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Current status and prospects of clinical proteomics studies on detection of colorectal cancer:Hopes and fears

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World Journal of Gastroenterology 2006年第41期12卷 6594-6601页

作者： me de Noo RAEM Tollenaar AM Deelder LH Bouwman Department of Surgery Leiden University Medical CenterLeidenThe Netherlands Biomolecular Mass Spectrometry Unit Department of ParasitologyLeiden University Medical CenterLeidenThe Netherlands

Colorectal adenocarcinoma （CRC） is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specificities for early detection of several solid tumors. This emerging field uses mass spectrometry-based protein profiles/patterns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of：（i） proteins being abnormally produced or shed and added to the serum proteome, （2） proteins clipped or modified as a consequence of the disease process, or （3） proteins subtracted from the proteome owing to disease-related proteolytic degradation pathways. Therefore, protein pattern diagnostics would provide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will reflect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identification and nature of discriminating proteins/peptides.

关键词： Proteomics Colorectal cancer Protein profiling Diagnosis Biomarkers Statistical issues

Natural history, treatment and prevention of hepatitis C recurrence after liver transplantation: Past, present and future

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World Journal of Gastroenterology 2014年第32期20卷 11069-11079页

作者： Jérme Dumortier Olivier Boillot Jean-Yves Scoazec Unité de Transplantation Hépatique-Fédération des Spécialités Digestives HCL H?pital Edouard Herriot 69437 Lyon France Olivier Boillot Jean-Yves Scoazec Université Claude Bernard Lyon 1 69437 Lyon France Service d’Anatomie et Cytologie Pathologiques HCL H?pital Edouard Herriot 69437 Lyon France

Hepatitis C virus(HCV)-related liver disease, including cirrhosis and hepatocellular carcinoma is the main indication for liver transplantation(LT) worldwide. Posttransplant HCV re-infection is almost universal and results in accelerated progression from acute hepatitis to chronic hepatitis, and liver cirrhosis. Comprehension and treatment of recurrent HCV infection after LT have been major issues for all transplant hepatologists and transplant surgeons for the last decades. The aim of this paper is to review the evolution of our knowledge on the natural history of HCV recurrence after LT, including risk factors for disease progression, and antiviral therapy. We will focus our attention on possible ways(present and future) to improve the final longterm results of LT for HCV-related liver disease.

关键词： Hepatitis C Liver transplantation Recurrence Fibrosis Treatment

Interactions between rodents and weeds in a lowland rice agro-ecosystem:the need for an integrated approach to management

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Integrative Zoology 2019年第4期14卷 396-409页

作者： Nyo me HTWE Grant R.SINGLETON David E.JOHNSON Plant Protection Division Department of AgricultureMinistry of AgricultureLivestock and IrrigationMyanmar International Rice Research Institute DAPO Box 7777Metro ManilaPhilippines Natural Resources Institute University of GreenwichChatham MaritimeKentUK

Rodents and weeds are important pests to rice crops in Southeast *** interaction between these 2 major pests is poorly *** temperate cereal systems,seeds of grass weeds can be an important food source for rodents and weed cover along crop margins provides important refuge for *** 2012 and 2013,a replicated study(n=4)in Bago,Myanmar compared 4 treatments(rodents and weeds;no rodents and weeds;rodents and no weeds;no rodents and no weeds)each of 0.25 ha in transplanted *** were managed with hand weeding in the wet season,and hand weeding and herbicides in the dry *** fences were installed to exclude *** examined the weed cover and relative abundance of weed species,rodent damage,rodent population dynamics and rice yield loss caused by rodents and *** dominant rodent species was Bandicota *** the dry season,Cyperus difformis was dominant at the tillering stage and Echinochloa crus-galli was the dominant weed species at the booting *** the wet season ***-galli was a dominant weed throughout the *** by rodents was higher in the dry *** were larger economic benefits for best weed management and effective rodent control in the dry season(258 US$/ha)than in the wet season(30 US$/ha).Concurrent control of weeds in and around rice fields combined with coordinated community trapping of rodents during the early tillering stage and ripening stage of rice are recommended management options.

关键词： Bandicota bengalensis Myanmar rice rodents weeds

结核分枝杆菌耐热抗原(MTB-HAg)对γδ T细胞影响的研究进展

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细胞与分子免疫学杂志 2024年第2期40卷 186-190页

作者：魏婧袁美丽王楚彤李柏青许涛汪洪涛蚌埠医科大学检验医学院免疫学教研室安徽蚌埠233030 蚌埠医科大学慢性疾病免疫学基础与临床安徽省重点实验室安徽蚌埠233030 蚌埠医科大学检验医学院临床检验诊断学教研室安徽蚌埠233030

结核分枝杆菌耐热抗原(MTB-HAg)是从结核分枝杆菌(MTB)减毒菌株H37Ra经121℃,20 min,高温高压处理后从菌体释放到上清液中一种多肽类抗原。γδ T细胞是一类广泛分布于非淋巴组织的非常规T细胞,可分泌肿瘤坏死因子α(TNF-α)、γ干扰素(... 详细信息

