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lenalidomide regulates the CCl21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： WEN yANG BIN tang DAN XU WENXIU yANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DlBCl)has been reported ***,the detailed mechanisms of CCR7 in DlBCl,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHl-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DlBCl were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DlBCl to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DlBCl cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DlBCl via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCl21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHl-2 and OCI-ly3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total lDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHl-2 xenograft model in nude mice(plusion:Our study clarifies the potential role of the CCl21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DlBCl treatment.

关键词： CCR7 CCl21 ERK1/2 lenalidomide Diffuse large B-cell lymphoma(DlBCl)

Dispatchable Capability of Aggregated Electric Vehicle Charging in Distribution Systems

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Energy Engineering 2025年第1期122卷 129-152页

作者： ShiqianWang Bo liu yuanpeng Hua Qiuyan li Binhua tang Jianshu Zhou yue Xiang Economic and Technology Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China College of Electrical Engineering Sichuan UniversityChengdu610065China

This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable *** methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable *** results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly ***,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.

关键词： Aggregated charging dispatchable capability peak shaving and valley filling the economics of charging demand response

A six-variable quasi-3D isogeometric approach for free vibration of functionally graded graphene origami-enabled auxetic metamaterial plates submerged in a fluid medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 157-176页

作者： Wei CHEN Zhihong tang yufen lIAO linxin PENG College of Civil Engineering University of South China College of Civil Engineering and Architecture Guangxi University Key laboratory of Disaster Prevention and Structural Safety of Ministry of Education Guangxi University

This paper presents, for the first time, an effective numerical approach based on the isogeometric analysis(IGA) and the six-variable quasi-three dimensional(3D)higher-order shear deformation theory(HSDT) to study the free vibration characteristics of functionally-graded(FG) graphene origami(GOri)-enabled auxetic metamaterial(GOEAM) plates submerged in a fluid medium. The plate theory incorporates the thickness stretching and the effects of transverse shear deformation without using any shear correction factors. The velocity potential function and Bernoulli's equation are used to derive the hydrodynamic pressure acting on the plate surface. Both horizontally and vertically immersed plate configurations are considered here in the form of inertia *** plates are composed of multilayer GOEAMs, with the GOri content varying through the plate's thickness in a layer-wise manner. This design results in graded auxetic *** material properties are evaluated by mixing rules and a genetic programming(GP)-assisted micromechanical model. The governing equations of motion for the FG-GOEAM plates immersed in a fluid medium are derived by Hamilton's principle. After validating the convergence and accuracy of the present model, a comprehensive parametric study is carried out to examine the effects of the GOri content, GOri distribution pattern, GOri folding degree, fluid level, immersed depth, and geometric parameter on the natural frequencies of the FG-GOEAM plates. The results show that the natural frequencies for the four GOri distribution patterns increase with the increase in the layer number when the lay number is fewer than 10, and then stabilize after the layer number reaches ***, in general, the natural frequency of the FG-GOEAM plate in a vacuum or fluid increases when the GOri content increases, while decreases when the GOri folding degree increases. Some additional findings related to the numerical results are presented in the conclusions. It is belie

关键词： Equations of motion

Preparation of Modified Composite Nanofiltration Membrane Synergistically Using Carboxylic Multi- walled Carbon Nanotube and β-cyclodextrin

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 232-239页

作者： lIU Peng MAO Junpeng FANG yanfeng yU yunwu CHEN Changxiu tang Ning WAN ye GU yaxin lIU yunxue WANG lihua School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new modified blend ultrafiltration(UF)membrane with good hydrophilicity,high porosity and excellent anti-fouling performance was developed by using carboxylic multi-walled carbon nanotube(CMWCNT)as casting solution ***,a composite nanofiltration(NF)membrane with large water flux and good retention rate was fabricated by using the PVDF/CMWCNT blend UF membrane as the substrate,and polyvinyl alcohol(PVA),β-cyclodextrin(β-CD)and polyethylenimine(PEI)as the coating *** results show that with the appropriate addition of CMWCNT in the casting solution,the surface roughness,porosity and recovery rate of the PVDF/CMWCNT blend UF membrane is obviously *** water flux of blend UF membrane is significantly improved when the CMWCNT content increases from 0 wt%to 0.2 wt%.The water flux of blend UF membrane with 0.2 wt%CMWCNT is 162.7 l/(m^(2)·h),which is 44.3%higher than that of the pure PVDF ***β-CD content is 0.8 wt%,the retention rate of Congo red by PVDF/CMWCNT/β-CD composite NF membrane reaches 98.7%,which is 28.3%higher than that of single PVA/PEI modified *** research will provide a new idea and simple method for developing novel high-performance composite NF membranes.

关键词： CMWCNT cyclodextrin nanofiltration membrane

Integration of perioperative features and intragraft TCF7l2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China life Sciences 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing lian Xuanyu Zhang linsong tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key laboratory of Combined Multi-Organ Transplantation Key laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, liver transplantation(lT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after lT, is one of the major post-transplant complications(Toshima et al., 2020).

