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C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong gong min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/ml,and alanine aminotransferase(AlT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(Il)-21 concentration via ElISA and to analyze CXCR5 and programmed death-ligand 1(PD-l1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-l1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(Ply,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-l1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum Il-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele l Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

Corrosion performance of Al–Al2O3 cold sprayed coatings on mild carbon steel pipe under thermal insulation

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Chinese Journal of Chemical Engineering 2017年第4期25卷 533-539页

作者： Xiaomin Bai Jianqun Tang Jianming gong Xiaoliang lü School of mechanical and Power Engineering Nanjing Tech UniversityNanjing 211816China

This paper focused on the corrosion resistance of cold spray Al–Al_2O_3composite coatings used on carbon steel pipe surfaces under thermal insulation. Al–Al_2O_3coatings were produced on the carbon steel pipe surface by cold spray(CS) technology. Experimental apparatus was built to test the corrosion resistance of coatings beneath mineral wool insulation under isothermal, thermal cycling and wet/dry conditions. The results showed that when α-Al_2O_3 was added in spraying powder, the coating could obtain higher hardness and a denser microstructure. From corrosionunder-insulation(CUI) tests, Al–Al_2O_3CS coatings were proven to be efficient in protecting carbon steel pipe from CUI mainly owning to lamellar microstructures of coatings. There was no evidence to show that α-Al_2O_3 might bring any negative effect on corrosion resistance. Al–Al_2O_3CS coatings were sensitive to the chloride ion concentration. When these coatings were exposed to higher concentrations of NaC l, the coating's exhibited faster degradation.

关键词： insulation spray lamellar cycling pipe hardness faster isothermal owning exposed

A semi-analytical approach for calculating the equilibrium structure and radial breathing mode frequency of single-walled carbon nanotubes

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Acta mechanica Sinica 2016年第6期32卷 1075-1087页

作者： J.gong l.Thompson G.li Department of mechanical Engineering Clemson University

A semi-analytical model for determining the equilibrium configuration and the radial breathing mode (RBm) frequency of single-wall carbon nanotubes (CNTs) is presented. By taking advantage of the symmetry characteristics, a CNT structure is represented by five independent variables. A line search optimization procedure is employed to determine the equilibrium values of these variables by minimizing the potential energy. With the equilibrium configuration obtained, the semi-analytical model enables an efficient calculation of the RBm frequency of the CNTs. The radius and radial breathing mode frequency results obtained from the semi-analytical approach are compared with those from molecular dynamics (mD) and ab initio calculations. The results demonstrate that the semi-analytical approach offers an efficient and accurate way to determine the equilibrium structure and radial breathing mode frequency of CNTs.

关键词： Carbon nanotubes Equilibrium structure Radial breathing mode frequency

Amygdala-Inspired Affective Computing: to Realize Personalized Intracranial Emotions with Accurately Observed External Emotions

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China Communications 2019年第8期16卷 115-129页

作者： Chao gong Fuhong lin Xianwei Zhou Xing lü School of Computer and Communication Engineering University of Science and Technology Beijing

Artificial intelligence technology has revolutionized every industry and trade in recent years. However, its own development is encountering bottlenecks that it is unable to implement empathy with human emotions. So affective computing is getting more attention from researchers. In this paper, we propose an amygdala-inspired affective computing framework to realize the recognition of all kinds of human personalized emotions. Similar to the amygdala, the instantaneous emergency emotion is first computed more quickly in a low-redundancy convolutional neural network compressed by pruning and weight sharing with hashing trick. Then, the real-time process emotion is identified more accurately by the memory level neural networks, which is good at handling time-related signals. Finally, the intracranial emotion is recognized in personalized hidden markov models. We demonstrate on Facial Expression of Emotion Dataset and the recognition accuracy of external emotions(including the emergency emotion and the process emotion) reached 85.72%. And the experimental results proved that the personalized affective model can generate desired intracranial emotions as expected.

