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Journal of Thermal Science 2014年第6期23卷 564-571页

作者： E.Gómez-Arias J.Ibarra-Bahena l.Velazquez-Avelar R.J.Romero A.Rodriguez-Martinez M.Montiel-González Centro de Investigación en Ingeniería y Ciencias Aplicadas Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavacaMorelosCP 62209MéXICO Facultad de Ciencias Químicas e Ingeniería Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavacaMorelosCP 62209MéXICO Posgrado en Ingeniería y Ciencias Aplicadas Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavacaMorelosCP 62209MéXICO

The generator is the starter device of single stage heat transformer(SSHT) and its characteristics have main effects on the overall efficiency of this kind of absorption *** article reports a study of the generation of steam and changes in the concentration of the working solution(Water/Carrol mixture) into a plate heat exchanger as a function of its horizontal and vertical position by gravity *** is considered the analysis of six experimental tests;two were evaluated in a plate heat exchanger in a horizontal position and four in a vertical position(90 degree inclination).The generation of steam and increased concentration of the working solution are more sensitive to the vertical position of exchanger than in horizontal *** results of numerical-experimental analysis indicates that a heat exchanger in horizontal position,the steam generation and the change in the concentration of the working solution occurring in the middle of the plate(or at greater distance depending to the thermodynamic conditions) and instantly in vertical position(at the input of the plate).

关键词： Single stage heat transformer Plate heat exchanger Numerical modeling Temperature and concentration field Water/Carrol mixture

Response of coleoptiles to water deficit: growth, turgor maintenance and osmotic adjustment in barley plants (Hordeum vulgare l.)

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Agricultural Sciences 2011年第3期2卷 159-166页

作者： águeda González luís Ayerbe Centro de Recursos Fitogenéticos Alcalá de Henares Spain Departamento de Investigación Agroambiental CAM Apdo. 127 28800 Alcalá de Henares Spain

Cereal crop improvement programmes involve the analysis of a great number of lines every year;the availability of a simple, rapid method that would allow the identification of a trait in the early stages of plant development would facilitate the selection process. This work reports two experiments involving the germination of seeds in Petri dishes, performed to study the effect of water deficit on the growth of barley coleoptiles. In one experiment water stress was induced by allowing evaporation from the Petri dishes;in the other water stress was achieved by adding polyethylene glycol 6000. The growth of the control coleoptiles was greater than that of the treatment coleoptiles in all cases, but with differences between the different genotypes. A significant correlation (P lative growth of the coleoptiles and turgor maintenance in the seedlings. Significant correlations were also seen between the relative growth of the coleop-tiles and the osmotic adjustment of the flag leaf (P lt plants. The genotypes that showed the greatest relative growth also showed the greatest capacity for osmotic adjustment in the flag leaf and produced the greatest yields in experiments with adult plants. The results indicate that the growth of coleoptiles subjected to water deficit could be used as a selection criterion in breeding programmes designed to improve the tolerance of barley to drought.

关键词： Barley Drought Tolerance Water Potential Osmotic Potential Grain Yield

Review of natural products with hepatoprotective effects

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World Journal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： Eduardo Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela álvarez-González María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-luna y González-Rubio J leopoldo Aguilar-Faisal José A Morales-González laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are *** to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the *** enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic ***,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less *** use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called *** present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vinifera l Opuntia ficus-indica Spirulina Propolis Glucans Alcoholic liver disease

Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report

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World Journal of Gastroenterology 2006年第32期12卷 5244-5246页

作者： M Isabel lucena Raúl J Andrade luis Vicioso F Jesús González Ketevan Pachkoria Beatriz García-Mu(n|~)oz Clinical Pharmacology Service Virgen de la Victoria University Hospital School of MedicineMalagaSpain liver Unit Gastroenterology Service Virgen de la Victoria University HospitalSchool of MedicineMálagaSpain Department of Pathology Virgen de la Victoria University Hospital School of MedicineMálagaSpain Institute of Biopathology and Regenerative Medicine University of Granada Spain Clinical Pharmacology Service Virgen de la Victoria University Hospital School of MedicineMálagaSpain

Assigning causality in drug-induced liver injury is challenging particularly when more than one drug could be responsible. We report a woman on long-term therapy with raloxifen who developed acute cholestasis shortly after starting fenofibrate. The picture evolved into chronic cholestasis. We hypothesized that an interaction at the metabolic level could have triggered the presentation of hepatotoxicity after a very short time of exposure to fenofibrate in this patient. The findings of an overexpression of vascular endothelial growth factor in the liver biopsy suggest that angiogenesis might play a role in the persistance of toxic cholestasis.

