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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAps).

关键词： function supporting

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Volumetric changes in the focal areas of seismic events corresponding to destress blasting

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International journal of Mining Science and Technology 2019年第4期29卷 541-547页

作者： p.Konicek j.Schreiber l.Nazarova Department of Geomechanics and Mining Research Institute of Geonics of the Czech Academy of SciencesOstrava 70800Czech Republic laboratory of Mining Informatics Chinakal Institute of Mining of the Siberian Branch of the Russian Academy of ScienceNovosibirsk 630091Russia

The typical development of total volumetric change in the focal areas of seismic events,corresponding to destress blasting,is characterized as an explosive phase followed by an implosive phase and with alternating additional phases following on from *** a few cases,a non-typical development of volumetric change was identified,where the first phase was implosive and the second phase,*** development is mainly typical for induced seismic events recorded during mining,not for destress *** events were recorded during longwall mining in the Czech part of the Upper Silesian Coal Basin,where the destress blasting technique is used as a rockburst prevention active *** source processes in the focal areas of selected seismic events were analyzed by the seismic moment tensor inversion method,as well as by studying geomechanical rock mass conditions at the localities of the seismic *** main goal of the analysis was to attempt to identify the reasons for non-typical development of volumetric changes in these *** changes were analyzed for seismic events with energy greater than 104 j,recorded in the period of time from 1993 to 2009(1109 events).80%(891)of the recorded seismic events were induced seismic events that were registered during longwall mining and 20%(218)corresponded to destress blasting *** shows that the main reason for the non-typical development of volumetric changes in the focal areas of seismic events is an association with destress blasting in the rock mass,which is very close to rock mass *** detonation of explosives in boreholes,which would dominate the first phase of volumetric changes,probably obscured stress release in the rock mass,as manifested in the first implosion phase of the volumetric changes in this case.

关键词： Destress blasting Seismic event Volumetric changes Stress release

Development and Electrochemical Studies of Ruthenium Based Mixed Oxide Catalyst Electrodes for Chlorine Evolution

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Chemical Research in Chinese Universities 2002年第2期18卷 133-138页

作者： l.X.Yang j.p.G.Farr Department of Chemical and processing Engineering University of Newcastle Merz CourtNewcastle upon Tyne NE17RU School of Metallurgy and Materials The University of Birmingham EdgbastonBirmingham B152TTUK

Experimental results are presented which allow comparison of the electrochemical performance of RuO 2/Ti, Ru 0 3 Sn 0 7 O 2/Ti and Ru 0 3 V 0 7 O 2/Ti catalysts prepared on a titanium substrate by thermal decomposition from respective precursors. The highest activity for chlorine evolution is observed on the Ru 0 3 V 0 7 O 2/Ti electrode, lower on Ru 0 3 Sn 0 7 O 2/Ti and least on RuO 2/Ti. Voltammograms obtained in the polarisable region are used to characterize the different electrodes. Further more an analysis of the catalytic activity and reaction kinetics of the developed electrodes in NaCl are presented.

关键词： Catalyst Cl_(2) evolution Ruthenium oxide

Comparison of Different Formulations for the Numerical Calculation of Unsteady Incompressible Viscoelastic Fluid Flow

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Advances in Applied Mathematics and Mechanics 2010年第4期2卷 483-502页

作者： l.j.Amoreira p.j.Oliveira Departamento de Fisica Unidade de Detecccao RemotaUniversidade da Beira InteriorP6201-001 CovilhãPortugal Departamento de Engenharia Electromecânica Unidade de Materiais Têxteis e PapeleirosUniversidade da Beira InteriorP6201-001 CovilhãPortugal

In this paper we compare different methods currently used in the stabilization of numerical simulations of time-dependent viscoelastic fluid flows described with the Oldroyd-B and related *** methods under consideration,based on the separation of newtonian-like components from the stress tensor,are applied to a finite volume analysis of two simple benchmark problems(the plane poiseuille startup and pulsated flows),for which analytical solutions are *** relative performances of each method are evaluated regarding stability,accuracy and efficiency.

关键词： Time-dependent viscoelastic flows oscilating flow start-up flow computational rheology

FINITE ElEMENT NUMERICAl SIMUlATION OF TEMpERATURE FIElD IN METAl pATTERN CASTING SYSTEM AND "REVERSE METHOD" OF DEFINING THE THERMAl pHYSICAl COEFFICIENT

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Acta Metallurgica Sinica(English letters) 2007年第3期20卷 217-224页

作者： l. Chen p.l. Wang p.N. Song j.Y. Zhang Mechanical Engineering College Tianjin University of Technology Tianjin 300191China

With the technology support of virtual reality and ANSYS software, an example on the simulation of temperature distribution of casting system during the solidification process was provided, which took the latent heat of phase change, the conditions for convection, and the interface heat transfer coefficient into consideration. The result of ANSYS was found to agree well with the test data. This research offers an unorthodox way or ＂reverse method＂ of defining the relevant thermal physical coefficient.

