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Exploration of the regulatory effect of miR-21 on breast cancer cell line proliferation and invasion as well as the downstream target genes

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Asian Pacific j.urnal of Tropical Medicine 2016年第5期9卷 456-459页

作者： Ying Kuang Ying-j.e nie Central Lab Guizhou Provincial People's Hospital

Obj.ctive: To study the regulatory effects of miR-21 on breast cancer cell line proliferation and invasion as well as the downstream target genes. Methods: Breast cancer cell lines MCF-7 were cultured and transfected with miR-21 mimics and the corresponding negative control mimics(NC mimics), and then MTS kits were used to detect cell viability. Transwell experiment was used to detect cell invasion ability, and fluorescence quantitative PCR was used to detect the expression of proliferation and invasion-related genes in cells. Results: 24 h after transfection of miR-21 mimics and NC mimics, cell Od value and the number of invasive cells of miR-21 group were significantly higher than those of NC group, and m RNA contents of PdCd-4, Fas L, PTEN, Rho B, Maspin, TIMP3 and RECK in cells were significantly lower than those of NC group. Conclusion: miR-21 can promote the proliferation and invasion of breast cancer cell lines, and its downstream target genes include PdCd-4, Fas L, PTEN, Rho B, Maspin, TIMP3 and RECK.

关键词： Breast cancer Micro RNA Proliferation Invasion

A Review on Theoretical and Numerical Research of Axial Compressor Surge

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j.urnal of Thermal Science 2023年第1期32卷 254-263页

作者： ZHAO Hongliang dU j.an ZHANG Wenqiang ZHANG Hongwu nie Chaoqun School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China Advanced Gas Turbine Laboratory Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced Energy and Power Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Innovation Academy for Light-duty Gas Turbine Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

Surge is an unstable operating condition of the aero-engine that can move the engine into a destabilized state and cause devastating *** of the most popular topics in the academic and industrial communities is to figure out the mechanism of the surge and withdraw from the surge *** on rig test results and practical data from engine operation,various theories of surge mechanisms have been proposed by researchers,and some classical analytical models have been developed for modelling and *** recent years,with the rapid development of numerical simulation and the improvement of computational capability,computational fluid dynamics(CFd)has been widely applied to the investigation of axial compressor surge *** this review,the principles and general characteristics of the surge phenomenon are first ***,the main theoretical models and CFd simulations are presented,and their advantages and disadvantages are *** conclusion,we have proposed potential improvements and future technical routes for the surge *** purpose of this paper is to provide a valuable reference for surge studies on axial compressors.

关键词： axial compressor surge theoretical numerical CFd

Nationality and Universality: Cultural Consciousness and Fusion of Horizons in Mo Yan’s Novels from an Intercultural Perspective

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学术界 2019年第7期 214-224页

作者： Zhou j.nghui nie Yingj.e School of Foreign Languages dalian Polytechnic University

Within the structure of globalisation,the field of world culture faces challenges that are manifested in the decline of national culture and the crisis of homogeneity of world *** this case,world culture should be promoted as a viable path to prosperity and development if it is done on the basis of adhering to the higher consciousness of national culture,developing intercultural dialogue,with the intention forming a situation of mutual learning and promoting the fusion of *** Chinese Culture,Qilu genetic code and native writing embody Mo Yan’s conscious adherence to national culture,his thorough knowledge of “Seeking Roots” and “Vanguard”,the fusion of national and international characteristics and the integration of his hometown and other *** show his enthusiasm and courage in launching intercultural dialogue and reaching towards the fusion of *** to face cultural challenges under this changing world pattern?The successful experience of Mo Yan’s novels provides us with vivid examples.

关键词： Mo Yan's Novels Intercultural Nature Cultural Consciousness Fusion of Horizons

Benchmark calculations and error cancelations for bond dissociation enthalpies of X-NO_(2)

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defence Technology（防务技术） 2023年第4期22卷 144-155页

作者： j.an Liu Xudong He Ying Xiong Fude nie Chaoyang Zhang Institute of Chemical Materials China Academy of Engineering PhysicsP.O.Box 919-311China

