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Search for two-neutrino double-beta decay of^(136)Xe to the 0^(+)_(1)excited state of 136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 1-9页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.Daniels l.Darroch S.j.Daugherty j.Davis S.Delaquis A.Der Mesrobian-Kabakian R.DeVoe j.Dilling A.Dolgolenko M.j.Dolinski j.Echevers W.Fairbank jr. D.Fairbank j.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen j.Hoessl P.Hufschmidt M.Hughes A.Iverson A.jamil C.jessiman M.j.jewell A.johnson A.Karelin l.j.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.lan A.larson B.G.lenardo D.S.leonard G.S.li S.li Z.li C.licciardi Y.H.lin R.Maclellan T.McElroy T.Michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.l.Robinson P.C.Rowson j.Runge S.Schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado j.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel j.-l.Vuilleumier M.Wagenpfeil j.Watkins M.Weber l.j.wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne l.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler 无 Physics Department McGill UniversityMontrealQuebec H3A 2T8Canada Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-University Erlangen-NürnbergErlangen 91058Germany Physics Department Carleton UniversityOttawaOntario K1S 5B6Canada Department of Physics Duke Universityand Triangle Universities Nuclear Laboratory(TUNL)DurhamNorth Carolina 27708USA Physics Department University of IllinoisUrbana-ChampaignIllinois 61801USA Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre“Kurchatov Institute” Moscow 117218Russia Department of Physics University of South DakotaVermillionSouth Dakota 57069USA SlAC National Accelerator laboratory Menlo ParkCalifornia 94025USA TRIUMF VancouverBritish Columbia V6T 2A3Canada Institute of High Energy Physics Beijing 100049China Department of Physics Laurentian UniversitySudburyOntario P3E 2C6Canada Physics Department Colorado State UniversityFort CollinsColorado 80523USA Department of Physics and Physical Oceanography University of North Carolina at WilmingtonWilmingtonNC 28403USA Physics Department and CEEM Indiana UniversityBloomingtonIndiana 47405USA Physics Department Stanford UniversityStanfordCalifornia 94305USA Department of Physics Drexel UniversityPhiladelphiaPennsylvania 19104USA Amherst Center for Fundamental Interactions and Physics Department University of MassachusettsAmherstMA 01003USA Technische Universität München Physikdepartment and Excellence Cluster UniverseGarching 80805Germany Physics Department University of MarylandCollege ParkMaryland 20742USA Department of Physics and Astronomy University of AlabamaTuscaloosaAlabama 35487USA Wright laboratory Department of PhysicsYale UniversityNew HavenConnecticut 06511USA IBS Center for Underground Physics Daejeon 34126Korea Department of Physics and Astronomy Stony Brook UniversitySUNYStony BrookNew York 11794USA Kellogg lab CaltechPasadenaCalifornia 91125USA lHEP Albert Einstein CenterUniversi

A new search for two-neutrino double-beta(2νββ)decay of^(136)Xe to the 0+1 excited state of 136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase II dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2νββdecay to the 0+1 state of 136Ba is 2.9×10^(24)yr using a total^(136)Xe exposure of 234.1 kg *** statistically significant evidence for 2νββdecay to the 0^(+)_(1)state is observed,leading to a lower limit of T2ν1/2(0^(+)→0^(+)_(1))>1.4×10^(24)yr at 90%confidence level,improved by 70%relative to the current world's best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

