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Initial coin offerings(ICOs):Why do they succeed?

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Financial Innovation 2022年第1期8卷 233-267页

作者： JoséCampino Ana Brochado Álvaro rosa Instituto Universitário de lisboa(ISCTE-IUl) Business Research Unit(BRU-IUL)LisbonPortugal Instituto Universitário de lisboa(ISCTE-IUl) DINÂMIA’CETLisbonPortugal

Recent literature has addressed initial coin offering(ICO)projects,which are an innovative form of venture financing through cryptocurrencies using blockchain *** features of ICOs remain unexplored,leaving much room for additional research,including the success factors of ICO *** investigate the success of ICO projects,with our main purpose being to identify factors that influence a project’s *** a literature review,from which several potential variables were collected,we used a database comprising 428 ICO projects in the banking/financial sector to regress several econometric *** confirmed the impacts of several variables and obtained particularly valuable results concerning project and campaign *** confirmed the importance of a well-structured and informative *** proximity to certain markets with high availability of financial and human capital is also an important determinant of the success of an *** also confirm the strong dependency on cryptocurrency and the impact of cryptocurrency valuations on the success of a ***,we confirm the importance of social media in ICO projects,as well as the importance of human capital *** research contributes to the ICO literature by capturing most of the success factors previously identified and testing their impacts based on a large *** current research contributes to the building of systems theory and signaling theory by adapting their frameworks to the ICO *** results are also important for regulators,as ICOs are mainly unregulated and have vast future potential,and for investors,who can benefit from our analysis and use it in their due diligence.

关键词： Initial coin offering(ICO) Fintech Bank Financial services Technology Blockchain Innovation Venture capital Crowdfunding Success

Development and application of a SPE-lC-QTOF method for the quantification of micropollutants of emerging concern in drinking waters from the Brazilian capital

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Emerging Contaminants 2020年第1期6卷 72-81页

作者： Fernando Fabriz Sodre Thiago rosa Sampaio Institute of Chemistry University of BrasiliaBrasilia70910-000Brazil

The Brazilian Federal District is located under a savannah climate characterized by an intense dry season,resulting in severe problems related to water *** situation motivates the search for alternate water sources,leading to the indirect water reuse in the Paranoa lake,an artificial reservoir located in the heart of the Brazilian *** work aimed the assessment of 35 micropollutants of emerging concern by ultra-performance liquid chromatography coupled to high-resolution mass ***-phase extraction conditions(Oasis HlB)were optimized by a factorial *** were then assessed in 0.45 mm filtered samples(1 l)under three different pH by matrix-matched calibration with standard additions and high-resolution multiple reaction monitoring ***,bisphenol A and the insect repellant DEET were detected in all investigated samples(n=14),followed by atrazine(86%of the samples),carbamazepine(71%),paraxanthine(71%),mefenamic acid(64%),nicotine(57%),atenolol(43%)and sulfamethoxazole(43%).Although not frequently detected,the reproductive hormones,estrone,17β-estradiol and estriol,as well as the ovulation inhibitor 17α-ethinylestradiol were detected in a sample from the Paranoa lake WTP in concentrations ranging from 3.71±0.08 and 5.6±0.1 ng l^-*** these levels,risk quotients indicate the potential for adverse effects to both human health and the environment.

关键词： Emerging contaminants Drinking waters Endocrine disrupting chemicals Hormones Risk assessment

Differential diagnosis and management of liver tumors in infants

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World Journal of Hepatology 2014年第7期6卷 486-495页

作者： Israel Fernez-Pineda rosa Cabello-laureano Department of Pediatric Surgery Virgen del Rocio Children’s HospitalSevilla 41013 Spain

During the first year of life, most of the liver neoplasms are benign in origin, but some of these histologically benign lesions may be challenging in their management. Although most hepatic hemangiomas can be safely observed until involution is documented, some patients will need treatment due to progressive hepatomegaly, hypothyroidism and/or cardiac failure. large mesenchymal hamartomas may require extensive hepatic resection and an appropriate surgical plan is critical to obtain good results. For malignant neoplasms such as hepatoblastoma, complete surgical resection is the mainstay of curative therapy. The decision about whether to perform an upfront or delayed resection of a primary liver malignant tumor is based on many considerations, including the ease of resection, surgical expertise, tumor histology and stage, and the likely chemosensitivity of the tumor. This article reviews the initial management of the more common hepatic tumors of infancy, focusing on the differential diagnosis and treatment options.

