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The Consistency of lSE Estimators in Partial linear Regression Models under Mixing Random Errors

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1244-1272页

作者： Yun Bao yao Yu Tan lÜ Chao lU Wei WANG Xue Jun WANG School of Mathematical Sciences Anhui UniversityHefei 230601P.R.China School of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000P.R.China School of Big Data and Statistics Anhui UniversityHefei 230601P.R.China

In this paper,we consider the partial linear regression model y_(i)=x_(i)β^(*)+g(ti)+ε_(i),i=1,2,...,n,where(x_(i),ti)are known fixed design points,g(·)is an unknown function,andβ^(*)is an unknown parameter to be estimated,random errorsε_(i)are(α,β)-mix_(i)ng random *** p-th(p>1)mean consistency,strong consistency and complete consistency for least squares estimators ofβ^(*)and g(·)are investigated under some mild *** addition,a numerical simulation is carried out to study the finite sample performance of the theoretical ***,a real data analysis is provided to further verify the effect of the model.

关键词： (α,β)-mixing random variables partial linear regression model least squares estimator consistency

首发精神分裂症病人静息态脑活动的纵向改变:一项随访1年的功能MRI研究

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国际医学放射学杂志 2016年第4期 441-442页

作者： F.li S.lui l.yao J.Hu P.lv X.Huang 戴群瑶 Huaxi MR Research Center Department of RadiologyWest China Hospital of Sichuan University

摘要目的探讨未经治疗的首发精神分裂症病人历经1年的抗精神病治疗后脑功能异常的变化情况以及治疗前静息态功能MRI参数与临床症状的纵向改变是否相关。材料与方法本前瞻性研究获得了伦理委员会的批准,所有参与者均签署书面知情同意书... 详细信息

摘要目的探讨未经治疗的首发精神分裂症病人历经1年的抗精神病治疗后脑功能异常的变化情况以及治疗前静息态功能MRI参数与临床症状的纵向改变是否相关。材料与方法本前瞻性研究获得了伦理委员会的批准,所有参与者均签署书面知情同意书。纳入20例未经治疗的首发精

关键词：静息态 MRI 病人精神分裂症早发性痴呆功能

Geological reservoir and resource potential(10^(13)m^(3))of gas hydrates in the South China Sea

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China Geology 2024年第3期7卷 422-444页

作者： Pi-bo Su Wei Wei Yun-bao Sun yao-yao lü Huai Cheng Wei-feng Han Wei Zhang Jin-qiang liang National Engineering Research Center for Gas Hydrate Exploration and Development Guangzhou 511458China Sanya Institute of South China Sea Geology Guangzhou Marine Geological SurveySanya 572025China Central laboratory of Geological Sciences Research Institute of Petroleum Exploration and DevelopmentLangfang 065007China Qingdao Institute of Marine Geology Qingdao 266237China laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266237China

A detailed understanding of the distribution and potential of natural gas hydrate(NGHs)resources is crucial to fostering the industrialization of those resources in the South China Sea,where NGHs are *** this study,this study analyzed the applicability of resource evaluation methods,including the volumetric,genesis,and analogy methods,and estimated NGHs resource potential in the South China Sea by using scientific resource evaluation methods based on the factors controlling the geological accumulation and the reservoir characteristics of ***,this study compared the evaluation results of NGHs resource evaluations in representative worldwise sea areas via rational *** results of this study are as follows:(1)The gas hydrate accumulation in the South China Sea is characterized by multiple sources of gas supply,multi-channel migration,and extensive accumulation,which are significantly different from those of oil and gas and other unconventional resources.(2)The evaluation of gas hydrate resources in the South China Sea is a highly targeted,stratified,and multidisciplinary evaluation of geological resources under the framework of a multi-type gas hydrate resource evaluation system and focuses on the comprehensive utilization of multi-source heterogeneous data.(3)Global NGHs resources is n×10^(15)m^(3),while the NGHs resources in the South China Sea are estimated to be 10^(13)m^(3),which is comparable to the abundance of typical marine NGHs deposits in other parts of the *** the South China Sea,the NGHs resources have a broad prospect and provide a substantial resource base for production tests and industrialization of NGHs.

关键词： Reservoir characteristics Natural gas hydrates Gas migration Resource potential Resource evaluation methods Hierarchical evaluation system Volumetric method South China Sea Clean energy exploration engineering

Detection of Neospora caninum in aborted bovine fetuses and dam blood samples by nested PCR and ElISA and seroprevalence in Beijing and Tianjin,China

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Detection of Neospora caninum in aborted bovine fetuses and ...

