检索结果-南通市图书馆

AIE Featured Inorganic-Organic Core@Shell Nanocomplex for Highly efficient SiRNA Delivery and Real-time Monitoring

在线全文

学校读者我要写书评

暂无评论

AIE Featured Inorganic-Organic Core@Shell Nanocomplex for Hi...

Aptamer-Anchored Rubrene-Loaded Organic Nanoprobes for Cancer Cell Targeting and Imaging

中国化学会第十三届全国分析化学年会

作者： Xuewen He Feng yin Ling-Hong Xiong Zheng Zhao Ryan T.K.Kwok jacky w.y.lam Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction Institute for Advanced Study Division of Life Science and Division of Biomedical Engineering The Hong Kong University of Science and Technology

RNA interference（RNAi） is emerging as one of the most powerful technologies for sequence-specific suppression of genes and presents a great potential in biomedical applications ranging from gene analysis to diseases therapeutics. Considering the drawbacks of current si RNA delivery vehicles in biocompatibility and efficacy, the development of high efficient si RNA delivery nanocarrier associated with self-monitoring functionality is of great significance. Herein, by taking advantage of aggregation-induced emission luminogens（AIEgens）, a new generation of inorganic/organic core@shell nanocarrier that allowed efficient delivery and real-time monitoring of siRNA in living cells had been developed. The amine groups in the nanocarriers behaved as a proton-absorber and promoted the release of si RNA from endosome. The AIE properties provided a unique fluorescence imaging modality for long-term tracking and intracellular localization of si RNA during transfection. Comparing to the commercial si RNA transfection reagents, the present system displayed a pretty higher efficiency and reproducibility in terms of intracellular transfection and target down regulation with a much lower cytotoxicity.

关键词： aggregation-induced emission(AIE) nanocarrier siRNA real-time apoptosis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

CCS Chemistry 2019年第3期1卷 251-260页

作者： yuanyuan Li Chuansheng Li Tao Jiang Lihua Zhou Pengfei Zhang Ryan T.K.Kwok jacky wing yip lam Ping Gong Lintao Cai Ben Zhong Tang Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonChina HKUST Shenzhen Research Institute Shenzhen 518057China Guangdong Key Laboratory of Nanomedicine CAS Key Laboratory of Health InformaticsShenzhen Bioactive Materials Engineering Lab for MedicineInstitute of Biomedicine and Biotechnology.Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Pharmaceutical Sciences Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Dongguan Key Laboratory of Drug Design and Formulation Technology Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China Center for Aggregation-Induced Emission NSFC Center for Luminescence from Molecular AggregatesSCUT-HKUST Joint Research LaboratoryState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular,cellular,anatomical,and func-tional *** of advanced fluores-cent probes with superior sensitivity and biological selectivity for fluorescence imaging is thus *** move forward in this direction,we developed an easy self-assembly method for fabricating apta-mer-anchored rubrene-loaded organic fluorescent *** aptamer-modified organic nanop-robes integrated the best features of the organic light-emitting materials and the aptamers,thus endowing them with excellent cell-targeting capabil-ity,high stability,and good *** using this general method,a variety of biocompatible and highly bright organic fluorescent nanoprobes based on novel organic light-emitting materials with specific recognition could be easily constructed for real-time biosensing and long-term biomedical imaging.

关键词： aptamer organic nanoprobes fluores-cence cancer imaging biomedicine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

进化

家庭影院技术 2008年第8期 45-47页

作者： jacky.lam

进化（Evolution），这个词汇最能联想到达尔文有关自然界生物为了回应环境压力、自然选择和基因突变而逐渐（经过好几百万年）产生由低级到高级的发展变化过程。回顾单枪影院投影机的发展，数码工业化生产将这一进程微缩到不到10年的... 详细信息

进化（Evolution），这个词汇最能联想到达尔文有关自然界生物为了回应环境压力、自然选择和基因突变而逐渐（经过好几百万年）产生由低级到高级的发展变化过程。回顾单枪影院投影机的发展，数码工业化生产将这一进程微缩到不到10年的演变过程，从480p到720p再到1080p Full HD大约不到5年时间，而实际上早在2003年6月JVCD—ILA3840×2048像素数码投影机已开启4K时代。2004年6月SONy SXRD—R110已完成Digital Cinema 4096×2160的4Kp技术发展。

关键词：数码投影机工业化生产环境压力基因突变自然选择

LINEAR AND HyPERBRANCHED POLyMERS wITH HIGH THERMAL STABILITy AND LUMINESCENCE EFFICIENCy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2001年第6期19卷 585-590页

