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STCF conceptual design report (Volume 1): Physics & detector

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.l.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng l.S.Geng A.Gilman l.Gong T.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.lei E.levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.l.li J.M.li J.li l.li l.li l.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao l.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu l.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.l.liu Z.Q.liu Z.Y.liu Z.W.liu I.logashenko Y.long C.G.lu J.X.lu N.lu Q.F.lü Y.lu Y.lu Z.lu P.lukin F.J.luo T.luo X.F.luo Y.H.luo H.J.lyu X.R.lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.l.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de lausanne(EPFl) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Design of Data Communication Network and Communication Software in Rural Substations

Design of Data Communication Network and Communication Softw...

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International Conference on Industrial Technology and Management Science(ITMS 2015)

作者： Q.C.CHEN H.lI B.lI C.lIU J.Y.lIN l.CAI l.xia China Electric Power Research Institute

Combining with integrated Substation Automation Systems, this paper describes the data communications and the development trends of the Substation Automation Systems, which is suited to the new or modified rural substations. The paper also presents the design methods of the Supervisory Control and Data Acquisition（SCADA） software, which can meet a variety of interface types and protocols.

关键词： Rural electric network Substation automation Data communication network

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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

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Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia lIU xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/ml) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/ml significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(Pll doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(Pl/l 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(Pl asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(Plusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.l.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.l.Chen S.J.Chen S.l.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.l.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli l.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.l.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong l.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen l.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.l.Guan A.Q.Guo l.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.l.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.l.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.l.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang l.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.l.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.l.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.lane P.larin l.lavezzi T.T.lei Z.H.lei H.leithoff M.lellmann T.lenz C.li C.li C.H.li Cheng li D.M.li F.li G.li H.li H.B.li H.J.li H.N.li Hui li J.R.li J.S.li K.li l.J.li l.K.li lei li M.H.li P.R.li Q.M.li Q.X.li R.li S.X.li T.li W.D.li W.G.li X.li X.H.li X.l.li X.Y.li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Prediction and scheduling of multi-energy microgrid based on BiGRU self-attention mechanism and lQPSO

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Global Energy Interconnection 2024年第3期7卷 347-361页

作者： Yuchen Duan Peng li Jing xia School of Automation and Intelligence Beijing Jiaotong UniversityBeijing 100044P.R.China Goldwind Science&Technology Co.ltd. Beijing 100176P.R.China

To predict renewable energy sources such as solar power in microgrids more accurately,a hybrid power prediction method is presented in this ***,the self-attention mechanism is introduced based on a bidirectional gated recurrent neural network(BiGRU)to explore the time-series characteristics of solar power output and consider the influence of different time nodes on the prediction ***,an improved quantum particle swarm optimization(QPSO)algorithm is proposed to optimize the hyperparameters of the combined prediction *** final proposed lQPSO-BiGRU-self-attention hybrid model can predict solar power more *** addition,considering the coordinated utilization of various energy sources such as electricity,hydrogen,and renewable energy,a multi-objective optimization model that considers both economic and environmental costs was constructed.A two-stage adaptive multi-objective quantum particle swarm optimization algorithm aided by a lévy flight,named MO-lQPSO,was proposed for the comprehensive optimal scheduling of a multi-energy microgrid *** algorithm effectively balances the global and local search capabilities and enhances the solution of complex nonlinear *** effectiveness and superiority of the proposed scheme are verified through comparative simulations.

关键词： Microgrid Bidirectional gated recurrent unit Self-attention lévy-quantum particle swarm optimization Multi-objective optimization

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Eigenfrequency analysis of bridges using a smartphone and a novel low-cost accelerometer prototype

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 202-215页

作者： Seyedmilad KOMARIZADEHASl Ye xia Mahyad KOMARY Fidel lOZANO Department of Civil and Environment Engineering Universitat Politècnica de CatalunyaBarcelona 08034Spain Department of Bridge Engineering Tongji UniversityShanghai 200092China Department of Civil Engineering Universidad de Castilla-La ManchaCiudad Real 13071Spain

