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Efficacy and safety of rituximab therapy for systemic lupus erythematosus:a systematic review and meta-analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期13卷 731-744页

作者： lan lan fei HAN Jiang-hua CHEN Department of Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective:To review the efficacy and safety of rituximab therapy for systemic lupus erythematosus(SLE).Methods:We searched for randomized controlled trails and observational studies that evaluated the effect of rituximab based on the systemic lupus erythematosus disease activity index(SLEDAI),British Isles lupus assessment group index(BILAG),urine protein levels,and the prednisolone dose,and had adequate data to calculate the mean,standard deviation(SD),and 95% confidence intervals,and to systematically review and meta-analyze observational studies with fixed effects model or random effects ***:We included 2 randomized controlled studies and 19 observational clinical *** summarized the data from the 19 observational studies,analyzed the heterogeneity of the literature,and then used fixed effect model or random effect model for statistical *** SLEDAI,BILAG,and urine protein levels and the prednisolone dosage were decreased after rituximab treatment,and the decreases in the BILAG,urine protein levels,and the prednisolone dose were found to be significant(P<0.05),when compared with baseline ***'s adverse effects generally could be controlled with an effective dosing ***:Although there are still controversies about rituximab's treatment on SLE,but our study had showed that rituximab had favorable effects on refractory *** long-term efficacy and safety of rituximab require further study.

关键词： Systemic lupus erythematosus Rituximab Meta-analysis

RNA m^(6)A meets transposable elements and chromatin

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Protein & Cell 2021年第12期12卷 906-910页

作者： Chenxi He fei lan Shanghai Key Laboratory of Medical Epigenetics International Laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan Universityand Key Laboratory of Carcinogenesis and Cancer InvasionMinistry of EducationLiver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina

A^(6)-methyladenosine(m^(6)A)is the most abundant internal chemical mark in eukaryotic messenger RNAs(mRNAs),regulating various processes in the life cycle of mRNA including splicing,nuclear export,degradation and tra... 详细信息

关键词： RNAs elements

Humanity and Paternal Eros: The Father-Son Relationship in Comparative Perspective

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Frontiers of Philosophy in China 2015年第4期10卷 629-646页

作者： lan fei Department of Philosophy and Religion The University of Mississippi University MS 38677USA

This paper examines the human relational patterns presented in the philosophical writings of the Confucian thinker Dai Zhen (戴震1724-77) and the Jewish philosopher Emmanuel Levinas’s (1906-95) Totality and Infinity to uncover the ethical significance of the father-son relationship. I argue that for both thinkers the father-son relation is not just one type of human relationship among other social dyads, but rather, of greater significance, serves as the paradigmatic model of the ethical human relationship in bringing to light the idea of the ethical self as a responsible being in relation to others.

关键词： Confucianism Jewish thought Dai Zhen Emmanuel Levinas the father-son relationship responsibility

Outcome prediction value of National Early Warning Score in septic patients with community-acquired pneumonia in emergency department: A single-center retrospective cohort study

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World Journal of Emergency Medicine 2020年第4期11卷 206-215页

作者： Hai-jiang Zhou Tian-fei lan Shu-bin Guo Emergency Medicine Clinical Research Center Beijing Chao-yang HospitalCapital Medical University&Beijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijingChina Department of Allergy Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

