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Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

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Plant Communications 2024年第6期5卷 246-262页

作者： George Heslop-Harrison Kazumi Nakabayashi Ana Espinosa-Ruiz Francesca Robertson Robert Baines Christopher R.l.Thompson Katrin Hermann David Alabadí Gerhard leubner-Metzger Robin s.B.williams Centre for Biomedical.s.iences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Instituto de Biología Molecular y Celular de Plantas(CsIC-UPV) 46022 ValenciaSpain Centre for life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a cl.s. of natural products released by plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighboring *** how allelochemicals function to regulate plant responses may provide valuable new approaches to better control plant *** such allelochemical,Myrigalone A(MyA)produced by Myrica gale,inhibits seed germination and seedling growth through an unknown ***,we investigate MyA using the tractable modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carboxylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct binding of MyA to ACO within the catalytic *** ***,ablation of ACO mimics the MyA-dependent developmental delay,which is partially restored by exogenous ethylene,and MyA reduces ethylene *** Arabidopsis thaliana,MyA treatment delays seed germination,and this effect is rescued by exogenous *** also mimics the effect of establ.s.ed ACO inhibitors on root and hypocotyl extension,blocks ethylenedependent root hair production,and reduces ethylene ***,in silico binding anal.s.s identify a rangeof highlypotentethylene inhibitorsthatblock ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism by which the allelochemical MyA reduces ethylene biosynthesis and identify a range of ultrapotent inhibitors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carboxylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhibitors structure-activity relationship

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颈动脉狭窄报告标准的巨大差异性:127名退伍军人事务医疗中心的回顾性研究

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国际医学放射学杂志 2013年第2期 168-169页

作者： E.M. Cheng D.M. Bravata s. El.s.den s.D. Vassar s. Ofner l.s. williams 李宁 Departments of Neurology VA Greater Los Angeles Healthcare System 11301 Wilshire Blvd ML 127 Los Angeles CA 90073

目的确定放射学报告在描述临床上明显的颈动脉狭窄时是否采用可供临床医师参考的一致的标准。材料与方法本研究符合HIPAA。免除知情同意。本回顾性图表分析经机构审查委员会批准,包括2006—2007年间退伍军人医疗中心的127例缺血性中风... 详细信息

目的确定放射学报告在描述临床上明显的颈动脉狭窄时是否采用可供临床医师参考的一致的标准。材料与方法本研究符合HIPAA。免除知情同意。本回顾性图表分析经机构审查委员会批准,包括2006—2007年间退伍军人医疗中心的127例缺血性中风的住院病人的颈动脉成像的放射学报告。临床显著结果是指狭窄至少50%或者至少中度狭窄,不包括完全闭塞。评估临床显著结果报告为确切狭窄分数(例如,60%),范围(例如,50%～69%)或分级(例如,中度)的频率。评估当结果报告为一个范围时,该范围被界定为50%和70%的临床阈值的频率(通常用于确定合适的颈动脉血运重建)。结果在2675例病人的6618个颈动脉成像结果中,1015个(15%)结果被认为具有显著临床意义。超声显示的695个临床显著结果中,348个(50%)被描述为一个范围,另外314个(45%)报告为一个确切的狭窄百分数。在348个报告为一个范围的具有显著临床意义的超声结果中,259个(74%)结果阈值被界定为50%～70%。对于MR血管成像,48%(106/221)的临床显著结果定性描述为一个分级,38%(84/221)描述为确切的狭窄百分数,14%(31/221)描述为一个范围。结论对于临床显著的颈动脉狭窄的报告方式在国家医疗服务系统中存在巨大差别。

关键词：颈动脉狭窄放射学医疗中心退伍军人

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Artificial intelligence anal.s.s of videos to augment clinical assessment:an overview

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Neural Regeneration Research 2024年第4期19卷 717-718页

作者： David C.Wong stefan williams University of leeds leeds Teaching Hospitals Trust LeedsUK

Observation is a fundamental part of the practice of clinical *** of movement is particularly important for the *** such as Parkinson’s disease,multiple sclerosis,stroke,epilepsy,and many others affect a person’s movement in characteristic *** some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of *** clinician’s detection of a characteristic abnormality,and their judgment of its severity,plays a central role in both diagnosis and the assessment of prognosis or response to ***,that practice depends upon a limited resource of experienced *** addition,these experts are limited by human visual judgment,which cannot reliably or precisely detect and measure small or subtle changes in movement(williams et al.,2023).

