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Comparison of renal safety of tenofovir and entecavir in patients with chronic hepatitis B: Systematic review with meta-analysis

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World Journal of Gastroenterology 2019年第23期25卷 2961-2972页

作者： Hyo-Young lee Hyunwoo Oh Chan-hyuk Park Yee-Hui Yeo Mindie H Nguyen Dae-Won jun Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri 11923South Korea Division of Gastroenterology and Hepatology Stanford University Medical CenterStanford UniversityStanford 94305CAUnited States

BACKGROUND Recently, the American Association for the Study of Liver Disease suggested no preference between tenofovir(TDF) and entecavir(ETV) regarding potential long-term risks of renal complications. Over the years, renal safety has become a critical concern in nucleos(t)ide analog-treated patients due to the long-term use of these drugs. However, existing studies do not show significant differences in renal dysfunction between these two drugs. Further, there is a paucity of studies comparing the long-term renal effects of TDF and *** To investigate the effects of TDF and ETV on renal function, we performed systematic review and *** Two investigators independently searched the Cochrane Library, MEDLINE, and Embase databases for randomized controlled trials and nonrandomized studies(NRSs) using the keywords 'CHB', 'Tenofovir', and 'Entecavir', and additional references were obtained from the bibliographies of relevant articles published through December 2017. The quality of each study was assessed using the Newcastle-Ottawa scale and the Grading of Recommendations Assessment,Development and Evaluation criteria. The primary outcome was the change in serum creatinine level in the TDF and ETV groups at baseline, 6 mo, 12 mo and24 *** NRSs comprising 2263 participants met the inclusion criteria. Changes in creatinine levels were higher in the TDF group than in the ETV group at 6 mo[mean difference(MD) = 0.03 mg/dL;95%CI: 0.02-0.04;I2 = 0%], 12 mo(MD =0.05 mg/dL;95%CI: 0.02-0.08;I2 = 78%), and 24 mo(MD = 0.07 mg/dL;95%CI:0.01-0.13;I2 = 93%). The change in estimated glomerular filtration rate(eGFR) was significantly higher in the TDF group than in the ETV group at 6 mo[standardized mean difference(SMD),-0.22;95%Cl:-0.36--0.08;I2 = 0%], 12 mo(SMD =-0.24;95%Cl:-0.43--0.05;I2 = 50%), and 24 mo(-0.35;95%Cl:-0.61--0.09;I2= 67%).CONCLUSION TDF statistically significantly increased serum creatinine levels and decreased the eGFR in 6-24 mo compa

关键词： Hepatitis B Chronic Tenofovir Entecavir Safety Review Systematic Meta-analysis

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Spontaneous rupture of ocular surface squamous neoplasia–a case report

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 357-359页

作者： jun hyuk Son Su-Ho Lim Department of Ophthalmology Yeungnam University College of MedicineDaegu 42415Republic of Korea Department of Ophthalmology Daegu Veterans Health Service Medical CenterDaegu 42835Republic of Korea

Dear Editor,Ocular surface squamous neoplasia(OSSN)typically occurs adjacent to limbus or in inter-palpebral fissures,over a preexisting pinguecula[1].The term OSSN includes mild dysplasia at one end of its disease spectrum and invasive squamous cell carcinoma at the other and is the most common non-pigmented malignancy of the ocular surface[2,3].

关键词： ocular squamous rupture

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Nanoscale Materials and Deformable Device Designs for Bioinspired and Biointegrated Electronics

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Accounts of Materials Research 2021年第4期2卷 266-281页

作者： Woongchan lee Huiwon Yun jun-Kyul Song Sung-hyuk Sunwoo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea

