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Efficacy of 2lPAPI^®, a Micro-Immunotherapy Drug, in Patients with High-Risk Papillomavirus Genital Infection

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Advances in Infectious Diseases 2016年第1期6卷 7-14页

作者： Gilles Thomas Hélène Cluzel Jacqueline lafon Jacques Bruhwyler Béatrice lejeune Private Gynecology Practice Perpignan France labo’life France sarl Pescalis Les Magny France ECSOR sa/nv Blanmont Belgium labo’life Belgium sprl Les Isnes Belgium

Human papillomaviruses (HPVs) are well known for being linked to the development of cervical cancers, most of them being caused by the high-risk (HR) oncogenic genotypes, mainly 16 and 18. The efficacy of 2lPAPI® (labo’life), a micro-immunotherapy homeopathic drug, has been evaluated in HR-HPV infected women (n = 18), in a private gynecology practice, by comparing them to an untreated control group (n = 18). Patients were 20 to 45 years old and had cytology with Atypical Squamous Cells of Undetermined Significance (ASCUS) or low grade Superficial Intra lesions/ Cervical Intraepithelial Neoplasia Grade I (lSIl/CINI). Patients freely chose to be treated with the drug or not. Those deciding not to take the drug remained untreated and were followed as a control group. The drug was taken at the regimen of one capsule per day during 6 months. HR-HPV and cytology were evaluated at 6 and 12 months. After 12 months, HR-HPV was cleared in 78% of the patients taking the drug versus 44% in those not taking it (p = 0.086). In patients over 25 years, HR-HPV clearance in the treated group was significantly higher (81.3%) than in the control group (20%) (p = 0.004). The difference in the regression of the lesion grades almost reached statistical significance (p = 0.053). This follow-up confirms that the micro-immunotherapy drug 2lPAPI® is a safe and effective therapeutic approach to treat HR-HPV cervical lesions in women over 25 years.

关键词： High-Risk Human Papillomavirus Micro-Immunotherapy Genital Infection Homeopathy 2lPAPI®

The animal cachexia score(ACASCO)

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Animal Models and Experimental Medicine 2019年第3期2卷 201-209页

作者： Angelica Betancourt Sílvia Busquets Marta Ponce Míriam Toledo Joan Guàrdia‐Olmos Maribel Peró‐Cebollero Francisco J.lópez‐Soriano Josep M.Argilés Cancer Research Group Departament de Bioquímica i Biomedicina MolecularFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Institut de Biomedicina de la Universitat de Barcelona BarcelonaSpain Advanced Statistical Data Analysis Applied to Psychology Departament de Metodologia de les Ciències del ComportamentFacultat de PsicologiaUniversitat de BarcelonaBarcelonaSpain Institut de recerca en Cervell Cogniciói Conducta(IR3C)BarcelonaSpain

Background:None of the published studies involving cancer cachexia experimental models have included a measure of the severity of the syndrome like the scoring system previously developed for human *** aim of the present investigation was to define and validate a cachexia score usable in both rat and mouse tumor ***:In order to achieve this goal,we included in the study one rat model(Yoshida AH‐130ascites hepatoma)and two mouse models(lewis lung carcinoma and Colon26 carcinoma).The Animal cachexia score(ACASCO)includes five components:(a)body and muscle weight loss,(b)inflammation and metabolic disturbances,(c)physical performance,(d)anorexia,and(e)quality of life measured using discomfort symptoms and behavioral ***:Using the ACASCO values,three cut‐off values were estimated by applying hierarchical cluster *** groups were originally described,one exactly below the observed mean,a second exactly over the mean,and two other groups adjusted to every cue(inferior and superior).The three cut‐off values were estimated through maximization of the classification *** was accomplished by using a similarity matrix based on the metric properties of the variables and assuming multinormal *** results show that the four groups were:no cachexia,mild cachexia,moderate cachexia and advanced ***:The results obtained allow us to conclude that the score could be very useful as an endpoint in pre‐clinical studies involving therapeutic strategies for cancer *** potential usefulness of ACASCO relates to the primary endpoint in pre‐clinical cancer cachexia drug evaluations.

