检索结果-南通市图书馆

Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第8期19卷 944-956页

作者： Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung lau Yinping Liu Wenwei Tu Department of Pediatrics and Adolescent Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARPR China The First Affliated Hospital Faculty of Medical ScienceJinan UniversityGuangzhou 510632 GuangdongPR China Zhuhai Precision Medical Center Zhuhai People's Hospital(Zhuhai Hospital Affliated with Jinan University)Jinan UniversityZhuhai 519000 GuangdongPR China The Biomedical Translational Research Institute Jinan UniversityGuangzhou 510632 GuangdongPR China GuangDong 999 Brain Hospital Guangzhou CityGuangdong ProvincePR China Department of Endocrinology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180PR China Computational and Systems Biology Interdepartmental Program University of CaliforniaLos AngelesLos AngelesCA 90095USA

Patients with type 2 diabetes mellitus(T2DM)have an increased risk of *** effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain ***,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in ***,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T *** results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance.

关键词： γδT cells Glucose metabolism Tumor surveillance Lactate AMPK T2DM

无症状大脑中动脉狭窄患者脑白质改变进展的危险因素

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国神经精神疾病杂志 2010年第7期36卷 389-392页

作者：范玉华孙健莫仲棠黄家星曾进胜中山大学附属第一医院神经科ICU 广州510080 中山大学肿瘤防治中心华南肿瘤学重点实验室香港中文大学内科及药物治疗学系

目的对一项随机研究进行分析,探讨无症状大脑中动脉狭窄患者脑白质改变(white matter changes,WMC)发生和进展的危险因素。方法对无中风症状,但存在动脉硬化危险因素的患者进行磁共振检查,入选大脑中动脉(middle cerebral artery,MCA)... 详细信息

目的对一项随机研究进行分析,探讨无症状大脑中动脉狭窄患者脑白质改变(white matter changes,WMC)发生和进展的危险因素。方法对无中风症状,但存在动脉硬化危险因素的患者进行磁共振检查,入选大脑中动脉(middle cerebral artery,MCA)狭窄的患者。记录临床特点和基础血生化指标,随访2年,随访结束时再次行磁共振检查。WMC采用定量分析,体积增加超过所有患者WMC体积增加的平均值被定义为有进展。Logistic回归分析确定WMC发生和进展的独立危险因素。结果 220例无症状MCA狭窄者患中,69例存在WMC,Logistic回归分析显示年龄(OR=1.096,P<0.001)和高血压(OR=2.370,P=0.024)是WMC发生的独立危险因素。在进入研究时,69例的WMC平均体积为4.23cm3,经过两年时间增加至5.49cm3,有6例未能完成随访。随访结束时发现63例中24例(38.1%)WMC有进展。Logistic回归分析发现仅有基础WMC体积是预测WMC进展的独立危险因素(OR=1.329,P=0.003)。结论年龄和高血压是WMC发生的独立预测因素,而对于WMC的进展则是基础WMC体积更有预测意义,也就是说发现时WMC越严重,进展的机会越多,尽早发现WMC可能对于预防进展更有意义。

关键词：脑白质改变磁共振进展

The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2015年第1期4卷 371-381页

作者： Juan Yang Mark Jit kathy S.Leung Ya-ming Zheng Lu-zhao Feng Li-ping Wang Eric H.Y.lau Joseph T.Wu Hong-jie Yu Key Laboratory of Surveillance and Early-warning on Infectious Disease Division of Infectious DiseaseChinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijing 102206China Modelling and Economics Unit of Public Health in England LondonUK Department of Infectious Disease Epidemiology London School of Hygiene and Tropical MedicineLondonUK WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong Kong2/F North WingPatrick Manson Building7 Sassoon RoadPok Fu LamHong Kong Special Administrative RegionChina

Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy ***:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal *** participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in ***-reported costs from the survey were validated by a review of hospital accounts for a small sample of the ***:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying *** average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),*** medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,*** influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 ***$146;inpatients:US$1,800 ***$1,189).In the baseline ana

