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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.l.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei l.l.Cham-Pérez Jeroen leijten Su Ryon shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA leijten lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National laboratory for Agriculture(lNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna Jung Chaesun Kwon Taeyeon Kim Jin Woo lee Min-Kyoo shin Sang Hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROESY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/l of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

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Euler Product Expressions of Absolute Tensor Products of Dirichlet l-Functions

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Advances in Pure Mathematics 2024年第6期14卷 451-486页

作者： Hidenori Tanaka shin-ya Koyama Department of Biomedical Engineering Toyo University Saitama Japan Department of Mechanical Engineering Toyo University Saitama Japan

In this paper, we calculate the absolute tensor square of the Dirichlet l-functions and show that it is expressed as an Euler product over pairs of primes. The method is to construct an equation to link primes to a series which has the factors of the absolute tensor product of the Dirichlet l-functions. This study is a generalization of Akatsuka’s theorem on the Riemann zeta function, and gives a proof of Kurokawa’s prediction proposed in 1992.

关键词： Dirichlet l-Function Absolute Tensor Product (Kurokawa Tensor Product) Euler Product

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非急诊的小肠梗阻:通过CT检查评估是否需要手术

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国际医学放射学杂志 2011年第4期 395-395页

作者： S.D.Deshmukh D.S.shin J.K.Willmann J.Rosenberg l.shin R.B.Jeffrey 李志明 Department of Radiology Stanford University School of Medicine

目的认识需要手术处置的非急诊小肠梗阻的CT表现。方法 129例非急诊的小肠梗阻病人接受腹部CT增强检查,然后进行一系列评估,包括小肠的管径、肠壁的厚度、是否存在小肠粪便症(扩张小肠腔内的颗粒状物质)、梗阻的长度、梗阻点、黏膜下水... 详细信息

目的认识需要手术处置的非急诊小肠梗阻的CT表现。方法 129例非急诊的小肠梗阻病人接受腹部CT增强检查,然后进行一系列评估,包括小肠的管径、肠壁的厚度、是否存在小肠粪便症(扩张小肠腔内的颗粒状物质)、梗阻的长度、梗阻点、黏膜下水肿、肠系膜脂肪浑浊(条索状影)、腹

关键词：小肠梗阻 CT 外科手术梗阻程度小肠粪便症

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Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： shin Woo Kang Sung Hee lim Min-Ji Kim Jeeyun lee Young Suk Park Ho Yeong lim Won Ki Kang Seung Tae Kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-l1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of *** This analysis included CRC patients who received bevacizumab plus FOlFOX or FOlFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-l1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-l1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOlFIRI or FOlFOX as the first-line *** 77%of patients received FOlFOX,23%received FOlFIRI as backbone first-line *** numbers of patients with a PD-l1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDl1 CPS less than 1 and those with PD-l1 CPS of 1 or more(PD-l1l1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-l1 CPS less than 5 and of 5 or more(PD-l1l1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-l1 CPS less than 10 and of 10 or more(PD-l1l1≥10%;PFS:P=0.529,OS:P=0.568).CONClUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-l1 expression.

关键词： Bevacizumab Colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji lee Dae-Geun Song Jae Woo Jung Haesong lee Eun-Ae shin Yangie Pinanga Kyung-hee Pyo Eun Hae lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon liu Jung Weon lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 l six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MlCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MlCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MlCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MlCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Numerical study on the performance of nozzle flow for supersonic chemical oxygen-iodine lasers

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Acta Mechanica Sinica 2008年第2期24卷 133-142页

作者： Zongmin Hu Junming lā Zonglin Jiang Rho-shin Myong Tae-Hwan Cho lHD Institute of MechanicsCAS Beijing 100080 China Research Center for Aircraft Parts Technology Geyongsang National University Jinju 660-701 South Korea

laser performance is greatly dependent on its operating conditions due to the strong coupling among multi- physics such as gas-dynamics, chemical reaction kinetics and optics in the mixing nozzle of COIl. In this paper, 3D CFD technology is used to simulate the mixing and reactive flow of subsonic cross jet scheme at different conditions. Results obtained show that the jet penetration depth plays a dominant role in the spatial distribution of small signal gains. In the case of over-penetration, unsteady flow structures are induced by impinging between the opposing jets. The optimum spatial distribution of the chemical performance cannot be obtained even if the full penetration condition is achieved through the subsonic transverse jet mixing scheme in the COIl nozzle flow.

