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2005年全国高分子学术论文报告会

作者：姚桂君佟斌董宇平张茂锋 jacky wing yip lam 唐本忠北京理工大学材料科学与工程学院北京理工大学材料科学与工程学院北京理工大学材料科学与工程学院北京大学化学与分子工程学院香港科技大学化学系香港科技大学化学系

＜正＞随着超大规模集成技术的不断改进,已经要求亚微米级的电子元件尺寸进一步缩小,并能达到材料智能化和超薄膜化。作为实现上述目标的基本材料,高分子-无机纳米粒子复合超薄膜的研究与应用始终是一个非常活跃的领域。而以聚电解质自... 详细信息

＜正＞随着超大规模集成技术的不断改进,已经要求亚微米级的电子元件尺寸进一步缩小,并能达到材料智能化和超薄膜化。作为实现上述目标的基本材料,高分子-无机纳米粒子复合超薄膜的研究与应用始终是一个非常活跃的领域。而以聚电解质自组装膜为纳米反应器制备

关键词：聚苯胺聚(4-羧酸苯基)乙炔自组装 CdS纳米粒子光电转换

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X射线平板照相法研究电场诱导的侧链液晶型聚炔取向行为

X射线平板照相法研究电场诱导的侧链液晶型聚炔取向行为

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第八届全国X射线衍射学术会议

作者：耿建新王淑云李杲周恩乐 jacky wing yip lam 唐本忠中科院长春应化所高分子物理与化学国家重点实验室中科院长春应化所高分子物理与化学国家重点实验室中科院长春应化所高分子物理与化学国家重点实验室中科院长春应化所高分子物理与化学国家重点实验室香港科技大学化学系香港科技大学化学系

＜正＞近年来,侧链液晶聚炔引起了人们的广泛兴趣。因为,聚乙炔有着广泛的应用前景, 但是其不稳定性和难加工性限制了这一领域的发展。作为侧基的液晶基元连接到聚乙炔主链上,赋予了聚炔液晶性[1],同时也提高了聚炔的稳定性、改善了其... 详细信息

＜正＞近年来,侧链液晶聚炔引起了人们的广泛兴趣。因为,聚乙炔有着广泛的应用前景, 但是其不稳定性和难加工性限制了这一领域的发展。作为侧基的液晶基元连接到聚乙炔主链上,赋予了聚炔液晶性[1],同时也提高了聚炔的稳定性、改善了其加工性[2]。

关键词： X射线平板照相法电场诱导侧链液晶聚炔取向行为

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Potential of a COX-2 inhibitor in lowering chemotherapy-induced neutropenia

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中华乳腺病杂志（电子版） 2010年第5期4卷 8-13页

作者： Louis wing-Cheong Chow Adrian Yun-San yip Eleanor Yuen-Yuen Ong Chi-Kei lam Masakazu Toi Clinical Trials Centre Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Organisation for Oncology and Translational Research Comprehensive Centre for Breast Diseases UNI MED Medical Institute Department of Surgery Kyoto UniversityJapan

Objective This study was initially designed to evaluate the effect of celecoxib on the regimen of 5-fluorouracil,epirubicin,and cyclophosphamide(FEC)combination,followed by docetaxel(T)in neoadjuvant *** unplanned preliminary review on safety was conducted after a halt of the study due to the concerned potential cardiovascular risk of using COX-2 *** We studied 23 consecutive cases of operable breast cancer having received four cycles of FEC(500 mg/m2,100 mg/m2,500 mg/m2)followed by four cycles of T(100 mg/m2)with concurrent celecoxib(400 mg twice daily)(group A)or same chemotherapy regimen but without concurrent celecoxib(group B).These combined chemotherapies were administered every 3 *** Chi-square test or Fisher's exact test were used to assess the difference in incidence of limiting hematological toxicites between *** 23 patients(group A:n=12;group B,n=11)received a total of 183 out of 184 planned treatment cycles;one(4%,1/23)of them omitted the fourth cycle of FEC owing to repeated incidences of febrile *** dose intensity(RDI)for FEC in group A(90%±11%)was higher than that in group B(80%±8%)while RDI for T was similar between group A(93%±8%)and group B(96%±9%).Of the first 91 treatment cycles of FEC,limiting hematological toxicity,severe neutropenia including febrile neutropenia,was significantly different between group A and B [(10.4%,5/48)vs.(32.6%,14/43),P=0.009].Other toxicities commonly observed in chemotherapy receiving patients were *** Neoadjuvant use of FEC followed by T with concurrent celecoxib appeared to be safe for treatment of operable invasive breast *** observed lower incidence of chemotherapy-induced neutropenia is possibly contributed by the administration of *** believe that further investigation might provide more evidence on the use of COX-2 inhibitors in breast cancer.