Safety plays an important role in determining the applicability of energetic compounds,and the bond dissociation enthalpy(BdE)of the“trigger bond”X-NO_(2) provides useful information to evaluate various safety *** and rapid calculation of the BdE of X-NO_(2) is of great significance to perform the high-throughput design of energetic compounds,which becomes an increasingly popular means of materials *** conduct a benchmark BdE calculation for 44 X-NO_(2) samples extracted from the iBond database,with the accuracies of 55 quantum chemistry calculation levels evaluated by the experimentally measured *** four levels have the global mean-absolute deviation(MAd)less than 10 kj.mol,but no calculation level can achieve that all the local MAds of each category less than 10 kj.*** propose a simple correction strategy for the original calculation deviations,and apply it to 30 calculation levels screened out through a series of accuracy assessments and obtain the corrected MAdj.mol in some *** define a normalized time-cost(NTC)to evaluate the time-cost of each calculation level,and confirm that PBE0-d3/6-31G^(**)(MAd=6.4 kj.mol,NTC?0.8)works the best for most cases,followed by M062X/6-31g^(**),M062X/6-311g^(**)andɷB97Xd/6-311g^(**),based on an insight into the accuracy-cost *** present work provides an accurate and fast solution for calculating XNO_(2) BdE via quantum chemical methods,and is expected to be beneficial to enhance the safety prediction efficiency of energetic compounds.

关键词： Complex waveform scaling Analytical blast modeling Hopkinson-Cranz Scaled distance

Fluid structure interaction of supersonic parachute with material failure

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Chinese j.urnal of Aeronautics 2023年第10期36卷 90-100页

作者： Shunchen nie Li YU Yanj.n LI Zhihong SUN Bowen QIU College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Aircraft Environment Control and Life Support MIITNanjing University of Aeronautics and AstronauticsNanjing 210016China

The material damage of parachute may occur in parachutes at high speeds,and the growth of tearing may finally lead to failure of aerospace *** order to study the damage mechanism of parachute,a material failure model is proposed to simulate the failure of canopy *** inflation process of supersonic parachute is studied numerically based on Arbitrary Lagrange Euler(ALE)*** ALE method with material failure can predict the transient parachute shape with damage propagation as well as the flow characteristics in the parachute inflation process,and the simulated dynamic opening load is consistent with the flight *** damage propagation mechanism of parachute is then investigated,and the effect of parachute velocity on the damage process is *** results show that the canopy tears apart by the fast flow from the initial damaged area and the damaged canopy shape leads to the asymmetric change of the flow *** the increase of Mach number,the canopy tearing speed increases,and the tearing directions become uncertain at high Mach *** dynamic load when damage occurs increases with the Mach number,and is proportional to the dynamic pressure above the critical Mach number.

关键词： Arbitrary Lagrange Euler method dynamic loads Fluid structure interaction Material failure model Parachute damage

Bifurcation analysis of dual-sidestay landing gear locking performance considering j.int clearance

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Chinese j.urnal of Aeronautics 2022年第7期35卷 209-226页

作者： Kui XU Yin YIN Yixin YANG Hong nie Xiaohui WEI State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Fundamental Science for National defense-Advanced design Technology of Flight Vehicle Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Sidestay lock mechanism is an important part of landing gear system,and the locking performance can be analyzed based on changes in its ***,during numerical continuation analysis of fully-rigid dual-sidestay landing gear without clearance,it has been found that the appearance of bifurcation points does not necessarily imply that both sidestay links can be locked *** problem reveals the limitations of fully-rigid model with ideally-articulated in solving dual-sidestay mechanisms with extremely high motion ***,this study proposes a bifurcation analysis method for synchronous locking of dual-sidestay landing gears,which takes into consideration the j.int *** in-depth analysis of this problem,we initially build kinematic and mechanical models of a landing gear mechanism that consider j.int ***,the models are solved based on *** fundamental causes of synchronous locking are discussed in detail,and the number of bifurcation points is found to be closely related to whether the landing gear is completely ***,the effects of structural parameters on the synchronous locking are analyzed,and the feasible region of parameters satisfying synchronous locking condition is given,which agrees well with the test results.

关键词： Bifurcation Clearance dual-sidestay landing gear Numerical continuation Synchronous locking

Reliability analysis of arresting hook engaging arresting cable for carrier-based aircraft influenced by multifactors

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Chinese j.urnal of Aeronautics 2023年第1期36卷 311-323页

作者： Yiming PENG Yin YIN Pengpeng XIE Xiaohui WEI Hong nie State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Fundamental Science for National defense-Advanced design Technology of Flight Vehicle Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shanghai Institute of Spacecraft Equipment Shanghai 200240China

