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In situ TEM investigation of electron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3Y-1Zn-0.5Zr alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1841-1853页

作者： M.lv h.l.Ge q.q.Jin X.h.Shao Y.T.Zhou B.Zhang X.l.Ma Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ electron irradiation and aging are applied to introduce high-density precipitates in an Mg-10Gd-3Y-1Zn-0.5Zr(GWZ1031K,wt.%)alloy to improve the *** results show that the hardness of the Mg alloy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approximately 64% higher than that of the samples before being *** is mainly attributed to γ'precipitates on the basal plane after irradiation and the high-density nanoscale β'precipitates on the prismatic plane after aging,which should be closely related to the irradiation-induced homogenous *** latter plays a key role in precipitation *** result paves a way to improve the mechanical properties of metallic materials by tailoring the precipitation through irradiation and aging.

关键词： Mg alloy Electron beam irradiation hardening Precipitates In-situ TEM

Precipitation of multi-type nano-quasicrystals in a Mg-Zn-Y alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 997-1008页

作者： W.Z.Wang X.Z.Zhou l.F.Zhang h.q.Ye Z.q.Yang Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of ScienceShenyang 110016China Ji hua laboratory Foshan 528251China Foshan University Foshan 528231China

Mg-6Zn-1Y(at.%)ribbons with strengthening precipitates of multi-type nanoquasicrystals were prepared by melt-spinning followed by aging *** evolution of the rapidly solidified ribbons during isothermal aging was comprehensively studied using various electron microscopy *** new kinds of decagonal quasicrystals were formed in aged ribbons,in addition to precipitation of nanometer icosahedral ***-resolution observations reveal that both decagonal quasicrystals can be modeled by quasiperiodic tiling with decagonal clusters of 2.5 nm in diameter,but overlap of neighboring clusters in both decagonal quasicrystals is different from the Gummelt model observed in other quasicrystals.A shell composed of complex laves Mg-Zn domains was formed surrounding each decagonal quasicrystal precipitate upon prolonged *** addition,all kinds of nanoprecipitates exhibit excellent structure and size stability at 573 *** findings may have implications for not only fundamental studies about quasicrystals,but also microstructural manipulation of high-performance Mg alloys.

关键词： quasicrystal Mg alloys Rapid solidification Scanning-transmission electron microscopy.

Rational design of AgGaS/ZnS/ZnS quantum dots with a near-unity photoluminescence quantum yield via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： h.X.lu h.liu Z.Z.Fu Y.Y.Chen h.q.Dai Z.hu W.l.Zhang R.q.Guo Institute for Electric light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University YiwuZhejiang 322000China Zhongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study,a two-step method was used to synthesize highly luminescent AgGaS/ZnS/ZnS quantum dots(qDs).In the first step,an inner ZnS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer ZnS shell,thereby facilitating the formation of a thick outer *** the two-step shelling process,the synthesized AgGaS/ZnS/ZnS qDs showed an excellent photoluminescence quantum yield(PlqY)of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PlqY reported thus far for AgGaS ***,the effect of halogen ions in Zn precursors on the shelling process was *** was proposed that the capacity of halogen ions to coordinate with the qDs influenced the balance between Zn cation diffusion and ZnS shelling ***,the ZnS shelling reaction was dominant when ZnCl_(2)was employed,while Zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the ZnS shelling and offers a clear map for the tailored synthesis of core/shell qDs.

关键词： AgGaS quantum dots Photoluminescence Core/shell Alloyed core/shell interface

Electron kinetic effects in back-stimulated Raman scattering bursts driven by broadband laser pulses

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： q.K.liu l.Deng q.Wang X.Zhang F.q.Meng Y.P.Wang Y.q.Gao h.B.Cai S.P.Zhu Graduate School China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Physics and Computational Mathematics Beijing 100094China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Shanghai Institute of laser Plasma Shanghai 201800China hEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China School of Physics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(BSRS)bursts using particle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity spikes and generating large numbers of hot ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate the interference of the broadband laser’s random intensity *** the simplified model,we isolate and characterize the spectrum of electron plasma *** spectrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asymmetry in the spectrum is *** asymmetry is amplified and transferred to electron phase space by high-intensity broadband laser pulses,leading to violent vortex-merging and generation of hot *** proportion of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects profoundly influence the BSRS evolution driven by broadband lasers.