结核分枝杆菌耐热抗原(MTB-HAg)是从结核分枝杆菌(MTB)减毒菌株H37Ra经121℃,20 min,高温高压处理后从菌体释放到上清液中一种多肽类抗原。γδ T细胞是一类广泛分布于非淋巴组织的非常规T细胞,可分泌肿瘤坏死因子α(TNF-α)、γ干扰素(IFN-γ)等细胞因子,在抗MTB感染的免疫应答中发挥重要作用。MTB-HAg可在体外有效刺激γδ T细胞增殖活化,使其更加高效地参与抗结核感染的过程,故MTB-HAg可作为设计新型结核疫苗或药物的潜在靶点。但由于MTB-HAg组成复杂,具体是何种成分刺激γδ T细胞发挥抗MTB感染功能还不清楚。

关键词：结核分枝杆菌耐热抗原(MTB-HAg) γδT细胞增殖综述

Distributed location model and algorithm with position uncertainty

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The Journal of China Universities of Posts and Telecommunications 2014年第2期21卷 48-56页

作者： SHI Yu-long CUI Qi-me CAO Si-qi TAO Xiao-feng Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications

The localization of multiple mobile terminals （MTs） is an encouraging paradigm of applications in wireless networks. Peer-to-peer communication between MTs facilitates the cooperative localization of multiple MTs. For sake of low complexity and high robustness, investigations often focus on the distributed algorithm in cooperative localization. However, the impact from position uncertainty of cooperative MT lacks of analysis in related works. A new distributed location model, as well as corresponding algorithm, is devised when considering both the distance measurement error and the position uncertainty of MTs, which is more judicious than the traditional model for distributed cooperative localization scenario. In addition, the performance of proposed algorithm is analyzed through Cramér-Rao lower bound （CRLB）. Simulations indicate that the algorithm outperforms traditional methods in terms of accuracy and robustness.

关键词： distributed algorithm cooperative localization position tmcertainty

Shrinkage of magnetosphere observed by TC-1 satellite during the high-speed solar wind stream

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Science China(Technological Sciences) 2008年第10期51卷 1695-1703页

作者： H. Rme I. DANDOURAS C. M. CARR Centre d'Etude Spatiale des Rayonnements BP 4346 31028 Toulouse cedex 4 France The Blackett Laboratory Imperial College London SW7 2BZ UK

During the interval 06:14―07:30 UT on August 24, 2005, since the Earth’s magneto- pause was suddenly compressed by the persistent high-speed solar wind stream with the southward component of the interplanetary magnetic field (IMF), the magnetopause moved inward for about 3.1 RE. meanwhile, TC-1 satellite shifted from northern plasma sheet to the northern lobe/mantle region, although it kept inward flying during the interval 06:00―07:30UT. The shift of TC-1 from the plasma sheet to the lobe/mantle is caused by the simultaneous inward displacements of the plasma sheet and near-Earth lobe/mantle region, and their inward movement velocity is larger than the inward motion velocity of TC-1. The joint inward dis-placements of the magnetopause, the lobe/mantle region and the plasma sheet indicate that the whole magnetosphere shrinks inward due to the magnetospheric compression by the high-speed solar wind stream, and the magnetospheric ions are attached to the magnetic field lines (i.e. ‘frozen’ in magnetic field) and move inward in the shrinking process of magnetosphere. The large shrinkage of magne-tosphere indicates that the near-Earth magnetotail compression caused by the strong solar wind dynamic pressure is much larger than its thickening caused by the southward component of the IMF, and the locations of magnetospheric regions with different plasmas vary remarkably with the variation of the solar wind dynamic pressure.

关键词： solar wind dynamic pressure shrinkage of magnetosphere storm sudden commencement substorm

Results of the First 10 Cases of Coronary Bypass Surgery in Senegal

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World Journal of Cardiovascular Surgery 2024年第4期14卷 45-60页

作者： Papa Amath Diagne Jean Claude Ndiogou Dione Papa Ousmane Ba Momar Sokhna Diop El Hadji Boubacar Ba Momar Dioum Marième Soda Mbaye Moussa Seck Diop Mory Camara Abdou Lahad Mbengue Abdou Aziz Thiaw Abdoul Khoudoss Diallo Moussa Mareme Samba Dialtabé Ibrahima Guéssé Ba Anta Mbaye Sall Papa Salmaneba Amadou Gabriel Ciss Department of Cardiovascular and Thoracic Surgery FANN National University Hospital Dakar Senegal

