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Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1031-1042页

作者： ka-On Lam Man-Chi Fu Kin-Sang lau kam-Mo Lam Cheuk-Wai Choi Wan-Hang Chiu Cheng-Man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan Pui-Ying Ho To-Wai Leung Ho-Fun Lee Department of Clinical Oncology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology Queen Mary HospitalHong KongChina Clinical Oncology Centre The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Pharmacy Queen Mary HospitalHong KongChina Department of Diagnostic Radiology LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective analysis to compare oral FP with infusional FP in combination with cetuximab in Chinese *** To compare the efficacy and safety profile of cetuximab in combination with oral FP and infusional FP in Chinese population in the real-world *** A retrospective cohort study was done to analyse consecutive patients with Kras wild-type mCRC who received first-line treatment with cetuximab and FP-based chemotherapy in our unit from January 2010 to December ***-five eligible patients were *** median follow-up of our cohort was 65.0 *** The median progression-free survival(mPFS)and median overall survival(mOS)of the entire cohort were 9.66 mo(95%CI:7.72–12.5)and 25.8 mo(95%CI:18.7–35.6),*** oral FP and infusional FP,there was no statistical significant difference in the mPFS[9.79 mo(95%CI:7.49–12.7)vs 9.63 mo(95%CI:6.34–13.4);P=0.72]and mOS[25.8 mo(95%CI:15.2–35.6)vs 26.3 mo(95%CI:18.7–41.2);P=0.63].Grade 3 or above adverse events were reported in 28.4%of patients,being similar with oral and infusional FP,and included 10.5%of neutropenia and 2.1%of diarrhoea *** The current analysis demonstrates comparable efficacy and safety profiles of cetuximab in combination with oral and infusional FP in Chinese *** results expand treatment options for Chinese patients and invite revision of existing treatment guidelines to incorporate oral FP-based chemotherapy plus cetuximab.

关键词： Capecitabine 5-Fluorouracil Cetuximab Metastatic colorectal cancer Chinese

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Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong

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World Journal of Gastroenterology 2006年第14期12卷 2223-2228页

作者： kam Hoi Chan Chun Wing Chan Wai Hung Chow Wai Keung Kwan Chi Kwan Kong ka Fung Mak Miu Yi Leung Lin Kiu lau Department of Medicine Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Surgery Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Radiology Yah Chai Hospital Tsuen Wan Hong Kong SAR Chin Department of Pathology Yah Chai Hospital Tsuen Wan Hong Kong SAR China

AIM： To investigate the prevalence and clinical pattern of gastrointestinal stromal tumors （GISTs） in Hong Kong Chinese, and to assess the impact of introduction of CD117 on the disease incidence. METHODS： From the database of the Department of Pathology of Yan Chai Hospital, 47 patients, with GISTs from September 1995 to December 2003 were included in this study. Ten GISTs were diagnosed before the introduction of CD117. The clinical features, tumor characteristics, and treatment were analyzed. Factors predicting tumor related death or recurrence were studied with Cox proportional hazard model. RESULTS： The patients included 26 males and 21 females, with a mean age of 66.6 years （SD 13.1, range 29-87 years）. The estimated prevalence of GISTs was 13.4-15.6 per 100 000 people, with an annual inddence of 1.68-1.96 per 100 000 people. The annual incidence of GISTs before and after the introduction of CD117 was 1.1 per 100 000 people and 2.1 per 100 000 people respectively. Stomach （34 patients, 72.3%） was the most common location for the tumor, followed by the small intestine （8 patients, 17.0%）, esophagus （2 patients, 4.3%）, omentum （2 patients, 4.3%） and colon （1 patient, 2.1%）. Thirty-one patients （66%） had complete tumor resection. Eleven out of 16 deaths （23%） were tumor-related. The median survival time was 26 too. Five-year survival rate was 61.3%. The significant factors associated with tumor-related death or recurrence were incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis, CONCLUSION： The incidence of GIST in Hong Kong is comparable to that in the United States but lower than that in Finland. The true incidence of GISTs could be underestimated before the introduction of CD117. Incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis are factors predicting tumor-related death or recurrence.

