检索结果-南通市图书馆

Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn's disease

World Journal of Gastroenterology 2019年第14期25卷 1764-1774页

作者： Ignacio Alfaro Maria Carme Masamunt nuria Planell Alicia lópez-García Jesús Castro Marta Gallego Rebeca Barastegui Angel Giner Alejandro Vara Azucena Salas Elena Ricart Julián Panés Ingrid Ordás Gastroenterology Department Hospital Clínic de Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona

BACKGROUnD Identifying predictors of therapeutic response is the cornerstone of personalized *** To identify predictors of long-term mucosal healing(Mh) in patients with Crohn's disease(CD) treated with tumor necrosis factor α(TnF-α) *** Prospective single center study. Consecutive patients with clinically active CD requiring treatment with a TnF-α inhibitor were included. A baseline segmental CD Endoscopic Index of Severity(CDEIS) ≥ 10 in at least one segment or the presence of ulcerations were required for inclusion. Clinical, biological and endoscopic data were obtained at baseline, weeks 14 and 46. Endoscopic response(ER) was defined as a decrease ≥ 50% from baseline CDEIS and Mh as partial CDEIS ≤ 5 in all *** Of 62 patients were included. At baseline, median CD Activity Index and CDEIS were 201 and 6.7, respectively with a significant reduction after one year of treatment(53 and 3.0 respectively, P nts achieved ER and 34% Mh. At week 46, the corresponding percentages were 52%and 44%. Baseline disease characteristics or biomarkers did not predict Mh. A decrease from baseline CDEIS at week 14 of at least 80% was the best predictor of Mh at week 46(59% sensitivity and 91% specificity; area under the curve =0.778).COnClUSIOn Clinical and biomarker data are not useful predictors of response to TnF-αinhibitors in CD, whereas ER to induction therapy, defined as 80% reduction in global CDEIS, is a robust predictor of long-term Mh. Achievement of this endoscopic endpoint may be considered as a therapeutic target for anti-TnF-αtherapy.

关键词： Crohn’s disease Endoscopy Mucosal healing Crohn’s Disease Endoscopic Index of Severity Tumor necrosis factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

leaching of rare earths from fine-grained zirconosilicate ore

引用

Journal of Rare Earths 2016年第9期34卷 908-916页

作者： h.lim D.Ibana J.Eksteen Western Australia School of Mines Curtin University7 Conlon StreetWaterford6152 Australia Mining and Metallurgy Western Australia School of MinesLocked Bag l7Kalgoorlie6433Australia

leaching of rare earths Y, la and Ce by sulphuric acid from fine-grained zirconosilicate ore was investigated using Ta-guchi method of experimental design. An orthogonal array of l8, 27 which denotes 7 factors at 2 levels was chosen to consider the various factors relevant to the leaching process： baking time, baking temperature, acid dosage, leaching time, leaching temperature, grind size and dilution. Statistical analysis showed that sulphation baking was a significant step for the leaching of rare earths from the whole-of-ore and optimized leaching of rare earths involved the following condition： baking for 3 h at 320 ℃ at 3.2 g acid/g ore acid dosage followed by water leaching at 20 ℃ for 1 h and dilution of 20 ml water/g ore using 300 um grind size. The effect of each leaching factor was also discussed.

关键词： rare earths yttrium lanthanum cerium zirconosilicate leaching Taguchi

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physicochemical properties and volatile components of pea flour fermented by lactobacillus rhamnosus l08

引用

Food Bioscience 2022年第2期46卷 793-800页

作者： Mengqi Pei Zifu Zhao Song Chen E.I.Reshetnik S.l.Gribanova Chun li Guofang Zhang libo liu lin Zhao Key laboratory of Dairy Sciences Ministry of EducationCollege of Food SciencesNortheast Agricultural UniversityHarbin150030China Inner Mongolia Yili Group Co.ltd Hohhot010080China Far Eastern State Agrarian University Blagoveshchensk675005Russia heilongjiang Green Food Research Institute Harbin150028China Quality&Safety Institute of Agricultural Products Heilongjiang Academy of Agricultural SciencesHarbin150086China

