检索结果-南通市图书馆

国家公园生态产品价值实现的机制及模式——以神农架国家公园为例

在线全文

学校读者我要写书评

暂无评论

生态学报 2024年第13期44卷 5786-5800页

作者：唐承财刘嘉仪秦珊江玲吕君北京第二外国语学院旅游科学学院北京100024 北京旅游发展研究基地北京100024 内蒙古财经大学旅游学院呼和浩特010070

探究生态产品价值实现的机制及模式是国家公园加快生态文明建设、推动“绿水青山”向“金山银山”转化的关键。构建了国家公园社会-经济-自然复合生态系统,分析国家公园生态产品特征并划分类别,以神农架国家公园试点为例,探究了国家公... 详细信息

探究生态产品价值实现的机制及模式是国家公园加快生态文明建设、推动“绿水青山”向“金山银山”转化的关键。构建了国家公园社会-经济-自然复合生态系统,分析国家公园生态产品特征并划分类别,以神农架国家公园试点为例,探究了国家公园生态产品价值的实现路径与机制,建立了国家公园生态产品价值实现模式。结果表明:(1)国家公园复合生态系统由社会、经济和自然生态系统构成,形成一个相互影响、相互关联的整体。(2)国家公园生态产品具有生物生产性、资源稀缺性、人类收益性、地域整体性、政策依赖性、利益平衡性等特征,识别与分类生态产品有助于复合生态系统的平稳运行与健康发展,进而实现生态产品价值。(3)国家公园生态产品总体分为公共性、准公共性和经营性三类,并由政府主导、社区主导、市场主导与多主体复合型路径组成的价值实现路径体系完成价值实现。(4)国家公园生态产品价值实现机制由生态保护机制、经济发展机制、社区进步机制和协调保障机制四部分构成,服务于生态保护、产业发展和社区振兴三个目标。(5)国家公园生态产品价值实现过程中存在一定问题,以生态保护为首要任务、旅游发展为实现路径、社区振兴为核心目标,构建神农架国家公园“生态保护-旅游发展-社区振兴”共生模式,并进一步提出生态产品价值实现的生态旅游模式,以协调处理神农架国家公园复合生态系统结构内的矛盾,实现国家公园生态产品价值的最大化。综上所述,丰富了生态产品价值实现理论,并为国家公园生态产品价值实现模式提供了重要的科学依据与决策参考。国家公园“生态保护-旅游发展-社区振兴”的共生模式以及国家公园生态产品实现的生态旅游模式,将为国家公园生态产品价值的实现提供更加全面与有效的路径与模式。

关键词：国家公园生态产品价值生态旅游共同富裕生态文明建设共生模式神农架国家公园

Inhibitory Effect of Flavonoid Glycosides from Chlorophytum comosum on Nasopharyngeal Carcinoma 5-8F Cells and Its Mechanism

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Medicinal Plant 2024年第1期15卷 66-70页

作者： Chenliang CHU Xinchen WANG Kuan lU liang qin lu JIN College of Food and Pharmaceutical Engineering Zhaoqing UniversityZhaoqing 526061China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

[Objectives]To study the inhibitory activity of two flavonoid glycosides isolated from Chlorophytum comosum laxum *** on human nasopharyngeal carcinoma(NPC)cell line 5-8F in vitro and its mechanism.[Methods]The flavonoid glycosides were isolated and purified from the ethanol alcoholic extract of the roots of liliaceae plant Chlorophytum comosum by silica gel column chromatography,macroporous resin column chromatography,Sephadex lH-20,and reverse column chromatography(ODS).The inhibitory activity of flavonoid glycosides on human nasopharyngeal carcinoma cells was analyzed by CCK-8 method,and the potential mechanism was preliminarily analyzed by molecular docking.[Results]Two flavonoid glycosides were identified as isovitexin 2″-0-rhamnoside and 7-2″-di-O-β-*** flavonoid glycosides showed promising inhibitory effect on human nasopharyngeal carcinoma cell line 5-8F,with IC_(50) values of 24.8 and 27.5μmol/l,*** docking results showed that the potential targets of two flavonoid glycosides include CyclinD1,Bcl-2β-Catenin,IlK,TGF-β,in addition,two glycosides showed higher predicted binding affinity towards CyclinD1,which verifies the cytotoxicity of the two compounds on human nasopharyngeal carcinoma cell line 5-8F in vitro.[Conclusions]Two flavonoid glycosides are the active molecules in Chlorophytum comosum that can inhibit the proliferation of human nasopharyngeal carcinoma cells,and have the potential to be used in the research and development of anti nasopharyngeal carcinoma drugs.

