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Infiltration mechanism of mine water from abandoned mines through coal rock mass

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Infiltration mechanism of mine water from abandoned mines th...

The International Young Scholars’ Symposium on Rock Mechanics

作者： X.l.li l.liu College of Civil and Architectural Engineering liaoning Technical University Fuxin liaoning China l.G.Wang College of Mechanics and Engineering liaoning Technical University Fuxin liaoning China T.G.Deng School of Environmental Science and Engineering Tianjin University Tianjin China

＜正＞In order to understand the mechanism and regularity of the groundwater contamination from abandoned mines,taking an abandoned coal mine as an example in Fuxin,a representative city with lots of mine water in northeast *** water-rock interaction mechanism is discussed in the process of mine water infiltration through saturated coal rock mass by soil column experiment under the conditions of mine water leaching and clear water leaching（similar to rainwater leaching）.The results show that water rock interactions such as adsorption ＆ transformation,dissolution ＆ desorption and ion exchange,happen during the mine water *** experiments also suggest that at first dissolution rate of some kinds of dissoluble salts is high, but it decreases with leaching time,even to zero during both the mine water leaching and clear water leaching.

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Voltage-Gated Ion Channels in Nociceptors： Modulation by the cGMP-PKG pathway

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中国药理通讯 2004年第2期21卷 66-66页

作者： FuHui l.liu T.Yang S.A.Simon DepartmentofPharmacology TongjiMedicalcollegeHuazhongUniversityofScienceandTechnologyWuhanHubeiChina430030 DepartmentsofAnesthesiologyandNeurobiology DukeUniversityMedicalCenterDurhamNC27710

AIM: Nociceptors contain a variety of ion channels that are modulated by proinflammatory mediators that may arise from tissue or nerve injury. The changes in activity of these channels, which primarily occurs through changes in intracellular pathways, may lead to the pathological states of hyperalgesia and allodynia. METHODS &RESUlTS:

关键词：电离子通道伤害感受器调制路径 cGMP-PKG 神经损害

The protein tyrosine kinase inhibitor, genistein, decreases the excitability of capsaicin-sensitive neurons

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中国药理通讯 2004年第2期21卷 65-65页

作者： l.liu FuHui T.Yang S.A.Simon DepartmentofPharmacology TongjiMedicalcollegeHuazhongUniversityofScienceandTechnologyWuhanHubeiChina430030 DepartmentsofAnesthesiologyandNeurobiology DukeUniversityMedicalCenterDurhamNC27710

AIM : One of the primary mechanisms by which neurons regulate their excitability is through of ion channel phosphorylafion. Compounds that increase noeiceptor excitability can cause hyporalgesia or allodynia whereas compounds that decrease noeiceptor excitability can be used as analgesics to relieve pain arising from inflammation or trauma. METHODS:

关键词：蛋白质酪氨酸激酶抑制剂三羟异黄酮辣椒素神经元炎性疼痛

Correlation between the ionospheric WN4 signature and the upper atmospheric DE3 tide

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Correlation between the ionospheric WN4 signature and the up...

中国科学院地质与地球物理研究所第十届(2010年度)学术年会

作者： W.Wan,J.Xiong,Z.Ren,l.liu,M.-l.Zhang,F.Ding,B.Ning,B.Zhao, and X.Yue 1 Beijing National Observatory of Space Environment,Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing,100029,China.

[1]The present work studies the correlation relationship between the longitudinal ionospheric structure of wave number 4(WN4) and the upper atmospheric tide of nonmigrating tidal mode DE3(diurnal eastward wave number 3).Global ionospheric maps produced by the Jet Propulsion laboratory were used to deduce the latitudinal integration of total electron content in the low-latitude ionosphere,and TIDI/TIMED observations were used to retrieve the atmospheric zonal and meridional *** applying Fourier filtering and fitting techniques,the WN4 wave and DE3 tidal components are derived from the ionospheric and upper atmospheric observations,*** found that the observed WN4 wave and DE3 zonal wind components experience very similar annual and interannual variations,but the DE3 meridional wind component behaves in a quite different *** WN4 and DE3 zonal winds are very intense during northern summer and autumn;they also appear in the later spring,but tend to vanish in winter. Their amplitudes increase as the solar activity decreases,and both are stronger in the quasi-biennial oscillation(QBO) eastward wind phase than in the westward *** the same time,the DE3 meridional wind likes to occur only in winter and seems not change with solar activity and QBO *** further studied the correlation between the WN4 wave and the two wind components of the DE3 *** found that the cross-correlation coefficient between the WN4 wave and the DE3 zonal wind is much larger,while that between the WN4 wave and the DE3 meridional wind is relatively *** different correlations are attributed to the different latitudinal symmetry of different DE3 wind *** DE3 zonal wind is likely in latitudinally symmetric tidal mode;hence,it can efficiently affect the F region ion *** contrast,the meridional wind is mainly in antisymmetric mode and thus seldom affects the ionospheric *** present results support the suggestion that the longitudinal WN4 s

