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Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： marco A.Fornazieri Bruno m.Cunha Samuel P.Nicácio lucas K.Anzolin Josél.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard l.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

Properties and Characterization of Two Clays Raw material from mountain District (West of Côte d’Ivoire) for Use in low-Carbon Cements

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Advances in materials Physics and Chemistry 2024年第8期14卷 137-145页

作者： Wedjers max Robin manouan Bi Irié Hervé Gouré Doubi lébé Prisca marie-Sandrine Kouakou Atta Kouamé Brice Koffi Alfred Niamien Kouamé Namory méité UFR Sciences et Technologies Universit de Man Man Cte dIvoire UFR Sciences Biologiques Universit Peleforo GON COULIBALY Korhogo Cte dIvoire laboratoire de constitution et de raction de la matire Universit Felix Houphout-Boigny Abidan Cte dIvoire

This work was devoted to the study of the physico-chemical properties of two clay minerals from the mountain District (West Côte d'Ivoire) referenced mE1.and mE2. These samples were characterized by the experimental techniques, such as X-ray diffraction (XRD), Infrared spectroscopy (IR), Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES), Differential Thermal Analysis and Thermogravimetry (DTA-TG), Brunauer, Emett and Teller method (BET), laser particle size analysis and Scanning Electron microscope (SEm). The main results of these analyses reveal that the two clay samples mainly contain quartz (52.91% for mE1.and 51.72% for mE2), kaolinite (36.60% for mE1.and 41.6% for mE2) and associated phases, namely goethite and hematite (13.47% for mE1.and 11.00% for mE2). The specific surface values obtained for samples mE1.and mE2 are 34.78 m2/g and 29.18 m2/g respectively. The results obtained show that the samples studied belong to the kaolinite family. After calcination, they could have good pozzolanic activity and therefore be used in the manufacture of low-carbon cements.

关键词： Quartz Kaolinite mountain District low-Carbon Cements

Decision-making and management of Self-Care in Persons with Traumatic Spinal Cord Injuries: A Prel.m.nary Study

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Journal of Behavioral and Brain Science 2024年第2期14卷 47-63页

作者： Paul E. Plonski Jasmin Vassileva Ryan Shahidi Paul B. Perrin William Carter lance l. Goetz Amber Brochetti James m. Bjork Institute for Drug and Alcohol Studies Virginia Commonwealth University Richmond VA USA Richmond Veterans Affairs medical Center Richmond VA USA Department of Psychiatry Virginia Commonwealth University Richmond VA USA Department of Psychology Virginia Commonwealth University Richmond VA USA Department of Physical.m.dicine and Rehabilitation Virginia Commonwealth University Richmond VA USA Department of Spinal Cord Injury Cleveland Veterans Affairs Medical Center Cleveland OH USA Department of Pharmacology and Toxicology Virginia Commonwealth University Richmond VA USA

Patients and physicians understand the importance of self-care following spinal cord injury (SCI), yet many individuals with SCI do not adhere to recommended self-care activities despite logistical supports. Neurobehavioral determinants of SCI self-care behavior, such as impulsivity, are not widely studied, yet understanding them could inform efforts to improve SCI self-care. We explored associations between impulsivity and self-care in an observational study of 35 US adults age 18 - 50 who had traumatic SCI with paraplegia at least six months before assessment. The primary outcome measure was self-reported self-care. In lASSO regression models that included all neurobehavioral.m.asures and demographics as predictors of self-care, dispositional.m.asures of greater impulsivity (negative urgency, lack of premeditation, lack of perseverance), and reduced mindfulness were associated with reduced self-care. Outcome (magnitude) sensitivity, a latent decision-making parameter derived from computationally modeling successive choices in a gambling task, was also associated with self-care behavior. These results are prel.m.nary;more research is needed to demonstrate the utility of these findings in clinical settings. Information about associations between impulsivity and poor self-care in people with SCI could guide the development of interventions to improve SCI self-care and help patients with elevated risks related to self-care and secondary health conditions.

关键词： Spinal Cord Injury Self-Care Decision-making Paraplegia Impulsive Behavior Health Care

long-Term mortality of Children with Congenital Heart Disease Admitted to the Departmental University Hospital of Borgou/Alibori from 2011 to 2022

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World Journal of Cardiovascular Diseases 2024年第3期14卷 166-186页

作者： Serge Hugues mahougnon Dohou Nicolas Hamondji Amegan Ahmad Ibrahim Gérard médétinmè Kpanidja Chabi Olaniran Alphonse Biaou Houétondji léopold Codjo Cardiology Teaching and Research Unit (CHUD-B/A) Faculty of Medicine University of Parakou Parakou Benin 1 cole de Sant&#233 Publique de l&#8217Universit&#233 de Montr&#233al (ESPUM) Montr&#233al Qu&#233bec Canada Paediatrics and medical Genetics Teaching and Research Unit (CHUD-B/A) Faculty of Medicine University of Parakou Parakou Benin Regional Institute of Public Health University of Abomey-Calavi Cotonou Benin Cardiology Department Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin

