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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark l.Dell’Acqua brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Unsuitable use of spin and pseudospin symmetries with a pseudoscalar Cornell potential

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Chinese Physics b 2014年第9期23卷 60-61页

作者： l.b.Castro A.S.de Castro Departamento de Física CFM Universidade Federal de Santa Catarina Departamento de Física Universidade Federal do Maranho Campus Universtitrio do Bacanga Departamento de Física e Química Campus de Guaratinguet Universidade Estadual Paulista

The concepts of spin and pseudospin symmetries has been used as mere rhetorics to decorate the pseudoscalar potential [Chin. Phys. b 22 090301 （2013）]. It is also pointed out that a more complete analysis of the bou... 详细信息

关键词： Dirac equation pseudoscalar Comell potential spin symmetry pseudospin symmetry

lu–Hf constraints on pre-,syn,and post-collision associations of the Gurupi belt,brazil:Insights on the Rhyacian crustal evolution

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Geoscience Frontiers 2022年第5期13卷 336-349页

作者： Evandro l.Klein Joseneusa b.Rodrigues Geological Survey of brazil SBNQuadra 02Bloco HEd.Central Brasília1andarAsa NorteBrasília-DF CEP:70040-904Brazil GPGE–Grupo de Pesquisa em Geologia Econômica(Economic Geology Research Group) PPGG–Programa de Pós-Graduação em Geologia e GeoquímicaUniversidade Federal do ParáBelém-PABrazil

The Gurupi belt(together with the São luís cratonic fragment),in north-northeastern brazil,has been described in previous studies that used extensive field geology,structural analysis,airborne geophysics,zircon U–Pb dating,and whole-rock Sm–Nd isotope and geochemical data as a polyphase orogenic belt,with the Rhyacian being the main period of crust *** was related to a 2240 Ma to 2140 Ma accretionary processes that produced juvenile crust,which has subsequently been reworked during a collisional event at 2100±20 Ma,with little evidence of Archean *** this study,we use lu–Hf isotopic data in zircon from granitoids(including gneiss)of variable magmatic series,and amphibolite to improve the knowledge of this scenario,and investigate additional evidence of recycling of Archean ***-collisional high ba-Sr and ferroan granitoids and amphibolite formed in island arc(2180–2145 Ma),show only zircons with suprachondriticεHf values(ca.+1 to+8)indicating the large predominance of juvenile *** 10%of the data show slightly negativeεHf values(0 to-4),which have been observed in granodiorite-gneiss formed in continental arc(2170–2140 Ma),and in strongly peraluminous collisional granites(2125–2070 Ma),indicating the rework of older Paleoproterozoic to Archean components(Hf_(TDM)=2.11–3.69 Ga).A two-component mixing model using both Hf and published Nd isotope data are in line with this interpretation and indicate more than 90%of juvenile material,and less influence of Archean *** with other Rhyacian terranes that are interpreted to have been close to Gurupi in a pre-Columbia configuration(ca.2.0 Ga),our results differ from those of SEGuiana Shield,which show strong influence of Archean protoliths,and are very similar to those of the central-eastern portion of the baoulé-Mossi Domain of the West African Craton,which has also been formed largely by juvenile magmas in an accretionary-collisional orogen.

关键词： Paleoproterozoic Accretion Collision Isotope geology lu–Hf isotopes Rhyacian

Rock mechanics for design of brisbane tunnels and implications of recent thinking in relation to rock mass strength

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 676-683页

作者： l.b.McQueen A.Purwodihardjo S.V.l.barrett Golder Associates Pty ltd. 124 Pacific HighwaySt.LeonardsNSW2065Australia Golder Associates Pty ltd. 147 Coronation DriveMiltonQueensland4064Australia Golder Associates Pty ltd. Building 7Botanicca Corporate Park570 e 588 Swan StreetRichmondVictoria3121Australia

This paper explores the potential implications of recent thinking in relation to rock mass strength for future tunnelling projects in brisbane,Australia,particularly as they are constructed within deep horizons where the in situ stress magnitudes is *** mass failure mechanisms for the current tunnels in brisbane are generally discontinuity controlled and the potential for stress-induced failure is relatively *** the road tunnels which have been constructed in brisbane over the last 12 years,the strength of the more massive rock masses for continuum analysis has been estimated by the application of the Hoek-brown(H-b)failure criterion using the geological strength index(GSI)to determine the H-b parameters mb,s and *** the last few years,alternative approaches to estimating rock mass strength for‘massive to moderately jointed hard rock masses’have been proposed by others,which are built on the work completed by *** and *** in this area over their joint *** paper explores one of these alternative approaches to estimating rock mass strength for one of the geological units(the brisbane Tuff),which is often encountered in tunnelling projects in *** potential implications of these strength forecasts for future tunnelling projects are discussed along with the additional work which will need to be undertaken to confirm the applicability of such alternative strength criteria for this rock mass.

