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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George j.msheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi j.mes d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Proj.ct to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular j.nction Schwann cell

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Network analysis to inform invasive species spread among lakes

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j.urnal of Oceanology and Limnology 2019年第3期37卷 1037-1041页

作者： ESCOBAR Luis E. ROMERO-ALVAREZ d.nie. larkin d.nie. j. PHELPS Nicholas B. d. department of Fish and Wildlife Conservation Virginia TechBlacksburgVirginiaUSA department of Ecology and Evolutionary Biology-Biodiversity Institute University of KansasLawrenceUSA department of Fisheries Wildlifeand Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Minnesota Aquatic Invasive Species Research Center University of MinnesotaSt.PaulMinnesotaUSA

Often facilitated by human-mediated pathways,aquatic invasive species are a threat to the health and biodiversity of global *** present a novel approach incorporating survey data of watercraft movement in a social network analysis to reconstruct potential pathways of aquatic invasive species spread between *** an example,we use the green alga Nitellopsis obtusa,also known as starry stonewort,an aquatic invasive species affecting the Great Lakes region in the United States and *** movement of algal fragments via human-mediated pathways(i.e.,watercraft)has been hypothesized as the primary driver of starry stonewort *** used survey data collected at boat ramps during the 2013 and 2014 openwater seasons to describe the flow of watercraft from Lake Koronis,where *** was first detected in Minnesota,to other lakes in the *** results suggest that the risk of *** expansion is not highly constrained by geographic proximity and management efforts should consider highly connected *** human movement via network analysis may help to explain past and future routes of aquatic invasive species infestation between lakes and can improve evidence-based prevention and control efforts.

关键词： Nitellopsis obtusa starry stonewort lake network invasion

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“OBE+混合一流”教学模式研究与实践——以国家级混合式一流课程“Web服务与RESTful技术”为例

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职业技术 2025年第1期24卷 80-88页

作者：聂鹏江西财经大学软件与物联网工程学院南昌330013

“双一流”建设背景下,为了提升软件工程专业课的课程品质,依托国家级混合式一流课程“Web服务与RESTful技术”,提出一种适用于软件工程专业的“OBE+混合一流”教学模式。在分析专业课程特征及“OBE+混合一流”教学理念基础上,从OBE混... 详细信息

“双一流”建设背景下,为了提升软件工程专业课的课程品质,依托国家级混合式一流课程“Web服务与RESTful技术”,提出一种适用于软件工程专业的“OBE+混合一流”教学模式。在分析专业课程特征及“OBE+混合一流”教学理念基础上,从OBE混合课程内容重构、OBE混合课程教学过程设计、学习成果认定与质量提升等方面,对该模式的设计与应用展开论述。实践证明,该模式能够有效覆盖课程成果目标,提升学生基于Web服务解决综合问题的工程能力,“OBE+混合一流”教学模式在软件工程专业教学中具备良好的适应性,教学产出效果符合预期。

关键词： OBE 混合式教学一流课程软件工程 Web服务

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生成式人工智能对数据安全保护的挑战及刑法应对

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河南社会科学 2025年第1期33卷 56-63页

作者：聂立泽王祯中山大学法学院广东广州510006

随着生成式人工智能在多个领域的应用,数据安全保护面临新的挑战。在数据安全保护的路径选择上,传统模式选择以数据主体为锚定权利的基准,在赋予数据主体相关权利的基础上,以告知—同意原则作为数据主体的权利边界,建立涉及刑法、民法... 详细信息

随着生成式人工智能在多个领域的应用,数据安全保护面临新的挑战。在数据安全保护的路径选择上,传统模式选择以数据主体为锚定权利的基准,在赋予数据主体相关权利的基础上,以告知—同意原则作为数据主体的权利边界,建立涉及刑法、民法等多个领域的数据安全制度。但不得不承认,伴随人工智能的发展,这种基于数据主体权利的数据保护模式逐渐表现出认知与结构性困难,需要从路径选择上进行转变。相对于以数据主体权利为核心的保护模式,刑法可以从风险的角度考虑,以贝克的风险社会理论作为理论参考,从承认数据主体具有完全理性转变为承认其具有有限理性,将数据安全保护的主要关注点从数据主体的权利保障转移到数据安全风险的预防和管控。此外,在数据安全保护的实质层面上,生成式人工智能侵害数据法益的行为可以概括为行为人利用或针对生成式人工智能实施的行为,以及生成式人工智能在演化、运行过程中“自主”实施的行为。刑法应以风险作为主要考量因素,结合已有规定对上述两种行为进行评价。

关键词：生成式人工智能风险预防数据安全刑法规制

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson department of Genetics College of MedicineHarvard UniversityBostonMAUSA j.mes L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain inj.ry(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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Emergence of magnetic order in kagome antiferromagnets

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Frontiers of physics 2019年第2期14卷 47-51页

作者： d. j. j. Farnell School of dentistry Cardiff UniversityCardiff CF14 /XYWales UK

Exotic quantum spin liquid (QSL) states and fractionalized quasiparticles in frustrated magnets are of much current interest in theoretical and experimental studies of quantum magnetism. The kagome-lattice Heisenberg antiferromagnet (KAFM) provides a possible realization of j.st such novel topological states of matter. The kagome lattice shown in Fig. 1 is one of eleven Archimedean lattices in two spatial dimensions, where the word kagome itself means uweave pattera" in j.panese.

