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Mutation in the leucinerich repeat of platelet glycoprotein Ibαresults in defects in its interaction with immobilized von Willebrand factor under flow

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Chinese Medical journal 2000年第8期113卷 21-26页

作者：董京飞 Chesterli Alicia j.Schade Becky j.Fredrickson lily Sun larry V.McIntire josé A.lópez From the Division of Hematology/oncology Department of Internal Medicine Cox Laboratory for Bioengineering Rice University Houston TX 77030 USA Department of Molecular and Human Genetics Baylor College of Medicine and Veterans Affairs Medical Center Houston Cox Laboratory for Bioengineering Rice University Houston TX 77030 USA

objectiveTo characterize effects of the GP Iba mutation(A156V)on its interaction with von Willebrand factor(vWf)under high fluid shear stress.MethodsThe residue A156 of GP Iba was converted to a valine and the mutant expressed in CHo cells expressing wild-type GP Ibβ and GPIX. The transfected cells were tested for their interaction with a panel of GP Iba antibodies and for rolling on immobilized vWf under high shear.ResultsThe mutation led to surface expression of a GP Iba polypeptide that adopted a different conformation at its N-terminus because binding of the GP Iba antibody AN51, which has a binding epitope it the N-terminal 35 residues, was eliminated, whereas binding of the others(AK2, MB45, and SZ2, all of which bind to regions C-terminal to the AN51 epitope)was normal. Mutant-expressing cells could adhere and roll on immobilized vWf under high fluid shear stress and rolled significantly faster than wild-type cells.ConclusionThese studies demonstrate that the mutation A156V results in a conformation change at the N-terminus of GP Ibα, which leads to an increase in the dissociation rate of the bond between the GP Ibα mutant and vWf. Chin Med j 2000; 113(8): 693-698

关键词： mutation glycoprotein von Willebrand factor defects

子宫颈根治切除术后放置Malecot导管有助于胚胎移植

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 24-25页

作者： Aust T.R. Herod j.j.o. Gazvani R. 郭培奋 Hewitt Centre for Reproductive Medicine Liverpool Women' s Hospital Crown Street Liverpool L8 7SS United Kingdom Dr.

objective: To describe the use of a Malecot catheter as a stent after radical trachelectomy (RT). Design: Case report. Setting: Assisted conception unit at a teaching hospital in the United Kingdom. Patient(s): A 36-year-old woman undergoing IVF after her cervix had been excised for cervical carcinoma. Previous attempts at embryo transfer (ET) had been very traumatic and required a transmyometrial transfer on one occasion. Intervention(s): A Malecot catheter was inserted into the uterine cavity after a dilatation procedure had been performed and removed before ovarian stimulation. Main outcome Measure(s): Ease of ET. Result(s): The subsequent ET was much more straightforward. Conclusion(s): This technique can facilitate ET after RT if the passage is found to be stenosed.

关键词：胚胎移植根治切除术 Malecot 卵巢刺激体外受精宫颈狭窄教学医院子宫腔子宫肌层

Evaluation of improved quality of life and therapeutic effect of duragesic on cancerous pain in patients with and advanced tumors

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中国临床康复 2002年第16期6卷 2500-2501页

作者： Fan l. Ren j. Zhang Y.-j. You X.-H. Sheng R. li Y.-Q. Xijing Hospital Fourth Military Medical University Xi'an 710032 China

objective To investigate therapeutic effect of duragesic in the treatment of cancerous pain in patients with advanced tumors,Method Before entering the study,all patients suffered from moderate to sever cancerous pain,All patients were given 5 doses of duragesic within 15 days,Evaluation was performed every 12 hous,We assessed pain intensity and pain relief by using numoral rating scale(NRS).Quality of life was also *** Eventual dose was 2.5 mg in 10cases,5 mg in 49 cases.,7.5 mg in 5 cases,10 mg in 3cases,and 12.5 mg in 1 cases,15mg in 1 case complete relief was observed in 13 cases,partial relief observed in 45 cases, effective rate was 84.06%,The therapeutic effect of duragesic was similar to that of MS contin,Therapeutic dffect occurred 48-72house later and became most significant 2-4 days later,and maintain at constant level,Conclusion By the special pattern for delivery via transdermal system,duragesic produces lasting and stable analgesic effect,In addition,it is characterized by simple operation,convenient application,insignificant adverse .Hence,duragesic can replace oral strong opiod drugs.

关键词：多瑞吉晚期癌痛镇痛疗效生存质量

Zebrafish as a possible bioindicator of organic pollutants with effects on reproduction in drinking waters

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journal of Environmental Sciences 2015年第7期27卷 254-260页

作者： M.Martínez-Sales F.García-Ximénez F.j.Espinós Aquaculture and Environmental Research Group (ACUMA) Polytechnic University of Valencia

organic contaminants can be detected at low concentrations in drinking water, raising concerns for human health, particularly in reproduction. In this respect, we attempted to use the zebrafish as a bioindicator to detect the possible presence of these substances in drinking water, aiming to define the most relevant parameters to detect these substances, which particularly affect the development and reproduction of zebrafish. To this end, batches of30 embryos with the chorion intact were cultured in drinking waters from different sources,throughout their full life-cycle up to 5 months, in 20 l tanks. Six replicates were performed in all water groups, with a total of 24 aquariums. Two generations（F0 and F1） were studied and the following parameters were tested： in the F0 generation, survival and abnormality rates evaluated at 5 dpf（days post-fertilization） and at 5 mpf（months post-fertilization）,the onset of spawning and the fertility rate from 3 mpf to 5 mpf, and the sex ratio and underdeveloped specimens at 5 mpf. Furthermore, in the F0 offspring（F1）, survival and abnormality rates were evaluated at 5 dpf and the hatching rate at 72 hpf. These results revealed that the hatching rate is the most sensitive parameter to distinguish different levels of effects between waters during the early life stages, whereas the rate of underdeveloped specimens is more suitable at later life stages. Regarding adult reproduction, fertility rate was the most sensitive parameter. The possible reversibility or accumulative nature of such effects will be studied in future work.

关键词： organic pollutants Bioindicator Development and reproduction parameters Drinking water Zebrafish

Photometric observations of three high mass X-ray binaries and a search for variations induced by orbital motion

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Research in Astronomy and Astrophysics 2011年第8期11卷 947-964页

作者： Gordon E. Sarty Bogumil Pilecki Daniel E. Reichart Kevin M. