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Emergent ultra-high temperature ferromagnetism in la_(2)CoO_(4±x) thin films

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Nano Research 2024年第8期17卷 7250-7255页

作者： Ziang Meng Han Yan Peixin qin Zhuo Yin Peiheng Jiang Xiaorong Zhou Xiaoning Wang Hongyu Chen li liu Zhiyuan Duan Guojian Zhao Weisheng Zhao Fengxia Hu qinghua Zhang Zhicheng Zhong Zhiqi liu School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beijing National laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China CAS Key laboratory of Magnetic Materials and Devices and Zhejiang Province Key laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Fert Beijing Institute School of Integrated Circuit Science and EngineeringBeihang UniversityBeijing 100191China

Searching for novel ferromagnetic oxides with high Curie temperature(TC)has been one of the main goals for oxide *** well-known perovskite cobaltate laCoO_(3) is a classical ferromagnet in its thin-film form;however,it suffers from a low TC(~85 K).Here we report a new type of ferromagnetic la-Co-O films with an ultrahigh TC of~820 *** are fabricated by pulsed laser deposition from a laCoO_(3) target at low oxygen partial *** structural analysis indicates that they crystallize in terms of the Ruddlesden–Popper phase of la_(2)CoO_(4±x).In sharp contrast to the antiferromagnetism of bulk la_(2)CoO_(4),the strong ferromagnetism in the la_(2)CoO_(4±x) thin films is firmly demonstrated by magnetometry measurements,X-ray magnetic circular dichroism characterization,and magnetotransport *** importantly,density functional theory calculations indicate that the nonstoichiometric oxygen induces an antiferromagnetic-to-ferromagnetic phase transition,accompanied by the orbital reconstruction of Co 3d ***,our study provides an attractive strategy for designing or synthesizing exotic magnetic oxides with high ordering temperatures.

关键词： ferromagnetic oxides ultra-high Curie temperature la_(2)CoO_(4) spin current transport oxygen engineering

Understanding cachexia and its impact on lung cancer and beyond

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第2期2卷 95-105页

作者： Meiting Yue Zhen qin liang Hu Hongbin Ji State Key laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of life Science and Technology ShanghaiTech UniversityShanghai 201210China School of life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China

Cancer cachexia is a multifactorial syndrome characterized by loss of body weight secondary to skeletal mus-cle atrophy and adipose tissue *** not only has a significant impact on patients’quality of life but also reduces the effectiveness and tolerability of anticancer therapy,leading to poor clinical *** cancer is a prominent global health concern,and the prevalence of cachexia is high among patients with lung *** this review,we integrate findings from studies of lung cancer and other types of cancer to provide an overview of recent advances in cancer *** focus includes topics such as the clinical criteria for di-agnosis and staging,the function and mechanism of selected mediators,and potential therapeutic strategies for clinical application.A comprehensive summary of current studies will improve our understanding of the mecha-nisms underlying cachexia and contribute to the identification of high-risk patients,the development of effective treatment strategies,and the design of appropriate therapeutic regimens for patients at different disease stages.

关键词： Cancer cachexia Staging systems Mediators Signaling pathways Therapeutic strategies

Concomitant epidermal growth factor receptor mutation/c-ros oncogene 1 rearrangement in non-small cell lung cancer: A case report

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World Journal of Clinical Oncology 2024年第7期15卷 945-952页

作者： Gui-qin Peng Hai-Chi Song Wan-Yi Chen Department of Pharmacy Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Epidermal growth factor receptor(EGFR)mutation and c-ros oncogene 1(ROS1)rearrangement are key genetic alterations and predictive tumor markers for non-small cell lung cancer(NSClC)and are typically considered to be mutually ***/ROS1 co-mutation is a rare event,and the standard treatment appr-oach for such cases is still *** SUMMARY Herein,we report the case of a 64-year-old woman diagnosed with lung adenocar-cinoma,with concomitant EGFR l858R mutation and ROS1 *** patient received two cycles of chemotherapy after surgery,but the disease *** 1-month treatment with gefitinib,the disease progressed ***,after switching to crizotinib,the lesion became ***,crizotinib has been administered for over 53 months with a remarkable treatment *** The efficacy of EGFR tyrosine kinase inhibitors and crizotinib was vastly different in this NSClC patient with EGFR/ROS1 *** report will aid future treatment of such patients.

关键词： Non-small cell lung cancer Epidermal growth factor receptor C-ros oncogene 1 Co-mutation Treatment strategies Case report

MNQ的一种衍生物对lPS体外诱导的牛卵巢卵泡颗粒细胞炎性损伤的保护作用

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畜牧兽医学报 2024年第5期55卷 2032-2041页

作者：杨小峰秦小伟吕丽华忻州师范学院生物系忻州034000 山西农业大学动物科学学院太谷030801

旨在采用凤仙花(Impatiens balsamina l)提取物2-甲氧基-1,4-萘醌(MNQ)的衍生物D_(19)消除体外暴露于脂多糖(lPS)中牛卵巢卵泡颗粒细胞(GCs)的炎症反应,并缓减由lPS引起的卵泡GCs功能性紊乱。本研究采集性成熟且健康的荷斯坦牛卵巢组织... 详细信息

旨在采用凤仙花(Impatiens balsamina l)提取物2-甲氧基-1,4-萘醌(MNQ)的衍生物D_(19)消除体外暴露于脂多糖(lPS)中牛卵巢卵泡颗粒细胞(GCs)的炎症反应,并缓减由lPS引起的卵泡GCs功能性紊乱。本研究采集性成熟且健康的荷斯坦牛卵巢组织,分离并培养卵泡GCs。MTT法测定D_(19)和lPS对卵泡GCs存活率的影响。试验分为3组:对照组、lPS处理组和D_(19)联合lPS处理组,每组3个重复。qRT-PCR测定炎性因子和类固醇合成相关基因的相对表达量。TEM观察D_(19)对细胞炎性损伤的保护作用。ElISA检测培养液上清中雌二醇(E_(2))和孕酮(P_(4))的含量。结果表明,D_(19)对卵泡GCs作用12 h的最大安全浓度为64μmol·l^(-1)。lPS浓度为10μg·ml^(-1)时,作用12 h对卵泡GCs存活率影响不大,但炎性因子Il-6、Il-1β和TNF-α的相对表达量显著升高(Pl组与lPS组比较炎性因子的相对表达量却显著降低(PlPS引起的细胞器结构性损伤具有保护作用。ElISA结果表明,lPS处理后培养液中E_(2)和P_(4)的含量显著降低(PlPS处理后,E_(2)和P_(4)分泌量以及类固醇合成相关基因的相对表达量均比lPS组显著升高(PlPS体外诱导卵泡GCs炎症反应的功能,并能一定程度缓减lPS导致的卵泡GCs功能性紊乱。

关键词： MNQ D_(19) lPS GCs 炎症反应

EPSPS regulates cell elongation by disrupting the balance of lignin and flavonoid biosynthesis in cotton

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Journal of Integrative Agriculture 2024年第10期23卷 3437-3456页

作者： qingdi Yan Wei Hu Chenxu Gao lan Yang Jiaxian Yang Renju liu Masum Billah Yongjun lin Ji liu Pengfei Miao Zhaoen Yang Fuguang li Wenqiang qin State Key laboratory of Cotton Bio‑breeding and Integrated Utilization/Institute of Cotton Research Chinese Academy ofAgricultural SciencesAnyang 455000China National Key laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Huazhong AgriculturalUniversityWuhan 430070China State Key laboratory of Cotton Bio-breeding and Integrated Utilization/Zhengzhou University Zhengzhou 450066China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572025China

EPSPS is a key gene in the shikimic acid synthesis pathway that has been widely used in breeding crops with herbicide ***,its role in regulating cell elongation is poorly *** the overexpression of EPSPS genes,we generated lines resistant to glyphosate that exhibit an unexpected dwarf phenotype.A representative line,DHR1,exhibits a stable dwarf phenotype throughout its entire growth *** for plant height,the other agronomic traits of DHR1 are similar to its transgenic explants *** section observations showed that DHR1 internodes are shortened due to reduced elongation and division of the internode *** hormones confirmed that DHR1 is not a classical brassinolide(BR)-or gibberellin(GA)-related dwarfing *** analysis and fine mapping confirmed that the EPSPS gene is the causal gene for dwarfism,and the phenotype can be inherited in different *** and metabolome analyses showed that genes associated with the phenylpropanoid synthesis pathway are enriched in DHR1 compared with *** metabolites are enriched in DHR1,whereas lignin metabolites are *** enhancement of flavonoids likely results in differential expression of auxin signal pathway genes and alters the auxin response,subsequently affecting cell *** study provides a new strategy for generating dwarfs and will accelerate advancements in light simplification in the cultivation and mechanized harvesting of cotton.

