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In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica Sinica B 2021年第4期11卷 989-1002页

作者： Ana lMartínez-lópez Carlos JGonzález-Navarro Paula Aranaz JosélVizmanos Juan MIrache NANO-VAC Research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition Research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health Research(IdiSNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of *** nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/*** intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium *** therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose *** this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in *** finding was associated with a signifcant reduction in the formation of reactive oxygen species(ROS)as well as an important decrease in the glucose and fat content in *** effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： Nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans ROS

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Simulation factors of steel continuous casting

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International Journal of Minerals,Metallurgy and Materials 2010年第3期17卷 267-275页

作者： A.Ramírez-lópez R.Aguilar-lópez A.Kunold-Bello J.González-Trejo M.Palomar-Pardavé Department of Materiales Metropolitan Autonomous University Institute Polytechnic National Institute Technologic Autonomous of Mexico

The factors involved in simulating the continuous casting process of steel and the effects of the factors on the thermal behavior were investigated. The numerical methods and the influence of some assumptions were also analyzed, such as nodes used to discretize the steel in array size and computing time to obtain good approaches. The results show that some of these factors are related with the design of the continuous casting plant （CCP）, such as geometrical configuration, and the operating conditions, such as water flow rate, heat removal coefficient in the mold, casting times, and casting speed in the strand, which affect the heat removal conditions over the temperature and solidification profiles.

关键词： continuous casting thermal behavior numerical method computer simulation

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Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

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Acta Pharmaceutica Sinica B 2017年第4期7卷 517-522页

作者： Mark A.Doll Raúl A.Salazar-González Srineil Bodduluri David W.Hein Department of Pharmacology and Toxicology and James Graham Brown Cancer Center University of LouisvilleLouisvilleKY 40202USA

Cryopreserved human hepatocytes were used to investigate the role of arylamine N-acetyltransferase 2 (NAT2; EC 2.***.1.5) polymorphism on the N-acetylation of isoniazid (INH). NAT2 genotype was determined by Taqman allelic discrimination assay and INH N-acetylation was measured by high performance liquid chromatography. INH N-acetylation rates in vitro exhibited a robust and highly significant (Plism. N-acetylation rates in situ were INH concentration- and time-dependent. Following incubation for 24 h with 12.5 or 100 µmol/l INH, acetyl-INH concentrations varied significantly (P = 0.0023 and P = 0.0002) across cryopreserved human hepatocytes samples from rapid, intermediate, and slow acetylators, respectively. The clear association between NAT2 genotype and phenotype supports use of NAT2 genotype to guide INH dosing strategies in the treatment and prevention of tuberculosis.

关键词： Isoniazid N-Acetyltransferase 2 Acetylation polymorphism Human hepatocytes Genotype Phenotype

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Effects of fire history on animal communities:a systematic review

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Ecological Processes 2022年第1期11卷 248-258页

作者： Tania Marisol González Juan David González‑Trujillo Alberto Muñoz Dolors Armenteras laboratorio de Ecología del Paisaje y Modelación de Ecosistemas ECOl‑MOD Departamento de BiologíaFacultad de CienciasUniversidad Nacional de ColombiaEdificio 421111321 BogotáColombia Departamento de Biología Facultad de CienciasUniversidad Nacional de ColombiaEdificio 421111321 BogotáColombia Departamento de Didáctica de Ciencias Experimentales Sociales y MatemáticasFacultad de EducaciónUniversidad Complutense de Madrid28040 MadridSpain CREAF 08193 Cerdanyola del VallèsCataloniaSpain

Fire is a natural agent with a paramount role in ecosystem functioning and biodiversity ***,it can also act as a negative force against many *** some knowledge of the interactions of fire and vegetation,there is no clear understanding of how different components of fire regimes(i.e.,severity,history,or frequency)influence known patterns of animal ***,we performed a systematic review on the global responses of arthropods,birds,mammals,reptiles,and amphibians to different fire ***,we focused on assessing how fire severity,history,and frequency modulate the effect of fire on the richness and abundance of faunal *** conducted a systematic review of 566 papers retrieved from the Scopus *** also scrutinized all the documents included in the meta‑analysis of Pastro et al.(Pastro et *** Ecol Biogeogr 23:1146–1156,2014).Our selection criteria excluded studies without data on species richness or *** also excluded studies without adequate controls and those without information about the fire regime of the study *** careful examination,we used data from 162 studies to perform a quantitative meta‑*** the 162 studies meeting our selection criteria,nearly 60%of the studies are from North America,25%from Australia,11%from Europe,and 4%from the *** to the ecological role of fire,90%of the studies were carried out in fire‑dependent ecosystems(i.e.,conifer forests,natural savannas,pastures).Finally,40%of the studies analyzed birds,22%mammals,and 20%*** meta‑analysis of the available evidence indicates that fire history is an important modulator of animal richness and *** negative or positive,animal responses depended on the time since the last fire *** that short‑term studies may not capture such a long‑term effect on fauna,this translates to more challenges at implementing fire management *** or not we can