关键词： Gastrointestinal tumor GIST Prognostic factors, Clinical features Incidence

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Pandemic of the aging society—sporadic cerebral small vessel disease

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Chinese Medical Journal 2021年第2期134卷 143-150页

作者： Alexander Yuk Lun lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin ka Lam Lin Shi karen ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok Division of Neurology Department of Medicine and TherapeuticsThe Faculty of MedicineThe Chinese University of Hong KongHong KongChina Gerald Choa Neuroscience Centre Faculty of MedicineLui Che Woo Institute of Innovative MedicineThe Chinese University of Hong KongHong KongChina Faculty of Medicine School of Biomedical SciencesLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina Margaret Cheung K.L.Cheung Research Centre for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong KongChina Shenzhen Research Institute The Chinese University of Hong KongShenzhenGuangdongChina.

Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging *** widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic *** this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD.

关键词： Cerebral small vessel disease Clinical spectrum Pathophysiology

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HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model

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Cancer Biology & Medicine 2020年第4期17卷 986-1001页

作者： Wu Zeng Betty Yuen Kwan Law Vincent kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam lau Christopher Wai Kei Lam Manson Fok State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina At he nex Hong Kong Irmo vative Limited Hong Kong China Faculty of Medici ne Macao Un iversity of Science and TechnologyMacaoChina Athenex Inc. New York 14203USA

Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic *** aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant ***:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer *** and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse ***:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did *** study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this ***-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans.

关键词： HM30181A glioma pharmacokinetics paclitaxel P-glycoprotein

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Wideband Vertical Patch Antenna

Wideband Vertical Patch Antenna

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2005'全国微波毫米波会议

作者： T.P.Wong ka-lam lau K.M.Luk K.F.Lee

＜正＞Vertical patch antennas（VPAs） based on Koch loop fractal structure[1-6]are *** between Koch fractal VPAs in different iterations and a circular VPA with same size and same height are *** a dual Koch loop structure,a wideband VPA with 42%bandwidth and 8dBi gain at the center frequency is designed and *** broadside patterns are obtained at the passband.

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A novel design of Vertical Patch Antenna with corrugated ground structure

A novel design of Vertical Patch Antenna with corrugated gro...

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2005'全国微波毫米波会议

作者： ka-lam lau T.P.Wong K.M.Luk K.F.Lee

＜正＞This paper presents a novel design for a circular vertical patch antenna （VPA）.The circular-VPA is surrounded by a circular corrugated ground and it has around 10%impedance bandwidth and 8dBi *** design yields a significant reduction in cross-polarization radiation and back radiation levels over a bandwidth in excess of 9.5%.A 15dB reduction in the cross polarization and 15dB suppression in the backlobe were obtained at the center *** and broadside patterns are maintained across the matching *** of the proposed antenna,simulation and experimental results are presented and discussed.

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澳大利亚多地示好中国购房者不为所动 006

澳大利亚多地示好中国购房者不为所动

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环球时报

作者： Lam ka-sing 崔晓冬

香港《南华早报》1月9日文章，原题：中澳关系：中国购房者等待关系解冻，澳各州的退税和恳求被当成耳旁风在中澳关系陷入深度冻结前的2019年，中国购房者曾是澳楼市第五大外国投资群体，但如今随着他们坐等双边关系解冻，这个群体正... 详细信息

香港《南华早报》1月9日文章，原题：中澳关系：中国购房者等待关系解冻，澳各州的退税和恳求被当成耳旁风在中澳关系陷入深度冻结前的2019年，中国购房者曾是澳楼市第五大外国投资群体，但如今随着他们坐等双边关系解冻，这个群体正把（澳）吸引其回归的退税政策和其他恳求当

关键词：购房者澳大利亚

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A Study of Address Shortage in a Tree Based ZigBee Network for Mobile Health Applications

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Wireless Sensor Network 2012年第5期4卷 147-153页

作者： ka Lun Lam Hoi Yan Tung King Tim Ko Kim Fung Tsang Hoi Ching Tung Yat Wah Leung Wing Hong lau Department of EE City University of Hong Kong Hong Kong China Department of SEEM City University of Hong Kong Hong Kong China