关键词： Raloxifene Fenofibrate Drug-drug interactions Hepatotoxicity Causality assessment

Hepatic osteodystrophy: An important matter for consideration in chronic liver disease

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World Journal of Hepatology 2011年第12期3卷 300-307页

作者： Germán lópez-larramona Alfredo J lucendo Sonia González-Castillo José M Tenias Department of Internal Medicine Hospital General de Tomelloso 13700 Ciudad Real Spain Department of Gastroenterology Hospital General de Tomelloso 13700 Ciudad Real Spain Research Support Unit Complejo Hospitalario Mancha Centro Alcázar de San Juan 13700 Ciudad Real Spain

Hepatic osteodystrophy (HO) is the generic term defining the group of alterations in bone mineral metabolism found in patients with chronic liver disease. This paper is a global review of HO and its main pathophysiological, epidemiological and therapeutic aspects. Studies examining the most relevant information concerning the prevalence, etiological factors, diagnostic and therapeutic aspects involved in HO were identified by a systematic literature search of the PubMed database. HO generically defines overall alterations in bone mineral density (BMD) (osteoporosis or osteopenia) which appear as a possible complication of chronic liver disease. The origin of HO is multifactorial and its etiology and severity vary in accordance with the underlying liver disease. Its exact prevalence is unknown, but different studies estimate that it could affect from 20% to 50% of patients. The reported mean prevalence of osteoporosis ranges from 13%-60% in chronic cholestasis to 20% in chronic viral hepatitis and 55% in viral cirrhosis. Alcoholic liver disease is not always related to osteo-penia. HO has been commonly studied in chronic cholestatic disease (primary biliary cirrhosis and primary sclerosing cholangitis). Several risk factors and pathogenic mechanisms have been associated with the loss of BMD in patients with chronic liver disease. However, little information has been discovered in relationship to most of these mechanisms. Screening for osteopenia and osteoporosis is recommended in advanced chronic liver disease. There is a lack of randomized studies assessing specific management for HO.

关键词： Hepatic osteodystrophy liver disease Osteoporosis Osteopenia

New Applications of Zirconium Phosphate Nanomaterials

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Accounts of Materials Research 2021年第9期2卷 793-803页

作者： Mario V.Ramos-Garcés Julissa González-Villegas Aleannette lópez-Cubero Jorge l.Colón Cain Department of Chemical Engineering Louisiana State UniversityBaton RougeLouisiana 70803United States Department of Chemistry University of Puerto RicoSan JuanPuerto Rico 00925-2537United States

CONSPECTUS:The 2-D layers of the inorganic ion exchangerα-zirconium phosphate(Zr(HPO_(4))2·H_(2)O,α-ZrP)make this compound particularly stable to low pH,high temperature,and ionizing *** studied for its ion exchange properties,once the conditions for its synthesis in crystalline form was accomplished by James Stynes and Abraham Clearfield in 1964,numerous other types of studies and applications *** studies in the 1960s and 1970s on the thermodynamics of ion exchange led to insights into the intercalation mechanism of this *** Clearfield group solved the crystal structure in 1968 and refined it in *** methods were pioneered by the Clearfield group to solve the structure of this type of *** 1968 Giulio Alberti reported means to prepare zirconium phosphonates expanding the chemistry of these layered *** phases of ZrP were also discovered(e.g.,γ,θ,λ,τ)and the applications ranged from heterogeneous catalysis to intercalation chemistry and solid-state proton *** to exfoliate the layers of ZrP were developed in the 1990s as interest grew in new applications of these types of *** example,protein and enzyme intercalation was accomplished starting in the 1990s by the Mclendon,Mallouk,and Kumar *** the early 2000s,the Colon group pioneered the use of théθphase of ZrP for the direct intercalation of large inorganic metal complexes that could not be directly intercalated into theα*** studies in the Colon group ranged from applications of these directly intercalated ZrP derivatives in photophysics and photochemistry,́amperometric biosensors,vapochromism,and *** the past decade,new applications of these materials have been developed in anticancer drug delivery and electrocatalysis of the oxygen evolution reaction(OER).ZrP has now proven to be a promising drug nanocarrier and its unique chemical microenvironment provided by theα-type layers and the interlay