关键词： Hepatoblastoma Hepatic hemangioma Mesenchymal hamartoma Undifferentiated embryonal sarcoma of the liver Focal nodular hyperplasia

Selective Gold Deposition on a Nanostructured Block Copolymer Film Crystallized by Epitaxy

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Nano Research 2011年第3期4卷 241-248页

作者： Claudio De rosa Finizia Auriemma Rocco Di Girolamo Rossella Aprea Annette Thierry Dipartimento di Chimica ＂P. Corradini＂ Universit~t di Napoli ＂Federico II＂ Complesso Monte S. Angelo Via Cintia 80126 Napoli Italy Institut Charles Sadron University de Strasbourg CNRS-UPR 22 B. E 84047 23 rue du Loess 67034 Strasbourg France

An ordered nanostructure formed by epitaxial crystallization of a semicrystalline block copolymer on a substrate has been used as a patterned template for the selective deposition of thermally evaporated gold nanoparticles, resulting in the formation of structure-guiding host nanocomposites in which the ordered distribution of the guest particles is guided by the ordering of the host nanostructured block copolymer matrix. This opens new perspectives in the field of polymeric composites related to the maximum enhancement of effective physical properties and to the numerous possible applications that arise due to the presence of long-range order in the spatial distribution of functional nanoparticles.

关键词： Crystalline block copolymers nanostructures nanocomposites gold deposition

Experimental evidence for heritable reproductive time in 2 allochronic populations of pine processionary moth

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Insect Science 2017年第2期24卷 325-335页

作者： Manuela Branco Maria-rosa Paiva Helena Maria Santos Christian Burban Carole Kerdelhue Centro de Estudos Florestais (CEF) Instituto Superior de Agronomia (ISA) Universidade de Lisboa (ULisboa) 1349-017 Lisboa Portugal CENSE Faculty of Sciences and Technology (FCT) Universidade Nova de Lisboa (UNL) 2829-516 Caparica Portugal INRA Centre de Bordeaux UMR1202 BIOGECO Cestas cedex France INRA Centre de Montpellier UMR CBGP F-34988 Montferrier-sur-Lez cedex France

Phenology allows organisms to overcome seasonally variable conditions through life-cycle adjustment. Changes in phenology can drastically modify the evolutionary tra- jectory of a population, while a shift in the reproductive time may cause allochronic differentiation. The hypothesis of heritable reproductive time was experimentally tested, by studying a unique population of the pine processionary moth Thaumetopoeapityocampa （Den. ＆ Schiff.） which has a shifted phenology, and however co-occurs with the typical population following the classical life cycle. When populations of both types were reared under controlled conditions, the reproductive time was maintained asynchronous, as ob- served in the field. The shifted population was manipulated in the laboratory to reproduce later than usual, yet the offspring emerged in the next year at the expected dates thus ＂com- ing back＂ to the usual cycle. Hybrids from crosses performed between the 2 populations showed an intermediate phenology. From the emergence times of parents and offspring, a high heritability of the reproductive time （h = 0.76） was observed. The offspring ob- tained from each type of cross was genetically characterized using microsatellite markers. Bayesian clustering analysis confirmed that hybrids can he successfully identified and separated from the parental genetic classes by genotyping. Findings support the hypothesis that, for this particular population, incipient allochronic speciation is due to a heritable shift in the reproductive time that further causes assortative mating and might eventually cause ecological adaptation/maladaptation in response to environmental changes.

关键词： allochronic speciation experimental crossings heritability phenology reproductive isolation Thaumetopoeapityocampa

Metabolic regulation of microglial phagocytosis:Implications for Alzheimer’s disease therapeutics

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Translational Neurodegeneration 2023年第1期12卷 205-224页

作者： Izabela lepiarz-Raba Ismail Gbadamosi Roberta Florea rosa Chiara Paolicelli Ali Jawaid laboratory for Translational Research in Neuropsychiatric Disorders(TREND) BRAINCITY:Center of Excellence for Neural Plasticity and Brain DisordersNencki Institute of Experimental BiologyWarsawPoland Swiss Federal Institute of Technology(ETH) ZurichSwitzerland Department of Biomedical Sciences University of LausanneLausanneSwitzerland