关键词： magnetic order kagome antiferromagnets quantum spin liquid (QSL)

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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基于卫星授时监测数据改善定时及定位方法研究

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大地测量与地球动力学 2025年第1期45卷 36-40页

作者：聂骊颖许龙霞李孝辉中国科学院国家授时中心西安市710600 中国科学院大学北京市100049 中国科学院时间基准及应用重点实验室西安市710600

为使卫星授时监测数据更好地服务于用户,研究使用其削弱标准单点定位中卫星端和传输路径误差的影响,改善用户端定时稳定度与定位精度;同时将用户相对于卫星导航系统时间的定时偏差改正到相对于国家标准时间。以GPS为例开展实验验证,短... 详细信息

为使卫星授时监测数据更好地服务于用户,研究使用其削弱标准单点定位中卫星端和传输路径误差的影响,改善用户端定时稳定度与定位精度;同时将用户相对于卫星导航系统时间的定时偏差改正到相对于国家标准时间。以GPS为例开展实验验证,短基线实验结果表明,定时方面,L1频段定时偏差的均值从-42.8 ns改善到5.4 ns,L2频段从-53.6 ns改善到2.8 ns;定位方面,L1频段X、Y、Z三个方向定位误差的均值改善55%以上,L2频段改善77%以上。证明使用卫星授时监测数据,卫星导航系统用户不仅可以将伪码定位精度提高至亚m级,还可以获得相对于国家标准时间的偏差,实现国家标准时间的ns级授时。

关键词：授时监测授时偏差伪码定时定位

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Convergence and exact solutions of spline finite strip method using unitary transformation approach

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Applied Mathematics and Mechanics(English Edition) 2011年第11期32卷 1407-1422页

作者： j. KONG d. THUNG division of Building Science and Technology City University of Hong Kong Hong Kong P. R. China School of Creative Media City University of Hong Kong Hong Kong P. R. China

The spline finite strip method （FSM） is one of the most popular numerical methods for analyzing prismatic structures. Efficacy and convergence of the method have been demonstrated in previous studies by comparing only numerical results with analytical results of some benchmark problems. To date, no exact solutions of the method or its explicit forms of error terms have been derived to show its convergence analytically. As such, in this paper, the mathematical exact solutions of spline finite strips in the plate analysis are derived using a unitary transformation approach （abbreviated as the U-transformation method herein）. These exact solutions are presented for the first time in open literature. Unlike the conventional spline FSM which involves assembly of the global matrix equation and its numerical solution, the U-transformation method decouples the global matrix equation into the one involving only two unknowns, thus rendering the exact solutions of the spline finite strip to be derived explicitly. By taking Taylor＇s series expansion of the exact solution, error terms and convergence rates are also derived explicitly and compared directly with other numerical methods. In this regard, the spline FSM converges at the same rate as a non-conforming finite element, yet involving a smaller number of unknowns compared to the latter. The convergence rate is also found superior to the conventional finite difference method.

关键词： spline finite strip U-transformation plate symmetry

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On the radiogenic heat production of igneous rocks

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Geoscience Frontiers 2017年第5期8卷 919-940页

作者： d. Hasterok j. Webb department of Earth Sciences University of Adelaide North Terrace SA 5005 Australia Ramelius Resources Ltd. East Perth WA 6005 Australia

Radiogenic heat production is a physical parameter crucial to properly estimating lithospheric temperatures and properly understanding processes related to the thermal evolution of the Earth. Yet heat production is, in general, poorly constrained by direct observation because the key radiogenic elements exist in trace amounts making them difficulty image geophysically. In this study, we advance our knowledge of heat production throughout the lithosphere by analyzing chemical analyses of 108,103 igneous rocks provided by a number of geochemical databases. We produce global estimates of the average and natural range for igneous rocks using common chemical classification systems. Heat production increases as a function of increasing felsic and alkali content with similar values for analogous plutonic and volcanic rocks. The logarithm of median heat production is negatively correlated(r^2=0.98)to compositionally-based estimates of seismic velocities between 6.0 and 7.4 km s^(-1), consistent with the vast maj.rity of igneous rock compositions. Compositional variations for continent-wide models are also well-described by a log-linear correlation between heat production and seismic velocity. However, there are differences between the log-linear models for North America and Australia, that are consistent with interpretations from previous studies that suggest above average heat production across much of Australia. Similar log-linear models also perform well within individual geological provinces with^1000 samples. This correlation raises the prospect that this empirical method can be used to estimate average heat production and natural variance both laterally and vertically throughout the lithosphere. This correlative relationship occurs despite a direct causal relationship between these two parameters but probably arises from the process of differentiation through melting and crystallization.

关键词： Heat generation lgneous rocks Heat producing elements Continental lithosphere Seismic velocity density

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