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Editorial committee meeting of Hepatobiliary& Pancreatic Diseases International

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 557-557页

作者： Shui-ying Lei

On September 5,2014,the 3rd editorial committee meeting of Hepatobiliary＆Pancreatic Diseases International（HBPD INT）was held at Mirror Lake Hotel,Shaoxing,*** include ***-Yee lau from Chinese University of Hong Kong,Prince of Wales Hospital,China,***-Mau Lo from University of Hong Kong,Queen Mary Hospital,China,*** *** from University of Miami Miller School

关键词： committee editorial Prince Hotel Wales Queen Mirror behalf deputy chief

International experts consensus guidelines on robotic liver resection in 2023

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世界胃肠病学杂志:英文版 2023年第32期29卷 4815-4830页

作者： Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee lau Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100000China Hepatobiliary Pancreatic Robotic&Laparoscopic SurgeryPoliambulanza Foundation HospitalBrescia 25100Italy Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalSaitama 362-0075Japan Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeoul 03080South Korea GEM Hospital&Research Centre GEM Hospital&Research CentreCoimbatore 641045India Division of General and Transplant Surgery University of PisaPisa 56126Italy Department of General Visceral and Thoracic SurgeryUniversity Hospital Hamburg-EppendorfHamburg 20251Germany Department of Surgery Yeungnam University HospitalDaegu 42415South Korea Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Division of Hepato-Biliary-Pancreatic Surgery Department of SurgerySeverance HospitalYonsei UniversityCollege of MedicineSeoul 03722South Korea Department of Surgery/Division of Robotic and HBP Surgery Montpellier University Hospital-School of MedicineMontpellier 34090France Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscow 111123Russia Department of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of General VisceralVascular and Transplant SurgeryUniversity Hospital MagdeburgMagdeburg 39120Germany Department of Surgery City of Hope Medical CenterDuarteCA 91010United States Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100000China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Ho

The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still *** on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical *** guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation *** to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were *** them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM *** international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future.

关键词： Robotic liver resection Laparoscopic liver resection Guidelines Expert consensus

人胎肝干细胞在重症联合免疫缺陷小鼠损伤肝脏中的植入

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第二军医大学学报 2005年第3期26卷 243-246页

作者：苏娟李文林陶欣荣朱海英王新民李建秀田棣余宏宇 Joseph T lau 胡以平第二军医大学基础医学部细胞生物学教研室第二军医大学长征医院病理科 The Department of Molecular and Cellular Biology Roswell Park Cancer InstituteElm and Carlton StreetsBuffaloNY 14263USA

目的:从孕4.5～6周的人胚胎肝脏中分离培养肝干细胞,并观察其在重症联合免疫缺陷(SCID)小鼠损伤肝脏中的植入.方法:从孕4.5～6周的人胚胎肝脏中分离干细胞并进行体外长期培养,用RT PCR方法检测肝干细胞相关分子标志以及八聚物结合蛋白4(... 详细信息

目的:从孕4.5～6周的人胚胎肝脏中分离培养肝干细胞,并观察其在重症联合免疫缺陷(SCID)小鼠损伤肝脏中的植入.方法:从孕4.5～6周的人胚胎肝脏中分离干细胞并进行体外长期培养,用RT PCR方法检测肝干细胞相关分子标志以及八聚物结合蛋白4(Oct-4)的表达,然后植入经四氯化碳(CCl4)造成急性肝损伤的SCID小鼠体内,在移植后2、l0、17d分别对受体鼠肝脏冰冻切片进行荧光观察和H-E染色.结果:所建立的胎肝细胞系不仅表达二肽水解酶Ⅳ(DPPⅣ)、白蛋白(Alb)、细胞角蛋白(CK)19、γ-谷氨酰转肽酶(γ-GT)、CK18、肝细胞生长因子受体(c-met)、干细胞因子受体(c-kit)等肝干细胞相关标志,还表达干细胞转录因子Oct-4.在细胞移植后2 d,肝脏冰冻切片未见绿色荧光;移植后10 d和17d肝脏冰冻切片见散在的绿色荧光.对同一切片做H-E染色,发现绿色荧光部位为肝板内的多个成熟肝细胞.结论:从人胚胎肝脏中分离的干细胞能够植入SCID小鼠的损伤肝脏.