Pea(Pisum sativum l.)is an important source of plant ***,the use of pea flour as a food ingredient is greatly limited due to its strong beany *** this work,we investigated the effects of lactobacillus rhamnosus l08(*** l08)fermentation on the physicochemical characteristics,amino acids composition and volatile flavor compounds of pea *** found that *** l08 had the probiotic potential of utilizing pea flour as fermentation *** l08 fermentation significantly increased the content of most amino acids,and total amino acid content increased from 222.18 mg/g at 0 h to 262.35 mg/g at 6 h.A total of 44 volatile compounds were identified in pea *** l08 fermentation increased the variety of acids and esters,while reduced the unpleasant flavor such as nonanal,decanal,octanal,1-hexanol and *** emulsifying stability and foam stability of pea flour were slightly enhanced during *** results illustrate that lactic acid bacteria fermentation is a promising approach to eliminate undesirable aroma of pea ***,this study provides theoretical support for the application of peas as high-quality protein source.

关键词： Pea flour lactic acid bacteria Fermentation Flavor component Physicochemical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aortic endovascular repair modeling using the finite element method

引用

Journal of Biomedical Science and Engineering 2013年第9期6卷 917-927页

作者： Ghizlane Mouktadiri Benyebka Bou-Said hélène Walter-le-Berre Universite de lyon CNRS INSA-LyonLaMCoSUMR5259F-69621LyonFrance

Aim: The goal is to simulate different stages of the endovascular procedure in the preoperative phase. Methods: We have developed a numerical model of the endovascular treatment of abdominal aortic aneurysms (AAA) using finite element analysis (FEA), we took into account the geometry of the biological region reconstructed from scans, a local characterization of the guidewire/catheter mechanical properties, a mapping of material properties depending on the degree of calcification, a real behavior of the vascular walls, and a projection of the aorta environment. Results: Our results present the endovascular system navigation from the femoral artery to the neck of the aneurysm, predict the deformation of femoral, iliac and aortic arteries while driving flexible and stiff endovascular devices, and detect stress concentration due to tortuous and calcified artery zones. A given group of patients with very angulated and calcified arteries were validated, based on a tuning between clinical data and our endovascular simulation. Conclusion: Our model allows controlling with accuracy the delivery system rise during surgery, predicting the feasibility of the surgery with reliability as well as choose the best guide for each patient, taking into account the risk of rupture of calcified areas in the case of high angulations, and using planning simulated images with deformation of artery walls to propose stent sizing.

关键词： AAA Endovascular Repair FEA Composite nonlinearity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Physiological Response of Advanced lines of Rice under Water Deficit in Campeche, Mexico

引用

Agricultural Sciences 2020年第10期11卷 932-945页

作者： Mónica Beatriz lópez-hernández Jesús Arreola-Enríquez Antonio Villalobos-González luis leonardo Pinzón-lópez Edwin Javier Barrios-Gómez Saúl Espinosa-Zaragoza Diana Sanzón-Gómez Instituto Tecnológico de Chiná Chiná México Colegio de Postgraduados Sihochac México Instituto nacional de Investigaciones Forestales Agrícolas y Pecuarias Campo Experimental Edzná Campeche México Instituto Tecnológico de Conkal Conkal México Instituto nacional de Investigaciones Forestales Agrícolas y Pecuarias Campo Experimental Zacatepec Morelos México Universidad Autónoma de Chíapas Facultad de Ciencias Agrícolas Huehuetán México Universidad de Guanajuato Campus Irapuato-Salamanca Irapuato México