This is a review of the first 10 coronary artery bypass surgeries performed by the local team. The mean age was 62 years old [45 - 74]. The patients were predominantly male, with a M/F ratio of 4:1. Cardiovascular risk factors were mainly myocardial infarction (MI) (60%), hypertension (50%), obesity (40%) and diabetes (30%), with at least two risk factors per patient. Angina was the main symptom (80%). The average time from presentation to surgery was 8 months. The mean Euroscore 2 was 2.92 ± 1.65 [1.33 - 6.60]. Coronary angiography revealed an average of 2 lesions per patient, with 3-vessel involvement in 70% of cases: the Interventricular artery (IVA) (100%), the right coronary artery (90%) and the circumflex artery (70%). On echocardiography, the mean Left ventricular ejection fraction (LVEF) was 59% [33% - 76%]. All patients underwent median sternotomy with bypass grafting. The average duration of the cardiopulmonary bypass was 150 min [46 - 275 min];that of aortic clamping, 120 min [43 - 232 min]. The grafts used were internal thoracic artery (ITA) in 100% of cases (80% on the left and 20% on the right), and the great saphenous vein (GSV) in 60% of cases (50% on the left and 10 on the right). Double bypass was performed in 60% of cases, single bypass in 30% and triple bypass in 10%. The bypasses were performed on the IVA (100%), the middle lateral of the circumflex (30%) and the bisector (20%). The average time to extubation was 11 hours and the length of stay in the intensive care unit was 7 days [03 - 17 days]. One patient had a reoperation on Day 0 post-op. The average hospital stay was 13 days [06 - 27 days]. Complications occurred in nine of the patients (90%), with a predominance of infectious and neurological complications. Overall operative mortality was 3%, all in intensive care.

关键词： Coronary Bypass Surgery Coronary Lesions Cardiac Surgery Senegal

Sexual audience affects male's reproduction investment without consequences on reproductive outputs

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Insect Science 2022年第4期29卷 1170-1180页

作者： Philippe Louâpre Karen Muller Soline Bettencourt-Amarante Denis Thiery Jérôme Moreau UMR CNRS 6282 Biogeosciences UniversitéBourgogne Franche-ComtéDijonFrance INRA UMR 1065 Santéet Agroecologie du Vignoble Institut des Science de la Vigne et du VinVillenave d'OrnonCedexFrance INRA UMR 1065 SaveUniversitéde BordeauxBordeaux Sciences AgroVillenave d'OrnonCedexFrance

Males evolved plastic strategies to respond to male-male competition and exhibit adaptive traits and behaviors maximizing their access to the females and limiting sperm *** behaviors allow males to express quick responses to current sexual audience,that is,the number of nearby conspecifics prone to *** contrast,physiological responses are frequently delayed because they are constrained by the time and resources having to be mobilized to produce and export sperm and associated *** is especially critical in species for which males produce *** we investigated in what extend moth males(the tortricid moth Lobesia botrana)producing spermatophores exhibit plastic behavioral and physiological responses to different sexual audiences before and during mating and the consequences for their reproductive *** found that males adjusted their mating behaviors and spermatophore size to a potentially elevated risk of sperm competition perceived before *** addition,males responded to the closed presence of females during mating by reducing their mating ***,the various behavioral and physiological responses we highlighted here were not fully reflected in their reproductive performance as we did not reveal any effect on fecundity and fertility of their *** selective pressure exerted on males experiencing male-male competition could thus be sufficient to trigger adjustment in male mating behaviors but constrains physiological responses according to the perception of competition.

关键词： Lobesia borrund male-male compeition mating behavior sexual conflict sexual scletion sperm competition

On attitudes about colorectal cancer screening among gastrointestinal specialists and general practitioners in the Netherlands

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World Journal of Gastroenterology 2006年第32期12卷 5201-5204页

作者： JS Terhaar sive Droste GDN Heine me Craanen H Boot CJJ Mulder Department of Gastroenterology and Hepatology VU University medical Centre AmsterdamThe Netherlands Department of Gastroenterology and Hepatology Antoni van Leeuwenhoek Hospital AmsterdamThe Netherlands

AIM： To find out whether there are differences in attitudes about colorectal cancer （CRC） screening among gastrointestinal （GI） specialists and general practitioners （GPs） and which method is preferred in a national screening program meTHODS： Four hundred and twenty Dutch GI specialists in the Netherlands and 400 GPs in Amsterdam were questioned in 2004. Questions included demographics, affiliation, attitude towards screening both for the general population and themselves, methods of screening, family history and individual risk. RESULTS： Eighty-four percent of the GI specialists returned the questionnaire in comparison to 32% of the GPs （P〈0.001）. Among the GI specialists, 92% favoured population screening whereas 51% of GPs supported population screening （P〈0.001）. Of the GI specialists 95% planned to be screened themselves, while 30% of GPs intended to do so （P〈0.001）. Regarding the general population, 72% of the GI specialists preferred colonoscopy as the screening method compared to 27% of the GPs （P〈0.001）. The method preferred for personal screening was colonoscopy in 97% of the GI specialists, while 29% of the GPs favoured colonoscopy （P〈0.001）. CONCLUSION： Screening for CRC is strongly supported by Dutch GI specialists and less by GPs. The major health issue is possibly misjudged by GPs. Since GPs play a crucial role in a successful national screening program, CRC awareness should be realized by increasing knowledge about the incidence and mortality, thus increasing awareness of the need for screening among GPs.

关键词： Colorectal cancer General practitioner Screening Colonoscopy Awareness