜蓿上的最适发病温度为29℃,但抗病性鉴定筛选可... 详细信息

本试验主要探讨了紫花苜蓿根结线虫病(Meloidogyne arenaria Chituood)的发病温度及从接种到病情调查所需的培养时间等,并对9个紫花苜蓿品种进行了抗病性评价。结果表明,***(?)ia在紫花苜蓿上的最适发病温度为29℃,但抗病性鉴定筛选可在25～33℃之间进行。线虫接种到病情调查的最适培养期为80天。抗病性鉴定中发现源于沙特阿拉伯的Hasawi NE—NAF—4和Hasawi SA19两品种对***表现高抗,其抗病植株所占比例分别达80.7%和81.8%,可作为今后紫花苜蓿抗***育种的抗源。美国品种UC Cibola、UC297和UC 298亦表现了良好的抗病性,抗病植株分别占鉴定苗数的58.9%、60.3%和65.8%。原产埃及的两个品种EgyptianIV和Egyptian II感病最重,它们的感病植株所占比例分别高达89.5%和93.3%。

关键词：紫花苜蓿根结线虫抗病性