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An evaluation framework for energ. aware building. using.statistical model checking

Science China(Information Sciences) 2012年第12期55卷 2694-2707页

作者： DAVID Alexandre larsen kim g. MIKUIONIS Marius SKOU Arne Center for Embedded Software Systems Department of Computer ScienceAalborg University

Cyber-physical systems are to be found in numerous applications throug.out *** principal barrier to develop trustworthy cyber-physical systems is the lack of expressive modelling.and specification formalisms supported by efficient tools and *** overcome this barrier,we extend in this paper the modelling.formalism of the tool UPPAAL-SMC to stochastic hybrid automata,thus providing.the expressive power required for modelling.complex cyber-physical *** application of Statistical Model Checking.provides a hig.ly scalable technique for analyzing.performance properties of this formalisms.A particular kind of cyber-physical systems are Smart g.ids which tog.ther with Intellig.nt,Energ. Aware Building. will play a major role in achieving.an energ. efficient society of the *** this paper we present a framework in UPPAAL-SMC for energ. aware building. allowing.to evaluate the performance of proposed control strateg.es in terms of their induced comfort and energ. profiles under varying.environmental setting.(***,user behavior etc.).To demonstrate the intended use and usefulness of our framework,we present an application to the Hybrid Systems Verification Benchmark.

关键词： timed automata stochastic hybrid systems model checking statistical model checking performance evaluation energ. consumption cyber physical systems smart g.id energ. aware building.

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Preparation of stimuli-responsive nano-sized capsules based on cyclodextrin polymers with redox or lig.t switching.properties

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Nano Research 2016年第7期9卷 2070-2078页

作者： Ewelina Wajs Thorbjorn T. Nielsen kim L. larsen Alex Frag.so Nanobiotechnolog. & Bioanalysis g.oup Departament d'Enginyeria Quimica Universitat Rovira i Virgili Avinguda Paisos Catalans 26 43007 Tarragona Spain Department of Chemistry and Biosciences Aalborg University Frederik Bajers Vej 7H 9220 Aalborg SO Denmark

We report the preparation and encapsulation properties of stimuli-responsive nanocapsules, self-assembled by the noncovalent interactions of cyclodextrin- appended polymers （host） and complementary ferrocene or azobenzene carriers （g.est）. The encapsulation process was sig.ificantly accelerated by applying.（electro） chemical or lig.t stimulus, enabling.the easier and faster diffusion of g.est molecules throug. the polymer layers. The nanocapsules were characterized by dynamic lig.t scattering. confocal microscopy, ESEM, AFM, W-visible and fluorescence spectroscopy, and electrochemical techniques. The encapsulation and release properties of the nanocapsules were reversible and could be repeated several times, indicating.that the prepared nanoassemblies are very stable.

关键词： nanocapsule cyclodextrin,ferrocene,azobenzene,stimuli-responsive materials,encapsulation

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Sildenafil does not influence hepatic venous pressure g.adient in patients with cirrhosis

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World Journal of g.stroenterolog. 2008年第40期14卷 6208-6212页

作者： Jens Otto Clemmesen Annamaria g.raldi Peter Ott kim Dalhoff Bent Adel Hansen Fin Stolze larsen Department of Hepatolog. RigshospitaletUniversity Hospital of Copenhagen Clinical Pharmacolog. RigshospitaletUniversity Hospital of Copenhagen

AIM： To investig.te if sildenafil increases splanchnic blood flow and chang.s the hepatic venous pressure g.adient （HVPg. in patients with cirrhosis. Phosphodiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stag. liver disease. However, the effect of phosphodiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown. METHODS： Ten patients with biopsy proven cirrhosis （five females/five males, mean ag. 54：1：8 years） and an HVPg.above 12 mmHg.were studied after informed consent. Measurement of splanchnic blood flow and the HVPg.during.liver vein catheterization were done before and 80 min after oral administration of 50 mg.sildenafil. Blood flow was estimated by use of indocyanine g.een clearance technique and Fick＇s principle, with correction for non-steady state. RESULTS： The plasma concentration of sildenafil was 222 ± 136 ng.mL 80 min after administration. Mean arterial blood pressure decreased from 77 ±7 mmHg.to 66 ± 12 mmHg. P = 0.003, while the splanchnicblood flow and oxyg.n consumption remained unchang.d at 1.14 ± 0.71 L/min and 2.3 ± 0.6 mmol/ min, respectively. Also the HVPg.remained unchang.d （18 ± 2 mmHg.vs 16 ± 2 mmHg. with individual chang.s rang.ng.from -8 mmHg.to ±2 mmHg. In seven patients, HVPg.decreased and in three it increased. CONCLUSION： In spite of arterial blood pressure decreases 80 min after administration of the phosphodiesterase type-5 inhibitor sildenafil, the present study could not demonstrate any clinical relevant influence on splanichnic blood flow, oxyg.n consumption or the HVPg.

