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Polypeptide from Moschus Suppresses Lipopolysaccharide-Induced Inflammation by Inhibiting NF-κB-ROS/NLRP3 Pathway

Chinese Journal of Integrative Medicine 2023年第10期29卷 895-904页

作者： YI jing LI Li YIN Zhu-jun QUAN Yun-yun TAN rui-rong CHEN Shi-long lang ji-rui LI jiao ZENG jin LI Yong SUN Zi-jian ZHAO Jun-ning Department of Pharmacology Southwest Medical UniversityLuzhouSichuan Province646000China Sichuan Institute for Translational Chinese Medicine Translational Chinese Medicine Key Laboratory of Sichuan ProvinceSichuan Academy of Chinese Medicine SciencesChengdu610000China Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations College of PharmacyChangsha Medical UniversityChangsha410219China Sichuan Fengchun Pharmaceutical Co. Ltd.DeyangSichuan Province618100China Sichuan Ant Recommendation Biotechnology Co. Ltd.Chengdu610000China

Objective To examine the anti-inflammatory effects and potential mechanisms of polypeptide from Moschus(PPM)in lipopolysaccharide(LPS)-induced THP-1 macrophages and BALB/c *** The polypeptide was extracted from Moschus and analyzed by high-performance liquid chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).Subsequently,LPS was used to induce inflammation in THP-1 macrophages and BALB/c *** LPS-treated or untreated THP-1 macrophages,cell viability was observed by cell counting kit 8 and lactate dehydrogenase release assays;the proinflammatory cytokines and reactive oxygen species(ROS)were measured by enzyme-linked immunosorbent assay and flow cytometry,respectively;and protein and mRNA levels were measured by Western blot and real-time quantitative polymerase chain reaction(qRT-PCR),*** LPS-induced BALB/c mice,the proinflammatory cytokines were measured,and lung histology and cytokines were observed by hematoxylin and eosin(HE)and immunohistochemical(IHC)staining,*** The SDS-PAGE results suggested that the molecular weight of purified PPM was in the range of 10–26 *** vitro,PPM reduced the production of interleukin 1β(IL-1β),IL-18,tumor necrosis factorα(TNF-α),IL-6 and ROS in LPS-induced THP-1 macrophages(Pruitment domain(ASC),and pro-caspase-1(P<0.05 or P<0.01).In addition,qRT-PCR revealed the inhibitory effects of PPM on the mRNA levels of TXNIP,NLRP3,ASC,and caspase-1(P<0.05 or P<0.01).Furthermore,in LPS-induced BALB/c mice,PPM reduced TNF-αand IL

关键词： Moschus polypeptide inflammation NLRP3 inflammasome thioredoxin interacting protein nuclear factorκB Chinese medicine

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麝香多肽分离纯化及其抗炎作用机制研究

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天然产物研究与开发 2022年第12期34卷 2040-2049页

作者：弋静尹竹君全云云陈世龙郎吉瑞黎勇赵军宁李莉西南医科大学药学院泸州646000 四川省中医药科学院中医药转化医学四川省重点实验室成都610000 四川逢春制药有限公司德阳618000

从天然麝香中提取、纯化麝香多肽,利用体外细胞模型筛选有抗炎活性的麝香多肽流分,并研究麝香多肽对小鼠急性肺损伤的保护作用及作用机制。采用冰浴超声、离子交换色谱法从天然麝香中提取、纯化获得5个流分,即为SXP1、SXP2、SXP3、SXP4... 详细信息

从天然麝香中提取、纯化麝香多肽,利用体外细胞模型筛选有抗炎活性的麝香多肽流分,并研究麝香多肽对小鼠急性肺损伤的保护作用及作用机制。采用冰浴超声、离子交换色谱法从天然麝香中提取、纯化获得5个流分,即为SXP1、SXP2、SXP3、SXP4、SXP5。在LPS诱导的THP-1巨噬细胞炎症模型中,SXP4(100μg/mL)可以显著抑制TNF-α和IL-1β产生,表现出明显的抗炎活性。SDS-PAGE初步检测SXP4主要分布在10~26 kDa范围内。在LPS诱导的急性肺损伤小鼠模型中,SXP4(5、15、50 mg/kg)可减少小鼠血清TNF-α和IL-6的含量(P<0.05或P<0.01);改善小鼠肺组织中炎症细胞浸润和改善肺泡壁增厚情况,减轻小鼠肺组织病理损伤;减少小鼠肺组织中IL-1β、IL-18产生,抑制NLRP3、ASC、Caspase-1、Gasdermin D蛋白表达(P<0.01)。综上,麝香多肽SXP4具有较强的抗炎活性,可减轻急性肺损伤小鼠的肺组织病理损伤,其机制可能与SXP4抑制了小鼠体内NLRP3/Caspase-1介导的细胞焦亡有关。

