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Whole-genome sequences shed light on the demographic history and contemporary genetic erosion of free-ranging jaguar(Panthera onca) populations

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Journal of Genetics and Genomics 2022年第1期49卷 77-80页

作者： Gustavo P.lorenzana Henrique V.Figueirò Jeremy Johnson Elinor karlsson Ronaldo G.Morato Dênis A.Sana laury Cullen Joares A.May Jr. Edsel A.Moraes Jr. Daniel l.Z.Kantek leandro Silveira William J.Murphy Oliver A.Ryder Eduardo Eizirik Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Christopher B.Kaelin Gregory S.Barsh HudsonAlpha Institute for BiotechnologyHuntsvilleAL 35806USA Vertebrate Genome Biology Broad InstituteCambridgeMA 02142USA CENAP/ICMBio AtibaiaSP 12952Brazil PPG Biologia Animal Instituto de Bioci^enciasUFRGSPorto AlegreRS 90650Brazil Instituto de Pesquisas Ecol ogicas Teodoro SampaioSP 19280Brazil UniSul TubarãoSC 88704Brazil Instituto Prò-CarnivorosAtibaiaSP 12945Brazil Instituto Biotr opicos DiamantinaMG39100Brazil Estacão Ecologica de Taiamã ICMBioCaceresMT 78200Brazil Instituto Onca-pintada-Jaguar Conservation Fund MineirosGO 75830Brazil Texas A&M University College StationTX 77843USA San Diego Zoo Institute for Conservation Research San DiegoCA 92027USA Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Instituto Pr o-Carni¬vorosAtibaiaSP 12945Brazil Centro Regional del Bajio INECOLP atzcuaroMIC61600Mexico Smithsonian Conservation Biology Institute WashingtonDC20008USA

Whole-genome sequences provide massive amounts of data that can illuminate many aspects of a species’biology and evolutionary history,as well as valuable information for conservation planning.This is particularly important for large carnivores,whose large area requirements and typical low densities make them prone to undergo rapid genetic erosion(e.***.accumulation of runs of homozygosity,Diez del Molino et al.,2018;leroy et al.,2018)in the face of habitat loss and human persecution.One such species is the jaguar(Pan-thera onca),the largest extant felid in the Americas,whose range has already declined by>50%and some of whose remaining popu-lations have been severely impacted by human-induced habitat frag-mentation(De la Torre et al.,2018).

关键词： Whole habitat erosion

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伽玛刀治疗脑转移瘤生存期观察

中华神经外科杂志 1996年第1期12卷 61-62页

作者： Kihlstrom l.karlsson B lindquist C 瑞典卡罗林斯卡医院瑞典瑞典林斯卡医院瑞典

伽玛刀治疗脑转移瘤生存期观察ＬＫｉｈｌｓｔｒｏｍ；ＢＫａｒｌｓｓｏｎ；Ｃｌｉｎｄｑｕｉｓｔ大约有５０％以上的全身肿瘤患者发生脑部转移（１）。无论原发病灶控制如何，脑转移瘤均严重影响生存期限并最终导致死亡。５０％以上放... 详细信息

伽玛刀治疗脑转移瘤生存期观察ＬＫｉｈｌｓｔｒｏｍ；ＢＫａｒｌｓｓｏｎ；Ｃｌｉｎｄｑｕｉｓｔ大约有５０％以上的全身肿瘤患者发生脑部转移（１）。无论原发病灶控制如何，脑转移瘤均严重影响生存期限并最终导致死亡。５０％以上放疗患者死于脑转移瘤的进展（２）。文...

关键词：脑肿瘤转移瘤伽玛刀治疗生存期

läxhjälp as Shadow Education in Sweden:The logic of Equality in“A School for All”

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ECNU Review of Education 2021年第3期4卷 494-519页

作者： Eva Forsberg Stina Hallsen Marie karlsson Helen Melander Bowden Tatiana Mikhaylova Johanna Svahn Uppsala University Uppsala University and University of Gavle

Purpose:Taking läxhjälp/homework support in Sweden as a case,this article aims to further explore shadow education,especially as a pedagogical object from curriculum theory perspective.Design/Approach/Methods:Approaches including policy analyses,ethnomethodological work based on video-recorded interaction,and narratives have produced empirically grounded knowledge.We use examples from several substudies and analyze the reentry and regulation of supplementary education and how tutors and tutees interact in tutoring settings and negotiate identities in läxhjälp as well as the relation to regular schooling.Findings:läxhjälp is conditioned by the logic of equality and changes in the governance of läxhjälp.The proliferation of different kinds of tutoring practices provided by various organizations calls for a broad definition of shadow education.With curriculum as boundary object,equality and academic success are foundational.Different settings and spatiotemporal arrangements affect modes of interaction,distribution of epistemic authority,and negotiations of identities.Originality/Value:With Sweden as a case,it is possible to explore shadow education in a new context,the Scandinavian welfare state,and its history of comprehensive education.Moreover,ethnomethodological interaction and narrative studies and curriculum perspectives are seldom employed within research on shadow education.A number of critical key boundary objects are identified.

