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Nine-year experience of doxorubicin-eluting beads chemoembolization for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 493-498页

作者： Alvin Ho-Kwan Cheung Colin siu-Chi lam Henry Shiu-Cheung Tam Tan-To Cheung Roberta Pang Ronnie Tung-Ping Poon Department of Surgery University of Hong Kong and Queen Mary Hospital

BACKGROUND: Chemoembolization with doxorubucin-eluting beads (DEB) has been used to treat hepatocellular carcinoma (HCC) since 2007. This study compared the efifcacy and sur-vival between transarterial chemoembolization (TACE) with DEB and conventional approach (cTACE) in HCC treatment. METHODS: This retrospective case-control study compared the overall survival and tumor response of HCC patients to cTACE (n=190) and DEB (n=143) by the reassessment of com-puted tomography and serum alpha-fetoprotein (AFP). Mul-tivariate analysis was used to determine the factors affecting tumor response. RESULTS: The median post-treatment to pre-treatment AFP level was 0.8 for a DEB session (n=258) and 1.0 for a cTACE session (n=452), showing a signiifcantly greater decrease in AFP after DEB (P80 months after the ifrst TACE session in the DEB group. CONCLUSION: DEB is a safe alternative to cTACE in HCC pa-tients with better therapeutic efifcacy.

关键词： doxorubicin-eluting beads transarterial chemoembolization hepatocellular carcinoma

A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason Chun Ho lam Yi lee Kwong Tak siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai Yiu lam Ho Yan Chan Yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih Li Ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

Novel biomarkers GEP/ABCB5 regulate response to adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 524-530页

作者： Charing Ching-Ning Chong siu Tim Cheung Yue-Sun Cheung Anthony Wing-Hung Chan Stephen lam Chan Simon Chun-Ho Yu Paul Bo-San Lai Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong4/F Clinical Science Building30-32 Ngan Shing StreetShatinHong KongChina Department of Anatomical and Cellular Pathology State Key Laboratory in Oncology in South ChinaPrince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Imaging and Interventional Radiology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina

Background: Transarterial chemoembolization(TACE) is the most commonly used adjuvant therapy for hepatocellular carcinoma(HCC) after curative resection. Responses to TACE are variable due to tumor and patient heterogeneity. We had previously demonstrated that expression of Granulin-epithelin precursor(GEP) and ATP-dependent binding cassette(ABC)B5 in liver cancer stem cells was associated with chemoresistance. The present study aimed to evaluate the association between GEP/ABCB5 expression and response to adjuvant TACE after curative resection for HCC. Methods: Patients received adjuvant TACE after curative resection for HCC and patients received curative resection alone were identified from a prospectively collected database. Clinical samples were retrieved for biomarker analysis. Patients were categorized into 3 risk groups according to their GEP/ABCB5 status for survival analysis: low(GEP-/ABCB5-), intermediate(either GEP +/ABCB5-or GEP-/ABCB5 +) and high(GEP +/ABCB5 +). Early recurrence(recurrence within 2 years after resection) and disease-free survival were analyzed. Results: Clinical samples from 44 patients who had followed-up for more than 2 years were retrieved for further biomarker analysis. Among them, 18 received adjuvant TACE and 26 received surgery alone. Patients with adjuvant TACE in the intermediate risk group was associated with significantly better overall survival and 2-year disease-free survival than those who had surgery alone( P = 0.036 and P = 0.011, respectively). Adjuvant TACE did not offer any significant differences in the early recurrence rate, 2-year disease-free survival and overall survival for patients in low and high risk groups. Conclusions: Adjuvant TACE can only provide survival benefits for patients in the intermediate risk group(either GEP +/ABCB5-or GEP-/ABCB5 +). A larger clinical study is warranted to confirm its role in patient selection for adjuvant TACE.

关键词： Adjuvant therapy Hepatocellular carcinoma Drug transporter Transarterial chemoembolisation Granulin-epithelin precursor

Clinical factors affecting rejection rates in liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 367-373页

作者： Kin Pan Au See-Ching Chan Kenneth siu-Ho Chok William Wei Sharr Wing-Chiu Dai Sui-Ling Sin Tiffany Cho-lam Wong Chung-Mau Lo Department of Surgery the University of Hong Kong Medical Center Queen Mary Hospital

With improvements in survival, liver trans- plant recipients now suffer more morbidity from long-term immunosuppression. Considerations were given to develop individualized immunosuppression based on their risk of re- jection. METHOD： We retrospectively analyzed the data of 788 liver transplants performed during the period from October 1991 to December 2011 to study the relationship between acute cel- lular rejection （ACR） and various clinical factors. RESULTS： Multivariate analysis showed that older age （P=0.04, OR=0.982）, chronic hepatitis B virus infection （P=0.005, OR= 0.574）, living donor liver transplantation （P=0.02, OR=0.648） and use of interleukin-2 receptor antagonist on induction （P〈0.001, OR=0.401） were associated with fewer ACRs. Patients with fulminant liver failure （P=.004, OR=4.05） were more likely to develop moderate to severe grade ACR. CONCLUSIONS： Liver transplant recipients with older age, chronic hepatitis B virus infection, living donor liver trans- plantation and use of interleukin-2 receptor antagonist on in- duction have fewer ACR. Patients transplanted for fulminant liver failure are at higher risk of moderate to severe grade ACR. These results provide theoretical framework for developing individualized immunosuppression.