关键词：血疗法乳腺癌治疗临床

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A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice

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World Journal of Gastroenterology 2006年第2期12卷 306-312页

作者： Yuan-Xiang Zhou Maggie Yuk-Ting Lee James Ming-Him Ng Mee-Len Chye wing-Kin yip Sze-Yong Zee Eric lam Department of Botany The University of Hong Kong PokfulamRoad Hong Kong China Biotech Center Rutgers University 59 Dudley RoadNew Brunswick NJ 08901-8520 United States

瞄准：表示 23-ku pE2 到花费有效地，肝炎 E 病毒(HEV ) 的 3'-portion 包括的 E2 碎片编码的最有希望的子单元疫苗打开读物框架 2 (ORF2 ) 在烟草的质体(Nicotiana 烟 cv。SR1 ) ，在质体调查 transgene 表示和 pE2 累积，并且评估反... 详细信息

瞄准：表示 23-ku pE2 到花费有效地，肝炎 E 病毒(HEV ) 的 3'-portion 包括的 E2 碎片编码的最有希望的子单元疫苗打开读物框架 2 (ORF2 ) 在烟草的质体(Nicotiana 烟 cv。SR1 ) ，在质体调查 transgene 表示和 pE2 累积，并且评估反在老鼠的导出质体的 pE2 的遗传因子的效果。方法：包含米饭 psbA 倡导者驾驶的 E2 碎片的指向质体的向量 pRB94-E2 被构造。在进烟草质体的交货之上，这构造能在质体染色体在 psaB-trnfM 和 trnG-psbC 碎片开始相应再结合，并且导致在二碎片之间插入的 transgene。pRB94-E2 与一个 biolistic 粒子轰炸方法被交付，并且转变质体的工厂被获得在补充 spectinomycin 的媒介上跟随炮轰的叶纸巾的新生。改革工厂的 Transplastomic 地位被 PCR 和南部的污点分析证实， transgene 表示被北污点分析调查，并且 pE2 的累积被 ELISA 测量。而且，蛋白浸出物被用来使老鼠免疫，并且在使免疫的老鼠的浆液样品的 pE2 反应的抗体的存在被 ELISA 学习。结果：PCR 和南部的污点分析证实的 Transplastomic 线能活跃地抄录 E2 mRNA。pE2 多肽象 13.27 microg/g 一样高被积累到水平新鲜叶子。pE2 能刺激使免疫的老鼠产生 pE2 特定的抗体。结论：HEV-E2 碎片能被插入到质体染色体，导出的 recombinant pE2 抗原是在老鼠遗传因子的反。因此，质体可以是为 HEV 疫苗的划算的生产的新奇来源。

关键词：肝炎 E病毒 E2病毒色素体变换疫苗烟草小鼠

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Application of biomarkers in sentinel lymph node biopsy for the management of breast cancer

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中华乳腺病杂志（电子版） 2012年第6期6卷 11-15页

作者： Qing Liu wings Tjing Yung Loo Adrian Yun San yip Louis wing Cheong Chow Elizabeth lam Yan Ng Mary Ngan Bing Cheung UNIMED Medical Institute Organization for Oncology and Translational Research

