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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen jansen van rensburg Anine Crous Heidi Abrahamse laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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甲醇转化为烃类——甲烷和乙烯的前两步生成

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煤炭综合利用译丛 1990年第2期13卷 81-84页

作者： l.jansen van rensburg R.Hunter G.J.Hutchings 赵振华湖南师范大学

近几年来,应用 H-ZSM-5沸石催化剂或者双功能的酸碱催化剂,例如 WO_3/Al_2O_3,使甲醇转化为烃类,已进行了专门的研究。沸石催化剂对于化石燃料转化为汽油所具有的主要优点是,在高转化率时甲烷的产率可以≤1%(摩尔);而对于竞争的一氧化... 详细信息

近几年来,应用 H-ZSM-5沸石催化剂或者双功能的酸碱催化剂,例如 WO_3/Al_2O_3,使甲醇转化为烃类,已进行了专门的研究。沸石催化剂对于化石燃料转化为汽油所具有的主要优点是,在高转化率时甲烷的产率可以≤1%(摩尔);而对于竞争的一氧化碳加氢工艺来说,甲烷的产率则高得多,一般为6～10%(摩尔)。然而,用 H-ZSM-5作催化剂。

关键词：甲醇烃类甲烷乙烯生成

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Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous Medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.H.jansen Sandra M.C.Schoenmakers Bas van Genabeek Marle E.J.Vleugels Bart W.l.van den Bersselaar E.W.Meijer Ghislaine vantomme Institute for Complex Molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

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Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.G.Gray Marc Hanauer Kristina Hettne Joep de ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon l.Willighagen Mascha jansen Barend Mons Marco Roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

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Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

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Synthetic and Systems Biotechnology 2022年第1期7卷 554-566页

作者： Aafke C.A.van Aalsta Sophie C.de Valk Walter M.van Gulik Mickel l.A.jansen Jack T.Pronka Robert Mans Department of Biotechnology Delft University of TechnologyVan der Maasweg 92629HZ Delftthe Netherlands DSM Biotechnology Centre Alexander Fleminglaan 12613AX Delftthe Netherlands

Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast Saccharomyces *** paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production,yeast growth and glycerol *** attention is paid to strategies aimed at altering energy coupling of alcoholic fermentation and to strategies for altering redox-cofactor coupling in carbon and nitrogen meta-bolism that aim to reduce or eliminate the role of glycerol formation in anaerobic redox *** addition to providing an overview of scientific advances we discuss context dependency,theoretical impact and potential for industrial application of different proposed and developed strategies.

关键词： Saccharomyces cerevisiae Synthetic biology Metabolic engineering Biofuels Redox metabolism Energy metabolism

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Associations between partial foot amputation level,gait parameters,and minimum impairment criteria in para-sport:A research study protocol

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Sports Medicine and Health Science 2022年第1期4卷 70-73页

作者： Fabio C.lucas de Oliveira Samuel Williamson Clare l.Ardern Neil Heron Dina Christa Janse van rensburg Marleen G.T.jansen Sean O'Connor linda Schoonmade Jane Thornton Babette M.Pluim Center for Interdisciplinary Research in Rehabilitation and Social Integration CIUSSS-CNUniversite LavalQuebec CityQuebecCanada Research Unit in Sport and Physical Activity(CIDAF) Faculty of Sport Sciences and Physical EducationUniversity of CoimbraCoimbraPortugal English Institute of Sport LondonUK Division of Physiotherapy Karolinska InstituteStockholmSweden Center for Public Health Queen's University BelfastBelfastUK Department of General Practice Keele UniversityStaffordshireUK Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa Royal Dutch lawn Tennis Association(KNlTB) Amstelveenthe Netherlands Centre for Human Movement Sciences University Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands School of Medicine Dentistry and Biomedical Sciences Centre for Public HealthQueen's University BelfastBelfastUK Medical library Vrije Universiteit AmsterdamAmsterdamthe Netherlands Department of Family Medicine Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada Department of Epidemiology&Biostatistics Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada AMC/VUmc IOC Research Center of Excellence Amsterdam Collaboration on Health&Safety in Sports(ACHSS)AmsterdamNetherlands