关键词：肝干细胞胚胎重症联合免疫缺陷细胞移植

香港瘰螈eDNA引物和Taq Man探针的设计与确认

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动物学杂志 2020年第5期55卷 624-636页

作者：杨泰昌李嘉华张颖刘彦芹袁智勇香港海洋公园环境实验室中国香港香港浸会大学生物系中国香港西南林业大学生物多样性保护学院昆明650224

环境DNA(e DNA)技术是近年来新兴的一种野外水生生物调查方法。本研究旨在设计一组香港瘰螈(Paramesotriton hongkongensis)特异的引物和TaqMan探针并确立此eDNA方法在水样中的实用性,以期进一步调查其野外种群分布。测定11种瘰螈物种... 详细信息

环境DNA(e DNA)技术是近年来新兴的一种野外水生生物调查方法。本研究旨在设计一组香港瘰螈(Paramesotriton hongkongensis)特异的引物和TaqMan探针并确立此eDNA方法在水样中的实用性,以期进一步调查其野外种群分布。测定11种瘰螈物种的线粒体细胞色素b(Cyt b)基因序列,然后使用Primer Express 3.0软件设计引物和TaqMan探针。通过比对NCBI基因库及进行退火温度梯度测试,验证引物和TaqMan探针的特异性。通过测试不同浓度的引物和TaqMan探针,优化q PCR扩增效率。然后检测养殖不同数量香港瘰螈的水缸水体中eDNA,以评估已建立的q PCR方法灵敏度。同时,测定香港瘰螈e DNA降解速度,以估计其在水中的持续时间。实验结果显示,本研究所设计的引物和探针只对香港瘰螈呈阳性扩增,而对同属的其他10个物种均呈阴性。优化的q PCR效率为93.9%、最低检测浓度为10DNA拷贝数。已建立的qPCR方法能灵敏地检测出在养殖1只香港瘰螈24h实验水缸水体的DNA拷贝数为(13.56±3.35)/ml水样。另外,降解实验发现,采用0.45μm孔径滤膜已有效检测香港瘰螈e DNA并能监测15 d。本研究成功设计并建立了一种能在水环境中检测香港瘰螈是否存在的e DNA技术,以期应用于野外考察。

关键词：香港瘰螈环境DNA 线粒体细胞色素b基因 TaqMan qPCR

辛伐他汀对老年高脂血症伴骨量减少病人骨代谢的干预研究

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药学服务与研究 2008年第4期8卷 269-271页

作者：杨宇红曹东华刘溯周海英曹梅芳上海市长宁区中心医院老年科上海200336

目的:探讨辛伐他汀对老年高脂血症伴骨量减少病人骨代谢的影响。方法:收集86例确诊为高脂血症的病人,随机分为试验组(49例)和对照组(37例)。两组病人均给予相似饮食以及等剂量阿法骨化醇和复方氨基酸螯合钙,试验组在此基础上加用辛伐他... 详细信息

目的:探讨辛伐他汀对老年高脂血症伴骨量减少病人骨代谢的影响。方法:收集86例确诊为高脂血症的病人,随机分为试验组(49例)和对照组(37例)。两组病人均给予相似饮食以及等剂量阿法骨化醇和复方氨基酸螯合钙,试验组在此基础上加用辛伐他汀40 mg/d,疗程3个月。于用药前、用药后3个月分别采集静脉血测定骨代谢指标及检查骨密度。结果:试验组和对照组病人用药后总碱性磷酸酶(TAP)及骨源性碱性磷酸酶(BAP)均有明显升高(P<0.01或P<0.05),试验组TAP及BAP比对照组用药后升高更显著(P<0.05)。试验组和对照组用药后尿脱氧吡啶啉与肌酐的比值、骨宽频超声衰减值差异均无统计学意义。结论:辛伐他汀短期内对骨形成的生化指标有促进作用,因时间较短,对骨吸收的生化指标和骨密度的影响尚无统计学意义,有待进一步研究。

关键词：辛伐他汀骨疾病代谢性老年人碱性磷酸酶尿脱氧吡啶啉与肌酐比值

多尺度PM_(2.5)分布特征的空间插值与遥感反演对比

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环境科学与技术 2017年第12期40卷 145-150页