Electronic devices whose structural and functional features are inspired by living creatures have unique performance and unconventional features that are not found in conventional electronic *** addition to such bioinspired electronics,with the rise of new fields such as personalized healthcare,mobile electronics,and big-data analysis,biointegrated electronic devices that can collect biomedical information from the human body through various biosensors and deliver appropriate therapeutic feedback stimulations in real time on the spot where immediate treatment is needed have become *** body parts and internal organs of living creatures,including humans,have curvilinear shapes and comprise mechanically soft tissues,such bioinspired and biointegrated electronic devices are required to match the soft and deformable features of biological *** soft and deformable features of electronic devices can be achieved by employing flexible and stretchable materials and unconventional device design *** soft materials and deformable device designs dissipate stress originating from mechanical deformation of the device and thus retard crack generation and/or propagation in the ***,technologies for nanoscale materials have shown a significant level of progress on their material performance and processing *** nanoscale dimension of the electronic materials could achieve extremely small flexural rigidity in comparison to the bulk state of the same ***,techniques to form a well-percolated network of nanomaterials in the elastomeric matrix and to build a pathway for the facile electron and hole transport inside the polymer have induced dramatic performance advances of soft electronic materials,which led to nanocomposites that can accomplish both high mechanical deformability and high electrical performance at the same *** addition,deformable device designs such as buckled structures and serpentine des

关键词： buckling rigidity electronics

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Roles of humidity and heat treatment temperatures on YBa_2Cu_3O_(7-x) coated conductors by trifluoroacetic acid-metal organic deposition process

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中国有色金属学会会刊：英文版 2009年第4期19卷 956-960页

作者： Seok-Hern JANG jun-Hyung LIM Chang-Min lee Eui-Cheol PARK Soo-Min HWANG jun-hyuk CHOI Jong-Hyun SHIM Jin-Hyun PARK Won KIM Jinho JOO School of Advanced Materials Science and Engineering Sungkyunkwan University

YBa2Cu3O7-x(YBCO) films were fabricated on an LAO substrate using the trifluoroacetic acid-metal organic deposition(TFA-MOD) method and the effects of the humidity and heat treatment temperatures on the microstructure,degree of texture and critical properties of the films were *** order to understand the combined effects of the humidity and the calcining and firing temperatures on critical properties,heat-treatment was performed at various temperatures with the other processing variables *** films were calcined at 400-430 ℃ and fired at 750-800 ℃ in a 0-12.1% humidified Ar-O2 *** texture was determined by pole-figure *** amount of the BaF2 phase was effectively reduced and a sharp and strong biaxial texture was formed under a humidified atmosphere,which led to increased critical *** addition,the microstructure varied significantly with firing temperature but changed little with calcining *** highest IC of 40 A/cm-width,which corresponds to JC value of 1.8 MA/cm2,was obtained for the films fired at 775 ℃(in 12.1% humidity) after calcining at 400-430 ℃.It is likely that the highest IC value is due to the formation of a more pure YBCO phase,c-axis grains,and a denser microstructure.

关键词： YBa2Cu3O7 热处理温度三氟乙酸沉积过程湿度涂层导体有机金属微观结构变化

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Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages

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Journal of Integrative Medicine 2017年第4期15卷 326-336页

作者： Byung hyuk Han Yun jung lee jung Joo Yoon Eun Sik Choi Seung Namgung Xian jun Jin Da Hye Jeong Dae Gill Kang Ho Sub lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Body-fluid Research Center Wonkwang University

OBJECTIVE： This study aimed to evaluate whether Hwangryunhaedoktang （HHT）, a herbal compound, has an inhibitory effect on lipopolysaccharide （LPS）-induced inflammation in RAW264.7 macrophages. METHODS： The effects of HHT were evaluated by confirming nitric oxide （NO） production and expression of inducible NO synthase （iNOS） and mitogen-activated protein kinases （MAPKs） in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB （NF-κB）. The secretion and expression of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were determined via enzyme-linked immunosorbent assay and Western blot analyses. RESULTS： HHT suppressed LPS-induced NO production and expression of iNOS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT. CONCLUSION： HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation.