关键词： Influenza Cost analysis China

Blastocyst-like embryo surrogates from stem cells in implantation models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2022年第4期6卷 225-233页

作者： Siyu Tian Hanzhang Ruan William Shu-Biu Yeung Yin lau Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterThe University of Hong Kong-Shenzhen HospitalShenzhen 518053China Centre for Translational Stem Cell Biology Building 17WThe Hong Kong Science and Technology ParkHong Kong 999077China

Successful embryo implantation requires highly coordinated maternal-embryo *** failure is a major factor contributing to ***,the mechanism underlying implantation failure remains *** improved understanding of the early implantation process not only improves the success rate of assisted reproductive treatments but also helps in studying the pathophysiology of reproductive *** to ethical concerns,in vivo studies of human embryo implantation are not ***,the results obtained from animal models cannot be directly applied to *** the years,in vitro implantation models have been developed to investigate implantation *** this review,we discuss the use of different models for generating embryo-like surrogates to study early embryo development and implantation in vitro,with a specific focus on stem cell-derived blastocyst-like embryo *** is no definitive evidence that the recently established embryo-like models re-capitulate all developmental events of human embryos during the peri-implantation ***,stem cell-derived embryo surrogates are the most valuable tools for studying the mechanisms of early cell lineage differentiation and developmental failures during implantation.

关键词： implantation models Stem cells Embryo surrogates Endometrium Trophoblastic spheroid Blastoids

在线全文

学校读者我要写书评

暂无评论

澳门特区免费幼儿教育政策研究

幼儿教育·教育科学 2013年第10期 5-9页

作者：李辉刘懿乐梁成安香港大学教育学院澳门大学教育学院

澳门特区自2007～2008学年开始实施15年免费教育,即9年义务教育、3年高中教育和3年学前教育免费.研究者运用网络调查及访谈法,对澳门特区免费幼儿教育政策进行研究,结果发现:(1)免费幼儿教育政策只适用于6家公办幼儿园和42家加入免费教... 详细信息

澳门特区自2007～2008学年开始实施15年免费教育,即9年义务教育、3年高中教育和3年学前教育免费.研究者运用网络调查及访谈法,对澳门特区免费幼儿教育政策进行研究,结果发现:(1)免费幼儿教育政策只适用于6家公办幼儿园和42家加入免费教育学校系统的私立幼儿园.(2)7家未加入免费教育学校系统的私立幼儿园需缴学费、补充服务费和选择性服务费,但可获政府发放的学费津贴和书簿费.家长很满意这一政策,并表示愿意继续送孩子上收费的私立幼儿园.(3)受访园(校)长、家长及教师对澳门的免费幼儿教育政策都很满意,教师特别满意政府推出的幼儿园教师津贴.(4)免费幼儿教育政策对私立园所的影响有所不同:有些私立园所为了生存而选择加入免费教育学校系统,有些私立园所则为了校政自主而选择不加入免费教育学校系统.客观上,高收费门槛令不同阶层家庭的幼儿自然分流.

关键词：澳门特区幼儿教育 15年免费教育分流

来源：评论

学校读者我要写书评

暂无评论

China CDC weekly 2022年第40期4卷 885-889,I0002-I0005页

作者： Yuan Bai Mingda Xu Caifen Liu Mingwang Shen Lin Wang Linwei Tian Suoyi Tan Lei Zhang Petter Holme Xin Lu Eric H.Y.lau Benjamin J.Cowling Zhanwei Du WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laboratory of Data Discovery for Health Limited(D24H) Hong Kong Science ParkHong Kong Special Administrative RegionChina China-Australia Joint Research Center for Infectious Diseases School of Public HealthXi’an Jiaotong University Health Science CenterXi’an CityShaanxi ProvinceChina Department of Genetics University of CambridgeCambridge CB23EHUK College of Systems Engineering National University of Defense TechnologyChangsha CityHunan ProvinceChina Department of Computer Science Aalto UniversityEspooFinland Center for Computational Social Science Kobe UniversityKobeJapan