Researchers are paying increasing attention to the development of low-cost and microcontroller-based accelerometers,in order to make structural health monitoring feasible for conventional bridges with limited monitoring *** with the low-cost sensor development,the use of the embedded accelerometers of smartphones for eigenfrequency analysis of bridges is becoming popular in the civil engineering *** paper,for the first time in the literature,studies these two promising technologies by comparing the noise density and eigenfrequency analysis of a self-developed,validated and calibrated low-cost Internet of things based accelerometer lARA(low cost adaptable reliable accelerometer)with those of a state of the art smartphone(iPhone XR).The eigenfrequency analysis of a footbridge in San Sebastian,Spain,showed that the embedded accelerometer of the iPhone XR can measure the natural frequencies of the under study bridge.

关键词： smartphone modal analysis eigenfrequency analysis low-cost accelerometers Arduino Raspberry Internet of things

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Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition

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Rare Metals 2024年第1期43卷 225-235页

作者： Feng-xia Wu Feng-Hua li xia-li lv Qi-xian Zhang Guo-Bao Xu Wen-Xin Niu State Key laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic ***,significant advance has been made in synthesizing metal nanocrystals with intrinsic ***,the majority reports are limited to ***,through a heteroepitaxial growth strategy,the synthesis of metal nanocrystals with intrinsic chirality to palladium was extended for the first time and their application in enantioselective recognition was *** heteroepitaxial growth strategy allows for transferring the chirality of homochiral Au nanocrystals to Au@Pd core–shell *** employing the chiral Au@Pd nanocrystals as enantiomeric recognizing elements,a series of electrochemical sensors for chiral discrimination were *** optimal conditions,the peak potential between D-dihydroxyphenylalanine(D-DOPA)and l-dihydroxyphenylalanine(l-DOPA)is about 80 m V,and the peak current of D-DOPA is 2 times as much as that of l-DOPA,which enables the determination of the enantiomeric excess(EE,%)of ***,this report not only introduces a heteroepitaxial growth strategy to synthesize metal nanocrystals with intrinsic chirality,but also demonstrates the superior capability of integrating intrinsic chirality and catalytic properties into metal nanocrystals for chiral recognition.

关键词： Core–shell nanostructures Chirality transfer Electrochemical sensors Chiral recognition Chiroplasmonics

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Unveiling a novel metal-to-metal transition in luH_(2):Critically challenging superconductivity claims in lutetium hydrides

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Matter and Radiation at Extremes 2024年第3期9卷 65-73页

作者： Dong Wang Ningning Wang Caoshun Zhang Chunsheng xia Weicheng Guo xia Yin Kejun Bu Takeshi Nakagawa Jianbo Zhang Federico Gorelli Philip Dalladay-Simpson Thomas Meier Xujie lü liling Sun Jinguang Cheng Qiaoshi Zeng Yang Ding Ho-kwang Mao Center for High-Pressure Science and Technology Advanced Research Beijing 100094China Beijing National laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Shanghai Key laboratory of Material Frontiers Research in Extreme Environments(MFree) Shanghai Advanced Research in Physical Sciences(SHARPS)Shanghai 201203China

Following the recent report by Dasenbrock-Gammon et al.[Nature 615,244–250(2023)]of near-ambient superconductivity in nitrogendoped lutetium trihydride(luH_(3-δ)N_(ε)),significant debate has emerged surrounding the composition and interpretation of the observed sharp resistance ***,we meticulously revisit these claims through comprehensive characterization and *** definitively identify the reported material as lutetium dihydride(luH_(2)),resolving the ambiguity surrounding its *** similar conditions(270–295 K and 1–2 GPa),we replicate the reported sharp decrease in electrical resistance with a 30%success rate,aligning with the observations by Dasenbrock-Gammon et ***,our extensive investigations reveal this phenomenon to be a novel pressure-induced metal-to-metal transition intrinsic to luH_(2),distinct from ***,nitrogen doping exerts minimal impact on this *** work not only elucidates the fundamental properties of luH_(2)andluH_(3),but also critically challenges the notion of superconductivity in these lutetium hydride *** findings pave the way for future research on lutetium hydride systems,while emphasizing the crucial importance of rigorous verification in claims of ambient-temperature superconductivity.