关键词：麝香多肽抗炎焦亡肺损伤

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Recent advances of nanoporous metal-based catalyst: synthesis, application and perspectives

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Journal of Iron and Steel Research International 2019年第8期26卷 779-795页

作者： rui-qi Yao Xing-you lang Qing jiang Key Laboratory of Automobile Materials (Ministry of Education) School of Materials Science and Engineering Jilin University Changchun 130022 Jilin China

Nanoporous metal-based catalysts with the specific bicontinuous interconnected ligaments/pores network exhibit highly active performances in application for energy conversion, which represent a broader trend in the design of catalyst materials. These promising nanomaterials commendably provide highly conductive porous morphologies with reduced contact resistances, large electrochemical surface areas with enhanced catalytic efficiency, and controllable synthesis for regulating the performances. Thus, we highlight recent designs of nanoporous metals, alloys, transition metal compounds and hierarchical structures mainly employed in catalysis process. We discuss applied strategies to utilize characteristics of nanoporous metals in the energetic field of catalytic reactions. Moreover, development and evolution of novel controllable synthesis methods are applied in preparation of nanoporous non-noble metals and transition metal compounds. Finally, we present some outlooks and perspectives on the nanoporous metal catalyst and suggest ways for achieving alternative materials in catalysis applications.

关键词： Nanoporous metal Electrochemical catalyst Hierarchical structure Metal-based compound Structure-activity correlation

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Astronomical Knowledge Entity Extraction in Astrophysics Journal Articles via Large language Models

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Research in Astronomy and Astrophysics 2024年第6期24卷 140-155页

作者： Wujun Shao rui Zhang Pengli ji Dongwei Fan Yaohua Hu Xiaoran Yan Chenzhou Cui Yihan Tao Linying Mi lang Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Data Center Beijing 100101China Research Institute of Artificial Intelligence Zhejiang LabHangzhou 311100China Guilin University Guangxi 541006China Xidian University Xi’an 710126China

Astronomical knowledge entities,such as celestial object identifiers,are crucial for literature retrieval and knowledge graph construction,and other research and applications in the field of *** methods of extracting knowledge entities from texts face numerous challenging obstacles that are difficult to ***,there is a pressing need for improved methods to efficiently extract *** study explores the potential of pre-trained Large language Models(LLMs)to perform astronomical knowledge entity extraction(KEE)task from astrophysical journal articles using *** propose a prompting strategy called PromptKEE,which includes five prompt elements,and design eight combination prompts based on *** select four representative LLMs(Llama-2-70B,GPT-3.5,GPT-4,and Claude 2)and attempt to extract the most typical astronomical knowledge entities,celestial object identifiers and telescope names,from astronomical journal articles using these eight combination *** accommodate their token limitations,we construct two data sets:the full texts and paragraph collections of 30 *** the eight prompts,we test on full texts with GPT-4and Claude 2,on paragraph collections with all *** experimental results demonstrate that pre-trained LLMs show significant potential in performing KEE tasks,but their performance varies on the two data ***,we analyze some important factors that influence the performance of LLMs in entity extraction and provide insights for future KEE tasks in astrophysical articles using ***,compared to other methods of KEE,LLMs exhibit strong competitiveness in multiple aspects.