作者：廖程浩曾武涛张永波李莹林常青刘启汉广东省环境科学研究院广东广州510045 广东省环境保护大气环境管理与政策模拟重点实验室广东广州510045 香港科技大学香港999077

精确识别污染物浓度的空间分布是进行区域大气污染防治的重要基础。利用MODIS卫星数据,采用基于地面气象和环境空气质量监测站点观测数据为基础的反演模型,反演获取2013年12月珠三角地区典型大气污染过程1 km分辨率的PM_(2.5)浓度数据,... 详细信息

精确识别污染物浓度的空间分布是进行区域大气污染防治的重要基础。利用MODIS卫星数据,采用基于地面气象和环境空气质量监测站点观测数据为基础的反演模型,反演获取2013年12月珠三角地区典型大气污染过程1 km分辨率的PM_(2.5)浓度数据,对比分析遥感反演及基于环境空气质量监测站点观测数据的空间插值方法对区域、城市和乡镇尺度PM_(2.5)浓度空间分布特征的再现效果差异。结果表明,珠三角地区PM_(2.5)遥感反演结果与地面观测数据的相关性达到0.74,相关性水平较好,遥感反演结果可描述区域、城市和乡镇尺度上PM_(2.5)污染浓度的空间分布特征,识别不同空间位置的污染程度差异;基于站点观测数据的空间插值方法对PM_(2.5)浓度空间分布特征的再现能力有限,在区域尺度PM_(2.5)浓度空间分布特征分析时效果尚可,在站点有限的城市和乡镇尺度分析中效果不佳,容易产生对高浓度污染地区的误判;在需要利用站点观测数据分析区域尺度PM_(2.5)浓度空间分布特征时,析取克里金、反距离权重或径向基函数插值方法的效果相对较好。

关键词： PM2.5 空间分布空间插值遥感反演

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冷冻导管消融治疗各种心律失常的初步观察

中国心脏起搏与心电生理杂志 2007年第2期21卷 132-136页

作者：陈艺贤刘俊良卢应强香港玛嘉烈医院内科和老年病科心脏病组

目的探讨冷冻导管消融术在治疗不同心律失常中的安全有效性。方法2004年12月1日至6月30日82例心律失常的患者入选本研究进行冷冻消融治疗。其中男42例,女40例,年龄54.8±15.5岁。共计84例次心律失常接受冷冻消融术。对于手术的急性成功... 详细信息

目的探讨冷冻导管消融术在治疗不同心律失常中的安全有效性。方法2004年12月1日至6月30日82例心律失常的患者入选本研究进行冷冻消融治疗。其中男42例,女40例,年龄54.8±15.5岁。共计84例次心律失常接受冷冻消融术。对于手术的急性成功率,临床长期有效性以及术后的并发症进行评价。结果70例为非心房颤动(简称房颤)心律失常的总急性成功率为93%,其中房室结折返性心动过速(AVNRT)的成功率为92%(22/24);左、右侧旁道参与的房室折返性心动过速(AVRT)的成功率分别为88%(15/17)、83%(5/6);心房扑动的成功率为100%(19/19)。1例进行了房室结、3例进行了右室流出道室性心动过速冷冻消融,均获成功。1例AVNRT发生了肺栓塞并发症。随访7.0±4.0个月,1例左侧旁道参与的AVRT及1例心房扑动患者复发。14例阵发性房颤患者,共对51根肺静脉进行了冷冻电隔离,急性成功率为100%。1例发生心包压塞。随访6.8±5.0个月,12例临床症状得到改善,其中9例不需服用抗心律失常药而无房颤发生。3例服药维持窦性心律,2例患者房颤复发。结论冷冻消融是一种安全有效的消融方法,可作为各种心律失常包括房颤的首选消融方法。

关键词：心血管病学心律失常冷冻消融安全性

Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer:Results from 24 hospitals in China

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World Journal of Gastrointestinal Surgery 2021年第2期13卷 176-186页