Background: Congenital heart disease is a public health issue due to its incidence and mortality rate. The aim of this study was to investigate the long-term mortality of children with congenital heart disease admitted to the Departmental University Hospital of Borgou/Alibori (CHUD-B/A) from 2011 to 2022. methods: This descriptive longitudinal study with analytical aims covered 11 years (April 1, 2011 to December 31, 2022). It consisted of a review of the records of children under 15 years of age with echocardiographically confirmed congenital heart disease. This was followed by an interview with the parents to assess the children’s current condition. Data were entered using Kobocollect software and analyzed using R Studio 4.2.2. software. Results: A total of 143 complete files were retained. The median age at diagnosis was 14 months (IIQ: Q1 = 4;Q3 = 60) with a range of 2 days and 175 months, and the sex-ratio (m/F) was 0.96. left-to-right shunts were the most frequent cardiopathy group (62.9%). Only 35 children (24.5%) benefited from restorative treatment. The mortality rate was 31.5%. median survival under the maximum bias assumption was 114 months and 216 months under the assumption of minimum bias. Survival was significantly better in children with right-to-left shunts (p = 0.0049) under the assumption of minimum bias. The death risk factors were: age at diagnosis less than 12 months (aHR = 7.58;95% CI = 3.36 - 17.24;p Conclusion: The long-term mortality of congenital heart disease is high and favoured by the absence of restorative treatment. local correction of congenital heart disease and medical follow-up will help to reduce this mortality.

关键词： Congenital Heart Disease long-Term mortality Parakou Risk Factors

The Use of Secondary Grape Biomass in Beef Cattle Nutrition on Carcass Characteristics, Quality and Shelf life of meat

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Food and Nutrition Sciences 2024年第6期15卷 447-469页

作者： Vitor l. molosse Guilherme l. Deolindo Rafael V. P. lago Bruna Klein Claiton A. Zotti marcelo Vedovato marcylene V. da Silveira Priscila m. Copetti maria R. C. Schetinger Juscivete F. Favero Eliana l. Fiorentin Aleksandro S. da Silva Universidade do Estado de Santa Catarina (UDESC) Chapec Brazil Department of Animal Science UDESC Chapec Brazil Department of Animal Science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean lee Research and Extension Center Louisiana State University Alexandria LA USA Department of Biochemistry Universidade Federal de Santa Maria Santa Maria Brazil Department of medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the inclusion of 100 g/kg dry matter of grape pomace silage (GPS) and grape pomace bran (GPB) as substitutes for other traditional fiber sources in the diet of steers (Charolais x Nellore) would improve carcass characteristics, meat quality and composition, and shelf life. Twenty-four animals (248 ± 19.32 kg of initial body weight) were fed a high concentrate diet for 121 days. Carcass characteristics were measured, and the longissimus dorsi muscle was analyzed for fatty acid (FA) profile and composition. The meat was sliced and stored in air-permeable packages for 10 days. On each sampling day (d 1, 3, 7, and 10), oxidative stability, bacterial load, lipid and protein oxidation, and staining were analyzed. The experimental diets influenced the pH of cold carcasses only. The GPS group had a higher pH than the control. The GPS and GPB groups showed improved oxidant status (i.e., lower lipid peroxidation and concentrations of reactive oxygen species were in the meat of both groups than in control). On the first day of storage, the antioxidant enzyme glutathione S-transferase activity was more significant in the meat of the GPS and GPB groups than in the control. The bacterial loads in the meat were attenuated by GPS inclusion;there were lower total coliform counts and a trend toward lower counts for enterobacteria in the control group. The diets altered the FA profile of the meat;i.e., the GPB diet allowed for a more significant amount of the n-6 omegas in the meat, while the GPS diet showed a tendency for a more significant amount of n-6 and 9 omegas. Both diets (GPS and GPB) increased the amounts of long-chain FAs. The GPS diet decreased saturated FA levels. We conclude that the dietary treatments GPS and GPB are a promising alternative to maintain meat quality standards throughout in real-world retail conditions. These treatments gave rise to an improvement in the nutritional value of the meat due to the more significant amounts of FAs that im

关键词： Animal Nutrition Antioxidant Biomass Grape meat Quality microbiology Residue

Compl.m.nt-dependent neuroinfl.m.ation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to l.m.t the progression of injury and optimize recovery in this *** the thorough investigation of the compl.m.nt system in triggering and propagating cerebral neuroinfl.m.ation,a similar role for compl.m.nt in spinal neuroinfl.m.ation is a focus of ongoing *** this work,we survey the current literature investigating the role of compl.m.nt in spinal cord injury including the sources of compl.m.nt proteins,triggers of compl.m.nt activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of compl.m.nt activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of compl.m.nt have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of compl.m.nt anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical.m.dels of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different compl.m.nt pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of compl.m.nt in white matter degeneration and regeneration using translational strategies to suppl.m.nt genetic models.