关键词： anorexia cachexia classification physical performance quality of life score wasting weight loss

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气泡-液体闭式多股射流的大涡模拟研究

工程热物理学报 2003年第1期24卷 127-130页

作者：杨玟周力行李荣先 l.S.Fan 清华大学工程力学系北京100084 Department of Chemical Engineering The Ohio State UniversityColumbusUSA

采用气泡-液体两相流动的欧拉-拉氏大涡模拟,研究了矩形通道内多股射流形成的气泡-液体两相湍流流动,得到了气液两相湍流瞬态结构,产生和发展过程。研究结果发现气泡和液体都有瞬态大涡结构,气泡脉动比液体的强。大涡模拟统计结果给出... 详细信息

采用气泡-液体两相流动的欧拉-拉氏大涡模拟,研究了矩形通道内多股射流形成的气泡-液体两相湍流流动,得到了气液两相湍流瞬态结构,产生和发展过程。研究结果发现气泡和液体都有瞬态大涡结构,气泡脉动比液体的强。大涡模拟统计结果给出了有无气泡两种情况下的液体湍流脉动速度均方根值分布。瞬态和统计结果都表明,气泡增大了液体湍流,液体湍流来源于其自身的剪切产生和气泡的作用。这与二阶矩模型模拟结果定性一致。

关键词：气泡-液体闭式多股射流气液两相射流两相湍流大涡模拟

Alcohols solubilization in a nonionic fluorinated surfactant based system: Effect on the mesoporous silica characteristics

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Alcohols solubilization in a nonionic fluorinated surfactant...

Evaluation of Maximum Power Point Controllers in Photovoltaic System

中国化学会第28届学术年会

作者： J.l.Blin M.J.Stébé Equipe Physico-chimie des Collodes Université Henri PoincaréNancy 1Vandoeuvre-les-Nancy cedexFrance 54000

＜正＞Porous materials have found wide applications in many traditional fields such as catalysis,adsorption,electronics and environmental technology because of their high surface area coupled with many other physical and chemical properties[1,2].Surfactant templating strategy affords a variety of porous networks with a wide range of pore sizes,well-defined morphologies on controllable length scales and various chemical functionalities to match the needs of different applications[3].Consequently,the behavior of the surfactant in aqueous solution,which can be affected by the presence of additives,is very important for the design of mesoporous materials.

关键词： Nonionic fluorinated surfactant Mesoporous silica material Alcohol addition Hexagonal liquid crystal phase

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Evaluation of Maximum Power Point Controllers in Photovoltai...

作者： N.Drir l.Barazane M.loudini Faculté d’Electronique et d’Informatique Université des Sciences et de la Technologie Houari Boumediene(USTHB) laboratoire de Communication dans les Systèmes Informatiques(lCSI) Ecole Nationale Supérieure d’Informatique(ESI)

The characteristics output of solar panels are nonlinear and change with the environmental factors, so we need a controller named maximum power point tracker MPPT to extract the maximum power at the terminals of photovoltaic generator. In this study we present the two most popular controllers refers to traditional approach based on the perturbation & observation(P&O) methods and incremental conductance(INC). Then we explore a new intelligent controller based on fuzzy logic. The obtained results under various conditions of functioning have shown the good tracking and rapid response to change in different meteorological conditions of intelligent controller compare with the conventional one.

关键词： Fuzzy logic maximum power point tracking photovoltaic P&O incremental conductance

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新型大涡数值模拟亚格子模型及应用

计算物理 2004年第3期21卷 289-293页

作者：崔桂香周海兵张兆顺 l.Shao 清华大学工程力学系北京100084 laboratory of Fluid Mechanics and Acoustics

　基于湍流大小尺度间动量输运的结构函数方程,提出了一种新的湍流大涡模型(les)亚格子涡粘模式.新亚格子涡粘系数正比于纵向速度增量的扭率,它表征大小尺度湍流间的能量输运和耗散之比.新模式通过各向同性湍流直接数值模拟数据库的检验... 详细信息

　基于湍流大小尺度间动量输运的结构函数方程,提出了一种新的湍流大涡模型(les)亚格子涡粘模式.新亚格子涡粘系数正比于纵向速度增量的扭率,它表征大小尺度湍流间的能量输运和耗散之比.新模式通过各向同性湍流直接数值模拟数据库的检验,并用于槽道湍流的大涡模拟计算,将所得结果与DNS结果进行了比较.

关键词：流体力学大涡数值模拟亚格子模式涡粘性结构函数湍流

Mineral Balance Plasticity of Cloudberry (<i>Rubus chamaemorus</i>) in Quebec-labrador Bogs

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American Journal of Plant Sciences 2013年第7期4卷 1508-1520页

作者： léon Etienne Parent Serge-étienne Parent Valérie Hébert-Gentile Kristine Naess line lapointe Centre d’études de la Forêt Department of Biology Université Laval Québec Canada Centre d’études de la Forêt Department of Biology Université Laval Québec Canada Centre de Recherches les Buissons Pointe-aux-Outardes Canada. Department of Soils and Agrifood Engineering Université Laval Québec Canada