BACKGROUND:To evaluate the accuracy of National Early Warning Score(NEWS)in predicting clinical outcomes(28-day mortality,intensive care unit[ICU]admission,and mechanical ventilation use)for septic patients with community-acquired pneumonia(CAP)compared with other commonly used severity scores(CURB65,Pneumonia Severity Index[PSI],Sequential Organ Failure Assessment[SOFA],quick SOFA[qSOFA],and Mortality in Emergency Department Sepsis[MEDS])and admission lactate ***:Adult patients diagnosed with CAP admitted between January 2017 and May 2019 with admission SOFA≥2 from baseline were *** characteristics were *** primary outcome was the 28-day mortality after admission,and the secondary outcome included ICU admission and mechanical ventilation *** prediction value of parameters above was compared using receiver operating characteristics(ROC)*** regression analyses were carried out to determine the risk factors for the 28-day ***-Meier survival curves were plotted and compared using optimal cut-off values of qSOFA and ***:Among the 340 enrolled patients,90 patients were dead after a 28-day follow-up,62 patients were admitted to ICU,and 84 patients underwent mechanical *** single predictors,NEWS achieved the largest area under the receiver operating characteristic(AUROC)curve in predicting the 28-day mortality(0.861),ICU admission(0.895),and use of mechanical ventilation(0.873).NEWS+lactate,similar to MEDS+lactate,outperformed other combinations of severity score and admission lactate in predicting the 28-day mortality(AUROC 0.866)and ICU admission(AUROC 0.905),while NEWS+lactate did not outperform other combinations in predicting mechanical ventilation(AUROC 0.886).Admission lactate only improved the predicting performance of CURB65 and qSOFA in predicting the 28-day mortality and ICU ***:NEWS could be a valuable predictor in septic patients with CAP in emergency depa

关键词： Community-acquired pneumonia Sepsis National Early Warning Score(NEWS) Intensive care unit Emergency departments

Two-Component Description for Relativistic Fermions

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Communications in Theoretical Physics 2009年第6期51卷 1095-1100页

作者： CHEN Yu-Qi SANG Wen-Long YANG lan-fei Institute of Theoretical Physics Academia Sinica Beijing 100080 China

We propose a two-component form to describe massive relativistic fermions in gauge theories. Relations between the Green＇s functions in this form and those in the conventional four-component form are derived. It is shown that the S-matrix elements in both forms are exactly the same. The description of the fermion in the new form simplifies significantly the γ-matrix algebra in the four-component form. In particular, in perturbative calculations the propagator of the fermion is a scalar function. As examples, we use this form to reproduce the relativistic spectrum of hydrodron atom, the S-matrix of e＋e-→μ＋μ- and QED one-loop vacuum polarization of photon.

关键词： fermions two-component description Dirac equation

Effects of bicarbonate and cathode potential on hydrogen production in a biocathode electrolysis cell

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Frontiers of Environmental Science & Engineering 2014年第4期8卷 624-630页

作者： Dawei LIANG Yanyan LIU Sikan PENG fei lan Shanfu LU Yan XIANG Key Laboratory of Bio-lnspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry & Environment Beihang University Beijing 100191 China Beijing Key Laboratory for Advanced Functional Materials and Thin Fihn Technology Beihang University Beijing 100191 China

A biocathode with microbial catalyst in place of a noble metal was successfully developed for hydrogen evolution in a microbial electrolysis cell （MEC）. The strategy for fast biocathode cultivation was demonstrated. An exoelectrogenic reaction was initially extended with an H2-full atmosphere to enrich Ha-utilizing bacteria in a MEC bioanode. This bioanode was then inversely polarized with an applied voltage in a half-cell to enrich the hydrogen-evolving biocathode. The electrocatalytic hydrogen evolution reaction （HER） kinetics of the biocathode MEC could be enhanced by increasing the bicarbonate buffer concentration from 0.05 mol·L-1 to 0.5 mol· L-1 and/or by decreasing the cathode potential from -0.9 V to - 1.3 V vs. a saturated calomel electrode （SCE）. Within the tested potential region in this study, the HER rate of the biocathode MEC was primarily influenced by the microbial catalytic capability. In addition, increasing bicarbonate concentration enhances the electric migration rate of proton carriers. As a consequence, more mass H＋ can be released to accelerate the biocathode-catalyzed HER rate. A hydrogen production rate of 8.44 m3. m 3. d1 with a current density of 951.6 A. m-3 was obtained using the biocathode MEC under a cathode potential of - 1.3 V vs. SCE and 0.4 mol· L-1 bicarbonate. This study provided information on the optimization of hydrogen production in biocathode MEC and expanded the practical applications thereof.

