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Answering Reachability Queries on Incrementally Updated Graphs by Hierarchical Labeling Schema

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Journal of Computer Science & Technology 2016年第2期31卷 381-399页

作者： tak-lam Wong Department of Mathematics and Information Technology The Hong Kong Institute of Education Hong Kong China

We proposed a novel solution schema called the Hierarchical Labeling Schema （HLS） to answer reachability queries in directed graphs. Different from many existing approaches that focus on static directed acyclic graphs （DAGs）, our schema focuses on directed cyclic graphs （DCGs） where vertices or arcs could be added to a graph incrementally. Unlike many of the traditional approaches, HLS does not require the graph to be acyclic in constructing its index. Therefore, it could, in fact, be applied to both DAGs and DCGs. When vertices or arcs are added to a graph, the HLS is capable of updating the index incrementally instead of re-computing the index from the scratch each time, making it more efficient than many other approaches in the practice. The basic idea of HLS is to create a tree for each vertex in a graph and link the trees together so that whenever two vertices are given, we can immediately know whether there is a path between them by referring to the appropriate trees. We conducted extensive experiments on both real-world datasets and synthesized datasets. We compared the performance of HLS, in terms of index construction time, query processing time and space consumption, with two state-of-the-art methodologies, the path-tree method and the 3-hop method. We also conducted simulations to model the situation when a graph is updated incrementally. The performance comparison of different algorithms against HLS on static graphs has also been studied. Our results show that HLS is highly competitive in the practice and is particularly useful in the cases where the graphs are updated frequently.

关键词： graph indexing reachability query Hierarchical Labeling Schema (HLS) incremental update directed cyclic graph

THREE NOVEL FOXL2 GENE MUTATIONS IN CHINESE PATIENTS WITH BLEPHAROPHIMOSIS-PTOSIS-EPICANTHUS INVERSUS SYNDROME

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Chinese Medical Journal 2006年第1期119卷 49-52页

作者： OR SIU-FONG JUNE TONG MING-FOR TONY LO FAI-MAN IVAN lam tak-sum stephen CLINICAL GENETIC SERVICE DEPARTMENT OF HEALTH HONG KONG SAR CHINA

Blepharophimosis-ptosis-epicanthus inversus Psyndrome （BPES, OMIM # 110100） is a rare autosomal dominant disorder affecting the eyelid and ovarian development. When co-occurred together, it is type Ⅰ and when only the eyelid abnormalities are present, it is type Ⅱ. Both types had been mapped to the same locus 3q23 on the basis of cytogenetic rearrangements 1-3 and linkage analyses. 4-6 Subsequently,

关键词： blepharophimosis-ptosis-epicanthus inversussyndrome FOXL2 gene mutation multiplex ligation-dependent probe amplification

A different spectrum of DMD gene mutations in local Chinese patients with Duchenne/Becker muscular dystrophy

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Chinese Medical Journal 2006年第13期119卷 1079-1087页

作者： Ivan Fai-man Lo Kent Keung-san Lai Tony Ming-for Tong stephen tak-sum lam Clinical Genetic Service Department of HealthHong KongChina

Background Duchenne muscular dystrophy （DMD） and Becker muscular dystrophy （BMD） are X-linked recessive, allelic disorders. This study was conducted to look into the spectrum of DMD gene mutations in Hong Kong Chi... 详细信息

关键词： Duchenne muscular dystrophy Becker muscular dystrophy Chinese DMD mutation deletion duplication

Evaluation of referrals for genetic investigation of short stature in Hong Kong

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Chinese Medical Journal 2002年第4期 127-131页

作者： lam Wai Fan Fanny, HAU Wai Lok Edgar and lam tak sum stephen Clinical Genetic Service, Department of Health, Hong Kong Special Administrative Region, China (lam WFF, Hau WLE and lam TSS)