作者： jacky wing yip lam Jing-dong Luo Han Peng Zhi-liang Xie Kai-tian Xue yu-ping Dong Lin Cheng Cheng-feng Qiu Hoi Sing Kwok Ben-zhong Tang Departments of Chemistry and Electrical & Electronic Engineering Hong Kong University of Science & Technology Clear water Bay, Kowloon, Hong Kong China Hong Kong Univ Sci & Technol Dept Chem Kowloon Hong Kong Peoples R China Hong Kong Univ Sci & Technol Dept Elect & Elect Engn Kowloon Hong Kong Peoples R China

New acetylene monomers, 6-{[(1-naphthylethynyl-4-phenyl)carbonyl]oxy}-1-phenyl-1-hexyne (1), 2,5-diethynyl-thiophene (3), and 4,4'-diethynylbiphenyl (6) were synthesized. Homopolymerization of 1 and copolycyclotrimerizations of 3 and 6 with 1-heptyne and 1-octyne have been achieved with wCl6- and TaCl5-Ph4Sn catalysts, respectively, giving soluble linear disubstituted polyacetylene (2) and hyperbranched polyarylenes (5 and 8) with high molecular weights (up to 1.2 x 10(5)) in high yields (up to 98%). The structures and properties of the polymers are characterized and evaluated by R NMR, TGA, UV, photoluminescence (PL), and electroluminescence (EL) analyses. All the polymers possess high thermal stability and emit strong blue light upon photoexcitation. The intensity of the emitted light is greater than that of poly(1-phenyl-1-octyne), a well-known highly luminescent disubstituted polyacetylene. Little aggregation-induced red shift in the PL was observed in the thin films of the polymers. By constructing a multi-layer EL device, high EL quantum yield (0.18%) has been achieved in 2, which are the best results for substituted polyacetylenes attainable so far.

关键词： disubstituted polyacetylene hyperbranched polyarylene light emission

基于C–H活化的炔烃聚合反应合成多功能稠(杂)环聚合物

在线全文

学校读者我要写书评

暂无评论

中国科学：化学 2021年第2期51卷 224-234页

作者：刘欣悦刘晓琳韩婷林荣业唐本忠香港科技大学化学系国家人体组织功能重建工程技术研究中心香港分中心香港999077 深圳大学材料学院 AIE研究中心深圳518061 香港科技大学深圳研究院深圳518057 华南理工大学发光材料与器件国家重点实验室广东省分子聚集发光重点实验室聚集诱导发光研究中心广州510640

稠(杂)环聚合物是一类重要的功能聚合物,因其优异的光电特性而被广泛应用于光电领域.这类聚合物的传统制备方法往往需要用到修饰有复杂官能团的稠(杂)环单体,这些单体种类有限且合成难度大,导致稠(杂)环聚合物的发展受到限制. C–H活化... 详细信息

稠(杂)环聚合物是一类重要的功能聚合物,因其优异的光电特性而被广泛应用于光电领域.这类聚合物的传统制备方法往往需要用到修饰有复杂官能团的稠(杂)环单体,这些单体种类有限且合成难度大,导致稠(杂)环聚合物的发展受到限制. C–H活化过程的发现与提出为利用惰性的C–H键作为潜在官能团提供了可能,有效避免了对单体进行复杂修饰的要求,大大扩增了单体的种类和来源.基于C–H活化的炔烃环化聚合反应,能够在聚合物骨架中原位直接形成稠(杂)环结构,具有原料简单易得、聚合效率高、产物结构丰富等诸多优势,因此受到广泛关注.本文分类总结了基于C–H活化的炔烃环化聚合领域的最新进展,包括合成手段和所得聚合物的性质与功能介绍,并对该领域的未来发展方向进行了展望.

关键词：稠(杂)环聚合物环化聚合 C–H活化内炔

基于四苯基乙烯双轴取向发光液晶分子的相结构

在线全文

学校读者我要写书评

暂无评论

基于四苯基乙烯双轴取向发光液晶分子的相结构

1-((12-Bromododecyl)oxy)-4-((4-(4-pentylcyclohexyl) phenyl)ethynyl) benzene：Liquid crystal with aggregation-induced emission characteristics

2012年两岸三地高分子液晶态与超分子有序结构学术研讨会（暨第十二届全国高分子液晶态与超分子有序结构学术论文报告会）

作者：余振强袁望章林杰生 lam jacky w.y 唐本忠深圳大学化学与化工学院深圳市功能高分子重点实验室上海交通大学化学与化工学院香港科技大学化学系

传统的有机发光材料在聚集状态下会导致荧光猝灭,而分子聚集或自组装是形成液晶相的内在要求,即发光与液晶之间存在矛盾。四苯基乙烯(TPE)是一类具有聚集诱导发光效应的类盘状分子,将其应用于液晶分子的设计将有望解决发光与液晶之间的... 详细信息