Machine learning and bioinformatics to identify biomarkers in response to Burkholderia pseudomallei infection in mice

中国畜牧兽医学会家畜寄生虫学分会第六次代表大会暨第十次学术研讨会

作者： l.yao,N.Yang,Q.liu~*,M.Wang,W.Zhang,W.F.Qian,Y.F.Hu,J.Ding (Key laboratory of Zoonosis of Ministry of Agriculture and National animal Protozoa laboratory,College of Veterinary Medicine, China Agricultural University,Beijing 100193,China)

*** infection is a significant cause of abortion in *** investigated the tissue distribution of Neospora caninum in aborted bovine fetuses and dam blood samples by a nested PCR assay,and compared the nested PCR with ElISA in the diagnosis of *** *** six aborted fetuses and 813 blood samples were collected from eight dairy herds in Beijing(n=212) and Tianjin(n=601),*** fetuses(57.7%) were tested *** positive by the nested *** DNA was detected from the brain of 52%,kidneys of 22%,skeletal muscle of 18%,and heart of 4%of the aborted *** PCR positive cases(55%,11/20) was higher than seropositive cows(40%,8/20) in a subset of 20 fetuses,but the PCR results of blood samples of the 20 cows were all *** seroprevalence of the 813 samples was 15.5%(43.4%of samples from Beijing,5.7%of samples from Tianjin),compared to the PCR positive blood samples of 0.9%.Our study showed that the nested PCR is a valuable diagnostic tool for the primary diagnosis of *** in aborted fetuses,while ElISA is the preferred assay for testing blood samples collected from *** two assays are complementary in determining whether abortions are associated with *** infection in cattle.

关键词： Neospora caninum ElISA Nested PCR Abortion Bovine fetus

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BIOCEll 2024年第4期48卷 613-621页

作者： yao FANG FEI XIA FEIFEI TIAN l EI QU FANG YANG JUAN FANG ZHENHONG HU HAICHAO lIU Department of Respiratory and Critical Care Medicine General Hospital of Center Theater of PLAWuhan430070China School of Medicine Wuhan University of Science and TechnologyWuhan430065China School of life Science and Engineering Southwest Jiaotong UniversityChengdu611756China

Objective:In the realm of Class I pathogens,Burkholderia pseudomallei(BP)stands out for its propensity to induce severe *** the intricate interactions between BP and host cells is imperative for comprehending the dynamics of BP infection and discerning biomarkers indicative of the host cell response ***:mRNA extraction from BP-infected mouse macrophages constituted the initial step of our *** gene expression arrays,the extracted RNA underwent conversion into digital *** percentile shift method facilitated data processing,with the identiﬁcation of genes manifesting signiﬁcant differences accomplished through the application of the ***,a comprehensive analysis involving Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway was conducted on the differentially expressed genes(DEGs).leveraging the ESTIMATE algorithm,gene signatures were utilized to compute risk scores for gene expression *** vector machine analysis and gene enrichment scores were instrumental in establishing correlations between biomarkers and macrophages,followed by an evaluation of the predictive power of the identiﬁed ***:The functional and pathway associations of the DEGs predominantly centered around G protein-coupled receptors.A noteworthy positive correlation emerged between the blue module,consisting of 416 genes,and the ***4,identiﬁed through support vector machine analysis among intersecting genes,indicated a robust interaction with macrophages,suggesting its potential as a robust ***4 exhibited commendable predictive efﬁcacy,with BP infection inducing its expression in both macrophages and mouse lung *** blotting in macrophages conﬁrmed a signiﬁcant upregulation of FZD4 expression from 0.5 to 24 h *** mouse lung tissue,FZD4 manifested higher expression in the cytoplasm of pulmonary epithelial cells in BP-infected lungs than in the

关键词： Burkholderia pseudomallei Microarray assay Machine learning Bioinformatics FZD4

Nanodiamond/Ti_(3)C_(2) MXene-coated quartz crystal microbalance humidity sensor with high sensitivity and high quality factor

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Rare Metals 2024年第6期43卷 2719-2729页

作者： yao yao Qiao Chen Yan-Qi li Xian-He Huang Wei-Wei ling Zhe-MiaoXie Jia-QiWang Chang-Ming Chen College of Communication Engineering Chengdu University of Information TechnologyChengdu 610225China School of Automation Chongqing University of Posts and TelecommunicationsChongqing 400065China School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Advanced Micro-/Nano-Devices lab Department of Systems Design EngineeringUniversity of WaterlooWaterlooON N2L 3GlCanada

To address the challenge of achieving both high sensitivity and a high quality factor in quartz crystal microbalance(QCM)humidity sensors,a nanodiamond(ND)/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor was *** material characteristics of ND,Ti_(3)C_(2)MXene,and ND/Ti_(3)C_(2)MXene composite were analyzed by transmission electron microscopy(TEM)and Fourier transform infrared(FTIR)*** experimental results demonstrated that the hydrophilic ND nanoparticles coated on Ti_(3)C_(2) MXene nanosheet prevented the self-stacking of Ti_(3)C_(2)MXene and enhanced the sensitivity of Ti_(3)C_(2) MXene-based QCM humidity ***,the high mechanical modulus of Ti_(3)C_(2) MXene material helped ND/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor to achieve a high quality factor(>20,000).ND/Ti_(3)C_(2)MXene compositecoated QCM humidity sensor exhibited a sensitivity of 82.45 Hz/%RH,a humidity hysteresis of 1.1%RH,fast response/recovery times,acceptable repeatability,and good stability from 11.3%RH to 97.3%*** response mechanism of ND/Ti_(3)C_(2) MXene composite-coated QCM humidity sensor was analyzed in combination with a bi-exponential kinetic adsorption ***,the potential application of ND/Ti_(3)C_(2)MXene composite-coated QCM humidity sensor was demonstrated through its frequency response to wooden blocks with different moisture contents.