There are increasing demands for mobile health applications. This paper reports the development of a mobile health profile which dedicates to mobile applications. The mobile health profile is developed in association with the ZigBee Health Care profile and the IEEE 11073 standard which is normally applied to non-mobile applications. Since mobile sensors have to be carried by patients, the mobile health profile must facilitate mobility. In this investigation, a ZigBee fixed-mobile network (ZFMN) is defined and developed to supplement the ZigBee Health Care Profile for patient monitoring. The mobility study of ZigBee is performed using a random waypoint OPNET simulation model. In a ZFMN, the critical issue of address shortage is identified and discussed. It is analyzed that the problematic address shortage in a ZFMN may generate a huge amount of orphaned end devices and thus the packet drop percentage may potentially rise to 70%, rendering the network unable to function properly. Without introducing additional governing schemes, it is evaluated that the communication of the entire ZigBee network may paralyze. Further vigorous test are performed (by OPNET) on the communication capability of ZFMN when devices are randomly moving and sending data in 1s. It is vital to point out that under the adverse condition of address shortage, the performance of a ZFMN is still encouraging as long as the packet drop percentage has been kept below 3% before running out of address. The conclusion drawn in this analysis is that the packet drop percentage should be kept below 3% to provide a satisfactory QoS for an effective mobile health application using ZFMN such as patient monitoring. Such finding is also important for other future mobile application design of ZigBee. The address shortage issue is left as an open problem that needs attention for a resolution.

关键词： Mobile Health Patient Monitoring Mobility ZigBee Tree Address Assignment Address Shortage

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检测实验室如何应对ISO/IEC 17025:2017标准新要求的经验分享

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食品安全质量检测学报 2020年第23期11卷 8989-8993页

作者：梁嘉声香港理工大学应用生物及化学科技学系香港999077

ISO/IEC 17025:2017标准引入风险为本的思维,要求实验室考虑与其活动相关的风险和机遇,并将应对措施整合到管理体系中。这包括识别风险、制定及实施适当的监控措施,并评价其效能。同时,2017年版的标准明确了报告符合性声明的要求,包括... 详细信息

ISO/IEC 17025:2017标准引入风险为本的思维,要求实验室考虑与其活动相关的风险和机遇,并将应对措施整合到管理体系中。这包括识别风险、制定及实施适当的监控措施,并评价其效能。同时,2017年版的标准明确了报告符合性声明的要求,包括实验室确定适用的规范或标准,制定判定规则及考虑相关的风险水平,并取得客户的同意。本文列举通过分析检测活动流程的例子,从行政管理、样本处置到报告结果所涉的过程,以及其他关联的实验室活动过程,帮助检测实验室识别可影响检测结果的潜在风险,接着利用矩阵半量化地因应风险水平分类。而有关判定规则方面,本文介绍如何利用测量不确定度及保护间距,判定检测结果是否符合适用的规范或标准,考虑误判的机率,并强调与客户沟通的重要性,以期为实验室管理提供参考。

关键词：实验室管理风险和机遇符合性声明判定规则

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CONGENITAL CARDIOVASCULAR MALFORMATIONS IN CHINESE CHILDREN WITH DOWN'S SYNDROME .

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中华医学杂志(英文版) 1989年第5期102卷 386-386页

作者： Lo Ngok sing Roxy Leung Ping Maurice lau kai Chiu Yeung Chap Yung Department of Pediatrics University of Hong Kong Queen Mary Hospital Hong Kong

149 Chinese children (70 boys, 79 girls) with Down’s syndrome and congenital heart disease were studied. Diagnosis of the cardiac abnormality was made by cardiac catheterisation in 119, two-dimensional echocardiography in 23 and autopsy in 7. The commonest lesion was ventricular septal defect which was present in 43.6%, a higher frequency than that reported in Caucasians. Other common lesions included atrioventricular septal defect (15.4%), atrial septal defect (13.4%), tetralogy in Fallot (13.4%) and patent ductus arteriosus (12.1%). Multiple lesions occurred in 36% of the cases, with patent ductus arteriosus, the most frequent coexisting lesion. Other cyanotic congenital heart conditions were very rare and coarctation of aorta was not seen. An aberrant right subclavian artery arising from the descending aorta was present in 16.5% and abnormalities of the radial artery at the wrist were found in 19%. The literature on patterns of congenital heart diseases seen in Down’s syndrome was reviewed.

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