关键词： Chlorophytum comosum laxum R.Br. Flavonoid glycosides 5-8F cells Antitumor mechanism

The Roadmap of 2D Materials and Devices Toward Chips

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro letters 2024年第6期16卷 343-438页

作者： Anhan liu Xiaowei Zhang Ziyu liu Yuning li Xueyang Peng Xin li Yue qin Chen Hu Yanqing Qiu Han Jiang Yang Wang Yifan li Jun Tang Jun liu Hao Guo Tao Deng Songang Peng He Tian Tian‑ling Ren School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100049People’s Republic of China School of Microelectronics Fudan UniversityShanghai 200433People’s Republic of China State Key laboratory of Dynamic Measurement Technology Shanxi Province Key Laboratory of Quantum Sensing and Precision MeasurementNorth University of ChinaTaiyuan 030051People’s Republic of China High‑Frequency High‑Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029People’s Republic of China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049People’s Republic of China IMECAS-HKUST-Joint laboratory of Microelectronics Beijing 100029People’s Republic of China

Due to the constraints imposed by physical effects and performance degra certain limitations in sustaining the advancement of Moore’s ***-dimensional(2D)materials have emerged as highly promising candidates for the post-Moore era,offering significant potential in domains such as integrated circuits and next-generation ***,in this review,the progress of 2D semiconductors in process engineering and various electronic applications are summarized.A careful introduction of material synthesis,transistor engineering focused on device configuration,dielectric engineering,contact engineering,and material integration are given *** 2D transistors for certain electronic applications including digital and analog circuits,heterogeneous integration chips,and sensing circuits are ***,several promising applications(artificial intelligence chips and quantum chips)based on specific mechanism devices are ***,the challenges for 2D materials encountered in achieving circuit-level or system-level applications are analyzed,and potential development pathways or roadmaps are further speculated and outlooked.

关键词： Two-dimensional materials Roadmap Integrated circuits Post-Moore era

TCERG1l hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 537-544页

作者： Yu Qian Ying Xiao Qiu-Rong lin Zhao-Yu Xiang li-Pu Cui Jia-Qi Sun Si-Cong li Xin-Ran qin Hai-Dong Zou Chen-Hao Yang Pei-Yao Jin Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai First People’s HospitalShanghai 200080China Shanghai Eye Diseases Prevention&Treatment Center Shanghai Eye HospitalShanghai 200040China National Clinical Research Center for Eye Diseases Shanghai Clinical Research Center for Eye DiseasesShanghai Key Clinical SpecialtyShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology Children’s Hospital of Fudan UniversityShanghai 201102China

●AIM:To identify the differential methylation sites(DMS)and their according genes associated with diabetic retinopathy(DR)development in type 1 diabetes(T1DM)children.●METHODS:This study consists of two surveys.A total of 40 T1DM children was included in the first *** no participant has DR,retina thinning was used as a surrogate indicator for *** lowest 25%participants with the thinnest macular retinal thickness were included into the case group,and the others were *** DNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay,and compared between the case and control *** DMS with a potential role in diabetes were *** second survey included 27 T1DM children,among which four had *** methylation patterns of the four DMS identified by 850K were compared between participants with and without DR by pyrosequencing.●RESUlTS:In the first survey,the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls(|Δβ|>0.1 and Adj.Plated and 432 were hypomethylated in the case group relative to the *** revealed that the transcription elongation regulator 1 like(TCERG1l,cg07684215)gene was hypermethylated in the four T1DM children with DR(P=0.018),which was consistent with the result from the first *** methylation status of the other three DMS(cg26389052,cg25192647,and cg05413694)showed no difference(all P>0.05)between participants with and without DR.●CONClUSION:The hypermethylation of the TCERG1l gene is a risk factor for DR development in Chinese children with T1DM.

关键词： DNA methylation 850K array pyrosequencing diabetic retinopathy type 1 diabetes children

Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第3期37卷 254-265页

作者： SHAN Xiao Yun ZOU Yan HUANG li Chun JIANG Shan ZHOU Wei Wen qin Qiu lan lIU Chang qing lUO Xiao Yan lU Jia Xi MAO De Qian lI Min YANG Zhen Yu YANG li Chen Key laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TSH,VA,and VD were *** The median UIC of total and lactating participants were 142.00µg/l and 139.95µg/l,*** median TSH,VA,and VD levels in all the participants were 1.89 mIU/l,0.44μg/ml,and 24.04 ng/ml,*** differences in the UIC were found between lactating and non-lactating *** and TSH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TSH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

在线全文

学校读者我要写书评

暂无评论

新型抗抑郁药托鲁地文拉法辛

中国新药与临床杂志 2024年第7期43卷 514-517页

作者：周琬琰吕钦谕易正辉上海交通大学医学院附属精神卫生中心精神科上海200030 复旦大学附属华山医院精神科上海200040 复旦大学精神卫生研究院上海200040

新型抗抑郁药托鲁地文拉法辛,又名安舒法辛,是我国自主研发的一种三重单胺类再摄取抑制剂,可通过与5-羟色胺转运体、去甲肾上腺素转运体和多巴胺转运体结合,阻断以上3种神经递质的再摄取而发挥抗抑郁作用。该药起效较快,能够显著改善抑... 详细信息