Introduction:Minimizing the importation and exportation risks of coronavirus disease 2019(COVID-19)is a primary concern for sustaining the“Dynamic COVID-zero”strategy in *** estimation is essential for cities to conduct before relaxing border control ***:Informed by the daily number of passengers traveling between 367 prefectures(cities)in China,this study used a stochastic metapopulation model parameterized with COVID-19 epidemic characteristics to estimate the importation and exportation ***:Under the transmission scenario(R0=5.49),this study estimated the cumulative case incidence of Changchun City,Jilin Province as 3,233(95%confidence interval:1,480,4,986)before a lockdown on March 14,2022,which is close to the 3,168 cases reported in real life by March 16,*** a total of 367 prefectures(cities),127(35%)had high exportation risks according to the simulation and could transmit the disease to 50%of all other regions within a period from 17 to 94 *** average time until a new infection arrives in a location in 1 of the 367 prefectures(cities)ranged from 26 to 101 ***:Estimating COVID-19 importation and exportation risks is necessary for preparedness,prevention,and control measures of COVID-19—especially when new variants emerge.

关键词： Export Changchun prevention

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

澳门免费幼儿教育政策民意调查报告

幼儿教育（教育科学） 2013年第11期 3-6页

作者：李辉刘懿乐梁成安香港大学教育学院澳门大学教育学院

澳门特区政府自2007-2008学年开始实施15年免费教育，至今已经实施5年了。为了解免费幼儿教育政策对澳门幼儿教育界的实际影响以及园（校）长、教师和家长对这一政策的态度，我们进行了相关研究，发现：（1）园（校）长、教师及家长大... 详细信息

澳门特区政府自2007-2008学年开始实施15年免费教育，至今已经实施5年了。为了解免费幼儿教育政策对澳门幼儿教育界的实际影响以及园（校）长、教师和家长对这一政策的态度，我们进行了相关研究，发现：（1）园（校）长、教师及家长大多对免费幼儿教育政策表示满意，其中家长满意度最高。（2）免费幼儿教育政策为澳门幼教发展带来了许多积极影响，负面影响较小。（3）免费幼儿教育政策对家长择园自主性的影响很小，对幼儿园课程与发展自主性的影响也很小，但会削弱入网私立幼儿园的行政自主性，在一定程度上增加了园（校）长和教师的工作压力。（4）政策的实施虽然对幼儿园收费标准的影响比较轻微，但是切实减轻了低收入家长的育儿负担。园（校）长、教师和家长均提出了改进免费幼儿教育政策的建议。

关键词：幼儿教育澳门 15年免费教育民意调查

片仔癀通过调节小鼠的肠道菌群和代谢物抑制非酒精性脂肪性肝炎

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第4期35卷 257-269页

作者： Xianyi Zeng Xiang Zhang Hao Su Hongyan Gou Harry Cheuk-Hay lau Xiaoxu Hu Ziheng Huang Yan Li Jun Yu Shenzhen Research Institute The Chinese University of Hong KongShenzhen 518057China Department of Medicine and Therapeutics Institute of Digestive DiseaseState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China