Altered biomechanics due to amputation can contribute to substantial limitations,influencing sporting *** with lower extremity amputations or congenital lower limb deficiency are encouraged to participate in ***,to compete in Paralympic sports,the candidate must have an impairment that results in lower extremity loss of function and meets or exceeds the sport's minimum impairment criteria(MIC).This review will focus on the MIC for competitive wheelchair *** deficiency is known as one of the MIC used to regulate participation in competitive para-sports since it impacts gait,kinematics,and biomechanics of both the upper and lower ***,it is questionable whether the MIC concerning limb deficiency is set at the correct level for determining eligibility for participating in Paralympic *** study aims to provide an overview of the evidence examining the impact of different partial foot amputation(PFA)levels on gait as a proxy for sporting *** scoping review will be based on a 6-step methodological framework and Preferred Reporting Items for Systematic Reviews and Meta-Analysis,extension for scoping reviews(PRISMA-ScR).Studies will be selected from PubMed,Embase,CINAHl,and *** authors will screen the titles/abstracts *** studies will be scrutinised,and the same authors will extract *** will be relevant to informing the evidence-based development of MIC for lower limb impairment after PFA and may be extrapolated to specific Paralympic sports,including wheelchair *** will be disseminated through scientific publications and conferences to audiences interested in Paralympic sports.

关键词： Amputees Congenital deficiency Gait analysis Paralympic sport Partial foot amputation Wheelchair tennis

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Journal of Agricultural Science and Technology(B) 2012年第6期2卷 703-712页

作者： Jaco Bezuidenhout leon van rensburg Peet jansen van rensburg School of Environmental Sciences and Development North-West University Potchefstroom Campus Potchefstroom 2520 SouthAfrica School of Physical and Chemical Sciences North-West University Potchefstroom Campus Potchefstroom 2520 South Africa

Besides control of the fungal plant pathogens, another interesting aspect observed when plants are treated with Trichoderma harzianum include effects such as complete and even stand of plants, improved seed germination, increases in plant height and overall enhanced plant growth. No research has yet been conducted to elucidate the mechanism by which these effects occur. Improved seed germination, in particular, suggest that Trichoderma harzianum produces a metabolite that may mimic the plant growth hormone gibberellic acid. The metabolite gliotoxin, produced by Trichoderma harzianum appear to be structurally most similar to gibberellic acid. In this study, common pharmacophore generation and molecular ligand docking simulations were used to evaluate the molecular similarity between gibberellic acid, specifically GA3, and gliotoxin. For the common pharmacophore evaluation, the structure of various gibberellic acids were used to construct a pharmacophore space to which gliotoxin was aligned, and during the molecular docking simulations the gibberellic acid receptor, GID1, served as ligand target for GA3 and gliotoxin. During the common pharmacophore evaluation, gliotoxin was successfully aligned to the common pharmacophore model constructed from various gibberellic acids. Furthermore, molecular docking simulations of gliotoxin and GA3 into the gibberellic acid receptor (GID1) yielded docking scores of -10.78 kcal/mol for the GA3 molecule from Corina and a docking score of -10.17 kcal/mol for gliotoxin. The docking scores suggest that gliotoxin may be able to competitively occupy the receptor space for gibberellic acid, and as such elicit the similar physiological responses observed in literature.

关键词：植物生长激素分子对接哈茨木霉霉毒素相似度机制赤霉素药效评价

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Assessment of muscle strength in para-athletes:A systematic review of observational studies

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Sports Medicine and Health Science 2022年第4期4卷 225-238页

作者： Sean R.O'Connor Kristina Fagher Samuel Williamson Babette M.Pluim Clare l.Ardern Dina C.Janse van rensburg Neil Heron Centre for Public Health Queen's University BelfastBelfastUK School of Psychology Queen's University BelfastBelfastUK Rehabilitation Medicine Research Group Department of Health SciencesLund UniversityLundSweden English Institute of Sport ManchesterUK Royal Netherlands lawn Tennis Association AmstelveenNetherlands Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa Amsterdam Collaboration on Health&Safety in Sports(ACHSS) IOC Research Center of ExcellenceAmsterdam UMCAmsterdamNetherlands Department of Family Practice University of British ColumbiaVancouverCanada Medical Board Member World NetballManchesterUK School of Medicine Keele UniversityStaffordshireUK

