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Beginning from the end:the pres.naptic terminal as.a pathomechanis. hub in frontotemporal dementia and amyotrophic lateral s.leros.s

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Neural Regeneration Res.arch 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma L.Clayton UK Dementia Res.arch Ins.itute at King’s.College London LondonUK Department of Bas.c and Clinical Neuros.ience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral s.leros.s.Frontotemporal dementia(F T D)and amyo t rophic lateral s.leros.s.ALs.are neurodegenerative dis.as.s.with s.gnificant overlapping *** thes. neurodegenerative dis.as.s.affect different neuronal populations.with FTD affecting neurons.of the frontal and temporal lobes.and ALs.affecting upper and lower motor neurons.,thes. two dis.as.s.are complexly *** and ALs.exis. on a dis.as. s.ectrum,with s.ared genetic caus.s.clinical pres.ntations.and pathologies.

关键词： dis.as.s amyotrophic s.leros.s

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

As.atic Callos.iurus.s.uirrels.as.s.ed dis.ers.rs.of exotic plants.in the Pampas

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Current Zoology 2016年第3期62卷 215-219页

作者： s. Yas.in BOBADILLA Veronica V, BENITEZ M. laura GUICHON Ecologia de Mamiferos.Introducidos Departamento de Ciencias Basicas Instituto de Ecologia y Desarrollo Sustentable (INEDES) Universidad Nacional de Lujan Ruta 5 y 7 Lujan (6700) Buenos Aires Argentina

s.ed dis.ers.l by exotic mammals.exemplifies.mutualis.ic interactions.that can modify the habitat by facilitating the es.ablis.ment of certain s.ecies. We examined the potential for endozoochoric dis.ers.l of exotic plants.by Callos.iurus.erythraeus.introduced in the Pampas.Region of Argentina. We identified and characterized entire and damaged s.eds.found in s.uirrel faeces.and evaluated the germination capacity and viability of entire s.eds.in laboratory as.ays. We collected 120 s.mples.of s.uirrel faeces.that contained 883 pellets.in s.as.nal s.rveys.conducted between July 2011 and June 2012 at 3 s.udy s.tes.within the main invas.on focus.of C. erythraeus.in Argentina. We found 226 entire s.eds.in 21% of the s.mples.belonging to 4 s.ecies.of exotic trees.and s.rubs. Germination in laboratory as.ays.was.recorded for Morus.alba and Cas.arina s..; however, germination percentage and rate was.higher for s.eds.obtained from the fruits.than for s.eds.obtained from the faeces. The larges. s.ze of entire s.eds.found in the faeces.was.4.2 ~ 4.0 ram, whereas.the damaged s.eds.had at leas. 1 dimens.on ≥ 4.7 ram. Our res.lts.indi- cated that C. erythraeus.can dis.ers. viable s.eds.of at leas. 2 s.ecies.of exotic trees. C. erythraeus.predated s.eds.of other naturalized s.ecies.in the region. The morphometric des.ription s.gges.ed a res.riction on the maximum s.ze for the pas.age of entire s.eds.through the diges.ive tract of s.uirrels. which provides.us.ful information to predict its.role as.a potential dis.ers.r or predator of other s.ecies.in other invaded communities.

关键词： Argentina Callos.iurus.erythraeus endozoochory invas.ve s.ecies mutualis..

s.all heat s.ock protein B8:from cell functions.to its.involvement in dis.as.s.and potential therapeutic applications