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微波近场显微镜及其在超导薄膜和衬底材料特性无损检测上的应用

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低温物理学报 1999年第4期21卷 39-43页

作者：冯一军刘雷刘庆国尤立星杨森祖吴培亨南京大学电子科学与工程系

高温超导薄膜的微波性能受制备工艺和衬底材料性能的影响，常常出现空间不均匀分布，因此，无损检测大面积超导薄膜及衬底材料的微波性能，研究影响局域微波性能的因素，是高温超导微波器件应用研究中的一个重要方面．我们设计和制造了... 详细信息

高温超导薄膜的微波性能受制备工艺和衬底材料性能的影响，常常出现空间不均匀分布，因此，无损检测大面积超导薄膜及衬底材料的微波性能，研究影响局域微波性能的因素，是高温超导微波器件应用研究中的一个重要方面．我们设计和制造了一套同轴谐振腔型微波近场扫描显微镜，利用该显微镜研究了金属薄膜样品微波表面电阻和介质材料的介电常数的空间分布，给出了其空间分辨率并分析了影响空间分辨率的因素．利用这套微波近场扫描显微镜，对大面积ＬａＡｌＯ３单晶衬底材料介电常数的空间分布进行了测量，并分析了其测量精度．最后，利用这套微波近场扫描显微镜，研究了ＹＢａＣｕＯ薄膜平面微波器件的微波表面电阻的分布情况，对影响其局域微波性能的因素做了初步分析

关键词：显微镜高温超导制备工艺实验设备衬底材料谐振腔表面电阻表面比电阻介质材料针尖半径微波性能介电常数电容率介电性质薄膜样品无损检测无损探伤材料试验微波电磁波近场电磁场

Wavenumber-4 patterns of the total electron content over the low latitude ionosphere

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Wavenumber-4 patterns of the total electron content over the...

中国科学院地质与地球物理研究所2008学术年会

作者： W.Wan,l.liu,X.Pi,M.-l.Zhang,B.Ning,J.Xiong,and F.Ding 1 Institute of Geology and Geophysics,Chinese Academy of Sciences, Beijing,China. 2 Jet Propulsion laboratory,California Institute of Technology, Pasadena,California,USA.

[1]The global ionospheric maps(GIMs) produced by JPl are used to investigate the longitudinal structure of the low latitude *** a proxy of the ionization parameter at low latitudes,the latitudinally integrated total electron content(ITEC) is first extracted from low latitude GIMs and then Fourier filtered to obtain the wavenumber-4 *** then study in detail the diurnal,seasonal and solar cycle variations of the wave *** is found that the wavenumber-4 patterns are intense and well developed in boreal summer and early boreal autumn,but quite weak in boreal *** seasonal variation is consistent with that of the zonal wind of the non-migrating tide mode *** also found that the wavenumber-4 patterns shift eastward with a shifting speed that is smaller in daytime than at *** is attributed to the contribution of both the eastward propagation of DE3 in E-region and the zonal E×B ion drifts in *** results support the suggestion that the longitudinal wavenumber-4 structure of the low latitude ionosphere should be originated from the non-migrating tide mode DE3.

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Planetary wave-type oscillations in the ionosphere and their relationship to mesospheric/lower thermospheric *** disturbances at Wuhan(30.61N,114.51E)

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Planetary wave-type oscillations in the ionosphere and their...

中国科学院地质与地球物理研究所2006学术年会

作者： J.Xiong~(a,_),W.Wan~a,B.Ning~a,l.liu~a,Y.Gao~b a Institute of Geology and Geophysics,The Chinese Academy of Sciences,P.O.Box 9825,Beijing 100029,PR China b Institute of Geophysics,China Seismological Bureau,Beijing,PR China