Accurate and reliable evaluation of muscle strength in para-athletes is essential for monitoring the effectiveness of strength training and/or rehabilitation programmes,and sport *** aim is to synthesise evidence related to assessing muscle strength in *** databases were searched from January 1990 to July 2021 for observational studies focusing on strength *** screening,data extraction,and quality assessment were performed in duplicate.A total of 1764 potential studies were *** met the inclusion criteria and were included in the *** mean age of participants was 30.7 years(standard deviation[SD]:2.4).The majority were men(88%)participating in wheelchair sports,including basketball,rugby,and tennis(23/30:76%).Overall quality varied,with more than half of the studies failing to identify strategies for dealing with confounding *** manual muscle testing being a standard component of para-sport classification systems,evidence examining strength characteristics in para-athletes is derived primarily from isometric and isokinetic *** studies that included comparative strength data,findings were *** studies found strength values were similar to or lower than able-bodied athletic ***,an important observation was that others reported higher shoulder strength in para-athletes taking part in wheelchair sports than both able-bodied and disabled *** need to develop accessible,standardised strength testing methods that account for training influence and establish normative strength values in *** is also a need for additional studies that include female para-athletes and para-athletes with greater functional impairments.

关键词： Systematic review Para-athletes Disabled sport Muscle strength Assessment

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A profile of personnel who work with retired volunteers at a service centre for elderly persons

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Advances in Aging Research 2012年第1期1卷 1-12页

作者： Sanet jansen van rensburg Herman Strydom Potchefstroom Service Centre for the Aged Potchefstroom South Africa Social Work Potchefstroom Campus of the North-West University Potchefstroom South Africa

This article focuses on a profile of personnel who work with retired volunteers. The data was sourced by using two standardised measuring instrument, interviews, focus groups and observation. The leadership Qualities Inventory (lQI-S) was used as one standardised measuring instrument. The following elements were measured namely leadership, people-oriented, task-oriented and self-oriented qualities. The Neethling Brain Instrument (NBI) was used as a second standardised instrument. This instru- ment measured the subconscious’ preferences in four quadrants namely analytical (l1), systematic (l2), emotional (R2) and holistic (R1). From the data an empowerment programme was developed for personnel involved at service centres for elderly persons.

关键词： Cell-Ploc Signal-CF Signal-3l MemType-2l EzyPred HIVcleave GPCR-CA ProtIdent QuatIdent FoldRate

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Impedancemetry of multiplexed quantum devices using an on-chip cryogenic complementary metal-oxide-semiconductor active inductor

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Chip 2023年第4期2卷 133-141页

作者： l.le Guevel G.Billiot S.De Franceschi A.Morel X.Jehl A.G.M.jansen *** UniversitéGrenoble Alpes CEALETIGrenoble F-38000France UniversitéGrenoble Alpes CEAGrenoble INPIRIGPHELIQSGrenoble F-38000France Department of Electrical and Computer Engineering University ofMassachusetts-AmherstMA 01003USA UniversitéSavoie Mont Blanc SYMMEAnnecy F-74000France

In the pursuit for scalable quantum processors,significanteffort has been devoted to the development of cryogenic classical hardware for the control and readout of a growingnumber of *** current work presented a novelapproach called impedancemetry that is suitable for measuringthe quantum capacitance of semiconductor qubits connected toa resonant *** impedancemetry circuit exploits theintegration of a complementary metal-oxide-semiconductor(CMOS)active inductor in the resonator with tunable resonance frequency and quality factor,enabling the optimizationof readout sensitivity for quantum *** realized cryogenic circuit allows fast impedance detection with a measuredcapacitance resolution down to 10 aF and an input-referrednoise of 3.7 aF/Hz *** 4.2 K,the power consumption of theactive inductor amounts to 120μW,with an additional dissipation for on-chip current excitation(0.15μW)and voltageamplification(2.9 mW)of the impedance *** to the commonly used schemes based on dispersiveRF reflectometry which require millimeter-scale passive inductors,the circuit exhibits a notably reduced footprint(50μm360μm),facilitating its integration in a scalable quantumclassical *** impedancemetry method has been applied at 4.2 K to the detection of quantum effects in the gatecapacitance of on-chip nanometric CMOS transistors that areindividually addressed via multiplexing.

关键词： Impedancemetry Qubit readout Cryogenic circuit Activeinductor CMOS

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