关键词： Boundary object curriculum theory homework support identities interaction shadow education

放疗前周围血淋巴细胞敏感性是骨盆放疗所致疾病的预示因素(英文)

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新乡医学院学报 2002年第6期19卷 445-455页

作者：李同光 Ron R.Allison Kevin F.O’Brien Roberta M.Johnke Karen I.Christie James l.Naves Ulf l.karlsson leo W.Jenkins癌症中心放射肿瘤科东卡罗来纳大学公共卫生学院生物统计中心

目的　探讨前列腺癌 (PC)治疗前体外照射诱导的Go淋巴细胞微核量是否与放疗 (xRT)相关疾病的发生有关。方法　对 3 8例PC周围血淋巴细胞 (PBl)以细胞因子阻止的微核法进行前瞻性观察。患者平均年龄 68.7± 1.0岁。临床分期 :T116例 ,T2... 详细信息

目的　探讨前列腺癌 (PC)治疗前体外照射诱导的Go淋巴细胞微核量是否与放疗 (xRT)相关疾病的发生有关。方法　对 3 8例PC周围血淋巴细胞 (PBl)以细胞因子阻止的微核法进行前瞻性观察。患者平均年龄 68.7± 1.0岁。临床分期 :T116例 ,T2 16例 ,T36例。治疗前前列腺癌特异性抗原 (PSA)≤ 4ng·ml-1者 5例 ,4～ 10ng·ml-1者 19例 ,>10ng·ml-1者 14例。所有患者均接受标准的骨盆外xRT(41.4～ 5 0 .4Gy) ,追加剂量 (16.4～ 2 6Gy)。平均随访 3 2 .8± 4.6个月。随访末 ,按RTOG标准对胃肠道 (GI)或泌尿生殖道 (GU)xRT相关疾病的发生率进行评定。结果　发生xRT相关疾病 2 4例为高敏 (HS) ,未发生者 14例为正常敏感性 (NS) ,HS患者均有GI(1～ 3级 )或GU(1～ 2级 )xRT相关疾病。体外照射暴露的血标本 ,与照射剂量相关的PBl微核量在HS和NS患者之间有显著差异 ,特别是当剂量≥ 3Gy时。xRT相关疾病的发生与治疗前PBl微核量相关 ,而与病情无关。

关键词：放疗周围血淋巴细胞微核剂量反应关系前列腺癌

电子计算机和运筹学在瑞典lKAB公司的应用

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国外金属矿采矿 1980年第3期 42-46页

作者： P.l.karlsson 袁砚池张民正

瑞典国营lKAB公司是世界上生产铁矿石最大的公司之一。lKAB公司的大部分矿石是由地下采出的,如果要成功的与露天开采进行竞争,那么必须要有很高的效率。因此,电子计算机和运筹学是该公司经营管理的重要组成部分。本文介绍了lKAB公司成... 详细信息

瑞典国营lKAB公司是世界上生产铁矿石最大的公司之一。lKAB公司的大部分矿石是由地下采出的,如果要成功的与露天开采进行竞争,那么必须要有很高的效率。因此,电子计算机和运筹学是该公司经营管理的重要组成部分。本文介绍了lKAB公司成功的应用电子计算机和运筹学的一些实例,同时对使用运筹学的费用和益处作了某些评论。

关键词：运筹学 lKAB 计算机模拟结果基律纳矿石运输纳尔维克铁矿石磷矿石瑞典北欧车辆数

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艰难的抉择:全球CEO更替新趋势

董事会 2011年第8期 42-49页

作者： Ken Favaro Per-Ola karlsson Gary l.Neilson 博斯公司

在全世界范围内,CEO更替大幅减少,更替率仅有11.6%;因为国有化程度高,中国公司的更替率更是低至5.2%。然而,这丝毫不意味着CEO的职业生涯变得更轻松,恰恰相反。

关键词： CEO更替继任中国公司职业生涯战前

Natural Regeneration on Planted Clearcuts—The Easy Way to Mixed Forest?

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Open Journal of Forestry 2016年第4期6卷 281-294页

作者： Emma Holmström Per Magnus Ekö Karin Hjelm Matts karlsson Urban Nilsson Southern Swedish Forest Research Centre Swedish University of Agricultural Science Alnarp Sweden Skogforsk Sval&oumlv Sweden

Establishing mixed stands by stimulating natural in combination with planting could potentially ensure adequate stocking and meet shifting demands for forest products. Two long-term experiments were separately established in former Norway spruce (Picea abies l. Karst) stands in southern Sweden to be able to evaluate mixed forest establishment and management. The treatment plots were treated with different intensity of soil scarification (disc trenching, soil inversion and control) to test effects of soil disturbance on regeneration success. Five years later, both experiments were used for a first evaluation, where seedlings of all naturally regenerated tree species were counted together with estimates of the cover and height of other vegetation. This was made in sample plots in symmetric grids. Testing the effects of scarification and distance to seed source on natural regeneration of silver birch (Betula pendula Roth.) and downy birch (B. pubescens Ehrh.) showed that both scarification type and degree of soil disturbance significantly affected seedling counts but only if seed sources were close. In conclusion, conventional management practices for regenerating coniferous forest may be suitable for establishing mixed forest stands with combinations of planted and naturally regenerated seedlings.