关键词： EPSPS cotton T-DNA dwarfism herbicide resistance

基于UPlC-MS/MS法结合BP神经网络模型在小槐花产地溯源中的应用

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药物分析杂志 2024年第7期44卷 1176-1185页

作者：杨婧符传武覃华亮覃冬杰覃子龙柳州市质量检验检测研究中心柳州545001

目的:建立超高效液相色谱-三重四极杆串联质谱(UPlC-MS/MS)法同时测定小槐花中9个成分(烟酸、山柰酚、当药黄素、槲皮素、木犀草素、芦丁、牡荆素、斯皮诺素、水杨酸)的含量并构建BP(back propagation)神经网络模型对不同产地的小槐花... 详细信息

目的:建立超高效液相色谱-三重四极杆串联质谱(UPlC-MS/MS)法同时测定小槐花中9个成分(烟酸、山柰酚、当药黄素、槲皮素、木犀草素、芦丁、牡荆素、斯皮诺素、水杨酸)的含量并构建BP(back propagation)神经网络模型对不同产地的小槐花进行产地预测。方法:采用安捷伦ZORBAX SB-C_(18)(50 mm×3.0 mm,1.8μm)色谱柱,以0.1%乙酸(含0.02 mol·l^(-1)乙酸铵)水溶液(A)-甲醇(B)为流动相,梯度洗脱,体积流量0.3 ml·min^(-1)。质谱采用ESI正负离子检测模式,多反应监测模式(MRM)的扫描模式。测得各成分含量进行相关性分析,并构建BP神经网络模型用于进行不同产地的小槐花药材的溯源。结果:小槐花中烟酸、山柰酚、当药黄素、槲皮素、木犀草素、芦丁、牡荆素、斯皮诺素、水杨酸9个成分质量浓度分别在0.3888~38.88、10.07~1006.6、34.22~34221.6、3.944~394.4、2.124~212.4、4.344~434.4、46.50~4650.1、1.649~164.9、4.880~488.0 ng·ml^(-1)范围内线性关系良好(r>0.9951),平均加样回收率96.9%~103.9%,RSD均<1.9%。40批小槐花中烟酸、山柰酚、当药黄素、槲皮素、木犀草素、芦丁、牡荆素、斯皮诺素、水杨酸9个成分的含量分别为1.657~7.407、15.801~64.488、1068.348~4270.780、10.608~123.228、3.897~16.802、1.269~97.834、405.285~1955.796、13.614~36.124、4.417~87.509μg·g^(-1)。通过相关性分析可知,当药黄素、芦丁、斯皮诺素、木犀草素4个成分相互呈高度线性正相关,表明小槐花中这4个成分具有一定互相协同的作用。构建BP神经网络模型用于预测不同产地的小槐花样品,检验集的正确率达到92.3%。结论:试验建立的方法简便、灵敏、高效,可用于小槐花成分的快速测定,结合BP神经网络模型对产地进行预测在小槐花产地的溯源中有一定作用。

关键词：小槐花超高效液相色谱-三重四极杆串联质谱相关性分析 BP神经网络模型烟酸山柰酚当药黄素槲皮素木犀草素芦丁牡荆素斯皮诺素水杨酸

Kriging水动力学代理模型在水库群优化调度中的应用

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长江科学院院报 2024年第2期41卷 7-13,20页

作者：徐杨吕昊刘帅方威覃晖三峡水利枢纽梯级调度通信中心湖北宜昌443000 中国电建集团华东勘测设计研究院有限公司杭州311122 华中科技大学土木与水利工程学院武汉430074 华中科技大学数字流域科学与技术湖北省重点实验室武汉430074

为解决传统水动力学模型结合调度模型求解耗时长的难题,使用代理模型模拟水动力学模型以提升求解效率。从金沙江下游—三峡梯级水库调度实际出发,结合水动力学和代理模型相关理论,建立了基于Kriging代理模型的水库群多目标调度模型并采... 详细信息

为解决传统水动力学模型结合调度模型求解耗时长的难题,使用代理模型模拟水动力学模型以提升求解效率。从金沙江下游—三峡梯级水库调度实际出发,结合水动力学和代理模型相关理论,建立了基于Kriging代理模型的水库群多目标调度模型并采用多目标进化算法对模型进行求解,最后采用投影追踪法对得到的多目标帕累托前沿进行决策。研究结果表明,代理模型的平均模拟误差≤1.5%,能够较为精确地替代原有长耗时水动力学模型并结合调度模型给出具有竞争关系的帕累托前沿及合理的折衷方案,对促进梯级水库综合效益发挥提供理论依据。

关键词：多目标优化调度 Kriging模型水动力学模型投影追踪法梯级水库

High energy storage density in NaNbO_(3) antiferroelectrics with double hysteresis loop

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Journal of Materiomics 2024年第5期10卷 1026-1035页