作者： Tai Ren Yong-Sheng Li Xue-Yi Dang Yang Li Zi-Yu Shao Run-Fa Bao Yi-Jun Shu Xu-An Wang Wen-Guang Wu Xiang-Song Wu Mao-Lan Li Hong Cao Kun-Hua Wang Hong-Yu Cai Chong Jin Hui-Han Jin Bo Yang Xiao-Qing Jiang Jian-Feng Gu Yun-Fu Cui Zai-Yang Zhang Chun-Fu Zhu Bei Sun Chao-Liu Dai Lin-Hui Zheng Jing-Yu Cao Zhe-Wei Fei Chang-Jun Liu Bing Li Jun Liu Ye-Ben Qian Yi Wang Ya-Wei Hua Xi Zhang Chang Liu Wan-Yee lau ying-Bin Liu Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Key Laboratory of Biliary Tract Disease Research Shanghai 200092China Department of Biliary-Pancreatic Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China State Key Laboratory for Oncogenes and Related Genes Shanghai 200127China Department of General Surgery Shanxi Provincial Cancer HospitalTaiyuan 030013Shanxi ProvinceChina Department of GI Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastrointestinal and Hernia Surgery The First Affiliated Hospital of Kunming Medical UniversityKunming 650031Yunnan ProvinceChina Department of Hepatobiliary Surgery Nantong Tumor HospitalNantong 226361Jiangsu ProvinceChina Department of General Surgery Taizhou Municipal HospitalTaizhou 318000Jiangsu ProvinceChina Department of Hepatobiliary Surgery Wuxi Second People's HospitalWuxi 214002Jiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325015Zhejiang ProvinceChina Department of Biliary Tract Surgery Second Military Medical UniversitySecondary Military Medical UniversityShanghai 200438China Department of General Surgery Changshu No.1 People’s Hospital Affiliated to Soochow UniversityChangshu 215500Jiangsu ProvinceChina Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina Department of General Surgery Shaoxing Second HospitalShaoxing 312000Zhejiang ProvinceChina Department of HPB Surgery Changzhou No.2 People’s HospitalChangzhou 213003Jiangsu ProvinceChina Department of Pancreatic and Biliary Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbin 150009Heilongjiang ProvinceChina Department of Hepatobiliary Surgery Shengjing Hospital of China Medical UniversityShenyang 1

BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of *** To investigate whether RL can improve the prognosis of patients with T1b *** We studied a multicenter cohort of patients with T1b GBC who underwent surgery between 2008 and 2016 at 24 hospitals in 13 provinces in *** logrank test and Cox proportional hazards model were used to compare the overall survival(OS)of patients who underwent cholecystectomy(Ch)+RL and those who underwent Ch *** investigate whether combined hepatectomy(Hep)improved OS in T1b patients,we studied patients who underwent Ch+RL to compare the OS of patients who underwent combined Hep and patients who did *** Of the 121 patients(aged 61.9±10.1 years),77(63.6%)underwent Ch+RL,and 44(36.4%)underwent Ch ***(9.1%)patients in the Ch+RL group had lymph node *** 5-year OS rate was significantly higher in the Ch+RL group than in the Ch group(76.3%vs 56.8%,P=0.036).Multivariate analysis showed that Ch+RL was significantly associated with improved OS(hazard ratio:0.51;95%confidence interval:0.26-0.99).Among the 77 patients who underwent Ch+RL,no survival improvement was found in patients who underwent combined Hep(5-year OS rate:79.5%for combined Hep and 76.1%for no Hep;P=0.50).CONCLUSION T1b GBC patients who underwent Ch+RL had a better prognosis than those who underwent ***+Ch showed no improvement in prognosis in T1b GBC *** recommended by both the National Comprehensive Cancer Network and Chinese Medical Association guidelines,RL was only performed in 63.6%of T1b GBC *** Ch+RL should be advised in T1b GBC.

关键词： Gallbladder cancer Lymphadenectomy Hepatectomy Staging Prognosis Surgery

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胆囊癌专题系列文章述评

中华消化外科杂志 2011年第2期10卷 81-82页

作者：刘允怡刘晓欣香港中文大学医学院、沙田威尔斯亲王医院

我们会同《中华消化外科杂志》编辑部组织了4位国内著名的肝胆外科专家,撰写了本期＂胆囊癌专题＂的一系列文章.这些专家从不同的角度,探讨了胆囊癌这一难以治愈性疾病的诊断和治疗方法,期望引起国内同行的关注,积极开展更加深入的研究.

关键词：胆囊肿瘤评估