关键词： Amphibians Arthropods Birds Fire regime components Mammals Reptiles

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Spectrophotometric determination of the formation constants of Calcium(Ⅱ) complexes with 1,2-ethylenediamine,1,3-propanediamine and 1,4-butanediamine in acetonitrile

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Green Energy & Environment 2017年第1期2卷 51-57页

作者： Jacqueline González González Mónica Nájera-lara Varinia lópez-Ramírez Juan Antonio Ramírez-Vázquez José J.N.Segoviano-Garfias Programa de Maestría en Biociencias División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca Colegio del Nivel Medio Superior de Salamanca(ENMS) Departamento de Ingeniería Bioquímica Instituto Tecnológico Superior de Irapuato (ITESI) Departamento de Ciencias Ambientales División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca

In this work, with the purpose to explore the coordination chemistry of calcium complexes which could work as a partial model of manganese-calcium cluster, a spectrophotometric study to evaluate the stability of the complexes: Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine in acetonitrile, were carried on. By processing the spectrophotometric data with the HypSpec program allows the determination of the formation constants. The logarithmic values of the formation constants obtained for Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine were log β_(110) = 4.69, log β_(110)= 5.25 and log β_(110) = 4.072, respectively.

关键词： Calcium(Ⅱ)complexes Solution equilibria Artificial photosynthesis Absorbance molar Speciation

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Ventilation during cardiopulmonary resuscitation in children: a survey on clinical practice

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World Journal of Pediatrics 2017年第6期13卷 544-550页

作者： Rafael González lázaro Pascual Alexandra Sava Sara Tolón Javier Urbano Jesus lópez-Herce Pediatric Intensive Care Department Gregorio Mara(n)ón General University HospitalSchool of MedicineComplutense University of MadridMadridSpain

Background:This study aimed to investigate the ventilation practice during cardiopulmonary resuscitation (CPR) and after return of spontaneous circulation (ROSC) in ***:An online survey of CPR practices was designed and sent to healthcare professionals treating ***:A total of 477 healthcare professionals from 46 countries responded to this survey;92.7% were physicians and 64.2% worked in pediatric intensive care *** CPR guidelines were used by 97.7% of *** respiratory rate most frequently used for children over 12 months was 13 to 20 respirations per minute (rpm) (46% in intubated and 41.8% in non-intubated).For infants under 12 months,the most frequently used respiratory rate was 21 to 30 rpm in intubated patients (37.3%):in non-intubated infants,13 to 20 rpm (26.5%) and 21 to 30 rpm (26.5%) were used with the same *** North America,the respiratory rate most widely used was 7 to 12 rpm;higher rates (13 to 20 rpm and 21 to 30 rpm) were used in Europe and latin America (Plthcare professionals had a target oxygen saturation below 94%;more than 10% used a target arterial PCO2 below 35 mmHg and more than 13% above 45 ***:There is considerable variation in the management of ventilation of children in cardiac arrest,and international recommendations are not being followed in a high percentage of cases.

关键词： cardiopulmonary resuscitation resuscitation ventilation

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Twenty-four-hour movement guidelines during middle adolescence and their association with glucose outcomes and type 2 diabetes mellitus in adulthood

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Journal of Sport and Health Science 2023年第2期12卷 167-174页

作者： Antonio García-Hermoso JoséFrancisco lópez-Gil Yasmin Ezzatvar Robinson Ramírez-Vélez Mikel Izquierdo Navarrabiomed Hospital Universitario de Navarra(HUN)Universidad Publica de Navarra(UPNA)IdiSNAPamplona 31008Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 16007Spain Department of Nursing Universitat de ValenciaValencia 46010Spain

Purpose:The aim of the present study was to determine the association between adherence to the 24-h movement guidelines during middle adolescence and glucose outcomes(glycated hemoglobin and fasting glucose)and type 2 diabetes mellitus(T2DM)in adulthood,14 and 22 years ***:We analyzed data from apparently healthy adolescents aged 12-18 years who participated in WavesⅠandⅡ(1994-1996,n=14,738),WaveⅣ(2008-2009,n=8913),and Wave V(2016-2018,n=3457)of the National longitudinal Study of Adolescent to Adult Health(Add Health)in the United *** activity,screen time,and sleep duration were measured using questionnaires,and the 24-h guidelines were defined as:5 or more times moderate-to-vigorous physical activity per week,≤2 h per day of screen time,and 9-11 h of sleep for 12-13 years and 8-10 h for 14-17 *** and venous whole blood was collected and analyzed to determine glycated hemoglobin and fasting glucose for WavesⅣandⅤ,***:Only 2.1%of the adolescents met all the 3 guidelines,and 37.8%met none of *** both wavesⅣandⅤ,adolescents who met physical activity and screen time guidelines had lower odds of T2DM in adulthood than those who did not meet any of these guidelines(WaveⅣ;prevalence ratio(PR)=0.57,95%confidence interval(95%CI):0.21-0.89;Wave V:PR=0.43,95%CI:0.32-0.74).Only for Wave V did adolescents who met all 3 guidelines have lower odds of T2DM at follow-up compared with those who did not meet any of these guidelines(PR=0.47,95%CI:0.24-0.91).Also,for each increase in meeting one of the 24-h recommendations,the odds of T2DM decreased by 18%(PR=0.82,95%CI:0.61-0.99)and 15%(PR=0.85,95%CI:0.65-0.98)in adulthood for WavesⅣandⅤ,***:Promoting all 24-h movement guidelines in adolescence,especially physical activity and screen time,is important for lowering the potential risk of T2DM in adulthood.