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Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao j.Cao j.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen j.Cheng Z.K.Cheng j.j.Cherwinka M.C.Chu j.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal j.Dove M.Dvorak D.A.Dwyer j.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu j.Y.Guo l.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu j.R.Hu T.Hu Z.j.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.jaffe K.l.jen X.l.ji X.P.ji R.A.johnson D.jones l.Kang S.H.Kettell S.Kohn M.Kramer T.j.langford j.lee j.H.C.lee R.T.lei R.leitner j.K.C.leung F.li j.j.li Q.j.li S.li S.C.li W.D.li X.N.li X.Q.li Y.F.li Z.B.li H.liang C.j.lin G.l.lin S.lin j.j.ling j.M.link l.littenberg B.R.littlejohn j.C.liu j.l.liu C.lu H.Q.lu j.S.lu K.B.luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng j.Napolitano D.Naumov E.Naumova j.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan j.Park S.Patton j.C.Peng C.S.j.Pun F.Z.Qi M.Qi X.Qian N.Raper j.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner j.l.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang j.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei l.H.Wei l.j.wen K.Whisnant C.G.White H.l.H.Wong E.Worcester D.R.Wu F.l.Wu Q.Wu W.j.Wu D.M.Xia Z.Q.Xie Z.Z.Xing j.l.Xu T.Xu T.Xue C.G.Yang l.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.l.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng l.Zhan C.Zhang F.Y.Zhang H.H.Zhang j.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.j.Zhang Z.P.Zhang Z.Y.Zhang j.Zhao l.Zhou H.l.Zhuang j.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 University of Wisconsin MadisonWisconsin 53706 Wright laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen University Shenzhen 518060 Sun Yat-Sen(Zhongshan)University Guangzhou North China Electric Power University Bejjing 102206 Chinese University of Hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 University of Science and Technology of China Hefei 230026 Charles University Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 lawrence Berkeley National laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 joint Institute for Nuclear Research DubnaMoscow Region Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250100 Guangxi University Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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Antineutrino energy spectrum unfolding based on the Daya Bay measurement and its applications

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Chinese Physics C 2021年第7期45卷 1-19页

作者： F.P.An A.B.Balantekin M.Bishai S.Blyth G.F.Cao j.Cao j.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen j.Cheng Z.K.Cheng j.j.Cherwinka M.C.Chu j.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal D.Dolzhikov j.Dove M.Dvorak D.A.Dwyer j.P.Gallo M.Gonchar G.H.Gong H.Gong M.Grassi W.Q.Gu j.Y.Guo l.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans a M.He K.M.Heeger Y.K.Heng Y.K.Hor Y.B.Hsiung B.Z.Hu j.R.Hu T.Hu Z.j.Hu H.X.Huang j.H.Huang X.T.Huang Y.B.Huang P.Huber D.E.jaffe K.l.jen X.l.ji X.P.ji R.A.johnson D.jones l.Kang S.H.Kettel S.Kohn M.Kramer T.j.langford j.lee j.H.C.lee R.T.lei R.leitner j.K.C.leung F.li H.l.li j.j.li Q.j.li R.H.li S.li S.C.li W.D.li X.N.li X.Q.li Y.F.li Z.B.li H.liang C.j.lin G.l.lin S.lin j.j.ling j.M.link26 l.littenberg B.R.littlejohn j.C.liu j.l.liu j.X.liu C.lu H.Q.lu K.B.luk B.Z.Ma X.B.Ma X.Y.Ma Y.Q.Ma R.C.Mandujano C.Marshall K.T.McDonald R.D.McKeown Y.Meng j.Napolitano D.Naumov E.Naumova T.M.T.Nguyen j.P.Ochoa-Ricoux A.Olshevskiy H.-R.Pan j.Park S.Patton j.C.Peng C.S.j.Pun F.Z.Qi M.Qi X.Qian N.Raper j.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner j.l.Sun T.Tmej1 K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang j.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei l.H.Wei l.j.wen K.Whisnant C.G.White H.l.H.Wong E.Worcester D.R.Wu F.l.Wu Q.Wu W.j.Wu D.M.Xia Z.Q.Xie Z.Z.Xing H.K.Xu j.l.Xu T.Xu T.Xue C.G.Yang l.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.l.Young H.Z.Yu Z.Y.Yu B.B.Yue V.Zavadskyi S.Zeng Y.Zeng l.Zhan C.Zhang F.Y.Zhang H.H.Zhang j.W.Zhang Q.M.Zhang S.Q.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.j.Zhang Z.P.Zhang Z.Y.Zhang j.Zhao R.Z.Zhao l.Zhou H.l.Zhuang j.H.Zou Institute of Modern Physics East China University of Science and TechnologyShanghai 200337 University of Wisconsin MadisonWisconsin 53706 Brookhaven National laboratory UptonNew York 11973 Department of Physics Nnational Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBeijing 100048 Shenzhen University Shenzhen 518061 Sun Yat-Sen(Zhongshan)University Guangzhou 510275 North China Electric Power University Beijing 102206 Chinese University of Hong Kong Hongkong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697 University of Science and Technology of China Hefei 230022 Charles University Faculty of Mathematics and PhysicsPrague joint Institute for Nuclear Research DubnaMoscow Region Department of Physics University of Illinois at Urbana-ChampaignUrbanaIllinois 61801 lawrence Berkeley National laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Wright laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250002 Guangxi University No.100 Daxue East RoadNanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics NCTUHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physics College of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHongkong 999077 School of Physics Nankai UniversityTianjin 300071 Department o