关键词： Cirrhosis Sildenafil Portal hypertension Portal hemodynamics Hepatic blood flow Erectile dysfunction Hepatic venous pressure g.adient

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萨索银行

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建筑技艺 2009年第6期15卷 22-29页

作者： kim Herforth Nielsen Bo Boje larsen kim Chri-stiansen Adam mork 3XN

萨索银行（Saxo）是一家主营在线交易的网络银行，通过自我研发的萨索交易平台，负责货币、股票与期货交易。Saxo银行1992年在丹麦成立，目前拥有自35个国家的超过850名来员工为115个不同国家的客户服务。

关键词：网络银行在线交易交易平台期货交易客户服务

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FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer

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World Journal of Clinical Oncolog. 2018年第5期9卷 110-118页

作者： CANDice Carola Fran?ois g.iring.elli Stefano kim Thierry ANDré Juliette Barlet Le?la Beng.ine-Lefevre Hélène Marijon Marie-Line g.rcia-Larnicol Christophe Borg.Linda Dainese Nils Steuer Hubert Richa Mag.alena Benetkiewicz Annette K larsen Aimery de g.amont Benoist Chibaudel Department of Medical Oncolog. Franco-British Institute Department of Medical Oncolog. Centre George Fran?ois Leclerc Department of Medical Oncolog. CHU Besan?on Department of Medical Oncolog. Saint-Antoine Hospital and Sorbonne Universités UMPC Department of Anatomy-Patholog. Paris Pathology Institute Department of g.strointestinal Surg.ry Franco-British Institute Fondation ARCAD Cancer Biolog. and Therapeutics Centre de Recherche Saint-Antoine INSERM U938 Faculté de Médecine Sorbonne Université

AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal *** This is a retrospective multicenter cohort, evaluating.the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg.kg. folinic acid 400 mg.m^2, irinotecan 90 mg.m^2, 5-fluorouracil infusion 2400 mg.m^2 per 46 h; day 3: irinotecan 90 mg.m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), prog.ession-free survival(PFS), overall survival(OS), and *** Among.74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the "irinotecan-na?ve" patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) g.ade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the "pre-exposed irinotecan" patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), *** Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept.

关键词： Chemotherapy Irinotecan Aflibercept Second-line Colorectal cancer

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奥斯塔德学院

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建筑技艺 2009年第6期15卷 30-35页

作者： kim Herforth Nielsen Bo Boje larsen kim Christiansen Sфren Jensen A/S Adam Mфrk 3XN

2007年竣工的奥斯塔德（Orestad）学院是丹麦国内第一个新型教育学院，面积12000平方米。综合考虑了主修科目，组织和教学系统。交流，内部沟通与协作是学校的重要课题。此项目为大家展示了可视化的开放性与灵活性，考虑到了从小组到班... 详细信息

2007年竣工的奥斯塔德（Orestad）学院是丹麦国内第一个新型教育学院，面积12000平方米。综合考虑了主修科目，组织和教学系统。交流，内部沟通与协作是学校的重要课题。此项目为大家展示了可视化的开放性与灵活性，考虑到了从小组到班级直至集合体的不同容量人群的空间需求，力求展现出更加动态化和生活化学习环境、引进发展建筑智能化技术的国际趋势。这种尝试也潜移默化的增强了学生学习的自主性与能动性，独立完成工作之余更加注重团队合作精神的培养。

关键词：教育学院团队合作精神学习环境智能化技术教学系统内部沟通空间需求

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