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Identification of recombination hotspots and quantitative trait loci for recombination rate in layer chickens

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Journal of Animal Science and Biotechnology 2019年第2期10卷 314-326页

作者： Ziqing Weng Anna Wolc Hailin Su Rohan l.fernando Jack C.M.Dekkers Jesus Arango Petek Settar Janet E.Fulton Neil P.O’Sullivan Dorian J.Garrick Department of Animal Science Iowa State UniversityAmesIA 50010USA Hy-line International Dallas CenterIA 50063USA Al Rae Centre for Genetics and Breeding Massey UniversityPalmerston North 4442New Zealand.

Background: The frequency of recombination events varies across the genome and between individuals, which may be related to some genomic features. The objective of this study was to assess the frequency of recombination events and to identify QTl(quantitative trait loci) for recombination rate in two purebred layer chicken ***: A total of 1200 white-egg layers(Wl) were genotyped with 580 K SNPs and 5108 brown-egg layers(Bl)were genotyped with 42 K SNPs(single nucleotide polymorphisms). Recombination events were identified within half-sib families and both the number of recombination events and the recombination rate was calculated within each0.5 Mb window of the genome. The 10% of windows with the highest recombination rate on each chromosome were considered to be recombination hotspots. A BayesB model was used separately for each line to identify genomic regions associated with the genome-wide number of recombination event per meiosis. Regions that explained more than 0.8% of genetic variance of recombination rate were considered to harbor ***: Heritability of recombination rate was estimated at 0.17 in Wl and 0.16 in Bl. On average, 11.3 and 23.2 recombination events were detected per individual across the genome in 1301 and 9292 meioses in the Wl and Bl,respectively. The estimated recombination rates differed significantly between the lines, which could be due to differences in inbreeding levels, and haplotype structures. Dams had about 5% to 20% higher recombination rates per meiosis than sires in both lines. Recombination rate per 0.5 Mb window had a strong negative correlation with chromosome size and a strong positive correlation with GC content and with CpG island density across the genome in both lines. Different QTl for recombination rate were identified in the two lines. There were 190 and 199 non-overlapping recombination hotspots detected in Wl and Bl respectively, 28 of which were common to both ***: Differences in the r

关键词： layer chicken QTl Recombination SNP

Y-chromosomal microdeletions and partial deletions of the Azoospermia Factor c(AZFc)region in normozoospermic,severe oligozoospermic and azoospermic men in Sri lanka

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Asian Journal of Andrology 2006年第1期8卷 39-44页

作者： l.fernando J.Gromoll T.R.Weerasooriya E.Nieschlag M.Simoni Institute of Reproductive Medicine of the University Münster University HospitalD-48129 MünsterGermany Reproductive Biology LaboratoryFaculty of MedicineKarapitiyaGalleSri Lanka Institute of Reproductive Medicine of the University Münster University HospitalD-48129 MünsterGermany Reproductive Biology laboratory Faculty of MedicineKarapitiyaGalleSri Lanka

Aim： To assess for the first time the occurrence of Y chromosomal microdeletions and partial deletions of the Azoospermia Factor c （AZFc） region in Sri lankan men and to correlate them with clinical parameters. Methods： In a retrospective study, we analyzed 96 infertile men （78 with non-obstructive azoospermia） and 87 controls with normal spermatogenesis. AZFa, AZFb, AZFc and partial deletions within the AZFc region were analyzed by multiplex polymerase chain reaction （PCR） according to established protocols. Results： No AZFa, AZFb or AZFc deletions were found in the control group. Seven patients in the group of infertile men were found to have deletions as following： one AZFa, two AZFc, two AZFbc and two AZFabc. The relative distribution of these patterns was significantly different compared with that found in the German population. Extension analysis confirmed that the deletions occurred according to the current pathogenic model, gr/gr deletions were found to be equally present both in the patients （n = 4） and in the control group （n = 4）. One b2/b3 deletion was found in the patient group. Conclusion： These results suggest that the frequency and pattern of microdeletions of the Y chromosome in Sri lankan men are similar to those found in other populations and confirm that gr/gr deletions are not sufficient to cause spermatogenetic failure. （Asian J Androl 2006 Jan; 8： 39-44）

关键词： Y chromosome male infertility gr/gr b2/b3 microdeletion normozoospermia azoospermia factor c

Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： fernando Jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

Resistance of stored bean varieties to Acanthoscelides obtectus （Coleoptera： Bruchidae）

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Insect Science 2008年第4期15卷 317-326页

作者： Edson l.l. Baldin fernando M. lara Department of Plant Production-Faculty of Agronomic Sciences/Sao Paulo State University Botucatu Sao Paulo State Department of Plant Protection Faculty of Agranan and Veterinary Sciences / Sao Paulo State University Zip Code 14884-900 Jaboticabal Sao Paulo State Brazil