关键词： Rock mass strength Hoek-brown(H-b)failure criterion Triaxial testing brittle failure brisbane Tuff

Fragile X mental retardation protein interacts with TDG

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Chinese Science bulletin 2000年第6期45卷 516-520页

作者： bardoni b MandelJ.-l IGbMC CNRS-INSERM-ULP67404 IllkirchFrance Correspondence should be addressed to Shen YanIGBMCCNRS-INSERM-ULP67404 IllkirchFrance Correspondence Should be addressed to Shen Yan

Fragiie X syndrome is the most common form of inherited mental retardation disease, resulting from absent of expression of its disease gene FMR1. To study the function of the fragiie X mental retardation protein (FMRP) through protein/protein interaction, a mouse embryo cDNA library was screened by the yeast two-hybrid system. A clone was found to interact specifically with FMRP. The cDNA of this clone ( Genbank accession number af102875 ) encoded a protein highly homologous to human G/T mismatch-specific DNA thymine glycosylase ( hTDG ). Interactions between various alternatively spliced FMRP isoforms and a series of mTDG deletion proteins were further studied in the yeast two-hybrid system and their interaction amino acid regions were determined. interaction between FMRP and TDG existed inside exon 13 of FMRP ( amino acid residue 397-425 ) and around amino acid residue 122-346 of TDG. These results will be helpful to the study of the biological role of FMRP.

关键词： fragile X mental retardation protein G/T mismatch-specific DNA thymine glycosylase yeast two-hybrid protein/protein interaction.

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik biverstål Nicolas Gbazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa b pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Structural coupling of the Dabie Orogen with Hefei basin

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Chinese Science bulletin 1997年第18期42卷 1566-1572页

作者： Wang, QC Cong, b Ma, l laboratory of lithosphere Tectonic Evolution Institute of Geology Chinese Academy of Sciences Beijing China Division of Oil-Gas Exploration in South China Chinese National Petroleum Company Hangzhou China

Geological, geophysical and geochemical data show that both of the Dabie Orogen and Hefei basin formed during a Mesozoic orogeny. A three-stage development of the Hefei basin includes down-warping, half grabben, and positive inversion. both the uplift in orogen and the depression in basin resulted from the 'de-rooting' of orogen and up-welling of the mantle.

关键词： Dabie Orogen Hefei basin structural coupling continental dynamics.

Effects of thermophoresis particle deposition and of the thermal conductivity in a porous plate with dissipative heat and mass transfer

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Acta Mechanica Sinica 2011年第3期27卷 389-398页

作者： Joaquín Zueco O.Anwar bég l.M.lpez-Ochoa Thermal Engineering and Fluids Department Technical University of CartagenaETSII Campus Muralla del Mar Aerospace Engineering Department of Engineering and MathematicsSheaf BuildingSheffield Hallam University Mechanical Engineering Departament University of RiojaC/Luís de UlloaLogrono (La Rioja)20E-26004Spain

Network simulation method（NSM） is used to solve the laminar heat and mass transfer of an electricallyconducting,heat generating/absorbing fluid past a perforated horizontal surface in the presence of viscous and Joule heating problem. The governing partial differential equations are non-dimensionalized and transformed into a system of nonlinear ordinary differential similarity equations,in a single independent variable,畏. The resulting coupled,nonlinear equations are solved under appropriate transformed boundary conditions. Computations are performed for a wide range of the governing flow parameters,viz Prandtl number,thermophoretic coeffcient（a function of Knudsen number）,thermal conductivity parameter,wall transpiration parameter and Schmidt number. The numerical details are discussed with relevant applications. The present problem finds applications in optical fiber fabrication,aerosol filter precipitators,particle deposition on hydronautical blades,semiconductor wafer design,thermo-electronics and problems including nuclear reactor safety.

关键词： Thermophoresis . MHD . Network simulation model . Heat and mass transfer- Hartmann number

Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human

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World Journal of Gastroenterology 2007年第7期13卷 1042-1052页

作者： Vasantha l Kolachala b Sesikeran K Madhavan Nair Department of Medicine Emory University Atlanta GA United States National Institute of Nutrition Indian Council of Medical Research Jamai-Osmania PO Hyderabad 500007 India

AIM: To elucidate the sequential transfer of iron amongst ferritin, transferrin and transferrin receptor under various iron status conditions. METHODS: Incorporation of 59Fe into mucosal and luminal proteins was carried out in control WKY rats. The sequential transfer of iron amongst ferritin, transferrin and transferrin receptor was carried out in iron deficient, control and iron overloaded rats. The duodenal proteins were subjected to immunoprecipitation and quantitation by specific ElISA and in situ localization by microautoradiography and immunohistochemistry in tandem duodenal sections. Human duodenal biopsy (n = 36) collected from subjects with differing iron status were also stained for these proteins. RESUlTS: Ferritin was identified as the major protein that incorporated iron in a time-dependent manner in the duodenal mucosa. The concentration of mucosal ferritin was significantly higher in the iron excess group compared to control, iron deficient groups (731.5 ± 191.96 vs 308.3 ± 123.36, 731.5 ± 191.96 vs 256.0 ± 1.19, P le that of luminal transferrin which was significantly higher than the mucosal did not differ among the groups (10.9 ± 7.6 vs 0.87 ± 0.79, 11.1 ± 10.3 vs 0.80 ± 1.20, 6.8 ± 4.7 vs 0.61 ± 0.63, P l transfer of iron. This was demonstrated to occur through the initial binding of iron to luminal transferrin then to absorptive cell surface transferrin receptors. The staining intensity of these proteins variedaccording to the iron nutrition in humans, with intense staining of transferrin receptor observed in iron deficient subjects. CONClUSION: It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin.

关键词： Mucosa lumen Iron-binding proteins