关键词： medicine, Chinese traditional lipopolysaccharide nitric oxide nuclear factor-κB mitogen-activatedprotein kinases tumor necrosis factor-a inflammation

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Direct Synthesis of Molybdenum Phosphide Nanorods on Silicon Using Graphene at the Heterointerface for Efficient Photoelectrochemical Water Reduction

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Nano-Micro Letters 2021年第5期13卷 135-150页

作者： Sang Eon jun Seokhoon Choi Shinyoung Choi Tae Hyung lee Changyeon Kim Jin Wook Yang Woon‑Oh Choe In‑hyuk Im Cheol‑Joo Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea

Transition metal phosphides(TMPs)and transition metal dichalcogenides(TMDs)have been widely investigated as photoelectrochemical(PEC)catalysts for hydrogen evolution reaction(HER).Using high-temperature processes to get crystallized compounds with large-area uniformity,it is still challenging to directly synthesize these catalysts on silicon photocathodes due to chemical incompatibility at the ***,a graphene interlayer is applied between p-Si and MoP nanorods to enable fully engineered interfaces without forming a metallic secondary compound that absorbs a parasitic light and provides an inefficient electron path for hydrogen ***,the graphene facilitates the photogenerated electrons to rapidly transfer by creating Mo-O-C covalent bondings and energetically favorable band *** a bridging role of graphene,numerous active sites and anti-reflectance of MoP nanorods lead to significantly improved PEC-HER performance with a high photocurrent density of 21.8 mA cm−2 at 0 V versus RHE and high ***,low dependence on pH and temperature is observed with MoP nanorods incorporated photocathodes,which is desirable for practical use as a part of PEC *** results indicate that the direct synthesis of TMPs and TMDs enabled by graphene interlayer is a new promising way to fabricate Si-based photocathodes with high-quality interfaces and superior HER performance.

关键词： Photoelectrochemical water splitting Silicon Molybdenum phosphide Hydrogen evolution Graphene

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Effects of Al addition on microstructure and mechanical properties of extruded Mg-3Bi alloy

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Journal of Magnesium and Alloys 2022年第7期10卷 1887-1898页

作者： Sang-Cheol Jin Jae Won Cha jun Ho Bae Hui Yu Sung hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

Effects of Al addition to a Mg±Bi binary alloy on its microstructural characteristics and tensile properties after extrusion are investigated via extrusion of Mg-3Bi±x Al(x=0,1,and 2 wt%)billets and analysis of the extruded *** Al addition negligibly affects the second-phase particles of the extruded alloy;however,an increase in the Al content causes significant decreases in the average grain size and maximum texture intensity of the extruded material owing to an increase in the area fraction of dynamically recrystallized(DRXed)*** Al addition improves the strength of the extruded alloy;this improvement is attributed to the enhanced grain-boundary hardening and solid-solution hardening effects induced by grain refinement and Al solute atoms,*** the Al content increases from 0 wt%to 1 wt%and 2 wt%,the tensile elongation increases substantially from 2.8%to 9.4%and 16.9%,*** reduction in the number and size of un DRXed grains with increasing Al content suppresses the formation and coalescence of cracks in the un DRXed grains during tension,which results in a significant improvement in the tensile ductility of the extruded *** tensile deformation,large undesirable twins that act as crack initiation sites are locally formed in the un DRXed grains of the Mg-3Bi alloy,whereas relatively smaller twins are uniformly formed in both the DRXed and the un DRXed grains of the Mg-3Bi-2Al ***,the extruded Mg-3Bi-2Al alloy has a substantially higher tensile yield strength±elongation product(2924 MPa%)than the extruded Al-free B3 alloy(381 MPa%).