关键词： Betula Birch Soil Scarification Seed Dispersal

建立儿童患者群体药代动力学依从性模型的研究

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中国临床药理学杂志 2013年第8期29卷 566-570页

作者：张弨翟所迪任远 Helen McIlleron Mats O.karlsson 北京大学第三医院药剂科北京100191 北京大学治疗药物监测和临床毒理中心北京1000191 Division of Clinical Pharmacology Department of MedicineUniversity of CapeTown Department of Pharmaceutical Biosciences Uppsala University

目的本研究通过儿童患者的拉米夫定群体药代动力学研究,建立了拉米夫定群体药代动力学模型,探讨进行患者依从性评价的参考浓度。方法 68名感染HIV的儿童患者接受常规抗逆转录病毒治疗,每名患者采集4～8个拉米夫定的稳态血药浓度数据,用N... 详细信息

目的本研究通过儿童患者的拉米夫定群体药代动力学研究,建立了拉米夫定群体药代动力学模型,探讨进行患者依从性评价的参考浓度。方法 68名感染HIV的儿童患者接受常规抗逆转录病毒治疗,每名患者采集4～8个拉米夫定的稳态血药浓度数据,用NONMEM 7软件建立群体药代动力学模型,探讨进行患者依从性评价的参考浓度。结果拉米夫定清除率随体重增加成指数增加,并随年龄的增加以Emax渐进性曲线模型达到成熟。10 kg儿童的成熟清除率为12.1 l·h-1,其成熟半衰期为4个月。本研究发现拉米夫定存在明显的昼夜节律,夜晚的清除率比白天低16.7%,因此在采集治疗药物监测样本时需要区分早、晚浓度。拉米夫定清除率的个体间变异非常小,可以用于预测患者依从性评价的参考药物浓度。结论本研究确立了评价儿童患者依从性的参考浓度,可用血药浓度监测结果与参考浓度相比较,简单、准确判断儿童患者的依从性。

关键词：拉米夫定依从性治疗药物监测群体药代动力学 NONMEM

每核子14.6和60GeV能量下氧离子诱发核反应的带电粒子谱

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高能物理与核物理 1989年第10期13卷 865-869页

作者： M.I.Adamovich M.M.A■■arwal R.Arora Y.A.Alexandrov S.A.Azimov S.K.Badyal E.Basova K.B.Bhalla A.Bhasin V.S.Badyal R.A.Bomadarenko T.H.Burnett 蔡(冒力) l.P.Chernova M.M.Chernyavski B.Dressel E.M.Friedlander S.I.Gerassimov E.R.Ganssau■e S.Garpman S.G.Gerassimov A.Gill J.Grote K.G.Gulamov V.G.Gulyamov V.K.Gupta S.Hackel H.H.Heckman B.Jakobsson B.Judek S.Katroo F.G.Kadyrov H.Kallies l.karlsson G.l.Kaul M.Kaur S.P.Kharlamov J.Kohli V.Kumar P.lal V.G.larinova P.J.lindstrom 刘连寿 S.lokanathan J.lord N.S.lukicheva l.K.Man■otra N.V.Maslennikova I.S.Mitta E.Monnand S.Moolerjee C.Mueller S.H.Nasyrov V.S.Nvtny G.I.Orlova I.Otterlund N.G.Peresadko S.Persson N.V.Petrov 钱琬燕 R.Raniwala S.Raniwana N.K.Rao J.Y.Rhee N.Shaidkhanov N.G.Salmanova W.Schulz F.Schussler V.S.Shukla D.Skeldin■ K.Soderstrom E.Stanlund R.S.Storey 孙君芬 l.N.Svechnilova M.I.Tretyakova T.P.Trofimova 王海桥翁智群 R.J.Wilkes 许国发张东海郑蒲英周代翠周景晨列比切夫研究所旁加贝大学物理技术研究所查漠大学拉加斯坦大学核物印研究所华盛顿大学华中师范大学菲利浦斯大学劳伦斯-伯克利实验室隆德大学国家研究委员会原子能研究中心 )列比切夫研究所山西师范大学高能物理研究所

本文给出了每核子14.6和60GeV能量下氧离子诱发核反应的带电粒子多重数分布和赝快度分布.实验数据取自EMU-01乳胶叠,并与lund Monte Carlo模型(FRITIOF)作了比较.

关键词：氧离子诱发核反应带电粒子谱