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The functional role of miRNAs in colorectal cancer: insights from a large population-based study

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Cancer Biology & Medicine 2019年第2期16卷 211-219页

作者： lila e.Mullany Martha l.Slattery Department of Internal Medicine University of Utah

Identification of causal microRNAs(miRNAs) in colorectal cancer(CRC) is elusive, due to our lack of understanding of how specific miRNAs affect biological pathways and outcomes. An miRNA can regulate many mRNAs and an mRNA can be associated with many miRNAs;appreciation of these complex networks in which miRNAs operate is necessary to transition from identifying dysregulated miRNAs to identifying individual miRNAs or groups of miRNAs that are suitable for therapeutic purposes. The aim of the paper is to compile results from a population-based study(n = 1,954 cases with matched carcinoma/normal tissue) of miRNAs in CRC. The information gained allows for cohesive and comprehensive insight into miRNAs and CRC in terms of function and impact. Comparison of miRNA expression with mRNA expression from nine signaling pathways in carcinogenic processes allowed us to identify miRNA targets within a biological context. MiRNAs that directly infl.e.ce mRNA expression may be effective biomarkers or therapeutic targets.

关键词： mRNA miRNA pathways colorectal cancer

How can the neutrino interact with the electromagnetic field？

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Chinese Physics C 2018年第1期42卷 23-31页

作者： M.Novello C.e.l.Ducap Centro Brasileiro de Pesquisas Fisicas (CeAC/CBPF) Rua Dr. Xavier Sigaud 150 CEP 22290-180 Rio de Janeiro Brazil

Maxwell.e.ectrodynamics in the fixed Minkowski space-time background can be described in an equivalent way in a curved Riemannian geometry that depends on the electromagnetic field and that we call the electromagnetic metric（e-metric for short）. After showing such geometric equivalence we investigate the possibility that new processes dependent on the e-metric are allowed. In particular, for very high val.e. of the field, a direct coupling of uncharged particles to the electromagnetic field may appear.

关键词： neutrino electromagnetic field effective metric

Analysis and design of axially loaded piles in rock

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Journal of Rock Mechanics and Geotechnical.e.gineering 2019年第3期11卷 535-548页

作者： C.M.Haberfield A.l.e.lochaden Gol.e. Associates Pty.ltd. MelbourneAustralia

Despite significant advancements in in situ test techniques,construction practices,understanding of rock joint and rock mass behaviours,and numerical analysis methods,the design of bored concrete cast-insitu piles in rock is still largely based on the assessment of bearing ***,for many of the rock conditions encountered,the bearing capacity of piles is a nebulous concept and a figment of the designer’s *** if it can be reasonably quantified,it has little,if any,significance to the performance of a pile in *** load carrying capacity of even low strength rock(in most situations)is far in excess of the strength of the structure(for example,a building column)transmitting the *** performance of a pile in rock is usually a displacement issue and is a function of rock mass stiffness rather than rock mass *** addition,poor pile performance is much more likely to result from poor construction practices than excessive displacement of the rock *** occur for footings that are undermined,or where unfavourable structure in the rock allows movement towards a free surface to ***,codes of practices,reference books and other sources of design information should focus foundation design in rock on displacement rather than strength *** investigations should measure rock mass stiffness and defect properties,as well as intact rock *** paper summarises the fundamental concepts relating to performance of piles in rock and provides a basis for displacement focused design of piles in *** also presents comments relating to how piles are model.e. in widely used commercial finite element software for soil-structure interaction analysis,within the context of the back-analysis of a pile load test,and proposes recommendations for pile analysis and design.

关键词： Pile design Pile analysis Pile load test Finite element analysis

Systematic study of the dependence of magnetic and structural properties of Nd2Fe14B powders on the average particle size

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Journal of Rare earths 2020年第9期38卷 961-968,I0002页

作者： J.F.Durán Perdomo G.A.Pérez Alcázar H.D.Colorado J.A.Tabares l.e.Zamora J.J.S.Garitaonandia Department of Physics University of ValleA.A.25360 CaliColombia Appl.e. Physics II Department Basque Country University48080 BilbaoSpain

A systematic study of the magnetic and structural properties dependence on the particle size was *** this,commercial NdFeB powder was separated into five different mean particle sizes using ***,from the original powder,eleven samples were also produced by mechanical milling assisted by surfactant,using various milling times.A total of sixteen samples were studied by scanning electron microscopy(SeM),X-ray diffraction(XRD),vibrating sample magnetometry(VSM),and Mdssbauer spectrometry(MS).The particle sizes of the samples vary from the micrometer to the nanometer *** crystallite size decreases with decreasing particle *** result indicates that the Nd2Fe14B phase is found in all the samples,and the presence of this phase is also corroborated by MS using six sextets for fitting their spectra,with an additional singlet corresponding to the Nd1.1Fe4B4 *** mean hyperfine magnetic field increases with increasing particle size because the magnetic dipolar interaction between the magnetic moment of the particles increases with particle *** the VSM measurements the magnetic energy density(BH)max val.e. were calculated for different particle sizes,and their maximum val.e.of 34.45 MGOe is obtained for the sample with the particle size of 60μm.