关键词： clinical epilepsy diagnosis

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.smith Jessica l.williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(Ms) is a chronic inflammatory and demyelinating disease of the central nervous system(CNs). Patients with Ms experience sensory and motor function l.s. due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout:Insights and therapeutic strategies

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World Journal of Gastroenterology 2024年第40期30卷 4404-4410页

作者： Abhay Kumar singh siva sundara Kumar Durairajan Ashok Iyaswamy leonard l williams Department of Microbiology School of Life SciencesCentral University of Tamil NaduTiruvarurTN 610005India school of Biomedical.s.iences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China school of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Biochemistry Karpagam Academy of Higher EducationCoimbatore 641021India Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State UniversityGreensboroNC 27411United States

Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney *** gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy *** article focused on the complex interconnection between alterations in the gut microbiota and the development of this *** studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establ.s.ing and progressing HUA and gout ***,we discussed how the gut microbiota contributes to HUA through purine metabol.s.,UA excretion,and intestinal inflammatory *** examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways ***,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and *** also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.

关键词： Gut microbiota Dysbiosis Gout Hyperuricemia Inflammation Intestinal barrier Probiotics Prebiotics Fecal microbiota transplantation

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Experimental implementation of phase triplicator gratings in a spatial light modulator

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Chinese Optics letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar sánchez-lópez Ignacio Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Física Aplicada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a triplicator,a phase grating that generates three equiintense diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be easily reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all cases,a liquid-crystal-on-silicon spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation triplicator spatial light modulators

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Effect of radiative l.s. mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite gl.s.es

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.l.s.lva l.A.O.Nunes s.M.lima l.H.C.Andrade Optical and Photothermal.s.ectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of são Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite gl.s.es are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite gl.s.(sampl.s.doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** resul.s.indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profil.s.caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for sampl.s.doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite gl.s. Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

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Weighted Probability Density Estimator with Updated Bandwidths

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Journal of systems science & Complexity 2024年第2期37卷 886-906页

作者： WU Yi YU Wei WANG Xuejun PRAKAsA RAO B l s school of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000China school of Big Data and statistics Anhui UniversityHefei 230601China CR Rao Advanced Institute of Mathematics Statistics and Computer ScienceHyderabad 500046India

In this paper,the authors study a cl.s. of weighted version of probability density *** is shown that the weighted estimator contains some existing estimators of probability density,no matter they are recursive or *** statistical resul.s.including weak consistency,strong consistency,rate of strong consistency,and asymptotic normality are establ.s.ed under some mild ***,the random weighted estimator is also *** numerical.s.mulations and a real data anal.s.s are presented to study the numerical performances of the estimators.

关键词： Asymptotic normality consistency numerical.s.mulation probability density real data anal.s.s updated bandwidths weighted estimator

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Model Change Active learning in Graph-Based semi-supervised learning

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1270-1298页

作者： Kevin s.Miller Andrea l.Bertozzi Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLos AngelesCA 90095USA

Active learning in semi-supervised cl.s.ification involves introducing additional labels for unlabelled data to improve the accuracy of the underlying cl.s.ifier.A challenge is to identify which points to label to best improve performance while limiting the number of new labels."Model Change"active learning quantifies the resulting change incurred in the cl.s.ifier by introducing the additional label.s..We pair this idea with graph-based semi-supervised learning(ssl)methods,that use the spectrum of the graph laplacian matrix,which can be truncated to avoid prohibitively large computational and storage *** consider a family of convex l.s. functions for which the acquisition function can be efficiently approximated using the laplace approximation of the posterior *** show a variety of multicl.s. exampl.s.that ill.s.rate improved performance over prior state-of-art.

关键词： Active learning Graph-based methods semi-supervised learning(ssl) Graph laplacian

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Resource management at the network edge for federated learning

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Digital Communications and Networks 2024年第3期10卷 765-782页

作者： silvana Trindade luiz F.Bittencourt Nelson l.s.da Fonseca Institute of Computing State University of CampinasCampinasBrazil

Federated learning has been explored as a promising solution for training machine learning models at the network edge,without sharing private user *** limited resources at the edge,new solutions must be developed to leverage the software and hardware resources as the existing solutions did not focus on resource management for network edge,specially for federated *** this paper,we describe the recent work on resource manage-ment at the edge and explore the challenges and future directions to allow the execution of federated learning at the *** such as the discovery of resources,deployment,load balancing,migration,and energy effi-ciency are discussed in the paper.

关键词： Resource management Edge computing Federated learning Machine learning

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