To establish a profile of the causes of apparently unexplained SS in genetic ref erral center and evaluate the current referral system Methods This was a retrospective database survey on patients who were referred our clini cal genetic service from 1988-1998 primarily because of SS We retrieved the st udy population from our computer database using "short stature" as a search han dle and then studied the demographic, clinical and laboratory data from their me dical records Results Three hundred and fifty three subjects were referred for genetic evaluation of SS in 1988-1998 The mean age of referred subjects was 11 5 years and the female to male ratio was 7 6 All referrals had undergone cytogenetic studies to exclude chromosomal abnormal ities, 19% of girls with apparently unexplained short stature had Turner syndrom e; at least 47 9% of the study population were normal variants and 25% of the referrals had inadequate information for classification Conclusions Genetic investigation is essential in the management of patients with SS, especi ally for girls suspected of having Turner syndrome, in which growth hormone trea tment has shown to improve final height We also highlight the inherited causes of short stature, which were often misdiagnosed as benign familial short statur e, and discussed the drawbacks of the current referral

关键词： genetic investigation · etiology · short stature

Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2009年第26期15卷 3288-3297页

作者： Elegance Ting Pui lam Cindy Lo Kuen lam Ching Lung Lai Man Fung Yuen Daniel Yee tak Fong Department of Medicine The University of Hong Kong Department of Nursing Studies The University of Hong Kong

AIM： To test the psychometric properties of a Chinese [（Hong Kong） HK] translation of the chronic liver disease questionnaire （CLDQ）. METHODS： A Chinese （HK） translation of the CLDQ was developed by iterative translation and cognitive debriefing. It was then administered to 72 uncomplicated and 78 complicated chronic hepatitis B （CriB） patients in Hong Kong together with a structured questionnaire on service utilization, and the Chinese （HK） SF-36 Health Survey Version 2 （SF-36v2）. RESULTS： Scaling success was ≥ 80% for all but three items. A new factor assessing sleep was found and items of two （Fatigue and Systemic Symptoms） subscales tended to load on the same factor. Internal consistency and test-retest reliabilities ranged from 0.58-0.90 for different subscales. Construct validity was confirmed by the expected correlations between the SF-36v2 Health Survey and CLDQ scores. Mean scores of CLDQ were significantly lower in complicated compared with uncomplicated CHB, supporting sensitivity in detecting differences between groups.CONCLUSION： The Chinese （HK） CLDQ is valid, reliable and sensitive for patients with CHB. Some modifications to the scaling structure might further improve its psychometric properties,

关键词： Chronic liver disease Health-related quality of life Hepatitis B Southern Chinese Validity

Intramolecular (4+3) cycloadditions of nitrogen-tethered epoxy enosilanes for the synthesis of heteropolycycles

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Chinese Chemical Letters 2019年第8期30卷 1523-1526页

作者： Jiayun He Shuk Mei lam Jerome PLNg Wing-tak Wong Pauline Chiu State Key Laboratory of Synthetic Chemistry Department of ChemistryThe University of Hong KongHong KongChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Furans bearing epoxy enolsilane units via a tether that incorporates a nitrogen heteroatom,undergo intramolecular(4+3)cycloadditions to generate bis-heteroatomic polycyclic adducts having piperidine moieties in their *** cycloadducts,ultimately derived from furfural,a renewal chemical feedstock,are obtained with up to 4:1 dr and with ee retained from the epoxide.

关键词： Heterocycles (4+3)cycloaddition Furan Intramolecular Epoxides Piperidine Polycyclic compounds

PHOX2B mutations in three Chinese patients with congenital central hypoventilation syndrome

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Chinese Medical Journal 2006年第20期119卷 1749-1752页

作者： Siu-Fong June Or Ming-for Tony Tong Fai-Man Ivan Lo Chi-Wai Law Ting-Yat Miu Delphine Trochet tak-sum stephen lam Clinical Genetic Service Department of Health Hong Kong SAR China Department of Paediatrics Queen Elizabeth Hospital Hong Kong SAR China Department de Genetique Hospital Necker-Enfants Malades Paris France