关键词： Hard magnetic material XRD Mossbauer spectrometry Magnetization Particle size Rare earths

Infl.e.ce of flooding and vegetation on carbon,nitrogen,and phosphorus dynamics in the pore water of a Spartina al.e.niflora salt marsh

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Journal of environmental Sciences 2011年第2期23卷 212-221页

作者： Vanesa l.Negrin Carla V.Spetter Raúl O.Asteasuain Gerardo M.e.Perillo Jorge e.Marcovecchio Argentine Institute of Oceanography (IADO CONICETCCT-Bahía Blanca)Camino La Carrindanga km 75Building E-1 CC 804Bahía Blanca 8000Argentina Department of Chemistry Southern National Institute of Chemistry (INQUISUR)Southern National University (UNS)Av Alem 1253Bahía Blanca 8000Argentina Department of Geology Southern National University (UNS)San Juan 670Bahía Blanca 8000Argentina National Technological University Regional Faculty of Bahía Blanca (UTN-FRBB)11 de Abril 461Bahía Blanca 8000Argentina University of the Fraternity of Associations Santo Toms de Aquino (FASTA) Gascón 3145Mar del Plata 7600Argentina

Four sites were selected in a salt marsh in the Bahia Blanca estuary （Argentina）：（1） low marsh （flooded by the tide twice daily） vegetated by S. al.e.niflora; （2） non-vegetated low marsh; （3） high marsh （flooded only in spring tides） vegetated by S. al.e.niflora; （4） non-vegetated high marsh. The pH and eh were measured in sediments, while dissol.e. nutrients （ammonium, nitrate, nitrite and phosphate） and particulate organic matter （POM） were determined in pore water, pH （6.2-8.7） was only affected by vegetation in low areas. eh （from -300 to 250 mV） was lower at low sites than at high ones; in the latter, the val.e. were higher in the non-vegetated sediments. The POM concentration was greater in the high marsh than in the low marsh, with no effect of vegetation. Ammonium was the most abundant nitrogen nutrient species in pore water, except in the non-vegetated high marsh where nitrate concentration was higher. All nitrogen nutrients were affected by both flooding and vegetation. Phosphate was always present in pore water at all sites throughout the year and its concentration varied within narrow limits, with no effect of flooding and greater val.e. always at non-vegetated sites. Our results showed that the variability of the pore water composition within the marsh is greater than the temporal variation, meaning that both tidal flooding and vegetation are important in the dynamics of nutrients and organic matter in the sediment pore water.

关键词： organic matter nutrients flooding Spartina al.e.niflora

Disturbance cue communication is shaped by emitter diet and receiver background risk in Trinidadian guppies

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Current Zoology 2022年第4期68卷 433-440页

作者： Jack A Goldman Adam l Crane laurence e A Feyten emily Collins Grant e Brown Department of Biology Concordia University7141 Sherbrooke Street WestMontrealQCCanada H4B 1R6

In animal communication systems,individuals that detect a cue(i.e.,“receivers”)are often infl.e.ced by characteristics of the cue *** instance,in many species,receivers avoid chemical cues that are released by emitters experiencing *** chemical“disturbance cues”appear to benefit receivers by warning them about nearby danger,such as a predator’s *** the active ingredients in disturbance cues have been largely unexplored,by-products of metabolized protein are thought to play a role for some *** so,the content(quality)and volume(quantity)of the emitter’s diet should affect their disturbance cues,thus al.e.ing how receivers perceive the cues and *** Poecilia reticulata are a species known to discriminate among disturbance cues from different types of donors,but dietary variation has yet to be *** this study,we found evidence that diet quality and quantity can affect disturbance cues released by guppy emitters(i.e.,experimental“donors”).Receivers discriminated between donor cue treatments,responding more strongly to cues from donors fed a protein-rich bloodworm diet(experiment 1),as well as an overall larger diet(experiment 2).We also found that receivers exposed to higher background risk were more sensitive to disturbance cue variation,with the strongest avoidance responses displayed by high-risk receivers toward disturbance cues from donors fed the high-quality ***,diet,and perhaps protein specifically,affects either the concentration or composition of disturbance cues released by *** variation may be important in information signaling in social species like the guppy.

关键词： alarm cues chemical cues diet quality diet quantity protein

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工业投资项目的经济分析

工业投资项目的经济分析

Analyzing neural degeneration of the retina with connectomics

作者： l.e.·布西(l.e. Bussey.)

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Neural Regeneration Research 2022年第1期17卷 113-114页

作者： Charles l.Zucker John e.Dowling Department of Molecular and Cellular Biology Harvard UniversityCambridgeMAUSA

electron microscopy(eM)provides a unique ability to visualize structural detail with a resolution orders of magnitude better than other imaging *** conventionally,its limitation is that each acquired image represents a small area with a section thickness significantly less than 100 ***,techniques have been developed that allow thousands of relatively large serial-sections to be col.e.ted and efficiently imaged at full.e. resolution,with the images then being stitched back together to produce a 3D volume.

关键词： neural image Appl.e.

Nonlinear transverse vibrations of a slightly curved beam carrying a concentrated mass

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Acta Mechanica Sinica 2009年第6期25卷 871-882页

作者： e.zkaya M.Sarigül H.Boyaci Department of Mechanical.e.gineering Celal Bayar UniversityMuradiye

In this study, a slightly curved euler Bernoulli beam carrying a concentrated mass was handled. The beam was resting on an elastic foundation and simply supported at both ends. effects of the concentrated mass on nonlin- ear vibrations were investigated. Sinusoidal and parabolic type functions were used as curvature functions. equations of motion have cubic nonlinearities because of elongations during vibrations. Damping and harmonic excitation terms were added to the equations of motion. Method of mul- tiple scales, a perturbation technique, was used for solving integro-differential.e.uation analytically. Natural frequen- cies were calculated exactly for different mass ratios, mass locations, curvature functions, and linear elastic foundation coefficients. Amplitude-phase modulation equations were found by considering primary resonance case. effects of nonlinear terms on natural frequencies were calculated. Frequency-amplitude and frequency-response graphs were plotted. Finally effects of concentrated mass and chosen curvature function on nonlinear vibrations were investigated.

关键词： Nonlinear vibrations . Slightly curved beamNonlinear elastic foundation. Concentrated mass