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Overexpression of Arabidopsis thaliana malonyl-CoA synthetase gene enhances cold stress tolerance by activating mitogen-activated protein kinases in plant cells

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Journal of Forestry Research 2021年第2期32卷 741-753页

作者： Wei tang Anna y.tang College of Arts and Science East Carolina UniversityGreenvilleNC 27858USA 101 Stadium Drive University of North Carolina at Chapel HillChapel HillNC 27514USA

Malonyl-CoA synthetases may modulate cell responses to abiotic stress by regulating stress-related signaling transduction pathways or activating expression of transcription ***,the molecular mechanism of cold stress tolerance enhanced by malonyl-CoA synthetase is not fully ***,we report that overexpression of the Arabidopsis thaliana malonyl-CoA synthetase gene AAE13.1 resulted in increased cell viability and growth rate and decreased thiobarbituric acid reactive substances under cold stress in rice(Oryza sativa l.),tobacco(Nicotiana tabacum),and slash pine(Pinus elliottii Engelm.).AAE13.1 was associated with cold stress tolerance by increasing the activity of ascorbate peroxidase,catalase,polyphenol oxidase,and peroxidase and the accumulation of acid phosphatase and alkaline *** six rice mitogenactivated protein kinase(MAPK)genes examined,AAE13.1 overexpression increased the expression of OsMAPK genes during cold ***13.1 activated expression of stressresponse genes OsMAPK1,OsMAPK2,and OsMAPK3,indicating that AAE13.1 enhances cold stress tolerance by regulating expression of MAPK genes in plant *** results increase our understanding of cold stress tolerance in species of monocotyledons,dicotyledons,and gymnosperms.

关键词： Cold stress Malonyl-CoA synthetase gene MAPK transcription factor Phosphatase Pinus

Overexpression of Arabidopsis thaliana cysteine2/histidine2-type transcription factor 6 gene enhances plant resistance to a bacterial pathogen

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Journal of Forestry Research 2021年第1期32卷 249-262页

作者： Wei tang Anna y.tang College of Arts and Science East Carolina UniversityGreenvilleNC 27858USA 2 Stadium Drive University of North Carolina at Chapel HillChapel HillNC 27514USA

Transcription factors can be used to engineer plants for enhanced ***,the mechanism(s)by which the C2H2-type zinc fi nger transcription factor enhances pathogen resistance in cells is not fully ***,Agrobacterium tumefaciens carrying the gene for Arabidopsis thaliana cysteine2/histidine2-type transcription factor 6(ZAT6)was used to engineer rice(Oryza sativa l.),cotton(Gossypium hirsutum l.),and slash pine(Pinus elliottii Engelm.)to generate transgenic cell *** cells were then inoculated with the pathogenic bacterium Pseudomonas *** to the control,cell viability of transgenic cells increased 39–47%and growth rate increased 9–15%by 7 days after inoculation in rice,cotton and slash *** phosphatase activity and alkaline phosphatase activity and transcript levels of Ca 2+-dependent protein kinase genes OsCPK1,OsCPK2,OsCPK6,and OsCPK8 and mitogen-activated protein kinase genes OsMAPK1,OsMAPK2,OsMAPK3,and OsMAPK8 increased signifi cantly in transgenic rice cells by 3 day after inoculation,and extracellular pH had decreased by 10–14%by 96 min after inoculation in transgenic rice,cotton and slash pine *** results suggest that ZAT6 enhances *** resistance in plant cells by modulating transcription of CPK and MAPK and oxidase activity.

关键词： Ca^2+-dependent protein kinase Mitogenactivated protein kinase Oxidase Pathogen Pinus

MicroRNAs associated with molecular mechanisms for plant root formation and growth

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Journal of Forestry Research 2016年第1期27卷 1-12页

作者： Wei tang Anna y.tang Department of Biology East Carolina University 101 Stadium Drive University of North Carolina at Chapel Hill

Although roots are so important for plant growth and crop productivity, the molecular mecha- nism（s） of root formation and growth is not fully under- stood. To increase our understanding of the underlying molecular mechanisms, here we review microRNA regu- lation of processes related to root formation： the regulation of transcription factors, nutrient uptake, stress signaling, and growth signaling. We have summarized the interaction, expression, transport, and signaling events that involve microRNAs in ideal and stressed conditions in a number of model plants, highlighting the involvement of microRNAs in root formation. MicroRNAs are now known to be important players in root initiation, development, and growth; understanding the precise mechanisms involved will be valuable for plant molecular breeding to develop high-yielding crops with high stress resistance and low nutrient requirements.

关键词： MicroRNAs, Nutrient. Root formationStress response Transcription factor

Genome engineering technologies for targeted genetic modification in plants

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Journal of Forestry Research 2018年第4期29卷 875-887页

作者： Wei tang Anna y. tang College of Arts and Science East Carolina University Greenville NC 27858 USA University of North Carolina at Chapel Hill 101 Stadium Drive Chapel Hill NC 27514 USA

Well-established targeted technologies to engi- neer genomes such as zinc-finger nuclease-based editing （ZFN）, transcription activator-like effector nuclease-based editing （TAlEN）, and clustered regularly interspaced short palindromic repeats and associated protein system-based editing （CRISPR/Cas） are proving to advance basic and applied research in numerous plant species. Compared with systems using ZFNs and TAlENs, the most recently developed CRISPR/Cas system is more efficient due to its use of an RNA-guided nuclease to generate double-strand DNA breaks. To accelerate the applications of these technologies, we provide here a detailed overview of these systems, highlight the strengths and weaknesses of each, summarize research advances made with these technologies in model and crop plants, and discuss their applications in plant functional genomics. Such targeted approaches for genetically modifying plants will benefit agricultural production in the future.

关键词： Double-stranded DNA break Genomeediting CRISPR system Transcription activator-likeeffector nucleases Zinc-finger nucleases