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GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 680-682页

作者： Junzi chen Zhongxia li Yi Wang liying chen Key laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province First Affiliated Hospital and School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou310053China Department of Pharmacy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Epilepsy,one of the most common central nervous system disorders,affects about 70 million people of all ages worldwide[1].It is characterized by hyperactive neuronal networks,resulting from imbalanced excitatory and inhibitory *** the development of multiple next-generation anti-seizure medicines,one-third of epilepsy patients are still drug-resistant[2].

关键词： epilepsy Therapy seizure

Terahertz sensing with a 3D meta-absorbing chip based on two-photon polymerization printing

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Photonics Research 2024年第5期12卷 895-903页

作者： XUEER chen lONGFANG YE DAqUAN YU School of Electronic Science and Engineering Xiamen UniversityXiamen 361005China Institute of Electromagnetics and Acoustics Xiamen UniversityXiamen 361005China Xiamen Sky Semiconductor Technology Co. Ltd.Xiamen 361026China

The narrowband meta-absorbers exhibit significantly enhanced electromagnetic confinement capabilities, showcasing broad application prospects in sensing fields. They can be applied for biomarker detection, chemical composition analysis, and monitoring of specific gas in the environment. In this work, we propose a 3D meta-absorber with an out-of-plane plasma mechanism based on a two-photon printing system. Compared to the conventional fabrication of a metal-insulator-metal 2D meta-absorber, the 3D absorber is composed of a metal layer and a resin layer from top to bottom;its manufacturing process is simpler, only including two-photon printing and magnetron sputtering deposition. A noticeable absorbing resonance appears at 0.3142 THz with perfect absorbance with a high q-factor of 104.67. The theoretical sensitivity to the refractive index of the sensor reaches up to172.5 GHz/RIU, with a figure of merit (FOM) of 19.56. In the experiments, it was validated as a meta-absorber with high sensitivity for doxycycline (DCH). As the DCH concentration increases from 0 to 4 mg/ml, the absorption intensity decreases around 49%, while the resonant frequency shift is around 70 GHz. It reflects the real-time residual content of DCH, and is potentially applied in trace antibiotic detection. The results showcase a perfect narrowband absorption capability with strong electromagnetic confinement in the terahertz spectrum, along with high-q sensing characteristics of DCH. Compared to 2D metamaterials, the diversity of3D metamaterial significantly expands, and introduces additional effects to provide greater flexibility in manipulating electromagnetic waves. The 3D device offers opportunities for the application of terahertz biochemical sensing.

关键词： absorber printing absorbing

Developing a novel quantitative parameter for characterizing spatial distribution of fish following exposure to chemicals and wastewater:Behavioral Gini coefficient

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Journal of Environmental Sciences 2024年第7期141卷 129-138页

作者： Xuanyue chen Yuanyuan li Zhanfen qin State Key laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

While the spatial distribution pattern of fish is increasingly used for toxicological test o chemicals or wastewater,no ideal parameter is available for quantitative assessment of spa tial distribution,especially uneven distribution with multiple ***,to develop a quantitative assessment parameter for spatial distribution,the zebrafish were exposed to ethanol,pentylenetetrazole(PTZ),paraquat dichloride(paraquat)and wastewater,followed by a behavioral test in a narrow *** data was acquired and analyzed by id Tracker and *** comparing the effects of all treatments on behavior parameters we confirmed that the spatial distribution was more easily altered rather than general loco motor parameters,e.g.0.7-70 mg/l PTZ and 5-20 mg/l paraquat being effective for altering spatial distribution but having little effects on general locomotor *** on the heatmap,i.e.,the cumulative proportion of grids and that of frequency in grids,we calcu lated the behavioral Gini coefficient(G_(b))for quantitative assessment of fish spatial distri *** Gini coefficient ranged from zero to 1,with larger values meaning poorer even ness of spatial *** note,G_(b)showed smaller coefficient of variations(CV)with3%-19%between replicate tanks in all treatments than the highest frequency(4%-79%),dis playing well ***,G_(b)addressed the challenge of the complicated heatmap with multiple ***,the behavioral Gini coefficient we established is an idea parameter to quantitatively assess spatial distribution of fish shoal,which is expected to be applied in toxicity testing for chemicals and wastewater and automatic quality monitoring for surface water and aquaculture water.