Using wind,ionospheric and geomagnetic intensity data observed simultaneously at Wuhan(30.61N,114.51E) in 2002 and 2003,planetary wave type oscillations(PWTO) in the ionosphere and their relationship with oscillations in the mesosphere/lower thermosphere(MlT) and geomagnetic intensity have been *** cases of 2- and 5-day oscillations in the ionosphere are analyzed to distinguish MlT drivers and geomagnetic *** geomagnetic oscillations are the most important drivers for the PWTO with dominant periods of 5-,10-, *** the planetary waves in MlT winds are the main drivers for the quasi-2-day oscillations in the *** correlation coefficient of the occurrence rates of the 2-day oscillation in winds and in ionospheric f0F2 is 0.82 for the data from February to *** oscillations in the geomagnetic intensity can drive 30-50%of 5-,10- and 13.5-day PWTO events in the *** we evaluate all of the possible events driven by geomagnetic oscillations, more than 70%of the events have a relationship with geomagnetic oscillations with 5- and 10-day *** 39.7 h PWTO in ionospheric plasma frequencies observed from day 161 to 166 in 2002,are generated by an upward propagating wave with period 43.8 *** events of 6-day oscillations in the ionosphere observed during May to July in 2003,have different *** first one is probably generated by 5.4-day upward propagating waves in MlT winds,but enhanced during a moderate geomagnetic *** second one is generated by the geomagnetic oscillations during a strong geomagnetic storm,r 2005 Elsevier *** rights reserved.

关键词： Planetary wave Ionosphere Mesosphere and lower thermosphere

The ionospheric responses to the 11 August 1999 solar eclipse:observations and modeling

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The ionospheric responses to the 11 August 1999 solar eclips...

中国科学院地质与地球物理研究所2008学术年会

作者： H.le~(1,2),l.liu~1,X.Yue~(1,2),and W.Wan~1 1 Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029,China 2 Graduate School of the Chinese Academy of Sciences,Beijing 100049,China

A total eclipse occurred on 11 August 1999 with its path of totality passing over central Europe in the latitude range 40°-50°*** ionospheric responses to this eclipse were measured by a wide ionosonde *** the basis of the measurements of foE,foF1,and foF2 at sixteen ionosonde stations in Europe,we statistically analyze the variations of these parameters with a function of eclipse *** model the eclipse effects more accurately,a revised eclipse factor,F,is constructed to describe the variations of solar radiation during the solar *** we simulate the effect of this eclipse on the ionosphere with a mid- and low-latitude ionosphere theoretical model by using the revised eclipse factor during this *** are highly consistent with the observations for the response in the E-region and *** of them show that the maximum response of the mid-latitude ionosphere to the eclipse is found in the *** the obvious ionospheric response at low altitudes below 500 km,calculations show that there is also a small response at high altitudes up to about 2000 *** addition,calculations show that when the eclipse takes place in the Northern Hemisphere,a small ionospheric disturbance also appeared in the conjugate hemisphere.

关键词： Ionosphere(Mid-latitude ionosphere Modeling and forecasting)

Novel Inhibitors of Sterol 14α-demethylase of Penicillium digitatum Discovered Using Combining Homology Modeling,Molecular Simulating and Virtual Screening

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Novel Inhibitors of Sterol 14α-demethylase of Penicillium d...

第五届全国化学生物学学术会议

作者： Qing Y.Zhang~+ li Zhao~q De l.liu(?) Jian Wan~(*,+) ~+Key laboratory of Pesticide and Chemical Biology(CCNU),Ministry of Education,College of Chemistry,Central ~qChina Normal University,Wuhan 430079,People''s Republic of China ~qCollege of life Sciences,Central China Normal University,Wuhan 430071,China

＜正＞Green mould,caused by Penicillium digitatum,is the most essential post-harvest disease of citrus *** 14α-demethylase inhibitors are the largest and most important group of current *** explore rational binding model and potent novel inhibitors an accurate theoretical model of the three-dimensional structure of *** CYP51（pd-CYP51）was obtained by homology modeling and dynamic simulating in this ***,ab initio calculations were performed to detect important interactions between ligands and individual residues of active site based on molecular docking *** results revealed important interactions between the ligands and amino acid *** on the above information we design a novel and rational structure-based pharmacophore *** the same time three-dimensional quantitative structure-activity relationship （3D-QSAR）with comparative molecular field analysis（CoMFA）was performed on a training set of known inhibitors of pd-CYP51 and obtained a well predictive model. Integrated with CoMFA 3D-QSAR predictive models,molecular surface property（electrostatic and steric）mapping and structure-based pharmacophore as performed in our previous paper virtual screening have been employed to explore potential novel hits for the pd-CYP51 *** 30 diverse chemical type top scoring molecules were experimentally screened for their ability to inhibit pd-CYP51 activity,five new, low micromolar,small molecular potential inhibitors were ***-CYP51 cDNA was cloned by RT-PCR（reverse transcription-polymerase chain reaction）,sequenced and expressed in *** using the pET-28a expression vector,yielding recombinant protein（516 amino acid residues）with molecular weight approximate 58 *** potential inhibitors were suitable as leads for further inhibitor *** current results support our screening strategy of combining 3D QSAR model and structure-based virtual screening is valid and powerful.

关键词： homology molecular dynamic virtual screening 3D-QSAR