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住院时间延长的胎粪吸入综合征新生儿临床特征及2岁患病情况分析

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岭南急诊医学杂志 2024年第4期29卷 370-373页

作者：卢燕玲王健兰卢珍通陈志凤南方医科大学第十附属医院东莞市人民医院新生儿科 523000

目的:探索新生儿胎粪吸入综合征(meconium aspiration syndrome,MAS)的临床特征及生后2岁内患病情况,为临床疾病管理提供参考。方法:回顾性收集2016年6月至2021年5月收治的87例MAS新生儿的临床资料及调查出院后2岁患病情况,根据住院时... 详细信息

目的:探索新生儿胎粪吸入综合征(meconium aspiration syndrome,MAS)的临床特征及生后2岁内患病情况,为临床疾病管理提供参考。方法:回顾性收集2016年6月至2021年5月收治的87例MAS新生儿的临床资料及调查出院后2岁患病情况,根据住院时长分为>7天组(42例)与≤7天组(45例),比较两组在院病例资料及2岁内患病调查资料。结果:较≤7天组,>7天组住院费用、患儿窒息比例、在院并发气漏比例、高频呼吸机辅助通气及有创呼吸机辅助通气占比、第1天白细胞数、发生血小板减少占比、第7天血小板平均体积更高,初始FiO_(2)、入院1小时FiO_(2)、总氧疗时长与使用抗生素总时长更长,差异显著(P7天组喘息人数高于≤7天组,差异显著(P<0.05)。结论:近一半的胎粪吸入综合征新生儿住院时间延长及住院费用增加。胎粪吸入综合征新生儿住院时间延长与窒息、气漏、有创呼吸机辅助通气、感染有关。住院时间延长的胎粪吸入综合征患儿生后2岁内更容易发生喘息。

关键词：住院时间胎粪吸入综合征临床特征并发症

Erythrocentaurin, Biosynthesis Postulation and Biomimetic Synthesis

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有机化学 2004年第Z1期24卷 300-301页

作者： LEI,Jun YUAN,Xiang-Hui LIU,Zhu-lan LIU,jian-Li Department of Chinese Material Medica Northwest University Xi''an 710069 Department of Chinese Material Medica Northwest University Xi''an 710069 Department of Chinese Material Medica Northwest University Xi''an 710069 Department of Chinese Material Medica Northwest University Xi''an 710069

　　Erythrocentaurin is a relatively simple nature product isolated from the root of Gentiana macrophylla Pall.[1] The co-existed of gentiopicroside from the same species led to speculation that erythrocentaurin is a biosynthesis product of gentiopicroside. The transformation of secologanin to carbocyclic aglycone under biomimetic condition has already known (Scheme 1).[2,3] The postulated biosynthesis pathway of erythrocentaurin may be in the same way. In the process the cyclic hemiacetal of the aglycone opened to the dialdehyde which then undergoes a vinylogous aldol reaction, and then dehydroxylation and double bond migration to the title compound (Scheme 2).……

关键词： aldol reaction double bond

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模块化集成医疗实验室关键技术

建筑技术 2024年第18期55卷 2241-2244页

作者：蓝建勋曾金亮赵俊杰陈嘉欣广东省粤建装饰集团有限公司广州510610 广东建雅室内工程设计施工有限公司广州510050

目前医院既有传统实验室固有空间模式已无法满足现代技术的多场景、多功能切换要求,针对传统既有实验室空间的单一性和功能管道的复杂性,通过研发模块化集成隔墙和集成吊顶来汇集水、电、气路及通风等管线,以实现场景化整合、空间快速切... 详细信息

目前医院既有传统实验室固有空间模式已无法满足现代技术的多场景、多功能切换要求,针对传统既有实验室空间的单一性和功能管道的复杂性,通过研发模块化集成隔墙和集成吊顶来汇集水、电、气路及通风等管线,以实现场景化整合、空间快速切换,解决实验室固有空间缺陷、多专业管线凌乱等难题,进而有效应对未来实验室研究的发展需求。

关键词：医疗实验室模块化吊顶集成隔墙模块化机电系统

Acute changes of blood pressure and heart rate induced by a strong earthquake

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Chinese Medical Journal 2010年第8期123卷 1084-1085页