关键词： Humidity sensor Quartz crystal microbalance Nanodiamond Ti_(3)C_(2)MXene High quality factor

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

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Marine life Science & Technology 2024年第3期6卷 502-514页

作者： Jian-Yu liu yao-yao Jiang Peng-Jie li Bo yao Yi-Jing Song Ji-Xiu Gao Gulab Said Yang Gao Jun-Yu lai Chang-lun Shao Key laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan laoshan laboratory Qingdao 266237China Key laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82(IC50=0.079 and 0.081μmol/l)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model(TGI=52.63%)and prolonged the survival time(IlS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKT EGFR/ERK T-cell infiltration

Enhancing crystal integrity and structural rigidity of CsPbBr_(3) nanoplatelets to achieve a narrow colorsaturated blue emission

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light(Science & Applications) 2024年第5期13卷 985-997页

作者： Qianqian Huang Wenxu Yin Bo Gao Qingsen Zeng Dong yao Hao Zhang Yinghe Zhao Weijia Zheng Jiaqi Zhang Xuyong Yang Xiaoyu Zhang Andrey l.Rogach Key laboratory of Automobile Materials MOE School of Materials Science&Engineeringand Jilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchunChina. State Key laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunChina. State Key laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanHubeiChina. Department of Chemistry University of VictoriaVictoriaBCCanada. Key laboratory of Advanced Display and System Applications of Ministry of Education Shanghai UniversityShanghaiChina. Department of Materials Science and Engineering and Centre for Functional Photonics(CFP)City University of Hong KongHong Kong S.A.RChina

Quantum-confined CsPbBr_(3) perovskites are promising blue emitters for ultra-high-definition displays,but their soft lattice caused by highly ionic nature has a limited ***,we endow CsPbBr_(3) nanoplatelets(NPls)with atomic crystal-like structural rigidity through proper surface engineering,by using strongly bound N-dodecylbenzene sulfonic acid(DBSA).A stable,rigid crystal structure,as well as uniform,orderly-arranged surface of these NPls is achieved by optimizing intermediate reaction stage,by switching from molecular clusters to mono-octahedra,while interaction with DBSA resulted in formation of a Cs_(x)O monolayer shell capping the NPl *** a result,both structural and optical stability of the CsPbBr3 NPls is enhanced by strong covalent bonding of DBSA,which inhibits undesired phase transitions and decomposition of the perovskite phase potentially caused by ligand ***,rather small amount of DBSA ligands at the NPl surface results in a short inter-NPl spacing in their closely-packed films,which facilitates efficient charge injection and *** photoluminescence of the produced CsPbBr_(3) NPls is bright(nearly unity emission quantum yield)and peaks at 457 nm with an extremely narrow bandwidth of 3.7 nm at 80 K,while the bandwidth of the electroluminescence(peaked at 460 nm)also reaches a record-narrow value of 15 nm at room *** value corresponds to the CIE coordinates of(0.141,0.062),which meets Rec.2020 standards for ultra-high-definition displays.

关键词： temperature stability narrow

Population genomic analysis reveals key genetic variations and the driving force for embryonic callus induction capability in maize

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Journal of Integrative Agriculture 2024年第7期23卷 2178-2195页

作者： Peng liu langlang Ma Siyi Jian yao He Guangsheng Yuan Fei Ge Zhong Chen Chaoying Zou Guangtang Pan Thomas lübberstedt yaou Shen State Key laboratory of Crop Gene Exploration and Utilization in Southwest China/Maize Research Institute Sichuan Agricultural UniversityChengdu 611130China Department of Agronomy Iowa State UniversityAmesIA 50011USA

Genetic transformation has been an effective technology for improving the agronomic traits of ***,it is highly reliant on the use of embryonic callus(EC)and shows a serious genotype *** this study,we performed genomic sequencing for 80 core maize germplasms and constructed a high-density genomic variation map using our newly developed pipeline(MQ2Gpipe).Based on the induction rate of EC(REC),these inbred lines were categorized into three *** low-REC germplasms displayed more abundant genetic diversity than the high-REC *** integrating a genome-wide selective signature screen and region-based association analysis,we revealed 95.23 Mb of selective regions and 43 REC-associated *** variants had phenotypic variance explained values ranging between 21.46 and 49.46%.In total,103 candidate genes were identified within the linkage disequilibrium regions of these REC-associated *** genes mainly participate in regulation of the cell cycle,regulation of cytokinesis,and other functions,among which MYB15 and EMB2745 were located within the previously reported QTl for EC *** leaf area-associated variants with large effects were closely linked to several REC-related loci,implying a potential synergistic selection of REC and leaf size during modern maize breeding.

关键词： maize genetic transformation embryonic callus selective signal association analysis