关键词： Chemical oxygen-iodine laser (COIl) Numerical simulation Small signal gains Unsteady structures

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Evaluation of leaching characteristic and kinetic study of lithium from lithium aluminum silicate glass-ceramics by NaOH

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Journal of Environmental Sciences 2021年第9期33卷 98-110页

作者： Dongseok lee Sung-Ho Joo Dong Ju shin Shun Myung shin Resources Recovery Research Center Korea Institute of Geoscience and Mineral Resources(KIGAM)124 Gwahak-roYuseong-guDaejeon 34132Republic of Korea Department of Resources Recycling University of Science and Technology(UST)217Gajeong-roYuseong-guDaejeon 34113Republic of Korea

The behavior and mechanism of li leaching from lithium aluminum silicate glass-ceramics which can be used as a secondary source of li using aqueous NaOH solution was *** li leaching efficiency is increased with increasing concentration of NaOH, specific surface area, and reaction *** leached under optimum conditions, 2 mol/l NaOH, 53 μm particle undersize, 1:10 solid/liquid ratio, 250 r/min stirring speed, 100℃ reaction temperature, 12 hr, the li leaching efficiency was approximately 70%.However, when the leaching experiment was performed for 48 hr, the concentration of li+ ions contained in the leach liquor decreased from 1160 to 236 mg/*** investigate the origin of this phenomenon, the obtained leach residue was analyzed by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray *** analyses show that zeolite was formed around the lithium aluminum silicate glass-ceramics, which affected the leaching of by adsorbing li+ *** addition, using the shrinking-core model and the Arrhenius equation, the leaching reaction with NaOH was found to depends on the chemical reaction of the two reactants, with a higher than 41.84 kJ/mol of the activation energy.

关键词： lithium aluminum silicate glass-ceramics NaOH lithium leaching

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Random lasing detection of structural transformation and compositions in silk fibroin scaffolds

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Nano Research 2019年第2期12卷 289-297页

作者： SungYeun Yang Soocheol Kim Hyeln shin Seung Ho Choi Young l. Kim Chulmin Joo WonHyoung Ryu Department of Mechanical Engineering Yonsei University Yonsei-ro 50 Seodaemun-gu Seoul 03722 Republic of Korea Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana 47907 USA Present address: Center of Bio Microsystems Korea Institute of Science and Technology (KIST) Hwarang-ro Seongbuk-gu Seoul 02792 Republic of Korea School of Electrical Engineering University of Ulsan Daehak-ro Nam-gu Ulsan 44610 Republic of Korea

In tissue engineering, microstructure and material composition of tissue scaffolds have major influences on the proliferation and differentiation of cells in the scaffolds. However, once tissue scaffolds implanted, it is extremely difficult to monitor the change of their microstructure and compositions during tissue regeneration. Here, we report how random lasing can be utilized to non-invasively monitor the structure and composition of scaffolds. We hypothesize that morphological and compositional change of silk fibroin (SF) scaffolds can be conveniently detected based on random lasing responses. Engineered SF scaffolds with hydroxyapatite (HAP) nanoparticles and controlled pore alignment were fabricated, and their random lasing responses were analyzed depending on the concentration of HAP nanoparticles and the degree of,:internal pore alignment. We also examined the real-time random lasing responses of porous SF scaffolds by applying a compressive force to' the scaffolds. Introduction of HAP nanoparticles lowered the lasing thresholds and narrowed the random lasing (Rl) width dramatically, which :is likely due to the increase in heterogeneity in both refractive index and physical arrangement within the SF and HAP composites. The strong dependency of Rl response on pore alignment was also measured and validated by numerical calculation with the finite element method (FEM).Finally, real-time monitoring of Rl on compressed scaffolds demonstrated the possibility of using Rl as a monitoring tool for structural change of SF scaffolds in vivo.

关键词： random lasing silk fibroin porous scaffolds aligned pore structure electrospinning hydroxyapatite

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Clinical application of repetitive transcranial magnetic stimulation in stroke rehabilitation

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Neural Regeneration Research 2012年第8期7卷 627-634页

作者： Joonho shin EunJoo Yang KyeHee Cho Carmelo l Barcenas Woo Jin Kim Nam-Jong Paik Department of Rehabilitation Medicine Bundang Hospital College of Medicine Seoul National University

Proper stimulation to affected cerebral hemisphere would promote the functional recovery of patients with stroke. Effects of repetitive transcranial magnetic stimulation on cortical excitability can be can be altered by the stimulation frequency, intensity and duration. There has been no consistent recognition regarding the best stimulation frequency and intensity. This study reviews the intervention effects of repetitive transcranial stimulation on motor impairment, dysphagia, visuospatial neglect and aphasia, and summarizes the stimulation frequency, intensity and area for repetitive transcranial magnetic stimulation to yield the best therapeutic effects.

关键词： stroke repetitive transcranial magnetic stimulation rehabilitation review

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