Yields of rice (Oryza sativa l.) respond to complex interactions between the genotype and the environment;rice has the particularity of being a semi-aquatic crop, and as a result of this, it presents lower adaptation to the limiting water content of soil and is extremely sensitive to stress from drought;therefore, it is the most important limiting factor in rice production. The objective of this study was to research the physiological response of rice genotypes to water stress. The grain yield and its components, leaf area and transpiration efficiency under irrigation (I) and drought (D) were evaluated in eight advanced lines from the nursery of the latin American Fund for Irrigated Rice (Fondo latinoamericano para Arroz de Riego, FlAR) and a control variety of rice. The experiment was established in Campeche, in the 2015 autumn-winter cycle. The grain yield and its components, as well as the leaf area were greater under irrigation conditions than under drought. The transpiration from the water stress was reduced and the plants under drought increased their transpiration efficiency. The genotypes P-V 2006 and P-V 2009 were identified, with genealogies Fl05392-3P-12-2P-2P-M and Fl08224-3P-2-1P-3P-M, respectively, as the most outstanding compared to the rest of the genotypes in the grain yield and its components, leaf area, total root biomass, and transpiration efficiency.

关键词： Oryza sativa l. Yield Drought

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Self-starting harmonic mode-locked Tm-Bi co-doped germanate f iber laser with carbon nanotube-based saturable absorber

引用

Chinese Optics letters 2013年第6期11卷 81-83页

作者： n.Saidin D.I.M.Zen S.S.A.Damanhuri S.W.harun h.Ahmad F.Ahmad K.Dimyati A.halder M.C.Paul M.Pal S.K.Bhadra Photonics Research Centre University of Malaya50603 Kuala LumpurMalaysia Department of Electrical Engineering Faculty of EngineeringUniversity of Malaya50603 Kuala LumpurMalaysia Department of Electrical and Electronic Engineering National Defense University of MalaysiaKem Sungai Besi57000 Kuala LumpurMalaysia Fiber Optics and Photonics Division Central Glass and Ceramic Research InstituteCSIRKolkataIndia

We report a ring cavity passively harmonic mode-locked fiber laser using a newly developed thulium- bismuth co-doped fiber （TBF） as a gain medium in conjunction with a carbon nanotube （CnT）-based saturable absorber. The TBF laser generates a third harmonic mode-locked soliton pulse train with a high repetition rate of 50 Mhz and a pulse duration of 1.86 ps. The laser operates at 1 901.6 nm with an average power of 6.6 mW, corresponding to a pulse energy of 0.132 nJ, at a 1 552 nm pump power of 723.3 roW.

关键词： mode Self-starting harmonic mode-locked Tm-Bi co-doped germanate f iber laser with carbon nanotube-based saturable absorber CnT Tm Bi

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On the Mechanism of CDOs behind the Current Financial Crisis and Mathematical Modeling with levy Distributions

引用

Intelligent Information Management 2010年第2期2卷 149-158页

作者： h.W. Du J.l. Wu W. Yang 不详

This paper aims to reveal the mechanism of Collateralized Debt Obligations (CDOs) and how CDOs extend the current global financial crisis. We first introduce the concept of CDOs and give a brief account of the de-velopment of CDOs. We then explicate the mechanism of CDOs within a concrete example with mortgage deals and we outline the evolution of the current financial crisis. Based on our overview of pricing CDOs in various existing random models, we propose an idea of modeling the random phenomenon with the feature of heavy tail dependence for possible implements towards a new random modeling for CDOs.

关键词： Collateralized Debt Obligations (CDOs) Cashflow CDO Synthetic CDO Mechanism Financial Crisis Pricing Models levy Stable Distributions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proso Millet Protein Elevates Plasma level of high-Density lipoprotein:A new Food Function of Proso Millet

引用

Biomedical and Environmental Sciences 1996年第2期9卷 209-212页

作者： n. nIShIZAWA S. ShIMAnUKI h. FUJIhAShI h. WATAnABE Y. FUDAMOTO AnD T. nAGASAWA (Department of Bioscience and Technology, Faculty of Agriculture, Iwate University Morioka, Iwate 020, Japan Research laboratory,nitto Best Co., ltd, Sagae, Yamagata 991 Ka Department of Bioscience and Technology Faculty of Agriculture Iwate University Morioka Japan.