关键词： affective computing emotion recognition personalized machines external emotions intracranial emotions

ACTPred: Activity Prediction in mobile Social Networks

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Tsinghua Science and Technology 2014年第3期19卷 265-274页

作者： Jibing gong Jie Tang A.C.m. Fong School of Information Science and Engineering Yanshan University Department of Computer Science and Technology Tsinghua University University of Glasgow in Singapore

A current trend for online social networks is to turn *** social networks directly reflect our real social life,and therefore are an important source to analyze and understand the underlying dynamics of human behaviors （activities）.In this paper,we study the problem of activity prediction in mobile social *** present a series of observations in two real mobile social networks and then propose a method,ACTPred,based on a dynamic factor-graph model for modeling and predicting users＇ *** approximate algorithm based on mean fields is presented to efficiently learn the proposed *** deploy a real system to collect users＇ mobility behaviors and validate the proposed method on two collected mobile *** results show that the proposed ACTPred model can achieve better performance than baseline methods.

关键词： social prediction activity prediction user modeling social networks

Tissue level microstructure and mechanical properties of the femoral head in the proximal femur of fracture patients

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Acta mechanica Sinica 2015年第2期31卷 259-267页

作者： linwei lü Guangwei meng He gong Dong Zhu Jiazi Gao Yubo Fan School of mechanical Engineering Tianjin University of Technology Department of Engineering mechanics Jilin University Department of Orthopaedic Surgery No.1 Hospital of Jilin University Key laboratory for Biomechanics and mechanobiology of ministry of Education School of Biological Science and Medical EngineeringBeihang University

This study aims to investigate the regional variations of trabecular morphological parameters and mechanical parameters of the femoral head,as well as to determine the relationship between trabecular morphological and mechanical *** femoral heads from patients with fractured proximal femur were scanned using a micro-CT *** femoral head was divided into 12 sub-regions according to the trabecular *** 125 mm^3 trabecular cubic model was reconstructed from each sub-region.A total of 81 trabecular models were reconstructed,except three destroyed sub-regions from two femoral heads during the *** morphological parameters,*** separation（***）,trabecular thickness（***）,specific bone surface（BS/B V）,bone volume fraction（BV/TV）,structural model index（SmI）,and degree of anisotropy（DA） were ***-finite element analyses were performed for each cube to obtain the apparent Young＇s modulus and tissue level von mises stress distribution under 1%compressive strain along three orthogonal directions,*** revealed significant regional variations in the morphological parameters（P〈0.05）.Young＇s moduli along the trabecular orientation were significantly higher than those along the other two *** general,trabecular mechanical properties in the medial region were lower than those in the lateral *** mechanical parameters along the trabecular orientation were significantly correlated with BS/BV,BV/TV,***,and *** this study,regional variations of microstructural features and mechanical properties in the femoral head of patients with proximal femur fracture were thoroughly investigated at the tissue *** results of this study will help to elucidate the mechanism of femoral head fracture for reducing fracture risk and developing treatment strategies for the elderly.

关键词： Femoral head Trabecular bone morphological parameters micro-finite element analysis Apparent level Tissue level

Effect of Nitrogen Content on microstructures and mechanical Properties of WB_2(N) Films Deposited by Reactive magnetron Sputtering

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Journal of materials Science & Technology 2015年第12期31卷 1217-1225页

作者： Y.m.liu D.Y.Deng H.lei Z.l.Pei C.l.Jiang C.Sun J.gong Institute of metal Research Chinese Academy of Sciences

In the present study,WB 2（N） films are fabricated on silicon and YG8 substrates at different N 2 pressures by reactive magnetron *** influence of N 2 partial pressure（P （N2）） on the film microstructure and characteristics is studied systematically,including the chemical composition,crystalline structure,residual stress,surface roughness as well as the surface and the cross-section ***,nano-indentation and ball-on-disk tribometer are performed to analyze the mechanical and tribological properties of the *** results show that the addition of nitrogen apparently leads to the change of the structure from（1 0 1） to（0 0 1） orientation then to the amorphous structure with the formation of BN *** the addition of nitrogen can greatly refine the grain size and microstructure of the ***,the residual stress of the film is also found to change from tensile to compressive stress as a function of P （N2）,and the compressive stress increases with P （N2）,The WB 2（N） films with small nitrogen content,which are deposited at P （N2） of 0.004 and 0.006 Pa,exhibit better mechanical,tribological and corrosion properties than those of other *** increase of nitrogen content accelerates the formation of BN phase and fast decreases the film *** addition,the large N 2 partial pressure gives rise to the target poisoning accompanied by the increase of the target voltage and the decrease of the deposition rate.

关键词： Reactive magnetron sputtering Nanocomposites WB 2(N) films Residual stress mechanical properties