关键词： Zebrafish Behavioral test Spatial distribution Behavioral Gini coefficient

Effect of biochar application on rice,wheat,and corn seedlings in hydroponic culture

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Journal of Environmental Sciences 2024年第1期135卷 379-390页

作者： Yingjie Yin Jikai li Sihang Zhu qing chen Chong chen Yukui Rui Jianying Shang College of land Science and Technology China Agricultural UniversityKey Laboratory of Plant-Soil InteractionsMinistry of Educationand Key Laboratory of Arable Land Conservation in North ChinaMinistry of Agriculture and Rural AffairsBeijing 100193China Agricultural Management Institute Ministry of Agriculture and Rural AffairsBeijing 102208China College of Resources and Environmental Sciences China Agricultural UniversityBeijing Key Laboratory of Farmland Soil Pollution Prevention and RemediationBeijing 100193China

In recent years,biochar has attracted considerable attention for soil quality improvement and carbon sequestration due to its unique physicochemical ***,the mechanism by which biochar application negatively affects the growth of crop seedlings has not been fully *** this study,a hydroponic experiment was conducted to evaluate the response of rice,wheat,and corn seedlings to biochar application(CK,0 g/l;BC1,0.5 g/l;and BC2,1.0 g/l).Compared with the CK treatment,the BC1 and BC2 treatments decreased the fresh shoot and root weights of rice and corn seedlings(Plings(P>0.05).For the contents of nutrient elements in seedlings,both BC1 and BC2 treatments hindered the roots from absorbing Fe and Cu and increased the uptake of Ca and *** with the CK treatment,the translocation factor(TF)values of Ca,Mn,and Zn were significantly decreased especially in rice seedlings(35.3%-36.8%,68.7%-76.5%,and 29.8%-22.0%,respectively)under the BC1 and BC2 treatments,while only Mn was significantly decreased in wheat and corn seedlings(Plectron microscope(TEM)analysis of root cross-sections showed that nano-sized biochar particles(10~23 nm)were found in the root cells under BC2 treatment *** findings reveal that a large amount of biochar application can reduce nutrient absorption and translocation,and hinder rice,wheat,and corn seedlings,particularly rice seedling,in hydroponic system.

关键词： Biochar Toxicity Seedling growth Hydroponic cultivation

Geometric phase-encoded stimuli-responsive cholesteric liquid crystals for visualizing real-time remote monitoring:humidity sensing as a proof of concept

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light(Science & Applications) 2024年第2期13卷 283-293页

作者： Shi-long li Zhao-Yi chen Peng chen Wei Hu Chaohong Huang Sen-Sen li Xuejia Hu Yan-qing lu lu-Jian chen Department of Electronic Engineering School of Electronic Science and EngineeringXiamen University361005 XiamenChina College of Engineering and Applied Sciences Nanjing University210093 NanjingChina Fujian Key laboratory of Ultrafast laser Technology and Applications Xiamen University361005 XiamenChina

liquid crystals are a vital component of modern photonics,and recent studies have demonstrated the exceptional sensing properties of stimuli-responsive cholesteric liquid ***,existing cholesteric liquid crystal-based sensors often rely on the naked eye perceptibility of structural color or the measurement of wavelength changes by spectrometric tools,which limits their practical ***,developing a platform that produces recognizable sensing signals is *** this study,we present a visual sensing platform based on geometric phase encoding of stimuli-responsive cholesteric liquid crystal polymers that generates real-time visual patterns,rather than frequency *** demonstrate this platform’s effectiveness,we used a humidity-responsive cholesteric liquid crystal polymer film encoded with a q-plate pattern,which revealed that humidity causes a shape change in the vortex beam reflected from the encoded cholesteric liquid crystal ***,we developed a prototype platform towards remote humidity monitoring benefiting from the high directionality and long-range transmission properties of laser beams carrying orbital angular *** approach provides a novel sensing platform for cholesteric liquid crystals-based sensors that offers promising practical *** ability to generate recognizable sensing signals through visual patterns offers a new level of practicality in the sensing field with stimuli-responsive cholesteric liquid *** platform might have significant implications for a broad readership and will be of interest to researchers working in the field of photonics and sensing technology.