关键词： scattering kinetic simplified

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Aliberti q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu F.M.Cai h.Cai J.J.Cao q.h.Cao X.Cao Z.Cao q.Chang K.T.Chao D.Y.Chen h.Chen h.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.q.Chen h.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.h.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.q.Feng X.Feng Y.T.Feng J.l.Fu J.Gao Y.N.Gao P.S.Ge C.q.Geng l.S.Geng A.Gilman l.Gong T.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.C.Gui A.q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.h.Guo A.Guskov K.l.han l.han M.han X.q.hao J.B.he S.q.he X.G.he Y.l.he Z.B.he Z.X.heng B.l.hou T.J.hou Y.R.hou C.Y.hu h.M.hu K.hu R.J.hu W.h.hu X.h.hu Y.C.hu J.hua G.S.huang J.S.huang M.huang q.Y.huang W.q.huang X.T.huang X.J.huang Y.B.huang Y.S.huang N.hüsken V.Ivanov q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.lei E.levichev C.h.li C.li D.Y.li F.li G.li G.li h.B.li h.li h.N.li h.J.li h.l.li J.M.li J.li l.li l.li l.Y.li N.li P.R.li R.h.li S.li T.li W.J.li X.li X.h.li X.q.li X.h.li Y.li Y.Y.li Z.J.li h.liang J.h.liang Y.T.liang G.R.liao l.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu h.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu l.liu q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.l.liu Z.q.liu Z.Y.liu Z.W.liu I.logashenko Y.long C.G.lu J.X.lu N.lu q.F.lü Y.lu Y.lu Z.lu P.lukin F.J.luo T.luo X.F.luo Y.h.luo h.J.lyu X.R.lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.l.Olsen q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi Y.q.qi W.B.qian Y.qian C.F.qiao J.J.qin J.J.qin l.q.qin X.S.qin T.l.qiu J.Rademacker C.F.Redmer h.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de lausanne(EPFl) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of Science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Chinese Expert Consensus on the Diagnosis and Treatment of Adult Dermatomyositis (2022)#

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International Journal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Cao h. Chen A.-J. Cui Y. Deng D.-q. Gao X.-h. he Y.-l. Kang X.-J. Jin h.-Z. li C.-X. li F. li h.-J. liao W.-J. liu X.-M. lu q.-J. lu Y. Pan M. Pan W.-h. Shu X.-M. Sun q. Tang K.-Y. Tao J. Wang Y. Xiao T. Zhang F.-R. Zhang h.-l. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopathic inflammatory myopathy, is characterized by distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, experts from the Dermatology Branch of the China International Exchange and Promotion Association for Medical and health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and expert advice. © 2024 Wolters Kluwer health. All rights reserved.

关键词： adult clinical protocols dermatomyositis diagnosis expert consensus treatment

Ab initio valence-space in-medium similarity renormalization group calculations for neutron-rich P,Cl,and K isotopes

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Chinese Physics C 2024年第7期48卷 181-190页

作者：谢萌冉沈留媛李健国李红蕙袁琪左维 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Neutron-rich P,Cl,and K isotopes,particularly those with neutron numbers of approximately N=28,have attracted extensive experimental and theoretical *** utilize the ab initio valence-space in-medium similarity renormalization group approach,based on chiral nucleon-nucleon and three-nucleon forces,to investigate the exotic properties of these *** calculations of the low-lying spectra are performed.A key finding is the level inversion between 3/2_(1)^(+)and 1/2_(1)^(+)states in odd-A isotopes,attributed to the inversion ofπ0xod_(3/2) andπls_(1/2) single-particle *** ab initio calculations,which incorporate the three-nucleon forces,correlate closely with existing experimental *** calculations of effective proton single-particle energies provide deeper insights into the shell evolution for Z=14 and 16 *** results indicate that the three-body force plays important roles in the shell evolution for Z=14 and 16 sub-shells with neutron numbers ranging from 20 to ***,systematic ab initio calculations are conducted for the low-lying spectra of odd-odd *** results correspond with experimental data and provide new insights for future research into these isotopes up to and beyond the drip line.

关键词： ab initio calculations shell evolution low-lying spectra

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.l.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.S.Chen M.l.Chen S.J.Chen S.l.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui h.l.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.q.Fang R.Farinelli l.Fava F.Feldbauer G.Felici C.q.Feng J.h.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.l.Fu Y.W.Fu h.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong l.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.h.Duan P.Egorov Y.h.Fan J.Fang JA.Gilman K.Goetzen l.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan Z.l.Guan A.q.Guo l.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.l.han T.T.han X.q.hao F.A.harris K.K.he K.l.he F.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou Z.l.hou B.Y.hu h.M.hu J.F.hu T.hu Y.hu G.S.huang K.X.huang l.q.h.ang X.T.huang Y.P.huang T.hussain F.h\"olzken N.h\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.h.Jeong q.Ji q.P.Ji W.Ji X.B.Ji X.l.Ji Y.Y.Ji X.q.Jia Z.K.Jia D.Jiang h.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.l.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.lane P.larin l.lavezzi T.T.lei Z.h.lei h.leithoff M.lellmann T.lenz C.li C.li C.h.li Cheng li D.M.li F.li G.li h.li h.B.li h.J.li h.N.li hui li J.R.li J.S.li K.li l.J.li l.K.li lei li M.h.li P.R.li q.M.li q.X.li R.li S.X.li T.li W.D.li W.G.li X.li X.h.li X.l.li X.Y.li Y Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI helmholtzcentre for heavy Ion Research Gmbh D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of Science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabolic Syndrome

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International Journal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-h. Wang R. Zhao Z.-K. Zhang Y. Sun J. Zhang X. Ding X.-Y. Bai J. liang X.-q. Wei X.-J. liu X.-l. Yang T. liang X.-l. li C.-X. lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. however, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. however, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: From January 2021 to June 2022 in PlA General hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and lC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting after in vitro culture of haCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, lC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of haCat cells. Next, we transfected ATG5 into haCaT cells to revert autophagy and used the specific PI3K inhibitor lY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of haCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and lSD-t post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: The serum l

关键词： autophagy keratinocyte differentiation leptin metabolic syndrome PI3K/AKT/mTOR psoriasis signal pathway