关键词： astronomical databases:miscellaneous virtual observatory tools methods:data analysis

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Direct synthesis of a disinfectant with fresh scent of green plants by semi-hydrogenation of alkynol on Pd single-atom catalysts

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Nano Research 2024年第5期17卷 3872-3878页

作者： Yan jiang Xuetong Yu Yuxia ji Xunzhu jiang Yalin Guo Tianbo Li Liang Gao rui lang Yanxiong Fang Botao Qiao jinxiang Dong School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116024China Guangdong Provincial Key Laboratory of Plant Resources Biorefinery Guangzhou 510006China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116China

Alcohol-based disinfectants have protected people in the coronavirus disease 2019(COVID-19)pandemic,but olfactory stimuli of ethanol may evoke unpleasant memories associated with stressful situations in the devastating infectious *** smell of ethanol in household cleaning and disinfectant products can be covered up by the fragrance additives,and 3-hexenol is especially appreciated for the characteristic,strong odor of green *** production of 3-hexenol relies on the selective hydrogenation of 3-hexyn-1-ol,where Lindlar catalyst is normally used for the superior *** achieving such catalytic transformation in ethanol solution seems as a direct way to produce a disinfectant with green aroma,a popular consumer product in the post-COVID era,severe leaching of toxic Pb hinders Lindlar catalyst as a promising *** find that the Fe_(2)O_(3) supported Pd single-atom catalyst is highly selective to fulfill semi-hydrogenation of 3-hexyn-1-ol in 75%ethanol,and the aforementioned household product is readily generated after filtrating the stable,solid catalyst out of reaction ***-atom catalysts have been frequently utilized for fine-chemical synthesis,while in this work they make stunning debut in practical manufacture of daily used products.

关键词： single-atom catalysis hydrogenation fragrance household product coronavirus disease 2019(COVID-19)

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Multiplicative forms on Poisson groupoids

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Science China Mathematics 2025年第01期 169-206页

作者： Zhuo Chen Honglei lang Zhangju Liu Department of Mathematical Sciences Tsinghua University College of Science China Agricultural University School of Mathematics and Statistics Henan University

First,we prove a decomposition formula for any multiplicative differential form on a Lie groupoid ***,we prove that if G is a Poisson Lie groupoid,then the space ?mult·（G） of multiplicative forms on G has a differential graded Lie algebra（DGLA） ***,when combined with ?·（M）,which is the space of forms on the base manifold M of G,?mult·（G） forms a canonical DGLA crossed *** supplements a previously known fact that multiplicative multi-vector fields on G form a DGLA crossed module with the Schouten algebra Γ（∧·A） stemming from the Lie algebroid A of G.

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ChMYB1-ChbHLH42-ChTTG1 module regulates abscisic acidinduced anthocyanin biosynthesis in Cerasus humilis

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Horticultural Plant Journal 2024年第1期10卷 51-65页

作者： Xiaolong ji Zhe Li Mingyu Zhang Shaoyu lang Xingshun Song State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbinHeilongjiang 150040China Department of Genetics College of Life ScienceNortheast Forestry UniversityHarbinHeilongjiang 150040China

Cerasus humilis is a kind of economic fruit tree peculiar to China,which is widely used in the food,landscape,and pharmaceutical *** are a phenolic metabolite that plays an essential role in fruit ***,the regulatory network of *** in anthocyanin biosynthesis is still *** this study,the R2R3-MYB transcription factor ChMYB1 was isolated from the full genome of the *** one-hybrid,dual-luciferase assays,and GUS staining showed that ChMYB1 significantly increased anthocyanin contents in *** fruit by promoting the expression of ChCHS and ChUFGT by binding MBS(MYB-binding elements).ChMYB1 interacted with ChbHLH42and ChTTG1 to form the MBW complex and further enhanced the expression of *** addition,abscisic acid(ABA)treatment promoted the expression of ChMYB1 and anthocyanin accumulation in *** ***,ABA treatment enhanced the interaction between ChMYB1 and ***,ChABI5 inhibited the interaction between ChMYB1 and *** data elucidated the primary molecular mechanism of anthocyanin biosynthesis in *** fruit,deepening the understanding of the regulatory network affecting anthocyanin metabolism in edible fruit crops.