关键词： humidity visual liquid

A coupled legendre-laguerre polynomial method with analytical integration for the Rayleigh waves in a quasicrystal layered half-space with an imperfect interface

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1539-1556页

作者： Bo ZHANG Honghang TU Weiqiu chen Jiangong YU l.ElMAIMOUNI School of Mechanical and Power Engineering Henan Polytechnic University Henan International Joint laboratory of Advanced Electronic Packaging Materials Precision Forming Henan Polytechnic University Department of Engineering Mechanics Zhejiang University Polydisciplinary Faculty of Ouarzazate Ibnou Zohr University

The laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space. However, it fails to obtain the correct stress at the interfaces in a layered half-space, especially when there are significant differences in material properties. Therefore, a coupled legendre-laguerre polynomial method with analytical integration is proposed. The Rayleigh waves in a one-dimensional(1D) hexagonal quasicrystal(qC) layered half-space with an imperfect interface are investigated. The correctness is validated by comparison with available results. Its computation efficiency is analyzed. The dispersion curves of the phase velocity, displacement distributions, and stress distributions are illustrated. The effects of the phonon-phason coupling and imperfect interface coefficients on the wave characteristics are investigated. Some novel findings reveal that the proposed method is highly efficient for addressing the Rayleigh waves in a qC layered half-space. It can save over 99% of the computation time. This method can be expanded to investigate waves in various layered half-spaces, including earth-layered media and surface acoustic wave(SAW) devices.

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An Isolable Phosphinogermylyne as a Synthon of One-Coordinate GeⅠRadical

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Chinese Journal of Chemistry 2024年第7期42卷 736-742页

作者： Dongmin Wang Haonan chen Yuhao He Xiaodan chen li Zhang Gengwen Tan Key laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education Guangdong Basic Research Center of Excellence for Functional Molecular EngineeringSchool of ChemistryIGCMESun Yat-Sen UniversityGuangzhouGuangdong 510275China School of Electronic Engineering Guangxi Universityof Science and TechnologyLiuzhouGuangxi 545000China College of Chemistry and Material Jinan UniversityGuangzhouGuangdong 510632China Innovation Center for Chemical Science College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China Key laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal UniversityHangzhouZhejiang 311121China

Reduction of chlorogermylene MsFluindtBu-GeCl 1 with potassium graphite(KC8)afforded putative germylyne radical MsFluindtBu-Ge 2 as confirmed by electron paramagnetic resonance(EPR)***,it slowly decayed via C—H bond activation at the fluorenyl moiety to yield a bis(germylene)3 at room *** using a lewis base to stabilize the unoccupied p orbital at the GeⅠradical center,acyclic two-coordinate GeⅠradicals MsFluindtBu-Ge(IMe4)4(IMe4=1,3,4,5-tetramethyl-imidazolin-2-ylidene),MsFluindtBu-Ge(IiPr)5(IiPr=1,3-diisopropyl-4,5-dimethyl-imidazolin-2-ylidene),MsFluindtBu-Ge(PMe3)6 were isolated in crystalline *** unpaired electron in 4-6 mainly resides at the Ge 4p orbital as revealed by EPR spectroscopic studies and theoretical ***,facile ligand exchange of PMe3 in 6 with IMe4 and IiPr was observed to afford 4 and 5,***,phosphinogermylyne 6 reacted with PhEEPh(E=S,Se),4-tetrabutylphenylacetylene(Ar'CCH),[CpMo(CO)3]2 and nBu3SnH to furnish germylenes MsFluindtBu-GeEPh(E=S 7,Se 8),MsFluindtBu-GeCH=CHAr'9,a germylyne complex MsFluindtBu-Ge≡Mo(CO)2Cp 10 and a Ge(Ⅳ)compound MsFluindtBu-GeH2SnnBu311,*** reactivity studies demonstrate that 6 can act as a synthon of one-coordinate germylyne radical attributing to labile coordination of trimethylphosphine.