关键词： liver transplantation acute rejection immunosuppression

Computer analysis of arbitrary reinforced concrete cross-section under bieccentric load

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Progress in Natural Science:Materials International 2000年第4期 64-71页

作者：刁波,叶英华,siu-Shu Eddie lam Department of Civil Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China Department of Civil Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hong Kong China

The computational aspects of the problem of ultimate strength analysis of arbitrary reinforced concrete cross-sections under normal force and biaxial bending are considered. The cross-section secant stiffness derived here insures the convergence of the solution for the equilibrium equations in any load case. The stress-strain relations of concrete and reinforcements are expressed in terms of the piece-wise continuous cubic polynomials. The coefficients of the cross-section equilibrium equations are evaluated numerically by applying the integration rules proposed by Rieckmann and Sommerfield. The present approach is demonstrated through several examples.

关键词： bieccentric load reinforced concrete arbitrary cross-section computer analysis.

Broadband Antenna with EBG Cells

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Broadband Antenna with EBG Cells

海岸侵蚀作用下海岸带地区极端风暴洪水风险评估——以上海石化为例

2005'全国微波毫米波会议

作者： lam siu Kwai-Man LUK Department of Electronic Engineering City University of Hong Kong 83 Tat Chee Avenue

＜正＞A wideband and low back radiation patch antenna is presented in this *** antenna is fed by an L-shaped probe and is designed to operate at *** cells are constructed and surrounded the L-probe antenna,through the special arrangement of the EBG cells;a reduction of back radiation can be *** antenna finds the front to back ratio around 36.6dB at -180 degree and yields the impedance bandwidth of 20.2% （SWR＜2） from 10.39GHz to 12.73GHz.

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海洋通报 2022年第2期41卷 200-207页

作者：刘青张卫国 Nina siu-Ngan lam 王军华东师范大学地理信息科学教育部重点实验室上海200241 华东师范大学地理科学学院上海200241 华东师范大学上海城市公共安全研究中心上海200241 华东师范大学河口海岸国家重点实验室上海200241 Department of Environmental Sciences Louisiana State UniversityBaton Rouge US 70803-5705

海堤是海岸带地区社会经济活动的重要保护屏障。海岸侵蚀的加剧将导致海堤稳定性和安全性降低,增加海岸带地区遭受极端风暴洪水的风险,进而影响到海岸带地区的安全。本文选择上海石化这一遭受海岸侵蚀较为严重的区域作为研究区,利用GIS... 详细信息

海堤是海岸带地区社会经济活动的重要保护屏障。海岸侵蚀的加剧将导致海堤稳定性和安全性降低,增加海岸带地区遭受极端风暴洪水的风险,进而影响到海岸带地区的安全。本文选择上海石化这一遭受海岸侵蚀较为严重的区域作为研究区,利用GIS分析了1972—2020年近岸海床侵蚀特征,并基于2000—2020年-5 m等深线变化评估了上海石化近岸海堤的稳定性。结果表明:1972—2020年间上海石化前沿海床整体以侵蚀为主,石化近岸东侧以及西侧局部的浅滩侵蚀明显,城市沙滩中段、第6次围堤处以及码头东岸海堤稳定性最低。基于上述研究结果,考虑海堤稳定性薄弱段出现极端风暴洪水漫堤或溃堤情景,模拟并分析了上海石化2010年、2030年和2050年遭受千年一遇极端风暴洪水的风险。结果显示:在2010年基准年情景下,受海岸侵蚀作用最明显的城市沙滩和第6次围堤区域遭遇极端风暴洪水的风险最高,到2050年,当前稳定性较好的海堤安全性也将大大降低,与2010年相比,上海石化近岸地区的直接经济损失将会增加近3倍。

关键词：海岸侵蚀海堤稳定性极端风暴洪水风险评估上海石化

THREE NOVEL FOXL2 GENE MUTATIONS IN CHINESE PATIENTS WITH BLEPHAROPHIMOSIS-PTOSIS-EPICANTHUS INVERSUS SYNDROME

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Chinese Medical Journal 2006年第1期119卷 49-52页

作者： OR siu-FONG JUNE TONG MING-FOR TONY LO FAI-MAN IVAN lam TAK-SUM STEPHEN CLINICAL GENETIC SERVICE DEPARTMENT OF HEALTH HONG KONG SAR CHINA

Blepharophimosis-ptosis-epicanthus inversus Psyndrome （BPES, OMIM # 110100） is a rare autosomal dominant disorder affecting the eyelid and ovarian development. When co-occurred together, it is type Ⅰ and when only the eyelid abnormalities are present, it is type Ⅱ. Both types had been mapped to the same locus 3q23 on the basis of cytogenetic rearrangements 1-3 and linkage analyses. 4-6 Subsequently,

关键词： blepharophimosis-ptosis-epicanthus inversussyndrome FOXL2 gene mutation multiplex ligation-dependent probe amplification

Anesthetic Management of Pheochromocytoma in Pediatric Patient—Case Report

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Open Journal of Anesthesiology 2021年第6期11卷 175-183页

作者： lam Wai Teng siu Man Kit Chan Si Wai Leong Fai Department of Anesthesiology Centro Hospitalar Conde de S?o Januário Macao Special Administrative Region China

Background: Pediatric pheochromocytoma is very rare, accounting for only about 1% of pediatric hypertension. Case Presentation: We presented a case of pediatric pheochromocytoma in a 12-year-old girl undergoing laparoscopic adrenalectomy, with the aim of highlighting an anesthetic challenge. Conclusion: Preoperative screening of hereditary conditions, investigations for end-organ dysfunction, preoperative blood pressure optimization, intensive intraoperative hemodynamic management and good communication with surgeons were the cornerstones for this successful surgery.

关键词： Anesthesia Hemodynamic Pediatrics Pheochromocytoma