The carrier-based aircraft landing and arrest process is complex and nonlinear,and includes the coupling effect between the aircraft and arresting *** has many uncertain factors,which lead to difficulty in the reliability *** make the reliability analysis more accurate and effective,this paper presents some *** a certain type of carrier-based aircraft as the research obj.ct,a dynamic model of the landing and arrest cable was established,and the accuracy of the model was verified using laboratory test *** on the model,this paper shows how the key parameters,including the sinking velocity,pitch angle and horizontal velocity,affect the collision rebound performance of the arresting *** that,a limit state equation of the arresting hook system’s reliability was *** the implicit limit state equation,a surrogate model of the reliability of the arresting hook was established using the Support Vector Machine(SVM)method,and then reliability analysis was carried out using the Monte Carlo ***,it was explained in detail how the key parameters affect the reliability of the hook engaging the arresting cable,and some meaningful conclusions were *** analysis method and its results can provide a reference for the top-level parameter design of carrier-based aircraft and reliability research on the arresting systems.

关键词： Arresting cable Arresting devices dynamics Reliability Support Vector Machines

Effect of particle type on the shear behaviour of granular materials

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Particuology 2021年第3期19卷 124-131页

作者： Shunkai Liu Zhihong nie Wei Hu j.an Gong Peng Lei School of Civil Engineering Central South UniversityChangsha 410075China Hunan Province Key Laboratory of Geotechnical Engineering Stability Control and Health Monitoring Hunan University of Science and TechnologyXiangtan 411201China School of Hydraulic Engineering Changsha University of Science and TechnologyChangsha 410114China

In discrete element method(dEM)simulations,multi-sphere(MS)clumped and convex particles are two main particle models that are used to study the mechanical behaviours of granular *** interest is the evaluation of the effect of multiple contacts between clumped particles or single contacts between convex particles on the mechanical behaviours of granular *** this context,a series of drained triaxial compression tests were conducted on convex true(CT)ellipsoids and MS ellipsoids with aspect ratios(ARs)ranging from *** microscale results indicate that at a given AR,the critical friction angleφ_(c)changes with the particle type,whereas the peak friction angleφ_(p)is nearly independent of the particle *** anisotropic analysis provides underlying mechanisms of the shear strength evolution from two ***,the anisotropies of granular materials are essential to shear strength as the deviatoric(q)-to-effective mean(p′)stress ratio can be expressed as the sum of the anisotropies,i.e.,q/p'≈0.4a_(c)+0.4a_(n)+0.6a_(t),where ac,an and at are the normal contact anisotropy,normal contact force anisotropy and tangential contact force anisotropy,*** all samples,a_(c)and a_(n)underpin the shear strength and are influenced by the particle *** similarφ_(p)displayed by the CT and MS ellipsoids does not translate to similar a_(n)and a_(c)but similar a_(c)+a_(n)for the two particle *** addition,owing to their larger a_(c)+a_(n),the CT ellipsoids have a higherφ_(c)than the MS ***,there is a satisfactory linear relationship between q/p'and ac within strong and non-sliding(sn)contacts a_(c)^(sn)(i.e.,q/p′=ka_(c)^(sn)),where k is the fitting ***,in the peak state,the subtle difference in shear strength is attributed to the greater acsn in the CT ellipsoids than in the MS ellipsoids that is counteracted by the smaller ***,in the critical state,the greater difference in a_(c)^(sn)between the CT

关键词： Multi-sphere clump Convex true particle dEM Particle type Anisotropy Shear strength

Ultrasonic excitation induced nanocrystallization and toughening of Zr46.75Cu46.75Al6.5 bulk metallic glass

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j.urnal of Materials Science & Technology 2020年第10期42卷 157-161页

作者： W.Zhai L.H.nie X.d.Hui Y.Xiao T.Wang B.Wei School of Physical Science and Technology Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory for Advanced Metals and Materials University of Science&Technology BeijingBeijing 100083China

Intensive power ultrasound is introduced to Zr46.75Cu46.75Al6.5bulk metallic glass(BMG)as an easy-procurable,non-destructive physical method to modulate its atomic rearrangement and shear deformation *** microstructure after ultrasonic excitation with amplitude about 15μm in 20 k Hz for 2 h is characterized by large amount of Cu10Zr7 nanocrystals with size of 20–50 nm embedded in the glass *** leads to a sharp increase in the critical stress for the first pop-in event of shear banding,and thus simultaneously improves both compressive plasticity and yield *** findings provide a novel approach for overcoming the strength-ductility trade-off dilemma.

关键词： Bulk metallic glass Nanocrystallization Plasticity Toughness Ultrasound