关键词： Phosphinogermylyne Germanium Radicals Donor-acceptor systems Radical reactions

All-optical image denoising using a diffractive visual processor

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light(Science & Applications) 2024年第3期13卷 429-445页

作者： Çağatay Işıl Tianyi Gan Fazil Onuralp Ardic Koray Mentesoglu Jagrit Digani Huseyin Karaca Hanlong chen Jingxi li Deniz Mengu Mona Jarrahi Kaan Akşit Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA University College london Department of Computer ScienceLondonUnited Kingdom

Image denoising,one of the essential inverse problems,targets to remove noise/artifacts from input *** general,digital image denoising algorithms,executed on computers,present latency due to several iterations implemented in,e.g.,graphics processing units(GPUs).While deep learning-enabled methods can operate non-iteratively,they also introduce latency and impose a significant computational burden,leading to increased power ***,we introduce an analog diffractive image denoiser to all-optically and non-iteratively clean various forms of noise and artifacts from input images–implemented at the speed of light propagation within a thin diffractive visual processor that axially spanslength of *** all-optical image denoiser comprises passive transmissive layers optimized using deep learning to physically scatter the optical modes that represent various noise features,causing them to miss the output image Field-of-View(FoV)while retaining the object features of *** results show that these diffractive denoisers can efficiently remove salt and pepper noise and image rendering-related spatial artifacts from input phase or intensity images while achieving an output power efficiency of~30–40%.We experimentally demonstrated the effectiveness of this analog denoiser architecture using a 3D-printed diffractive visual processor operating at the terahertz *** to their speed,power-efficiency,and minimal computational overhead,all-optical diffractive denoisers can be transformative for various image display and projection systems,including,e.g.,holographic displays.

关键词： remove rendering holographic

Evaluation of water management on arsenic methylation and volatilization in arsenic-contaminated soils strengthened by bioaugmentation and biostimulation

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Journal of Environmental Sciences 2024年第3期137卷 515-526页

作者： Peng chen Yi liu Guo-Xin Sun State Key laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As) fate in paddy fields has been one of the most significant current issues due to the strong As accumulation potential of rice plants under fooded conditions. However,no attempt was done to explore As methylation and volatilization under non-fooded conditions. Herein, we investigated the effects of water management on As methylation and volatilization in three arsenic-contaminated soils enhanced by biostimulation with strawderived organic matter and bioaugmentation with genetic engineered Pseudomonas putida KT2440(GE P. putida). Under fooded conditions, the application of biochar(BC), rice straw(RS)and their combination(BC+RS) increased total As in porewater. However, these effects were greatly attenuated under non-fooded conditions. Compared with RS amendment alone, the combination of GE P. putida and RS further promoted the As methylation and volatilization,and the promotion percentage under non-fooded conditions were significantly higher than that under fooded conditions. The combined GE P. putida and RS showed the highest efficiency in As methylation(88 μg/l) and volatilization(415.4 μg/(kg·year)) in the non-fooded soil with moderate As contamination. Finally, stepwise multiple linear regression analysis presented that methylated As, DOC and p H in porewater were the most important factors contributing to As volatilization. Overall, our findings suggest that combination of bioaugmentation with GE P. putida and biostimulation with RS/BC+RS is a potential strategy for bioremediation of arsenic-contaminated soils by enhancing As methylation and volatilization under non-fooded conditions.

关键词： Arsenic methylation Arsenic volatilization Water management Straw incorporation Bioaugmentation