关键词： properties zirconium inorganic

Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender

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World Journal of Hepatology 2018年第2期10卷 297-307页

作者： José A Morales-González María de lourdes Sernas-Morales ángel Morales-González laura ligía González-lópez Eduardo Osiris Madrigal-Santillán Nancy Vargas-Mendoza Tomás Alejandro Fregoso-Aguilar liliana Anguiano-Robledo Eduardo Madrigal-Bujaidar Isela álvarez-González Germán Chamorro-Cevallos laboratorio de Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico Nacional área Académica de Nutrición ICSa Universidad Autónoma del Estado de Hidalgo Depto. de Fisiología Laboratorio de Hormonas y Conducta ENCB campus Zacatenco Instituto Politécnico Nacional laboratorio de Farmacología Molecular Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina-Instituto Politécnico Nacional laboratorio de Genética Escuela Nacional de Ciencias Biológicas IPN Departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional

AIM To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in *** Wistar rats weighing 170-200 g were divided into groups as follows:(1) Control groups; and(2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations:(1) Group of males or females with a consumption of a solution of alcohol at 40%; and(2) group of males or females with a consumption of a solution of alcohol at 5%. At the end of the experiment, serum and liver samples were obtained. The following enzymes and metabolites were determined in serum: Alanine Aminotransferase(AlT), Aspartate Aminotransferase(AST), lactate Dehydrogenase, and Gamma-Glutamyltransferase, and glucose, triglycerides, cholesterol, bilirubin, and albumin. liver samples from each group were employed to analyze morphological abnormalities by light *** In all of the weekend alcohol-consumption groups, AST activity presented a significant, 10-fold rise. Regarding AlT activity, the groups with weekend alcohol consumption presented a significant increase that was six times greater. Bilirubin levels increased significantly in both groups of females. We observed a significant increase in the parameters of fatty change and inflammation due to weekend alcohol consumption. Only the group of females that consumed alcohol at 40% presented slight hepatocel ular disorganization CONClUSION The results obtained herein provide solid evidence that weekend alcohol consumption gives rise to liver damage, demonstrated by biochemical and histological alterations, first manifested acutely, and prolonged weekend alcohol consumption can cause greater, irreversible damage.

关键词： Weekend alcohol consumption liver morphology Transaminases Damage

A new early Visean coral assemblage from Azrou-Khenifra Basin,central Morocco and palaeobiogeographic implications

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Journal of Palaeogeography 2020年第1期9卷 1-20页

作者： Sergio Rodríguez Ian D.Somerville Pedro Cózar Javier Sanz-lópez Ismael Coronado Felipe González Ismail Said Mohamed El Houicha GEODESPAl Universidad Complutense de Madridc/Jose Antonio Novais.1228040 MadridSpain Instituto de Geociencias(CSIC UCM)c/Jose Antonio Novais 1228040 MadridSpain UCD School of Earth Sciences University College DublinBelfieldDublin 4Ireland Departmento de Geología Universidad de OviedoArias de Velasco s/n33005 OviedoSpain Institute of Paleobiology WarsawPoland Dpto.de Ciencias de la Tierra Universidad de HuelvaAvda.Fuerzas Armadas s/nCampus de El Carmen21071 HuelvaSpain laboratoire de Géodynamique et Géomatique Facultédes SciencesUniversite Chouaib DoukkaliBP.2024000 El JadidaMorocco