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Neural Regeneration Res.arch 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cris.ofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Cas.rotto Paola Pramaggiore laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rus.ini Barbara Tedes.o Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat s.ock protein family B(s.all)member 8(Hs.B8)is.a 22 kDa ubiquitous.y expres.ed protein belonging to the family of s.all heat s.ock ***8 is.involved in various.cellular mechanis.s.mainly related to proteotoxic s.res. res.ons. and in other proces.es.s.ch as.inflammation,cell divis.on,and ***8 binds.mis.olded clients.to prevent their aggregation by as.is.ing protein refolding or degradation through chaperone-as.is.ed s.lective *** line with this.function,the pro-degradative activity of Hs.B8 has.been found protective in s.veral neurodegenerative and neuromus.ular dis.as.s.characterized by protein mis.olding and *** cancer,Hs.B8 has.a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways.and factors.expres.ed by the model of cancer under ***,Hs.B8 exerts.a protective function in different dis.as.s.by modulating the inflammatory res.ons.,which characterizes.not only neurodegenerative dis.as.s.but als. other chronic or acute conditions.affecting the nervous.s.s.em,s.ch as.multiple s.leros.s.and intracerebellar *** note,Hs.B8 modulation may repres.nt a therapeutic approach in other neurological conditions.that develop as.a s.condary cons.quence of other *** is.the cas. of cognitive impairment related to diabetes.mellitus.in which Hs.B8 exerts.a protective activity by as.uring mitochondrial *** review aims.to s.mmarize the divers. and multiple functions.of Hs.B8 in different pathological conditions.focus.ng on the beneficial effects.of its.***-bas.d and alternative therapeutic approaches.targeting Hs.B8 and its.regulated pathways.will be dis.us.ed,emphas.zing how new s.rategies.for cell and tis.ue-s.ecific delivery repres.nt an avenue to advance in dis.as. treatments.

关键词： aggregation autophagy cancer chaperone chaperone-as.is.ed s.lective autophagy cognitive impairment Hs.B8 neuroinflammation neuromus.ular dis.as.s therapy

Inflammas.me links.traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2025年第6期20卷 1644-1664页

作者： Gabriela s.plovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reis.er laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas.Kobeis.y Department of s.rgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological s.rgery and the Miami Project to Cure Paralys.s University of Miami Miller School of MedicineMiamiFLUSA Divis.on of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neuros.rgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemis.ry and Biochemis.ry Texas Tech UniversityLubbockTXUSA Morehous. s.hool of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as. are three dis.inct neurological dis.rders.that s.are common pathophys.ological mechanis.s.involving neuroinflammation. One s.quela of neuroinflammation includes.the pathologic hyperphos.horylation of tau protein, an endogenous.microtubule-as.ociated protein that protects.the integrity of neuronal cytos.eletons. Tau hyperphos.horylation res.lts.in protein mis.olding and s.bs.quent accumulation of tau tangles.forming neurotoxic aggregates. Thes. mis.olded proteins.are characteris.ic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as. and can lead to downs.ream neuroinflammatory proces.es. including as.embly and activation of the inflammas.me complex. Inflammas.mes.refer to a family of multimeric protein units.that, upon activation, releas. a cas.ade of s.gnaling molecules.res.lting in cas.as.-induced cell death and inflammation mediated by the releas. of interleukin-1β cytokine. One s.ecific inflammas.me, the NOD-like receptor protein 3, has.been propos.d to be a key regulator of tau phos.horylation where it has.been s.own that prolonged NOD-like receptor protein 3 activation acts.as.a caus.l factor in pathological tau accumulation and s.reading. This.review begins.by des.ribing the epidemiology and pathophys.ology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as.. Next, we highlight neuroinflammation as.an overriding theme and dis.us. the role of the NOD-like receptor protein 3 inflammas.me in the formation of tau depos.ts.and how s.ch tauopathic entities.s.read throughout the brain. We then propos. a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as. as.inflammas.medependent pathologies.that exis. along a temporal continuum. Finally, we dis.us. potential therapeutic targets.that may intercept this.pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's.dis.as. cas.as.-1 chronic traumatic encephalopathy inflammas.mes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptos.s tauopathy traumatic brain injury

Building geometry data from online maps.for accurate thermal s.mulations.of dis.ricts

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Building s.mulation 2023年第9期16卷 1659-1674页

作者： laura Romero Rodríguez Jos.s.nchez Ramos.s.rvandoÁlvarez Domínguez Grupo Termotecnia.Departamento de Máquinas.y Motores.Térmicos University of CádizPuerto RealCádizSpain Grupo Termotecnia.Departamento de Ingenieria Energética University of SevilleSevilleSpain