关键词： Glucose metabolism Glycated hemoglobin Physical activity Screen time Sleep duration

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Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence

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World Journal of Gastroenterology 2006年第27期12卷 4296-4303页

作者： Paula Jakszyn Carlos Alberto González Unit of Nutrition Environment and CancerDepartment of Epidemiology and Cancer Registry. Institut Català d' Oncologia(ICO-IDIBELL)L'Hospitalet de Llobregat (08907)BarcelonaSpain

AIM： To study the association between nitrite and nitrosamine intake and gastric cancer （GC）, between meat and processed meat intake, GC and oesophageal cancer （OC）, and between preserved fish, vegetable and smoked food intake and GC. METHODS： In this article we reviewed all the published cohort and case-control studies from 1985-2005, and analyzed the relationship between nitrosamine and nitrite intake and the most important related food intake （meat and processed meat, preserved vegetables and fish, smoked foods and beer drinking） and GC or OC risk. Sixty-one studies, 11 cohorts and 50 case-control studies were included. RESUlTS： Evidence from case-control studies supported an association between nitrite and nitrosamine intake with GC but evidence was insufficient in relation to OC. A high proportion of case-control studies found a positive association with meat intake for both tumours （11 of 16 studies on GC and 11 of 18 studies on OC）. A relatively large number of case-control studies showed quite consistent results supporting a positive association between processed meat intake and GC and OC risk （10 of 14 studies on GC and 8 of 9 studies on OC）. Almost all the case-control studies found a positive and significant association between preserved fish, vegetable and smoked food intake and GC. The evidence regarding OC was more limited. Overall the evidence from cohort studies was insufficient or more inconsistent than that from case-control studies.CONClUSION： The available evidence supports a positive association between nitrite and nitrosamine intake and GC, between meat and processed meat intake and GC and OC, and between preserved fish, vegetable and smoked food intake and GC, but is not conclusive.

关键词： Nitrites N-nitrosodimethylamine Nitrosocompounds Dietary intake Gastric cancer

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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo lópez-lópez Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBl)in lED *** varied the Al composition in the EBl from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SIlVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUV-lED EBl simulation

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Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia

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World Journal of Gastroenterology 2015年第6期21卷 1749-1758页

作者： Raymond A Isidro Myrella l Cruz Angel A Isidro Axel Baez Axel Arroyo William A González-Marqués Carmen González-Keelan Esther A Torres Caroline B Appleyard Department of Physiology and Pharmacology Ponce School of Medicine and Health Sciences Ponce Department of Pathology Ponce School of Medicine and Health Sciences Ponce Department of Anatomy Ponce School of Medicine and Health Sciences Ponce Departments of Pathology and laboratory Medicine University of Puerto Rico School of Medicine Department of Medicine University of Puerto Rico School of Medicine

AIM:To determine the expression of neurokinin-1receptor(NK-1R),phosphorylated epidermal growth factor receptor(p EGFR),cyclooxygenase-2(Cox-2),and vitamin D receptor(VDR)in normal,inflammatory bowel disease(IBD),and colorectal neoplasia tissues from Puerto ***:Tissues from patients with IBD,colitisassociated colorectal cancer(CAC),sporadic dysplasia,and sporadic colorectal cancer(CRC),as well as normal controls,were identified at several centers in Puerto *** formalin-fixed,paraffin-embedded tissues were de-identified and processed by immunohistochemistry for NK-1R,p EGFR,Cox-2,and *** of representative areas of each tissues diagnosis were taken and scored by three observers using a4-point scale that assessed intensity of *** with CAC were further analyzed by photographing representative areas of IBD and the different grades of dysplasia,in addition to the areas of cancer,within each *** in the average age between the five patient groups were assessed with one-way analysis of variance and Tukey-Kramer multiple comparisons *** mean scores for normal tissues and tissues with IBD,dysplasia,CRC,and CAC were calculatedand statistically compared using one-way analysis of variance and Dunnett’s multiple comparisons *** between protein expression patterns were analyzed with the Pearson’s product-moment correlation *** are presented as mean±***:On average,patients with IBD were younger(34.60±5.81)than normal(63.20±6.13,Plasia(68.80±4.42,Plasia(2.00±0.45)were higher than in normal tissues(0.73±0.19).p EGFR was significantly increased in sporadic CRC(1.53±0.43)and CAC(2.25±0.47)when compared to normal tissue(0.07±0.25,Ply).Cox-2 was significantly increased in sporadic colorectal cancer(

关键词： Colitis Colon cancer Dysplasia Neurokinin Vitamin

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