Congenital central hypoventilation syndrome （CCHS, OMIM #209880） is a rare autosomal dominant disorder of the autonomic nervous system （ANS） characterized by an abnormal autonomic ventilatory response to progressive hypercarbia and sustained hypoxemia. Patients typically present in the newborn period with hypoventilation or apnea asleep, awake, or both, without any associated cardiac, pulmonary, neuromuscular or brainstem lesions. Rarely, some patients may present at a later age and are diagnosed to have late onset central hypoventilation syndrome （LOCHS）.1 Other features of ANS dysfunction such as feeding difficulty due to oesophageal dysmotility, severe constipation in the absence of Hirschsprung disease, poor regulation of basal body temperature, episodes of profuse sweating, pupillary and ocular abnormalities, decreased beat-to-beat variability of heart rate, attenuated response of heart rate to exercise, abnormal fluctuation of blood pressure, decreased perception to pain, and decreased perception to anxiety may be variably present but not essential for diagnosis Furthermore, this central hypoventilation can occur as an isolated feature or in association with a number of neurocristopathies, notably Hirschsprung disease （Haddad syndrome, OMIM #209880） and tumours of the sympathetic nervous system particularly neuroblastoma, ganglioneuro- blastoma, and ganglioneuroma, which were found in 20% and 5%--10% of CCHS patients, respectively.2 Studies of genes pertinent to the early embryologic development of the neural crest cells, specifically the endothelin and the RET-GDNF signaling pathways, have recently led to the identification of PHOX2B as the major disease causing gene for CCHS.2-6 PHOX2B was mapped to chromosome 4p12 and consists of 3 exons. It encodes a highly conserved paired-like homeobox transcription factor of 314 amino acids linked to the RET-GDNF signaling

关键词： congenital central hypoventilation syndrome PHOX2B Chinese mutation

Curriculum Adaptation in Special Schools for Students with Intellectual Disabilities(SID):A Case Study of Project Learning in One SID School in Hong Kong

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Frontiers of Education in China 2014年第2期9卷 250-273页

作者： ZHANG Jia-Wei WONG lam CHAN tak-Hang CHIU Chi-Shing Hong Kong Institute of Educational Research The Chinese University of Hong KongHong KongChina

Using a qualitative case study approach,the authors analyzed the curriculum adaptation process for one project learning activity in School K,which is a SID school in the context of school-university *** sources of data were collected for triangulation,including interviews,documents and *** adaptation strategies in this study were analyzed from five perspectives:instructional goals,instructional content,instructional strategies,instructional settings,and student behavioral *** was found that curriculum adaptation efforts could help students with ID develop potential at their own level through project learning activates and teachers could also gain professional development during the university-school collaboration *** for future studies,enlarging the sample size,involving teachers’past orientations and motivations in the project learning process,and collecting quantitative data could all be taken into account.

关键词： special education students with intellectual disabilities(SID) curriculum adaptation project learning

Sexual knowledge, attitudes and values among Chinese migrant adolescents in Hong Kong

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Health 2013年第12期5卷 2210-2217页

作者： Man-Yee Emmy Wong tak-Ming Lawrence lam Department of Health and Physical Education The Hong Kong Institute of Education Hong Kong China Department of Health and Physical Education The Hong Kong Institute of Education Hong Kong China

Internal migration in China has introduced critical challenges to the education and health of migrant adolescents. The aim of this study was to explore the differences in sexual knowledge and attitudes among migrate and local adolescents. Survey research with a total of 616 adolescents in grades equivalent to US 10th and 11th grades including 113 migrants completed a selfadministered questionnaire. Misconceptions of adolescent physical development, sexual activity, marriage, birth control, sexually transmitted diseases and the probability of pregnancy were found in most of the migrant adolescents. Significantly lower attitudinal scores were found for the sub-scales of clarity of personal sexual values, understanding of emotional needs, social behavior, sexual responses;attitudes towards gender role, birth control, premarital intercourse, use of force in sexual activity, the importance of family and satisfaction with social relationship in migrant adolescents. Migrant adolescents have a low level of knowledge of sexual activities. The content of education programs should include engagement in sexual behavior to equip adolescents with unbiased and factual knowledge. The adolescents have a high demand for family support. School based sex education programs should involve the participation of parents to address these issues.

关键词： Adolescent Attitude Knowledge Migration Sexuality