关键词： microbial electrolysis cell (MEC) biocathode hydrogen production bicarbonate cathode potential

Empyema and mediastinal abscess in pyriform sinus f istula: A case report

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World Journal of Emergency Medicine 2019年第4期10卷 244-247页

作者： Hai-jiang Zhou Wen-peng Yin Tian-fei lan Shu-bin Guo Department of Emergency Medicine Beijing Chao-yang HospitalCapital Medical UniversityBeijing 100020China Department of Allergy Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Dear editor,Though notorious for its tendency to induce recurrent neck abscess,pyriform sinus fistula is of importance despite its *** usually presents diagnostic and therapeutic *** of post-infectious fi brosis,the embryologic origin of pyriform sinus fi stula is diffi cult to appreciate in certain *** we present a case with empyema and mediastinal abscess caused by pyriform sinus fi stula and share our experience in the treatment of this patient.

关键词： Empyema mediastinal abscess pyriform sinus fistula

A new polymorphism in the GRP78 is not associated with HBV invasion

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World Journal of Gastroenterology 2009年第39期15卷 4958-4961页

作者： Xiao Zhu Yi Wang Tao Tao Dong-Pei Li fei-fei lan Wei Zhu Dan Xie Hsiang-Fu Kung Institute of Oncology Affiliated Tumor Hospital of Guangzhou Medical College Guangzhou 510095 Guangdong Province China State Key Laboratory of Oncology in South China CancerCenter Sun Yat-sen University Guangzhou 510060 GuangdongProvince China Department of Digestive Diseases Zibo Central Hospital Zibo 255000 Shandong Province China Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 Guangdong Province China Laboratory of Integrated Biosciences School of Life Sciences Sun Yat-sen University Guangzhou 510275 Guangdong Province China

AIM:To examine the association between -86 bp(T>A) in the glucose-regulated protein 78 gene(GRP78) and hepatitis B virus(HBV) ***:DNA was genotyped for the single-nucleotide polymorphism by polymerase chain reaction followed by sequencing in a sample of 382 unrelated HBV carriers and a total of 350 sex-and age-matched healthy *** markers for HBV infection were determined by enzyme-linked immunosorbent as-say kits or clinical chemistry ***:The distributions of allelotype and genotype in cases were not significantly different from those in *** addition,our fi ndings suggested that neither alanine aminotransferase/hepatitis B e antigen nor HBV-DNA were associated with the allele/genotype variation in HBV infected ***:-86 bp T>A polymorphism in GRP78 gene is not related to the clinical risk and acute exacerbation of HBV invasion.

关键词： Acute exacerbation Glucose-regulated protein 78 Hepatitis B virus Single-nucleotide polymorphism

Effects of tsaoko (Fructus tsaoko) cultivating on tree diversity and canopy structure in the habitats of eastern hoolock gibbon (Hoolock leuconedys)

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Zoological Research 2014年第3期35卷 231-239页

作者： Sheng-Dong YUAN Han-lan fei Shao-Han ZHU Liang-Wei CUI Huai-Sen AI Peng-fei FAN Key Laboratory of Forest Disaster Warning and Control in Yunnan Province Southwest Forestry University Institute of Eastern-Himalaya Biodiversity Research Dali University Gaoligongshan National Natural Reserve

In this study, the quadrat method was used to study the effects of tsaoko （Fructus tsaoko） plantation on tree diversity and canopy structure of two natural habitats of eastern hoolock gibbon （Hoolock leuconedys）： Nankang （characterized by extensive tsaoko plantation） and Banchang （relatively well reserved and without tsaoko plantation）. Totally, 102 tree species from 25 families and 16 woody liana species from 10 families were recorded in Nankang, whereas 108 tree species from 30 families and 17 woody liana species from 12 families were recorded in Banchang. Although the tree species between two habitats is different, both habitats are characterized by enriched food resources for eastern hoolock gibbons, sharing similar dominant plant families. Due to tsaoko plantation, tree density proportion and diversity of forest layer I （〉20 m） in Nankang were both significantly decreased, but the tree density of layerH （10-20 m） increased. Likewise, in conjunction with these behavioral observations, we also address potential impacts of tsaoko plantation on the behavior of eastern hoolock gibbon.

关键词： Eastern hoolock gibbon (Hoolock leuconedys) Habitat Tree diversity Canopy structure Fructus tsaoko plantation Mt.Gaoligong