The prediction of reactor antineutrino spectra will play a crucial role as reactor experiments enter the precision *** positron energy spectrum of 3.5 million antineutrino inverse beta decay reactions observed by the Daya Bay experiment,in combination with the fission rates of fissile isotopes in the reactor,is used to extract the positron energy spectra resulting from the fission of specific *** information can be used to produce a precise,data-based prediction of the antineutrino energy spectrum in other reactor antineutrino experiments with different fission fractions than Daya *** positron energy spectra are unfolded to obtain the antineutrino energy spectra by removing the contribution from detector response with the Wiener-SVD unfolding *** results are obtained with other unfolding methods.A technique to construct a data-based prediction of the reactor antineutrino energy spectrum is proposed and *** the reactor fission fractions,the technique can predict the energy spectrum to a 2%*** addition,we illustrate how to perform a rigorous comparison between the unfolded antineutrino spectrum and a theoretical model prediction that avoids the input model bias of the unfolding method.

关键词： reactor antineutrino energy spectrum Daya Bay application

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Tensile and shearing behaviors of the particle raft

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Acta Mechanica Sinica 2021年第6期37卷 904-909,I0001页

作者： P.C.Zuo H.Yu j.l.liu Z.j.wen College of Pipeline and Civil Engineering China University of Petroleum(East China)Qingdao266580China School of Science China University of Petroleum(East China)Qingdao266580China Key laboratory of Mining Disaster Prevention and Control Shandong University of Science and TechnologyQingdao266590China

The particle raft is a two-dimensional condensed soft matter,which is composed of hydrophobic solid particles floating on a liquid *** this study,we have realized to conduct tension and shear experiments on the particle raft by using the self-assembled loading *** crack initiation and propagation are observed by the camera,and the curve of the non-dimensional force with respect to the displacement is *** experimental results have been compared with the particle flow code 3D(PFC3D)simulation,and they are in excellent *** indicates that the particle raft possesses mechanical properties between solid and *** findings provide some inspirations on engineering new devices and new materials at the microscale.

关键词： Particle raft Tension Shear Crack Force–displacement curve

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A novel approach to enhance decrepitation temperature and reducibility of ultrafine iron ore concentrate pellets

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journal of Iron and Steel Research International 2024年第11期31卷 2622-2632页

作者： B.l.wen Z.H.Fan j.X.li D.l.liu j.l.Yang School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032AnhuiChina jianlong(liaoning)Energy Saving and Environmental Protection

Utilizing ultrafine iron ore concentrate for pellet production can expand domestic iron ore resources in China and promote the utilization of low-grade ***,a challenge arises with the low decrepitation temperature and reducibility in the preparation process of ultrafine iron ore concentrate *** address the challenge,a novel approach was proposed,which incorporated straw powder as an additive to enhance pellet porosity,thereby improving the decrepitation temper-ature and reducibility of ultrafine iron ore concentrate *** effect of varying proportions of straw powder(0.0-2.0%)on the characteristics of ultrafine iron ore concentrate pellets was *** indicate that at a 2.0%straw powder ratio,pellet decrepitation temperature notably rises from 380 to 540℃,while the reducibility index escalates from 25.7%to 48.1%.Nevertheless,the addition of straw powder results in diminished drop strength,compressive strength of green pellets,and cold crushing strength of fired *** addition,enhanced pellet reducibility leads to exacerbated reduction swelling index and reduction degradation *** these effects,all parameters remain within an acceptable range.

关键词： Ultrafine iron ore concentrate:Straw powder Green pellet quality Decrepitation temperature:Metallurgical property

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan lingqi Yu Xudong Zhuang Dongjing wen jin He jingmei Hong jiayu Xie Shengan ling Xiaoyue Du wenfeng Chen Xinrui Wang Institute of life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

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World journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen Bo An wen-Cheng An Gang Fu Wei Huang Hui-Xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/l,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

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