新型抗抑郁药托鲁地文拉法辛,又名安舒法辛,是我国自主研发的一种三重单胺类再摄取抑制剂,可通过与5-羟色胺转运体、去甲肾上腺素转运体和多巴胺转运体结合,阻断以上3种神经递质的再摄取而发挥抗抑郁作用。该药起效较快,能够显著改善抑郁障碍患者的心境低落、快感缺失、动力下降等症状,缓解伴发的焦虑症状,且治疗过程中不易导致性功能障碍等不良反应。临床在使用该药时应注意从小剂量开始,同时对患者进行转躁风险的评估和管理。由于该药可作用于多巴胺通路,临床还需关注治疗中是否会引起患者的精神病性症状。

关键词：托鲁地文拉法辛抗抑郁药多巴胺摄取抑制剂肾上腺素能摄取抑制剂

基于激光吸收光谱的CO/CO_(2)/H_(2)S浓度同步在线测量研究

在线全文

学校读者我要写书评

暂无评论

光谱学与光谱分析 2024年第5期44卷 1412-1416页

作者：张学军陈勤根杨展邓琴贺拴玲彭志敏浙江浙能中煤舟山煤电有限责任公司浙江舟山310007 浙江浙能技术研究院有限公司浙江杭州310015 清华大学能源与动力工程系电力系统与发电设备控制与仿真国家重点实验室北京100084

CO、CO_(2)、H_(2)S是燃煤锅炉炉内气氛重要组成部分,其浓度不仅能够反映燃烧工况,还可作为水冷壁高温腐蚀程度判断依据,因此实现CO、CO_(2)、H_(2)S浓度的准确测量意义重大。首先采用波长调制-直接吸收(WM-DAS)方法结合约40 m长光程Her... 详细信息

CO、CO_(2)、H_(2)S是燃煤锅炉炉内气氛重要组成部分,其浓度不仅能够反映燃烧工况,还可作为水冷壁高温腐蚀程度判断依据,因此实现CO、CO_(2)、H_(2)S浓度的准确测量意义重大。首先采用波长调制-直接吸收(WM-DAS)方法结合约40 m长光程Herriott池,在室温低压下,开展不同CO/CO_(2)浓度配比下三种气体吸收率同步测量实验,结果表明三种气体的吸收率测量值与理论计算值相近,相对误差在6.82%以内,测量结果可靠性较高;然后对不同浓度CO/CO_(2)(0~2000μl·l^(-1))、H_(2)S(0~20μl·l^(-1))进行动态测量,结果表明,测量系统对三种组分浓度变化的响应具有较好的线性度。

关键词：波长调制-直接吸收光谱 CO浓度 CO_(2)浓度 H_(2)S浓度同步测量

在线全文

学校读者我要写书评

暂无评论

征询式课堂回音意义建构的机制与过程

教育科学 2024年第2期40卷 60-66页

作者：秦乐琦程超华东师范大学外语学院上海200241 华东师范大学教育学部上海200062

教师通过征询式课堂回音可以建构理想的学习共同体,帮助学生完成对知识的递进式探索,并有可能引发课堂争论。这些意义的达成与教师在回音当下建构的多重身份,以及教师在再次提及学生回应内容基础上提供的新信息有关。教师可以通过征询... 详细信息

教师通过征询式课堂回音可以建构理想的学习共同体,帮助学生完成对知识的递进式探索,并有可能引发课堂争论。这些意义的达成与教师在回音当下建构的多重身份,以及教师在再次提及学生回应内容基础上提供的新信息有关。教师可以通过征询式课堂回音加强学习共同体成员之间的联系,从而建构理想的学习共同体。同时,教师应意识到话语策略的工具属性,加强对课堂话语的反思和探究,动态优化教学实践。

关键词：课堂回音征询式回音话语策略意义建构机制与过程

预制装配式混凝土结构新型墙-梁节点力学性能研究

在线全文

学校读者我要写书评

暂无评论

建筑科学 2024年第9期40卷 162-169页

作者：张秦杜翀中国建筑科学研究院有限公司北京100013

装配式混凝土结构柔性连接通常具备快速简单的节点连接方式,但是节点的受力性能、破坏模式等力学特性需要结合试验研究确定。为研究预制装配式混凝土结构新型墙-梁节点的力学性能,设计了墙-梁节点的受力性能试验,并结合有限元分析计算,... 详细信息

装配式混凝土结构柔性连接通常具备快速简单的节点连接方式,但是节点的受力性能、破坏模式等力学特性需要结合试验研究确定。为研究预制装配式混凝土结构新型墙-梁节点的力学性能,设计了墙-梁节点的受力性能试验,并结合有限元分析计算,对节点的应力水平、破坏模式、裂纹扩展等相关特性进行了研究。研究表明:试验结果与有限元模拟吻合较好;新型节点具备抗扭变形能力,符合延性设计原则;预埋件与混凝土结合部位易出现开裂,可以考虑局部适当加强,以保障整体工作性能;l型梁下部易受拉出现开裂,设计时应注意加强该部位。

关键词：预制装配式混凝土结构柔性连接墙-梁节点有限元分析