Microglia,the resident immune cells of the brain,are increasingly implicated in the regulation of brain health and *** perform multiple functions in the central nervous system,including surveillance,phagocytosis and release of a variety of soluble ***,a majority of their functions are closely related to changes in their *** natural inter-dependency between core microglial properties and metabolism offers a unique opportunity to modulate microglial activities via nutritional or metabolic *** this review,we examine the existing scientific literature to synthesize the hypothesis that microglial phagocytosis of amyloid beta(Aβ)aggregates in Alzheimer’s disease(AD)can be selectively enhanced via metabolic *** first review the basics of microglial metabolism and the effects of common metabolites,such as glucose,lipids,ketone bodies,glutamine,pyruvate and lactate,on microglial inflammatory and phagocytic ***,we examine the evidence for dysregulation of microglial metabolism in *** is followed by a review of in vivo studies on metabolic manipulation of microglial functions to ascertain their therapeutic potential in ***,we discuss the effects of metabolic factors on microglial phagocytosis of healthy synapses,a pathological process that also contributes to the progression of *** conclude by enlisting the current challenges that need to be addressed before strategies to harness microglial phagocytosis to clear pathological protein deposits in AD and other neurodegenerative disorders can be widely adopted.

关键词： Microglia Metabolism Alzheimer’s disease Neurodegeneration Inflammation Phagocytosis

Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases

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Neural Regeneration Research 2020年第9期15卷 1631-1638页

作者： Kevin Puertas-Neyra Ricardo Usategui-Martín rosa MCoco Ivan Fernandez-Bueno Instituto Universitario de Oftalmobiologia Aplicada Universidad de ValladolidValladolidSpain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y leon ValladolidSpain Red Tematica de Investigacion Cooperativa en Salud OftaredInstituto de Salud CarlosⅢValladolidSpain

Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients' daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs.

关键词： clinical trials growth factors intraocular injection intravitreal injection neuroprotection paracrine properties photoreceptors preclinical models retinal diseases stem cells

A Model Structured in Classes for the Study of Student Population Evolution

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上海大学学报（自然科学版） 2014年第2期20卷 127-137页

作者： PEREIRA Edgar rosa Cecilia SIlVA Jacques Department of Mathematics Universidade Federal do Rio Grande do Norte Department of Mathematics Instituto Politecnico da Guarda Department of Mathematics Universidade Federal do Rio Grande do Sul

This paper presents an application of a metapopulation model structured in classes for the study of population evolution of a network of *** global dynamics are considered in two parts,the local,where the evolution for each grade in a cycle is accounted,and the metapopulation or the movement of students between *** of the model is presented.

关键词：应用数学数学分析数学理论数学概念

Advances in diamond nanofabrication for ultrasensitive devices

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Microsystems & Nanoengineering 2017年第1期3卷 80-95页

作者： Stefania Castelletto lorenzo rosa Jonathan Blackledge Mohammed Zaher Al Abri Albert Boretti School of Engineering RMIT UniversityBundooraVictoria 3083Australia Swinburne University of Technology Centre for Micro-Photonics(H74)HawthornVictoria 3122Australia Department of Information Engineering University of ParmaParma 43121Italy Military Technological College Muscat 111Sultanate of Oman Dublin Institute of Technology Rathmines RoadDublin 6Ireland Department of Petroleum and Chemical Engineering Sultan Qaboos UniversityPO Box 33Al-KhoudMuscat 123Sultanate of Oman Water Research Center Sultan Qaboos UniversityPO Box 17Al-KhoudMuscat 123Sultanate of Oman Department of Mechanical and Aerospace Engineering Benjamin M.Statler College of Engineering and Mineral ResourcesWest Virginia UniversityP.O.Box 6106325 Engineering Sciences BuildingMorgantownWV 26506USA

This paper reviews some of the major recent advances in single-crystal diamond nanofabrication and its impact in nano-and micromechanical,nanophotonics and optomechanical *** constituents of integrated devices incorporating specific dopants in the material provide the capacity to enhance the sensitivity in detecting mass and forces as well as magnetic field down to quantum mechanical limits and will lead pioneering innovations in ultrasensitive sensing and precision measurements in the realm of the medical sciences,quantum sciences and related technologies.

关键词： nano-diamonds nanofabrication nanomechanics nanophotonics optomechanics