传统的有机发光材料在聚集状态下会导致荧光猝灭,而分子聚集或自组装是形成液晶相的内在要求,即发光与液晶之间存在矛盾。四苯基乙烯(TPE)是一类具有聚集诱导发光效应的类盘状分子,将其应用于液晶分子的设计将有望解决发光与液晶之间的矛盾。本文将二苯乙炔或联苯衍生物等棒状液晶基元连接到TPE上形成对称或不对称的具有双轴取向的发光液晶分子。采用差示扫描量热仪(DSC)、变温一维广角X-射线衍射(1D wAXD)和偏光显微镜等多种表征手段对其本体相结构进行研究。对于四取代的对称性分子,TPE通过分子间堆积形成的柱状结构与棒状液晶基元之间堆积形成的层状结构之间形成双轴取向的层状相结构。对于单取代的非对称性分子,则形成亚稳态的液晶相,随着温度的升高将转变为晶相结构。

关键词：聚集诱导发光四苯基乙烯液晶相结构 X-射线衍射

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国科学：化学 2013年第9期43卷 1204-1204页

作者： CHEN yaFei LIN JieSheng yUAN wangZhang yU ZhenQiang lam jacky wingyip TANG BenZhong Shenzhen Key Laboratory of Functional Polymers School of Chemistry and Chemical Engineering Shenzhen University Shenzhen 518060 China National Institutes for Food and Drug Control Beijing 100050 China School of Chemistry and Chemical engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Chemistry The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong China

The luminescent liquid crystals(LLCs)are expected to solve the conflicts between the aggregation caused quenching and the requirement of aggregation or self-organization for ***,we developed a new strategy of applying aggregation-induced emission(AIE)phenomenon to the molecular design of LCs towards *** this report,a calamitic liquid crystal based on tolane with AIE characteristics was successfully synthesized and the chemical structure was characterized by1H,13C NMR,and matrix-assisted laser desorption/ionization time-of-flight(MALDI-TOF)high-resolution mass *** fluorescence behavior was studied by fluorescence spectroscopy and the liquid crystal phase behaviors were investigated by differential scanning calorimetry(DSC),polarized optical microscopy(POM).The crystal structure was obtained by X-ray diffraction crystallography with P1 space *** demonstrated that the sample was AIE active and the LC phases sequence during cooling was nematic,smectic C and smectic B phase.

关键词：液晶发射特性诱导聚合乙炔基环己基 MALDI-TOF 基质辅助激光解吸

在线全文

学校读者我要写书评

暂无评论

从工业革命(工业1.0)到外科4.0

中华消化外科杂志 2020年第9期19卷 919-924页

作者：刘允怡林伟棋杨重光中华人民共和国香港特别行政区新界沙田香港中文大学医学院

外科1.0到外科4.0这一类名词均源自“工业4.0”。2011年德国汉诺威工业博览会提出工业4.0。18世纪工业革命起源于英国,其工业发展有4个重要阶段,分别被称为工业1.0、工业2.0、工业3.0和工业4.0,每个发展阶段均有重要科学发明和应用推广... 详细信息

外科1.0到外科4.0这一类名词均源自“工业4.0”。2011年德国汉诺威工业博览会提出工业4.0。18世纪工业革命起源于英国,其工业发展有4个重要阶段,分别被称为工业1.0、工业2.0、工业3.0和工业4.0,每个发展阶段均有重要科学发明和应用推广。基于工业发展的4个阶段,2018年Hooshair A首先提出外科发展从外科1.0到外科4.0的概念,与工业发展一致。虽然两者发展时间不同,但均以重大科学发现为基础。21世纪初标志着进入外科4.0,5个重要的科学成果包括大数据、人工智能、自动化、现代机器人、5G通讯,推动外科4.0的发展。20年间各环节发展均十分迅速,每个环节的发展均带动另一环节的需求,环环相扣,呈现一个急速向上发展的良性循环。笔者预测:外科4.0仍会迅速再发展,从环环相扣式发展变为不同环节融合发展和整体科技融合发展,进而到达外科5.0。在外科4.0起步时期预测外科5.0将会来临貌似具有野心,但笔者肯定这是科学发展的必然趋势,外科5.0不但会到临,还会在不远的将来到临。

关键词：工业革命工业4.0 外科4.0 外科5.0 科学发展

CdS纳米粒子与全共轭自组装膜的原位复合及其光电转换性质

在线全文

学校读者我要写书评

暂无评论

CdS纳米粒子与全共轭自组装膜的原位复合及其光电转换性质