A new early Visean coral assemblage has been recorded from turbidite facies in the southern part of the AzrouKhenifra Basin,northwest of Khenifra,central *** newly discovered Ba Moussa West(BMW)coral fauna includes Siphonophyllia khenifrense ***.,Sychnoelasma urbanowitschi,Cravenia lamellata,Cravenia tela,Cravenia rhytoides,Turnacipora megastoma and Pleurosiphonella *** early Visean age of the coral assemblage is supported by foraminiferal and conodont data,with the recognition of the basal Visean MFZ9 *** confirms that the first transgression in the Azrou-Khenifra Basin was during the earliest *** allochthonous coral assemblage was recovered from coarse-grained proximal limestone debris flow and turbidite beds within a faultbounded unit,lying to the west of a thrust syncline containing upper Visean *** evidence exists of the former early Visean shallow-water platform from which the corals were *** other in situ platform carbonate rocks around the southern margin of the Azrou-Khenifra Basin are probably of late Visean(Asbian–Brigantian)*** early Visean Ba Moussa West coral fauna can be compared with that at Tafilalt in eastern Morocco,as well as in other Saharian basins of *** of the genera and species in the Ba Moussa West assemblage are identical to those in NW Europe,with which it must have had marine *** new rugose species described,Siphonophyllia khenifrense,is probably endemic to North *** ecological niche in NW Europe was occupied by *** or ***.

关键词： Mississippian Visean Corals Foraminifers Conodonts Palaeobiogeography Morocco

Carbon nanotubes targeted to the tumor microenvironment inhibit metastasis in a preclinical model of melanoma

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Bioactive Materials 2024年第4期34卷 237-247页

作者： lorena García-Hevia Rym Soltani Jesús González Olivier Chaloin Cécilia Ménard-Moyon Alberto Bianco Mónica l.Fanarraga The Nanomedicine Group Universidad de Cantabria-IDIVALAvda Herrera Oria s/n39011SantanderSpain CNRS ImmunologyImmunopathology and Therapeutic ChemistryUPR 3572University of StrasbourgISIS67000StrasbourgFrance

Despite notable progress in cancer therapy,metastatic diseases continue to be the primary cause of cancer-related ***-walled carbon nanotubes(MWCNTs)can enter tissues and cells and interfere with the dynamics of the cytoskeletal nanofilaments *** endows them with intrinsic anti-tumoral effects comparable to those of microtubule-binding chemotherapies such as Taxol®.In this study,our focus was on exploring the potential of oxidized MWCNTs in selectively targeting the vascular endothelial growth factor receptor(VEGFR).Our objective was to evaluate their effectiveness in inhibiting metastatic growth by inducing anti-proliferative,anti-migratory,and cytotoxic effects on both cancer and tumor microenvironment *** findings demonstrated a significant reduction of over 80%in malignant melanoma lung metastases and a substantial enhancement in overall animal welfare following intravenous administration of the targeted biodegradable ***,the combination of these nanomaterials with the conventional chemotherapy agent Taxol®yielded a remarkable 90%increase in the antimetastatic *** results highlight the promising potential of this combined therapeutic approach against metastatic disease and are of paramount importance as metastasis is responsible for nearly 60,000 deaths each year.

关键词： Carbon nanomaterials Nanofilaments Vascularization Peptide conjugates Angiogenesis

Chitosan Nanoparticles as Biostimulant in lettuce (lactuca sativa l.) Plants

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 777-787页

作者： Silvia C.Ramírez-Rodríguez Pablo Preciado-Rangel Marcelino Cabrera-De la Fuente Susana González-Morales Hortensia Ortega-Ortiz Tecnológico Nacional de México Instituto Tecnológico de TorreónEjido AnaTorreónCoahuila27170México Departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Departamento de Materiales Avanzados Centro de Investigación en Química AplicadaSaltilloCoahuila25294México

Biodegradable nanoparticles such as chitosan nanoparticles (CSNPs) are used in sustainable agriculture since theyavoid damage to the environment;CSNPs have positive effects such as the accumulation of bioactive compoundsand increased productivity in plants. This study aimed to investigate the impact of applying CSNPs on lettuce,specifically focusing on enzymatic activity, bioactive compounds, and yield. The trial was conducted using a completelyrandomized design, incorporating CSNPs: 0, 0.05, 0.1, 0.2, 0.4, and 0.8 mg ml−1. The doses of 0.4 mg ml−1improve yields up to 24.6% increases and 0.1 mg ml−1 of CSNPs increases total phenols by 31.2% and antioxidantcapacity by 34.6%. In addition, when low concentrations of CSNPs (0.05 and 0.1 mg l−1) were applied, anincrease in catalase was determined. The CSNPs represent a good alternative to be used as a biostimulant in sustainableagriculture because they improve the yield and quality of lettuce by increasing the bioactive compounds.

关键词： Biostimulant bioactive compounds enzymatic activity