关键词： Mg-Bi-Al alloy Extrusion Microstructure Strength Ductility

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Comparative study of extrudability, microstructure, and mechanical properties of AZ80 and BA53 alloys

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Journal of Magnesium and Alloys 2023年第1期11卷 249-258页

作者： Sang-Cheol Jin Jae Won Cha Jongbin Go jun Ho Bae Sung hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The extrudability,microstructural characteristics,and tensile properties of the Mg–5Bi–3Al(BA53)alloy are investigated herein by comparing them with those of a commercial Mg–8Al–0.5 Zn(AZ80)*** AZ80 is extruded at 400℃,severe hot cracking occurs at exit speeds of 4.5 m/min or *** contrast,BA53 is successfully extruded without any surface cracking at 400℃ and at high exit speeds of 21–40 m/*** extruded at 3 m/min(AZ80–3)and 40 m/min(BA53–40),both AZ80 and BA53 exhibited completely recrystallized microstructures with abasal ***,BA53–40 has a coarser grain structure owing to grain growth promoted by the high temperature in the deformation ***80–3 contains a continuous network of Mg_(17)Al_(12) particles along the grain boundaries,which form via static precipitation during natural air-cooling after the material exits the extrusion ***53–40 contains coarse Mg_(3)Bi_(2) particles aligned parallel to the extrusion direction along with numerous uniformly distributed fine Mg_(3)Bi_(2) ***80–3 has higher tensile strength than BA53–40 because the relatively finer grains and larger number of solute atoms in AZ80–3 result in stronger grain-boundary and solid-solution hardening effects,*** BA53 is extruded at a high temperature and extrusion speed of 400℃ and 40 m/min,respectively,the extruded material has a high tensile yield strength of 188 *** can be primarily attributed to the large particle hardening effect resulting from the numerous fine Mg_(3)Bi_(2) particles.

关键词： Mg-Bi-Al alloy Extrusion Hot cracking Second phase Tensile properties

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Spatio-temporal change in forest cover and carbon storage considering actual and potential forest cover in South Korea

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Science China(Life Sciences) 2015年第7期58卷 713-723页

作者： NAM Kijun lee Woo-Kyun KIM Moonil KWAK Doo-Ahn BYUN Woo-hyuk YU Hangnan KWAK Hanbin KWON Taesung SUNG Joohan CHUNG Dong-jun lee Seung-Ho Division of Environmental Science and Ecological Engineering Korea University GIS/RS Center for Environmental Resources Korea University Division of Forest Ecology Korea Forest Research Institute National Forestry Cooperative Federation Division of Forest Economics & Management Korea Forest Research Institute

This study analyzes change in carbon storage by applying forest growth models and final cutting age to actual and potential forest cover for six major tree species in South Korea. Using National Forest Inventory data, the growth models were developed to estimate mean diameter at breast height, tree height, and number of trees for Pinus densiflora, Pinus koraiensis, Pinus rigida, Larix kaernpferi, Castanea crenata and Quercus spp. stands. We assumed that actual forest cover in a forest type map will change into potential forest covers according to the Hydrological and Thermal Analogy Groups model. When actual forest cover reaches the final cutting age, forest volume and carbon storage are estimated by changed forest cover and its growth model. Forest volume between 2010 and 2110 would increase from 126.73 to 157.33 m^3 hm^-2. Our results also show that forest cover, volume, and carbon storage could abruptly change by 2060. This is attributed to the fact that most forests are presumed to reach final cutting age. To avoid such dramatic change, a regeneration and yield control scheme should be prepared and implemented in a way that ensures balance in forest practice and yield.

关键词： climate change final cutting age carbon storage national forestry inventory forest growth model

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Simplified fistula dilation technique and modified stent deployment maneuver for EUS-guided hepaticogastrostomy

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World Journal of Gastroenterology 2014年第17期20卷 5051-5059页

作者： Woo Hyun Paik Do Hyun Park jun-Ho Choi Joon hyuk Choi Sang Soo lee Dong Wan Seo Sung Koo lee Myung-Hwan Kim jung Bok lee Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea Department of Internal Medicine Inje University Ilsan Paik HospitalKoyang 411-706South Korea Department of Clinical Epidemiology and Biostatics University of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

AIM: To evaluate the success rates, procedural time and adverse event rates of the modified methods in endoscopic ultrasonography-guided hepaticogastrostomy (EUS-HGS).

关键词： Endoscopic ultrasonography Biliary drainage Hepaticogastrostomy Treatment outcome Adverse event

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