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Investigating the Modulatory Role of Chronological and Biological Age on Performance Predictors in Youth Swimmers

Journal of Science in Sport and Exercise 2020年第4期2卷 349-358页

作者： M.A.McNarry l.lester J.Brown K.A.Mackintosh School of Sport and Exercise Sciences Swansea UniversityBay CampusSwansea SA18ENUK School of Human Science University of Western AustraliaPerth 6009Australia

Purpose The aim of this study was to determine the modulatory roles of biological maturity and age on the predictors of performance in youth swimmers and their stability over a six-month training *** In total,28 swimmers(10 pre-pubertal[6 boys],11.1±1.8 years;18 pubertal[8 boys],15.2±2.0 years old)and 26 untrained controls(15 pre-pubertal[10 boys],9.7±1.5 years;11 pubertal[6 boys],14.4±0.5 years old)were *** baseline,3-and 6-months,participants completed an incremental ramp cycle test,isometric handgrip strength test and countermovement jumps,with speed assessed as a measure of performance in *** component analysis(PCA)identified factors that described youth swimmers’physical profile,with linear mixed models subsequently used to determine their interaction with age and maturity on *** Aerobic fitness and upper body strength were significantly higher in the trained participants,irrespective of maturity status or *** key factors were identified through PCA(anthropometrics;strength;aerobic capacity;aerobic rate),accounting for 90%of the between parameter *** exerted a widespread influence on swimming performance predic-tors,influencing all four factors,whilst maturity only influenced the aerobic *** key age of divergence was 13 *** Overall,the present study found no evidence of a maturational threshold in the aerobic or strength-related response to training in *** influence of age on performance predictors suggests that utilising a single or select group of parameters to inform selection and/or talent identification throughout the dynamic processes of growth and maturation should be avoided.

关键词： Aerobic fitness Strength Maturity Pre-pubertal Pubertal Power

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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2D SnOx/SnS2的异质结构的忆阻器用于神经形态计算（英文）

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Science China Materials 2025年

作者：吴扬武李思凡季云翁正进邢厚英 lester Arauz Travis Hu 洪金华 Kah-Wee Ang 刘松 State Key laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Department of Electrical and Computer Engineering National University of Singapore Joint International Research laboratory of Information Display and Visualization School of Electronic Science and Engineering Southeast University Department of Mechanical Engineering California State University Los Angeles 5151 State University Dr College of Materials Science and Engineering Hunan University Shenzhen Research Institute Hunan University

层状金属二硫化物（lMDs）神经形态忆阻器为解决传统冯·诺依曼架构在速度和能效上的限制,提供了一个有前景的替代方案.然而由于环境稳定性,晶体lMDs忆阻器的阻变行为和操作电压仍面临挑战,这阻碍了神经网络硬件的开发.在此,我们通过臭...

层状金属二硫化物（lMDs）神经形态忆阻器为解决传统冯·诺依曼架构在速度和能效上的限制,提供了一个有前景的替代方案.然而由于环境稳定性,晶体lMDs忆阻器的阻变行为和操作电压仍面临挑战,这阻碍了神经网络硬件的开发.在此,我们通过臭氧处理控制氧化制备了SnOx/SnS2阻变层,优化了其阻变操作特性.该忆阻器表现出低的开关电压（～1 V）、快的开关速度（～20 ns）、高的开关比（10～2）,并具备模拟突触权重可塑性的能力.通过截面透射电子显微镜和X射线光谱等手段的分析,探测到了阻变开关层中的缺陷和Ti导电丝,这有助于实现均匀开关并减少操作可变性.此外,SnOx/SnS2忆阻器在MNIST手写识别中实现了90%的准确率,并成功地实现了基于忆阻器的图像卷积,展示了SnOx/SnS2忆阻器在神经形态应用中的潜力.

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Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science China Mathematics 2025年

作者： Xin lü Shengli Tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Online Demand Response Characterization Based on Variability in Customer Behavior

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 936-946页

作者： lester Marrero Daniel Sbárbaro luis García-Santander the Department of Electrical Engineering University of ConcepciónConcepción 4070409Chile

This paper proposes an online framework to characterize demand response(DR)over *** proposed framework facilitates obtaining and updating the daily consumption patterns of *** essential concept of response profile class(RPC)is introduced for characterization and complemented by the measure of the variability in customer *** paper uses a modified version of the incremental clustering by fast search and find of density peaks(CFSFDP)algorithm for daily profiles,considering the multivariate normal kernel density estimator and incremental forms of the Davies-Bouldin(i DB)and Xie-Beni(i XB)validity *** studies conducted using real-world and simulated daily profiles of residential and commercial Chilean end-users have demonstrated how the proposed framework can continuously characterize *** proposed framework is proven to achieve realistic customer models for effective energy management by estimating the customer response to price signals at the distribution system operator(DSO)level.

关键词： Demand response(DR) incremental indice online characterization online clustering response profile class(RPC)

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