Non-alcoholic steatohepatitis(NASH)is a severe form of non-alcoholic fatty liver disease without effective *** traditional Chinese medicine formulation Pien Tze Huang(PTH)can suppress inflammatory ***,we evaluate the effects of PTH on the evolution of NASH and its underlying *** found that PTH prevented the development of steatohepatitis induced by various dietary models,including a high-fat high-cholesterol(HFHC)diet,choline-deficient high-fat diet(CD-HFD),and methionine-and choline-deficient(MCD)diet,along with significant suppression of liver injury,hepatic triglyceride,and lipid ***,ten days of PTH treatment after the onset of NASH significantly ameliorated MCD diet-induced steatosis and liver injury in *** the metagenomic sequencing of stool samples,we found that PTH administration restored the gut microbiota with enrichment of probiotics including Lactobacillus acidophilus(***),Lactobacillus plantarum,Lactococcus lactis,and Bacillus *** enriched *** prevented MCD diet-induced *** addition,PTH restored the gut barrier function in mice with steatohepatitis,as evidenced by reduced intestinal permeability,decreased serum lipopolysaccharides(LPS)level,and increased epithelial tightjunction protein E-cadherin *** metabolomic analysis via liquid chromatography-mass spectrometry profiling identified the alteration in the metabolism of bile acids in the portal vein of PTHtreated *** further confirmed that an intact gut microbiota is necessary for PTH to exhibit antisteatohepatitis *** conclusion,PTH protects against steatohepatitis development by modulating the gut microbiota and *** is a potential promising prophylactic and therapeutic option for patients with NASH.

关键词： Pien Tze Huang Non-alcoholic steatohepatitis Gut barrier function Gut microbiota

Carboxyl Ester Lipase Protects Against Metabolic Dysfunction-Associated Steatohepatitis by Binding to Fatty Acid Synthase

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第10期41卷 204-215页

作者： Yang Song Wei Zhong Harry Cheuk-Hay lau Yating Zhang Huayu Guan Mingxu Xie Suki Ha Diwen Shou Yongjian Zhou Hongzhi Xu Jun Yu Xiang Zhang Department of Medicine and Therapeutics Institute of Digestive DiseaseState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China Shenzhen Research Institute The Chinese Unviersity of Hong KongShenzhen 518057China Department of Gastroenterology&Institute for Microbial Ecology&Xiamen Key Laboratory of Intestinal Microbiome and Human Health&Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province Zhongshan Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361004China Division of Gastroenterology and Hepatology Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200025China Department of Gastroenterology and Hepatology Guangzhou Digestive Disease CenterGuangzhou First People’s HospitalGuangzhou 510180China

Carboxyl ester lipase(CEL),a pivotal enzyme involved in lipid metabolism,is recurrently mutated in obese ***,we aimed to elucidate the functional significance,molecular mechanism,and therapeutic potential of CEL in metabolic dysfunction-associated steatohepatitis(MASH).Hepatocyte-specific carboxyl ester lipase gene(Cel)knockout(Cel^(DHEP))and wildtype(WT)littermates were fed with cholinedeficient high-fat diet(CD-HFD)for 16 weeks,or methionine-and choline-deficient diet(MCD)for three weeks to induce *** chromatography–mass spectrometry and co-immunoprecipitation were employed to identify the downstream targets of ***-HFD/MCD-fed WT mice received intravenous injections of CEL-adeno-associated viral,serotype 8(AAV8)to induce specific overexpression of CEL in the *** observed a decrease in CEL protein levels in MASH induced by CD-HFD or MCD in ***^(DHEP) mice fed with CD-HFD or MCD exhibited pronounced hepatic steatosis,inflammation,lipid peroxidation,and liver injury compared to WT littermates,accompanied by increased hepatic nuclear factor kappa-light-chain-enhancer of activated B cell(NF-jB)***,Cel knockdown in mouse primary hepatocytes and AML12 cells aggravated lipid accumulation and inflammation,whereas CEL overexpression exerted the opposite ***,CEL directly bound to fatty acid synthase(FASN),resulting in reduced FASN SUMOylation,which in turn promoted FASN degradation through the proteasome ***,inhibition of FASN ameliorated hepatocyte lipid accumulation and inflammation induced by Cel knockdown in vivo and in ***-specific CEL overexpression using AAV8-Cel significantly mitigated steatohepatitis in mice fed with CD-HFD or *** protects against steatohepatitis development by directly interacting with FASN and suppressing its expression for de novo *** overexpression confers a therapeutic benefit in steatohepatitis.

关键词： Metabolic dysfunction-associated steatohepatitis Carboxyl ester lipase Fatty acid synthase De novo lipogenesis Treatment