关键词： Cerasus humilis Anthocyanin ChMYB1 Fruit ABA

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Dual-level stress plateaus in honeycombs subjected to impact loading:perspectives from bucklewaves, buckling and cell-wall progressive folding

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Acta Mechanica Sinica 2019年第1期35卷 70-77,I0003页

作者： lang Li Zhenyu Zhao rui Zhang Bin Han Qiantheng Zhang Tian jian Lu State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong UniversityXi'an 710049China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China MOE Key Laboratory for Multifunctional Materials and Structures Xi'an Jiaotong UniversityXi'an 710049China School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049China School of Engineering Brown UniversityProvidenceRI 02912USA Research Institute of Xi'an jiaotong University ZhejiangHangzhou 311215China

Dual-level stress plateaus (i.e., relatively short peak stress plateaus, followed by prolonged crushing stress plateaus) in metallic hexagonal honeycombs subjected to out-of-plane impact loading are characterized using a combined numerical and analytical study, with the influence of the strain-rate sensitivity of the honeycomb pare nt material accounted for. The predicti ons are validated against existing experimental measurements, and good agreement is achieved. It is demonstrated that honeycombs exhibit dual-level stress plateaus when bucklewaves are initiated and propagate in cell walls, followed by buckling and progressive folding of the cell walls. The abrupt stress drop from peak to crushing plateau in the compressive stress versus strain curve can be explained in a way similar to the quasi-static buckling of a clamped plate. The duration of the peak stress plateau is more evident for strain-rate insensitive honeycombs.

关键词： Honeycomb Impact loading Dual-level stress Strain-rate sensitivity

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Effect of MgO promoter on Ni-based SBA-15 catalysts for combined steam and carbon dioxide reforming of methane

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Journal of Natural Gas Chemistry 2008年第3期17卷 225-231页

作者： Bingyao Huang Xiujin Li Shengfu ji Bao lang Fabien Habimana Chengyue Li State Key Laboratoly of Chemical Resource Engineering Beijing University of Chemical Technology. Beijing 100029. China Department of Environmental Engineering Beijing University of Chemical Technology Beijing 100029 China

A series of Ni/SBA-15 catalysts with Ni contents ranging from 5 wt% to 15 wt%, as well as another series of 10%Ni/MgO/SBA-15 catalysts, in which the range of the MgO content was from 1 wt% to 7 wt%, were prepared, and their catalytic performances for the reaction of combined steam and carbon dioxide reforming of methane were investigated in a continuous flow microreactor. The structures of the catalysts were characterized using the XRD, H2-TPR and CO2-TPD techniques. The results indicated that the CO selectivity for this reaction was very close to 100%, and the H2/CO ratio of the product gas could be controlled by changing the H2O/CO2 molar ratio of the feed gas. The simultaneous and plentiful existing of steam and CO2 had a significant influence on the catalytic performance of the 10%Ni/SBA-15 catalyst without modification. After reacting at 850 °C for 120 h over this catalyst, the CH4 conversion dropped from 98% to 85%, and the CO2 conversion decreased from 86% to 53%. However, the 10%Ni/3%MgO/SBA-15 catalyst exhibited a much better catalytic performance, and after reacting for 620 h, the CO2 conversion over this catalyst dropped from 92% to around 77%, while the CH4 conversion was not decreased. Oxidation of the Ni0 species as well as carbon deposition during the reaction were the main reasons for the deactivation of the catalyst without modification. On the other hand, modification by the MgO promoter improved the dispersion of the Ni0 species, and enhanced the CO2 adsorption affinity which in turn depressed the occurring of carbon deposition, and thus retarded the deactivation process.

关键词： MgO promoter Ni-based catalyst SBA-15 methane combined steam carbon dioxide reforming synthesis gas

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Epitaxial etching of organic single crystals

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Chinese Chemical Letters 2022年第1期33卷 533-536页

作者： Cong Zhang Daizong ji lang jiang Yunqi Liu Dacheng Wei State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Institute of Molecular Materials and Devices Fudan UniversityShanghai 200433China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

Organic single crystals(OSCs)have received increasing interest in the last decades for their potential applications in flexible *** there are various subtractive manufacturing methods of organic electronics,the subtractive manufacturing of OSCs is still a challenge,since OSCs are assembled via weak van-der-Waals interactions which are vulnerable and cannot afford damages and suffer the degradation of performances after the ***,we develop an epitaxial etching strategy which clips the OSCs and keeps high-quality crystalline nature of the resulting *** a result,high-quality organic micro-ribbon arrays are fabricated which maintains 89%charge mobility in average compared with original OSCs,showing great potential of this subtractive manufacturing method in future organic electronics.

关键词： Epitaxial etching Organic single crystals Subtractive manufacturing Field-effect transistor Organic semiconductor

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