关键词： resistance hydride superconductivity

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Machine learning and bioinformatics to identify biomarkers in response to Burkholderia pseudomallei infection in mice

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BIOCEll 2024年第4期48卷 613-621页

作者： YAO FANG FEI xia FEIFEI TIAN l EI QU FANG YANG JUAN FANG ZHENHONG HU HAICHAO lIU Department of Respiratory and Critical Care Medicine General Hospital of Center Theater of PLAWuhan430070China School of Medicine Wuhan University of Science and TechnologyWuhan430065China School of life Science and Engineering Southwest Jiaotong UniversityChengdu611756China

Objective:In the realm of Class I pathogens,Burkholderia pseudomallei(BP)stands out for its propensity to induce severe *** the intricate interactions between BP and host cells is imperative for comprehending the dynamics of BP infection and discerning biomarkers indicative of the host cell response ***:mRNA extraction from BP-infected mouse macrophages constituted the initial step of our *** gene expression arrays,the extracted RNA underwent conversion into digital *** percentile shift method facilitated data processing,with the identiﬁcation of genes manifesting signiﬁcant differences accomplished through the application of the ***,a comprehensive analysis involving Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway was conducted on the differentially expressed genes(DEGs).leveraging the ESTIMATE algorithm,gene signatures were utilized to compute risk scores for gene expression *** vector machine analysis and gene enrichment scores were instrumental in establishing correlations between biomarkers and macrophages,followed by an evaluation of the predictive power of the identiﬁed ***:The functional and pathway associations of the DEGs predominantly centered around G protein-coupled receptors.A noteworthy positive correlation emerged between the blue module,consisting of 416 genes,and the ***4,identiﬁed through support vector machine analysis among intersecting genes,indicated a robust interaction with macrophages,suggesting its potential as a robust ***4 exhibited commendable predictive efﬁcacy,with BP infection inducing its expression in both macrophages and mouse lung *** blotting in macrophages conﬁrmed a signiﬁcant upregulation of FZD4 expression from 0.5 to 24 h *** mouse lung tissue,FZD4 manifested higher expression in the cytoplasm of pulmonary epithelial cells in BP-infected lungs than in the

关键词： Burkholderia pseudomallei Microarray assay Machine learning Bioinformatics FZD4

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Synthesis of a High-Efficiency Demulsifier and Study on Optimal Demulsification Conditions

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 107-115页

作者： Zhu Shuai Zhang YingYu Gui xia College of Chemical Engineering Nanjing Tech University30 Puzhunan RoadNanjing 211816China

Oil and water separation has always been a top priority in the oil *** this study,a series of hyperbranched fluorinated polyamine-amine polymers(HFPA1-5)were synthesized directly using an improved“one-pot method.”The highly active fluorinated p-trifluoromethylaniline was used as the core raw material,while diethylenetriamine and methyl acrylate were used as the chain segment.A hyperbranched fluorine-containing polyamine-amine demulsifier(NHFPA6)was obtained through nano-grafting copolymerization of *** enhance the demulsification and dehydration performance,the copolymerized HFPA6 was modified and ***,the effects of the combination ratio,demulsifier concentration,demulsification time,and demulsification temperature on the demulsification effect were *** results revealed that a combination ratio of DE-401:NHFPA6=1:1,a demulsification temperature of 50℃,a demulsification time of 60 min,and a demulsifier concentration of 150 mg/l yielded a dehydration rate as high as 99.80%.A response surface optimization design of demulsification conditions was *** model verified that the optimal demulsification conditions were 50℃,300 mg/l,and 90 ***,considering the economic benefits of factories,it is more favorable to select demulsification conditions with a shorter time and lower concentration when the dehydration standard is ***,the demulsification conditions were selected as 50℃,150 mg/l,and 60 *** to existing demulsifiers,the demulsifier developed in this study exhibits a lower demulsification temperature and higher demulsification efficiency.

关键词： hyperbranched fluorinated polyamine-amine nano-SiO_(2)

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