Objective Sentinel lymph node in breast cancer is a predictor of the tumor's metastatic *** emerging from antitumor immune response might also target sentinel lymph node (SLN).In this study,we evaluated the cytokine profile including interleukin-8 (IL-8),interleukin-12 (IL-12),interferon-gamma (IFN-γ),and tumor necrosis factor alpha (TNF-α) for the T-cell *** From January 2008 to August 2010,35 patients with breast mass underwent SLN biopsy in UNIMED Medical *** specimens were formalin-fixed and paraffin-embedded for hematoxylin and eosin staining and immunohistochemistry with following markers:IL-8,IL-12,IFN-γ and TNF-α.The staining intensity was scored according to four grades:negative (-),weak expression (+),moderately positive expression (+ +),strong positive expression (+ + +).The correlation between the expression of cytokines and pathological characteristics were also analyzed using the Spearman Rank Correlation *** Out of 35 patients,SLN metastases were observed in 20 patients and among them,75% (15 /20) were strongly stained (+ + +) with IL-8 and moderately stained (+ +) with IL-12,but only 25% (5 /20) were strongly stained (+ + +) with IFN-γ and TNF-α.The expression of IL-8 was significantly associated with all tumor grades (r=0.639,P=0.00),estrogen receptor (r=0.778,P=0.01),progesterone receptor (r=0.759 P=0.00) and HER-2 /neu receptor (r=0.863 P=0.00).Conclusion The strong association between IL-8 expression and SLN metastases might highlight the prognostic significance of IL-8 in SLN.

关键词：临床治疗乳腺疾病医学

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Effect of Tai Chi Chuan on serotonin and cortisol for monitoring stress and quality of life in post-treatment breast cancer patients

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中华乳腺病杂志（电子版） 2014年第4期8卷 34-40页

作者： William Wai Nam Tsang wings Tjing Yung Loo Louis wing Cheong Chow Elizabeth lam Yan Ng Adrian Yun San yip Jianping Chen Department of Rehabilitation Sciences Hong Kong Polytechnic University UNIMED Medical Institute and Organisation for Oncology and Translational Research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective Immediate physical exercise has been recommended for patients in the recovery phase to improve survival and quality of life(QOL)and reduce recurrence of *** new NCCN Guidelines for Survivorship also highlighted the role of exercise in post-cancer health,encouraging patients to perform light physical activity following *** aim of our study is to effect of Tai Chi Chuan(TCC)on serotonin and cortisol for monitoring stress and QOL in post-treatment breast cancer *** Totally85 post-treatment breast cancer patients were enrolled in this study to observe the effects of practicing TCC on recovery,as well as stress and happiness which are indicators of QOL of in *** blood was drawn from study subjects to analyze the levels of serotonin,cortisol and high sensitive C-reactive protein(HSCRP)at baseline,and at 3,6 and 12 months of TCC *** was drawn from healthy subjects only at baseline.A QOL questionnaire was administered to study subjects at three time points throughout the study,and once for healthy *** data were processed by analysis of variance of repeated *** At 3,6 and 12 months time points following regular TCC exercise,WBC,RBC,hemoglobin in blood samples showed a statistically significant difference(F=161.55,172.14,289.73;all P=0.00);the level of serotonin(biomarker for well-being),cortisol(indicator of stress)and HS-CRP(biomarker for inflammation)showed a statistical improvement(F=307.46,182.85,102.23;all P=0.00).After 3,6 and 12 months of regular TCC exercise,according to the results of QOL questionnaire,the indicators including quality of sleep,perceived hunger,fatigue,contentment,stress and social interaction presented a significant difference(F=312.98,222.64,543.90,46.05,28.10,78.92,all P<0.05),while there was no statistical difference in life dissatisfaction(F=56.61,P=0.166)Conclusions TCC physical activity for post-treatment breast cancer patients improved QOL and overall

关键词：乳腺病患者临床分析治疗方法

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Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities

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World Journal of Pediatrics 2018年第5期14卷 482-491页

作者： Kam Lun Hon Yan Min Bao Kate C.Chan Kin Wai Chau Rong-Shan Chen Kun Tat Gary Cheok Wa Keung Chiu Li Deng Chun-Hui He Kin Mui Ieong Jeng Sum C.Kung Ping lam Shu Yan David lam Qun Ui Lee So Lun Lee Ting Fan Leung Theresa N.H.Leung Lei Shi Ka Ka Siu Wei-Ping Tan Maggie Haitian Wang Tak Wai Wong Bao-Jing Wu Ada Y.F.yip Yue-Jie Zheng Daniel K.Ng Department of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Department ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hong Kong Society of P ediatric Respirology and Aller gy Hong K ong S ARChina Pediatric Respiratory andSleep Disorders Center Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Department of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of P ediatrics Kiang Wu HospitalMacaoChina Department of P ediatrics and A dolescent Medicine United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Department of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Department of P ediatrics and A dolescent Medicine Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Department of P ediatrics and A dolescent Medicine Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Department of P ediatrics and A dolescent Medicine The University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Department of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Department of P ediatrics and A dolescent Medicine Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Department of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescen

Background Asthma is a significant chronic health problem worldwide. Management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. Methods The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macao hos-pitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ). Acceptability of a treatment is graded as very good/good/fair/poor. Results Good asthma control was only reported in 80% subjects in Hong Kong, but higher in sister cities (85–94%, P<0.001). Allergic rhinitis, 'incense burning', and 'smoker in family' were prevalent among the four cities. Logistic regres-sion showed better control of asthma was associated with better PADQLQ (B=?0.029, P < 0.001), better acceptability of bronchodilator (B=?1.488, P = 0.025), negatively with 'smoker in family' (B=?0.83, P = 0.015) and various PADQLQ domains. Conversely, worse PADQLQ was associated with allergic rhinitis severity (B=4.77, P <0.001), poor control of asthma (B=7.56, P <0.001), increased frequency of traditional Chinese medicine use (B=1.7, P < 0.05), increased fre-quency of bronchodilator usage (B=1.05, P < 0.05), 'smoker in family' (B=4.05, P < 0.05), and incense burning at home (B=3.9, P < 0.05). Conclusions There are some clinical and cultural differences among the four southern Chinese cities within the Guangdong province. This study identifies potentially modifiable environmental and treatment factors associated with poor asthma control and QoL for health-care interventions. Having a smoker in the family is independently associated with poor asthma control and QoL.

关键词： Asthma Complementary and alternative medicine Control Inhaled bronchodilator Inhaled corticosteroid Pediatric Allergic Disease Quality of Life Questionnaire Smoking Traditional Chinese medicine

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*** rescue in retinitis pigmentosa by the treatment of Lycium barbarum(Random Clinical Trial)

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Annals of Eye Science 2017年第1期 356-356页

作者： Henry Chan Hang-I lam Kwok-Fai So Raymond Chuen-Chung Chang Shiu-Ming Lai Chi-Wai Do Iris F.F.Benzie Chin-Pan Leung Kai-yip Choi Man-Pan Chin Zhe-Chuang Li wing-Yan Yu Laboratory of Experimental Optometry(Neuroscience) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Guangdong-Hongkong-Macao(GHM)Institute of CNS Regeneration Jinan UniversityGuangzhouChina School of Biomedical Sciences The University of Hong KongHong Kong SARChina Department of Ophthalmology The University of Hong KongHong Kong SARChina Laboratory of Experimental Optometry(Biophysic) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong SARChina Private practice Chinese medical doctor

Retinitis pigmentosa(RP)is a group of heredofamilial retinal diseases which is characterized by night blindness and progressive visual field *** study aims to study the treatment effect of Lycium barbarum(LB)on retinal functions and structure of RP *** study is a double-masked randomized controlled *** subjects received scheduled eye examination including visual acuity(VA),Humphrey field analysis(HFA),ganzfeld flash electroretinogram(ffERG)and optical coherence tomography(OCT).The suitable subjects were randomly allocated to either LB-treatment or placebo groups with the supply of LB or placebo for 12 *** were total 41 RP subjects(22 in LB group and 19 in placebo group)completed the 12 months *** compliance rates for LB and placebo groups were 89.8%±12.5%and 85.3%±7.7%*** compared with placebo group,there were no deteriorations of both high and low contrast VA in LB group(P<0.01).In addition,certain improvements of scotopic rod response and photopic cone response of ffERG were obtained in LB group(P<0.05).In the OCT measurement,an obvious thinning of macular thickness was observed in placebo group but not found in LB group(P<0.05).However,there were no changes found in the sensitivity of central visual field between two *** results confirm that the 12-month LB treatment for RP patients had neuroprotective effect on retina and is believed to delay or minimize the deterioration of visual function in RP.

关键词： Retinitis pigmentosa(RP) Lycium barbarum(LB) neuroprotection cone retina

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