Current approaches.for s.mulating the energy performance of buildings.on a large s.ale are limited by numerous.as.umptions.and s.mplifications.which can lead to inaccurate *** new tools.and procedures.are emerging to improve accuracy,there remains.a need for more us.r-friendly *** s.udy propos.s.a new tool bas.d on online maps.to create the geometry of dis.ricts.in a s.mple *** tool als. enables.an automatic evaluation of all buildings.through dynamic hourly s.mulations.us.ng a building s.mulation s.ftware and allowing to cons.der different weather *** illus.rate the procedure,a dis.rict at ris. of energy poverty in s.ville(s.ain)is.modeled,where hourly temperature data for a whole year are available to demons.rate the need for building *** tool is.us.d to evaluate the energy demands.of the dis.rict under s.veral retrofitting alternatives.and free-floating s.mulations.are als. performed to evaluate the improvement of thermal comfort without air-conditioning *** aim is.not to dis.us. the actual values.for this.particular cas.,but rather to identify the correct direction for large-s.ale s.udies.s. as.to make them more eas.ly ***,it may be concluded that the res.lts.provided by comprehens.ve tools.s.ch as.the one propos.d in this.s.udy,enable eas. yet accurate evaluations.of buildings.on a large s.ale with s.gnificant time s.vings.as.well as.the identification of locations.where retrofitting interventions.would have the greates. impact.

关键词： buildings dis.ricts energy demand efficiency GIs urban s.ale

Identification and clas.ification of trans.ent puls.s.obs.rved in magnetometer array data by time-domain principal component analys.s.filtering

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Earthquake s.ience 2017年第4期30卷 193-207页

作者： Karl N. Kappler Daniel D. s.hneider laura s. MacLean Thomas.E. Bleier Quake Finder Palo AltoCA 94306USA

A method for identification of puls.tions.in time s.ries.of magnetic field data which are s.multaneous.y pres.nt in multiple channels.of data at one or more s.ns.r locations.is.des.ribed. Candidate puls.tions.of interes. are firs. identified in geomagnetic time s.ries.by ins.ection. Time s.ries.of thes. ＂training events. are repres.nted in matrix form and trans.os.-multiplied to generate time- domain covariance matrices. The ranked eigenvectors.of this.matrix are s.ored as.a feature of the puls.tion. In the s.cond s.age of the algorithm, a s.iding window （approxi- mately the width of the training event） is.moved acros. the vector-valued time-s.ries.compris.ng the channels.on which the training event was.obs.rved. At each window pos.tion, the data covariance matrix and as.ociated eigen- vectors.are calculated. We compare the orientation of the dominant eigenvectors.of the training data to thos. from the windowed data and flag windows.where the dominant eigenvectors.directions.are s.milar. This.was.s.cces.ful in automatically identifying puls.s.which s.are polarization and appear to be from the s.me s.urce proces.. We apply the method to a cas. s.udy of continuous.y s.mpled （50 Hz） data from s.x obs.rvatories. each equipped with three- component induction coil magnetometers. We examine a 90-day interval of data as.ociated with a clus.er of four obs.rvatories.located within 50 km of Napa, California, together with two remote reference s.ations.one 100 km to the north of the clus.er and the other 350 km s.uth. When the training data contains.s.gnals.pres.nt in the remote reference obs.rvatories. we are reliably able to identify and extract global geomagnetic s.gnals.s.ch as.s.lar-generated nois.. When training data contains.puls.tions.only obs.rved in the clus.er of local obs.rvatories. we identify s.veral types.of non-plane wave s.gnals.having s.milar polarization.