关键词： solidification process reverse method ANSYS software

The microstructure evolution and tensile properties of medium-Mn steel heat-treated by a two-step annealing process

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journal of Materials Science & Technology 2021年第16期75卷 205-215页

作者： D.p.Yang p.j.Du D.Wu H.l.Yi State Key laboratory of Rolling and Automation Northeastern UniversityShenyang110819China

The martensitic hot-rolled 0.3 C-6 Mn-1.5 Si(wt%)steel was annealed at 630℃for 24 h to improve its cold rollability,followed by cold rolling and annealing at 670℃for 10 *** annealing process was designed based on the capacities of industrial batch annealing and continuous annealing lines.A duplex submicron austenite and ferrite microstructure and excellent tensile properties were obtained finally,proved the above process is feasible."Austenite memory"was found in the hot-rolled and annealed sample which restricted recrystallization of lath martensite,leading to lath-shaped morphology of austenite and ferrite grains."Austenite memory"disappeared in the cold-rolled and annealed sample due to austenite random nucleation and ferrite recrystallization,resulting in globular microstructure and refinement of both austenite and ferrite *** austenite to martensite transformation contributed most of strain hardening during deformation and improved the uniform elongation,but the dislocation strengthening played a decisive role on the yielding *** tensile curves change from continuous to discontinuous yielding as the increase of cold-rolled reduction due to the weakening dislocation strengthening of austenite and ferrite grains related to the morphology change and grain refinement.A method by controlling the cold-rolled reduction is proposed to avoid the lüders strain.

关键词： Medium-Mn steel Intercritical annealing Austenite memory Yielding behavior TRIp effect

Coercivity mechanisms in nanostructured permanent magnets

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Chinese physics B 2019年第7期28卷 1-13页

作者： G p Zhao l Zhao l C Shen j Zou l Qiu College of physics and Electronic Engineering & Institute of Solid State physics Sichuan Normal UniversityChengdu 610066 China State Key luboratory of Metastablc Materials Science and Technology Yunshnn University.Qinhuangdao 066004China Collaborative Innovation Center for Shunxi Advanced permanent Materials and Technology Lint'en 041004 China

Coercivity mechanism in permanent magnets has been debated for many *** this paper, various models of the coercivity mechanism are classified and re-examined by the comparison and *** rotation and curling models can reveal the underlying reversal mechanism clearly based on isolated grains with elliptic *** contrast, the numerical methods consider inter-grain interactions while simulating the evolution of the spins and hysteresis loops with complicated ***, an exact simulation of magnetic reversal in permanent nanomagnets requires many meshes to mimic the thin domain wall *** and pinning are the two main coercivity mechanisms in permanent *** former signifies the beginning of the magnetic reversal, whilst the latter completes ***, it is proposed that the large difference between the intrinsic magnetic properties of the nucleation centers and those of the main phase can result in a large pinning field(self-pinning), which has the attributes of both traditional nucleation and *** a pinning explains the experimental data of permanent magnets very well, including the enhancement of the coercivity by the grain boundary pinning.

关键词： coercivity mechanism permanent nanomagnets self-pinning

Effects of torpedo blasting on rockburst prevention during deep coal seam mining in the Upper Silesian Coal Basin

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journal of Rock Mechanics and Geotechnical Engineering 2017年第4期9卷 694-701页

作者： l. Wojtecki p. Konicek j. Schreiber polish Mining Group Powstanców 30 Katowice 40-039 Poland Department of Geomechanics and Mining Research Institute of Geonics Czech Academy of Sciences Studentska 1768 Ostrava-Poruba 708 00 Czech Republic

In the Upper Silesian Coal Basin(USCB),coal seams are exploited under progressively more difficult geological and mining conditions(greater depth,higher horizontal stress,more frequent occurrence of competent rock layers,etc.).Mining depth,dislocations and mining remnants in coal seams are the most important factors responsible for the occurrence of rockburst *** mining next to the mining edges of neighbouring coal seams is particularly *** levels of rockburst hazards are minimised via the use of rockburst prevention *** active prevention method is torpedo blasting in roof *** blastings are performed in order to decrease local stress concentrations in rock masses and to fracture the roof rocks to prevent or minimise the impact of high-energy tremors on *** estimation of the effectiveness of torpedo blasting is particularly important when mining is under difficult geological and mining *** blasting is the main form of active rockburst prevention in the assigned colliery in the polish part of the *** effectiveness of blasting can be estimated using the seismic effect method,in which the seismic monitoring data and the mass of explosives are taken into *** seismic effect method was developed in the Czech Republic and is always being used in collieries in the Czech part of the coal ***,this method has been widely adopted for our selected colliery in the polish part of the coal *** effectiveness of torpedo blastings in the faces and galleries of the assigned longwall in coal seam 506 has been *** results show that the effectiveness of torpedo blastings for this longwall was significant in light of the seismic effect method,which corresponds to the in situ *** seismic effect method is regularly applied to estimating the blasting effectiveness in the selected colliery.

关键词： Rockburst prevention Torpedo blasting Seismic effect Upper Silesian Coal Basin(USCB)