作者： HE Sen CHEN Xiao-ping LI jiang-bo LIN jian-lan LUO Xue-ju LUO Xiao-jia Department of Cardiology West China Hospital Sichuan University Chengdu Sichuan 610041 China

Ahigh death toll during an earthquake comes not only from injuries related to the destruction of buildings or road accidents but also from sudden death resulting from cardiovascular problems, as clearly shown in reports. The increased rate of cardiovascular mortality during an earthquake has been ascribed to the impact of a major emotional stress on the heart, mediated through an increase in cardiac sympathetic activity, and probably including some other neuroendocrine mechanisms. A rise in blood pressure （BP） and heart rate （HR） may be directly responsible for the increased rate of cardiovascular mortality during an earthquake. Previously published studies about the acute changes of BP and HR used indirect information,

关键词： ambulatory blood pressure acute changes earthquake stress

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

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Acta Pharmaceutica Sinica B 2024年第1期14卷 67-86页

作者： Chunhao Zhu Xiaobing lan Zhiqiang Wei jianqiang Yu jian Zhang School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Basic Medical Science Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Ocean University of ChinaQingdao 266100China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical ***,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse *** G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining *** research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse *** review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this *** will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased *** is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.

关键词： Neuropathic pain Allosteric modulators G protein-coupled receptors Analgesia

Atomic force microscopy-based nanoscale infrared techniques for liquid environments

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Science Bulletin 2024年第2期69卷 151-153页

作者： jian Li Jing Liang Mu-Hao lan Xing-Hua Xia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Infrared(IR)light energy matches well with the vibration and rotation of chemical bonds in molecules,hence IR spectroscopy is commonly used for accurate molecular identification[1].Conventional IR analysis involves bulk samples,providing averaged information of the entire *** spatially-resolved investigation of heterogeneous sample properties is constrained by the micrometer-level spatial resolution of optical IR microscopy.

关键词： spatially hence rotation

An Analysis of Authenticity in CET-4 and TEM-8

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Sino-US English Teaching 2007年第2期4卷 28-33页

作者： BO jian-lan Foreign language School Linyi Normal University Linyi Shandong 276005 China

This paper mainly investigates the authenticity in CET-4 and TEM-8. The main finding is that both CET-4 and TEM-8 basically satisfy the requirements of authenticity except that some improvements need to be made. Two conclusions from our discussion：（1） Authenticity is a relative term; （2） As a criterion, it must coalesce into other criteria are like validity and reliability; and （3） Authenticity must be determined for each specific testing situation.

关键词： authenticity CET-4 TEM-8

‘The Luster of Wood and Colour’The Virtual Exhibition of Woodcut New Year Painting:Culture and Folklore Exhibited in New Year Woodcut Paintings

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China & The World Cultural Exchange 2021年第3期87卷 37-38页

作者： lan jian 不详

Chinese New Year,also known as Spring Festival,is the most important holiday for Chinese *** the Spring Festival,people hang colourful paintings to celebrate good harvests and express best wishes and expectations for ... 详细信息

关键词： Painting folk painting

新时期高校辅导员队伍建设存在的问题及对策研究

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齐齐哈尔高等师范专科学校学报 2024年第1期 85-87页

作者：蒋吉颖才艳雪兰健陈梦宇王军齐齐哈尔医学院附属第二医院黑龙江齐齐哈尔161006

高校辅导员是大学生思想政治的引导者、社会生活的引路人。辅导员在大学生思想政治教育、职业发展规划、心理健康、日常生活管理等方面起着重要作用。在新时期,随着国家的发展,大学生的发展呈现出新的特点,这对高校辅导员职业素质及专... 详细信息

高校辅导员是大学生思想政治的引导者、社会生活的引路人。辅导员在大学生思想政治教育、职业发展规划、心理健康、日常生活管理等方面起着重要作用。在新时期,随着国家的发展,大学生的发展呈现出新的特点,这对高校辅导员职业素质及专业能力也提出新要求。本文通过对高校辅导员队伍建设中出现的新情况、新问题的分析,提出进一步加强高校辅导员队伍建设的对策和建议。

关键词：高校大学生辅导员对策