关键词： compl.m.nt neuroinfl.m.ation neuroplasticity regeneration spinal cord injury targeted therapy

Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： lieke C.E.Noij Jelle m.Blankestijn Coen R.lap marlies A.van Houten Giske Biesbroek Anke-Hilse maitland-van der Zee mahmoud I.Abdel-Aziz Johannes B.van Goudoever mattijs W.Alsem Caroline l.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UmC in the Netherlands between November 2021.and march *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep probl.m.,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1.and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters long COVID Pediatric Phenotypes Post-COVID syndrome

Sodium-glucose cotransporter-2 inhibitors protect tissues via cellular and mitochondrial pathways:Experimental and clinical evidence

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World Journal of Experimental.m.dicine 2024年第2期14卷 46-52页

作者： Raúl lelio Sanz Sebastián García menéndez Felipe Inserra leon Ferder Walter manucha Department of Pathology Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendoza 5500Argentina Department of Pharmacology Instituto de Medicina y Biología Experimental de CuyoCentro Científico TecnológicoMendoza 5500Argentina Department of Nephrology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina Department of Cardiology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina

mitochondrial dysfunction is a key driver of cardiovascular disease(CVD)in metabolic syndrome and *** dysfunction promotes the production of reactive oxygen species(ROS),which cause oxidative stress and *** II,the main mediator of the renin-angiotensin-aldosterone system,also contributes to CVD by promoting ROS *** activity of sirtuins(SIRTs),a family of proteins that regulate cellular metabolism,also worsens oxidative *** of energy production by mitochondria is a common feature of all.m.tabolic *** SIRT levels and 5’adenosine monophosphate-activated protein kinase signaling stimulate hypoxia-inducible factor 1 beta,which promotes ***,in turn,increases autophagy and mitophagy,processes that clear cells of debris and protect against *** cotransporter-2 inhibitors(SGlT2i),a class of drugs used to treat type 2 diabetes,have a beneficial effect on these *** clinical trials have shown that SGlT2i improves cardiac function and reduces the rate of cardiovascular and renal ***2i also increase mitochondrial efficiency,reduce oxidative stress and infl.m.ation,and strengthen *** findings suggest that SGlT2i hold great potential for the treatment of ***,they are proposed as anti-aging drugs;however,rigorous research is needed to validate these prel.m.nary findings.

关键词： Sodium-glucose cotransporter-2 inhibitors Cardiovascular diseases Sirtuins Oxidative stress Infl.m.ation mitochondrial dysfunction

Unraveling the nature of sensing in electrostatic mEmS gas sensors

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microsystems & Nanoengineering 2024年第3期10卷 109-117页

作者： Yasser S.Shama Sasan Rahmanian Hamza mouharrar Rana Abdelrahman Alaaeldin Elhady Eihab m.Abdel-Rahman Systems Design Engineering University of Waterloo200 University Ave WWaterloo N2L 3G1 ONCanada mechanical Engineering Benha Faculty of EngineeringBenha UniversityBenha 13511Egypt

This paper investigates the fundamental sensing mechanism of electrostatic mEmS gas *** compares among the responsivities of a set of mEmS isopropanol sensors before and after functionalization,and in the presence and absence of electrostatic fields when operated in static and dynamic detection *** the static mode,we found that the sensors do not exhibit a measurable change in displacement due to added *** the other hand,bare sensors showed a clear change in displacement in response to isopropanol *** the dynamic mode,functionalized sensors showed a measurable frequency shift due to the added mass of isopropanol *** the presence of strong electrostatic fields,the measured frequency shift was found to be threefold larger than that in their absence in response to the same concentration of isopropanol *** enhanced responsivity of dynamic detection allows the sensors to measure the vapor mass captured by the functional.m.terial,which is not the case for static *** detection of isopropanol by bare sensors in static mode shows that change in the medium permittivity is the primary sensing *** enhanced responsivity of dynamic mode sensors when operated in strong electrostatic fields shows that their sensing mechanism is a combination of a weaker added mass effect and a stronger permittivity *** findings show that electrostatic mEmS gas sensors are independent of the direction of the gravitational field and are,thus,robust to changes in *** is erroneous to refer to them as‘gravimetric’sensors.

关键词： mechanism electrostatic measurable