We examined the effects of dietary proso-millet protein on plasma levels of high-density lipoprotein (hDl) cholesterol in different rats from animals reported in our previous studies. The results showed also, in this animal, that the ingestion of the millet protein elevates plasma levels of hDl-cholesterol like our earlier works. Taking into account the anti-atherogenic function of hDl, therefore, the millet protein would be useful as a new food ingredient which has the function that regulates cholesterol metabolism

关键词： hDl Proso Millet Protein Elevates Plasma level of high-Density lipoprotein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An efficient synthetic approach towards new 5,5'-diaryl-2,2'-bipyridine-based fluorophores

引用

Chinese Chemical letters 2017年第5期28卷 1099-1103页

作者： Alexey P.Krinochkin Dmitry S.Kopchuk nikolay V.Chepchugov Grigory A.Kim Igor S.Kovalev Matiur Rahman Grigory V.Zyryanov Adinath Majee Vladimir l.Rusinov Oleg n.Chupakhin Ural Federal University Yekaterinburg 620002Russian Federation Postovsky Institute of Organic Synthesis of RAS(Ural Division) Yekaterinhurg 620990Russian Federation Department of Chemistry Visva-Bharati(A Central University)Santiniketan 731235India

An efficient approach has been developed for the synthesis of 5,5＇-diaryl-2,2＇-bipyridines via their 1,2,4-triazine *** notable advantages of the present method are：The possibility of varying the aromatic substituents in the positions 5 and 5＇ of bipyridine core and the possibility for obtaining 2,2＇-bipyridines bearing a fused cyclopentene core to increase the solubility in organic *** 5,5＇-diaryl-2,2＇-bipyridines exhibited an intense emission in a range of ca.422-521 nm in acetonitrile solution;depending on the nature of the aromatic substituents and the presence of annulated cyclopentene *** from that,the significant bathochromic shifts of the both absorption and emission maxima were observed in comparison with a number of previously described similar *** some cases the significant increasing of the fluorescence quantum yields took place.

关键词： 2 2'-Bipyridines 1 2 4-Triazines Aza-Diels-Alder reaction Fluorescence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phylogenetic relationships and morphological reappraisal of Melanommataceae(Pleosporales)

引用

Fungal Diversity 2015年第5期74卷 267-324页

作者： Qing Tian Jian Kui liu Kevin D.hyde Dhanushka n.Wanasinghe Saranyaphat Boonmee Subashini C.Jayasiri Zong long luo Joanne E.Taylor Alan J.l.Phillips Darbhe J.Bhat Wen Jing li hiran Ariyawansa Kasun M.Thambugala EBGareth Jones Putarak Chomnunti Ali h.Bahkali Jian Chu Xu Erio Camporesi Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Guizhou Key laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK UCIBIO Faculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal Formerly Department of BotanyGoa UniversityGoa-403206India Res:no.128/1–J Azad Housing SocietyCurcaP.O.Goa Velha-403108India Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia A.M.B.Gruppo Micologico Forlivese BAntonio Cicognani Via Roma 18ForlìItaly A.M.B.Circolo Micologico BGiovanni Carini C.P.314 BresciaItaly Societàper gli Studi naturalistici della Romagna C.P.144 BagnacavalloRAItaly

The family Melanommataceae is widespread in temperate and subtropical regions and species invariably occur on twigs or bark of various woody plants in terrestrial,marine or freshwater *** this paper,the type species of 26 genera of the family are re-described and illustrated.A multi-gene phylogeny based on maximum likelihood and Bayesian analyses of lSU,SSU,RPB2 and EF-1αsequence data of species of Melanommataceae is *** new genera,Muriformistrickeria,Pseudostrickeria and Thysanolaenae are *** is synonymized under ***,Astrosphaeriella,Beverwykella,Caryosporella,Sporidesmiella and Pseudotrichia are excluded from Melanommataceae based on molecular phylogenetic ***,20 genera are accepted in *** on the phylogenetic data,five new species,Byssosphaeria siamensis,herpotrichia vaginatispora,Pseudostrickeria muriformis,Pseudostrickeria ononidis and Muriformistrickeria rubi,are introduced.

关键词： Byssosphaeria herpotrichia Multi-gene Phylogeny Muriformistrickeria new species Pseudostrickeria Taxonomy Thysanolaenae Type

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：