During bean seed storage, yield can be lost due to infestations of Acanthoscelides obtectus Say, the bean weevil. The use of resistant varieties has shown promising results in fighting these insects, reducing infestation levels and eliminating chemical residues from the beans. The expression of resistance to A. obtectus in bean varieties is frequently attributed to the presence of phytohemagglutinins, protease inhibitors and alpha-amylase, and especially to variants of the protein arcelin, which reduce the larval viability of these insects. To evaluate the effect of bean seed storage time on the resistance expression of bean varieties to A. obtectus, tests with seeds of three ages （freshly-harvested, 4-month-old, and 8-monthold） were conducted in the laboratory, using four commercial varieties： Carioca Pitoco, Ipa 6, Porrillo 70, Onix; four improved varieties containing arcelin protein： Arc. 1, Arc.2, Arc. 3, Arc.4; and three wild varieties also containing arcelin protein： ***, Arc.3S, and Arc. 5S. The Arc.5S, ***, and Arc.2 varieties expressed high antibiosis levels against the weevil; Arc.1 and Arc3S expressed the same mechanism, but at lower levels. The occurrence of oviposition non-preference was also observed in Arc.5S and Arc. 1S. The Arc.3 and Arc. 4 varieties expressed low feeding non-preference levels against A. obtectus. The expression of resistance in arcelin-bearing, wild or improved varieties was affected during the storage of seeds, and was high under some parameters but low in others. The results showed that addition of chemical resistance factors such as protein arcelin via genetic breeding may be beneficial in improving the performance of bean crops.

关键词： antibiosis antixenosis bean weevil host plant resistance Phaseolus vulgaris

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Evaluation of effectiveness of polymer coatings in reducing blastinduced deformation of steel plates

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Defence Technology（防务技术） 2021年第6期17卷 1895-1904页

作者： Damith Mohotti P.l.N.fernando Dakshitha Weerasinghe Alex Remennikov School of Engineering and Information Technology The University of New South WalesCanberraACT2600Australia Department of Civil Engineering Faculty of EngineeringGeneral Sir John Kotelawala Defence UniversityRatmalanaSri Lanka School of Civil Engineering Faculty of EngineeringThe University of SydneyDarlingtonNSW2006Australia Centre for Infrastructure Protection and Mining Safety University of WollongongWollongongNSW2522Australia

Incorporating elastomers such as polymers in protective structures to withstand high energetic dynamic loads,has gained significant *** main objective of this study is to investigate the influence of a Polyurea coating towards the blast-induced response in steel *** such,Polyurea coated steel plates were tested under near-field blast loads,produced by the detonation of 1 kg of spherical nitromethane charges,at a standoff distance of 150 *** steel(XlERPlATE 350)and high-strength steel(BIS80)plates with thicknesses of 10 mm were Polyurea coated with thicknesses of 6 mm and 12 mm on either the front(facing the charge)or the back *** deformation profiles were measured using 3D *** simulations were performed using the non-linear finite element code *** strain-dependent behaviour of the steel and Polyurea were represented by Johnson-cook and Money-Rivlin constitutive models,*** numerical models were validated by comparing the plate deflection results obtained from the experiments and were then used in the subsequent parametric study to investigate the optimum thickness of the Polyurea *** results indicate that back face coating contributes towards an approximately 20%reduction in the residual deformation as well as the absence of melting of the Polyurea layer,while the front-face coating can be used a means of providing additional standoff distance to the steel plates.

关键词： Polyurea coating Near-field blast lS-DYNA Plate deformation AlE

Behavior of diatomaceous soil in lacustrine deposits of Bogota, Colombia

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 367-379页

作者： Bernardo Caicedo Cristhian Mendoza fernando lópez Arcesio lizcano Department of Civil and Environmental Engineering Universidad de Los AndesBogotáColombia Department of Civil Engineering Universidad Nacional de Colombia Sede ManizalesManizalesColombia Ecole Centrale Paris Laboratoire MSSMat-UMR CNRS 8579ParisFrance SRK Consulting VancouverCanada

This work presents a study on the behaviors of diatomaceous soils. Although studies are rarely reported on these soils, they have been identified in Mexico City, the Sea of Japan, the northeast coast of Australia,the equatorial Pacific, and the lacustrine deposit of Bogota(Colombia), among other locations. Features of this kind of soil include high friction angle, high initial void ratio, high compressibility index, high liquid limit, and low density. Some of these features are counterintuitive from a classical soil mechanics viewpoint. To understand the geotechnical properties of the diatomaceous soil, a comprehensive experimental plan consisting of more than 2400 tests was performed, including physical tests such as grain size distribution, Atterberg limits, density of solid particles, and organic matter content; and mechanical tests such as oedometric compression tests, unconfined compression tests, and triaxial *** tests were complemented with scanning electron microscope(SEM) observations to evaluate the microstructure of the soil. The test results show that there is an increase in liquid limit with increasing diatomaceous content, and the friction angle also increases with increasing diatomaceous content. In addition, several practical correlations were proposed for this soil type for shear strength mobilization and intrinsic compression line. Finally, useful correlations were presented, such as the relationship between the state consistency and the undrained shear strength, the friction angle and the liquid limit, the void ratio at 100 kPa and the liquid limit, the plasticity index and the diatomaceous content, among others.

关键词： Diatomaceous soil Soft soils Compressibility Friction angle Natural soil

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network