作者： li Ma Zhenpei Chen Gengguang luo Zhiyi Che Chao Xu Dongliang Shan Zhenyong Cen qin Feng Xiyong Chen Toyohisa Fujita Ye Zhu Yunya liu Jing-Feng li Shujun Zhang Nengneng luo State Key laboratory of Featured Metal Materials and life-cycle Safety for Composite Structures School of ResourcesEnvironment and MaterialsGuangxi UniversityNanning530004China School of Chemistry and Chemical Engineering Guangxi UniversityNanning530004China Department of Applied Physics Research Institute for Smart EnergyThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Key laboratory of low Dimensional Materials and Application Technology of Ministry of Education School of Materials Science and EngineeringXiangtan UniversityXiangtan411105HunanChina State Key laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Institute for Superconducting and Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNSW2500Australia

Antiferroelectrics(AFEs)possess great potential for high performance dielectric capacitors,due to their distinct double hysteresis loop with high maximum polarization and low remnant ***,the well-known NaNbO3 lead-free antiferroelectric(AFE)ceramic usually exhibits square-like P–E loop related to the irreversible AFE P phase to ferroelectric(FE)Q phase transition,yielding low recoverable energy storage density(Wrec).Herein,significantly improved Wrec up to 3.3 J/cm^(3) with good energy storage efficiency(η)of 42.4% was achieved in Na_(0.7)Ag_(0.3)Nb_(0.7)Ta_(0.3)O_(3)(30Agsingle bond30Ta)ceramic with well-defined double P–E loop,by tailoring the A-site electronegativity with Ag+and B-site polarizability with Ta^(5+).The Transmission Electron Microscope,Piezoresponse Force Microscope and in-situ Raman spectra results verified a good reversibility between AFE P phase and high-field-induced FE Q *** improved stability of AFE P phase,being responsible for the double P–E loop and improved Wrec,was attributed to the decreased octahedral tilting angles and cation *** mechanism was revealed by synchrotron X-ray diffraction and Scanning Transmission Electron *** work provides a good paradigm for achieving double P–E loop and high energy storage density in NaNbO_(3)-based ceramics.

关键词： Sodium niobate Antiferroelectrics Double hysteresis loop Energy storage performance Reversibility

Purple acid phosphatase promoted hydrolysis of organophosphate pesticides in microalgae

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Environmental Science and Ecotechnology 2024年第2期18卷 137-149页

作者： Xiang Wang Guo-Hui He Zhen-Yao Wang Hui-Ying Xu Jin-Hua Mou Zi-Hao qin Carol Sze Ki lin Wei-Dong Yang Yalei Zhang Hong-Ye li Key laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes College of Life Science and TechnologyJinan UniversityGuangzhou510632China School of Energy and Environment City University of Hong KongTat Chee AvenueKowloonHong Kong Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneyUltimoNSW2007Australia Southern Marine Science and Engineering Guangdong laboratory(Guangzhou) Guangzhou510000China State Key laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China

When organophosphate pesticides(OPs)are not used and handled in accordance with the current rules and standards,it results in serious threats to the aquatic environment and human *** tricornutum is a prospective microalgae-based system for pollutant removal and carbon *** engineered ***,designated as the OE line(endogenously expressing purple acid phosphatase 1[PAP1]),can utilize organic phosphorus for cellular ***,the competencies and mechanisms of the microalgae-based system(namely the OE line of ***)for metabolizing OPs remain to be *** this study,the OE line exhibited the effective biodegradation competencies of 72.12%and 68.2%for 30 mg l^(-1)of dichlorvos and 50 mg l^(-1)of glyphosate,accompanied by synergistic accumulations of biomass(0.91 and 0.95 g l^(-1))and lipids(32.71%and 32.08%),***,the biodiesel properties of the lipids from the OE line manifested a high potential as an alternative feedstock for microalgae-based biofuel production.A plausible mechanism of OPs biodegraded by overexpressed PAP1 is that sufficient inorganic P for adenosine triphosphate and concurrent carbon flux for the reduced form of nicotinamide adenine dinucleotide phosphate biosynthesis,which improved the OP tolerance and biodegradation competencies by regulating the antioxidant system,delaying programmed cell death and accumulating lipids via the upregulation of related *** sum up,this study demonstrates a potential strategy using a genetically engineered strain of *** to remove high concentrations of OPs with the simultaneous production of biomass and biofuels,which might provide novel insights for microalgae-based pollutant biodegradation.

关键词： Biodegradation lipid accumulation Organophosphate pesticide Phaeodactylum tricornutum Purple acid phosphatase