The “ionome”, or plant elemental signature, is the elemental composition of an organisms, that may vary with genotypic traits and phenotypic plasticity. Cloudberry (Rubus chamaemorus l.) is a circumboreal wild berry naturally growing in oligotrophic oceanic bogs ofQuebecandlabrador. Our objective was to relate cloudberry stand productivity to the ionomes of female ramets and explore the cause of nutrient imbalance in low-performing stands. We analyzed 13 elements in female ramets collected in 86 natural sites where crop productivity varied widely. We computed orthogonally arranged balances reflecting plant stoichiometric rules and soil biogeochemistry. Balances were expressed as isometric log ratios (ilr) between ad hoc sub-compositions. Balances were synthesized into a Mahalanobis distance optimized based on receiving operating characteristics (ROC). The critical Mahalanobis distance was found to be 5.29 for cutoff berry yield of3.8 g.m-2 with test performance of 0.88, as measured by the area under the ROC curve. Although past research on cloudberry focused mainly on the N/P ratio, this exploratory mineral balance analysis indicated that imbalance in the [P,N | S,C] and [Al | Nutrients] partitions appeared to be the factors limiting the most cloudberry productivity in the bogs. Some highly productive stands showed relatively high C fixation and K use efficiency. Due to the complexity of interactions, diagnosis should be conducted computing first a global imbalance index (Mahalanobis distance), then examining in the balance domain binary partitions departing most from reference, and finally appreciating relative shortage, sufficiency or excess of elements in the concentration domain.

关键词： Al Toxicity Cloudberry Compositional Data Analysis Isometric log Ratio Nutrient Balance Ionome

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通向舞蹈哲学(摘译)

当代舞蹈艺术研究 2022年第1期7卷 61-70页

作者： [美]柯蒂斯·l.卡特安静(译) 华盛顿地区莱斯·阿斯平政府研究中心中央民族大学文学院

舞蹈哲学的提出基于我出生在一个几代人与舞蹈保持密切联系的家庭之中。我对现代舞和当代舞的最新发展保持持续的关注,并参与诸多重要的舞蹈演出,对舞蹈的研究从最初的舞蹈批评到思考舞蹈与其他艺术之间的关系,这些都使舞蹈哲学的提出... 详细信息

舞蹈哲学的提出基于我出生在一个几代人与舞蹈保持密切联系的家庭之中。我对现代舞和当代舞的最新发展保持持续的关注,并参与诸多重要的舞蹈演出,对舞蹈的研究从最初的舞蹈批评到思考舞蹈与其他艺术之间的关系,这些都使舞蹈哲学的提出从一种设想具备了转变为现实的可能性。舞蹈作为一种表演艺术,需要舞者、编舞在表演过程中紧密合作,以舞蹈实践为基础,拓展理解舞蹈的概念和各种论题,是提出舞蹈哲学的现实实践前提。

关键词：舞蹈演出当代舞舞蹈实践舞蹈批评表演艺术现代舞表演过程编舞

The Influence of Insole with Metatarsal Retro-Capital on Posture, Plantar Pressure and Body Segments Positions in Runners

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International Journal of Clinical Medicine 2019年第5期10卷 326-335页

作者： Stéphane Vermand Sébastien Duc Marc Janin Frank-Jourdan Ferrari Micka&euml l Vermand Philippe Joly Performance Health Measurement Society (PSMS) University of Reims Champagne Ardennes Reims France Podiatrist Office 36 Rue Jean Catelas Amiens Amiens France Sport Podiatrist Association Podo’xygène Tourcoing France Movement Balance Performance and Health Laboratory (EA 4445) University of Pau & Pays de l’Adour Sport Sciences Department Tarbes France Podiatrsit Office 7 Rue de Treguel Poitiers France Podiatrist Office 76 Grande Rue Divonnes-les-Bains France Mines School Campus ARTEM Nancy France

Objectives. The aim of this study was to investigate the effects of orthopaedic soles on the body posture. Methods. Forty-eight runners (21 men and 28 women) maintained a standing-up position on both feet with bare feet with neutral soles and orthopedic soles which contained bilaterally a podiatrist element of 3 mm height behind the metatarsal heads (Metatarsal Retro Capital Bar, MRCB). Stabilometric, plantar pressure and kinematic data in the sagittal plane on both sides were measured at 40 and 60 Hz, respectively. The position of the center of pressure on the anteroposterior axis (YCoP), the forefoot plantar pressure (FPP) and the anteroposterior position of the knee (Yk), the hip (YH), the shoulder (YS) and the ears (YE) with respect to the vertical axis passing through the joint of the ankle were determined for each experimental condition. Findings. The addition of a MRCB orthopedic element induced in backward displacement of CoP, hip, shoulder and ears (p CoP and FPP changes were significantly correlated with YH, YS and YE changes (p Conclusion. These results suggest that the addition of an orthopedic element located behind the metatarsal heads influences the overall position of the body and can help podiatrist in the care of their patients.

关键词： Posture Pressure Insoles Thin Plantar Stimulation Podiatry