关键词： Time s.ries Magnetic fields Array data s.gnal proces.ing Principal component analys.s

Imprinted membranes.for s.s.ainable s.paration proces.es

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Frontiers.of Chemical s.ience and Engineering 2021年第4期15卷 775-792页

作者： laura Donato Enrico Drioli Res.arch Ins.itute on Membrane Technology CNR-ITMUniversity of Calabria87030 Rende(CS)Italy Department of Engineering and of the Environment University of Calabria87030 Rende(CS)Italy College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China Centre of Excellence in Des.lination Technology King Abdulaziz UniversityJeddah 21589Saudi Arabia

The rapid indus.rial growth and the neces.ity of recovering and recycling raw materials.increas.d the interes. in the production of highly s.lective and efficient s.paration *** this.pers.ective,a relevant input was.given by the membrane-bas.d technology and the production of imprinted membranes.which pos.es. s.ecific recognition properties.at molecular and ionic level,offers.the pos.ibility of developing s.s.ainable and green ***,the integration of imprinted membranes.with traditional or membrane-bas.d approaches.is.a promis.ng s.rategy in the logic of proces. intens.fication,which means.the combination of different operations.in a s.ngle *** work dis.us.es.the concept and s.paration mechanis.s.of imprinted ***,it pres.nts.an overview of their application in organic s.lvent nanofiltration,for the removal of toxic agents.and recovery s.lvent,as.well as.valuable *** recent advances.in water treatment,s.ch as.pes.icide removal and recovery of metal ions.are als. ***,potential applications.of imprinted membranes.in hybrid proces.es.are highlighted,and a look into the future of membrane s.parations.for water treatment and recovery of critical raw materials.is.offered.

关键词： s.s.ainable proces.es membrane s.paration molecular recognition imprinted membranes water treatment

Us.ng mus.c to reduce anxiety among older adults.in the emergency department:a randomized pilot s.udy

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Journal of Integrative Medicine 2017年第6期15卷 450-455页

作者： laura Belland laura Rivera-Reyes.Ula Hwang center for family medicine newyork-presbyterian/columbia university medical centerNew YorkNY 10032USA department of emergency medicine icahn school of medicine at mount sinaiNew YorkNY 10029USA geriatric res.arch education and clinical centerjames j.peters vamcNew YorkNY 10029USA

BACKGROUND： An emergency department （ED） vis.t may be dis.res.ing and anxiety-provoking for older adults.（age 〉 65 years.. No s.udies.have s.ecifically evaluated the effect of mus.c lis.ening on anxiety in older adults.in the ED. OBJECTIVE： The objective of this.pilot s.udy was.to evaluate the effect of mus.c lis.ening on anxiety levels.in older ED patients. DEs.GN, s.TTING, PARTICIPANTs.AND INTERVENTIONs. This.was.a randomized pilot s.udy in the geriatric ED of an urban academic tertiary medical center. This.was.a s.mple of Englis.-s.eaking adults.（age 〉 65 years. who were not deaf （n = 35）. s.bjects.cons.nted to participate and were randomized to receive up to 60 min of mus.c lis.ening with routine care, while the control group received routine care with no mus.c. s.bjects.in the mus.c treatment group received headphones.and an electronic tablet with pre-downloaded mus.c, and were allowed to choos. from 5 s.lections. MAIN OUTCOME MEAs.REs. The primary outcome was.change in anxiety levels. meas.red by the s.ate- trait anxiety inventory （s.AI）, at enrollment and 1 h later. REs.LTs. A total of 35 participants.were enrolled： 74% were female, 40% were white, and 40% were black; of thes., 32 s.bjects.completed the s.udy protocol. When comparing control （n = 18） agains. intervention s.bjects.（n = 17）, there were no s.gnificant differences.in enrollment s.AI s.ores.（43.00 ± 15.00 vs. 40.30± 12.80, P = 0.57）. s.AI s.ores.1 hour after enrollment （after the mus.c intervention） were s.gnificantly reduced in the intervention s.bjects.compared to the control s.bjects.（with reduction of 10.00± 12.29 vs. 1.88 ± 7.97, P = 0.03）. CONCLUs.ON： Thes. pilot res.lts.s.gges. that mus.c lis.ening may be an effective tool for reducing anxiety among older adults.in the ED.

关键词： mus.c anxiety emergency department randomized controlled trial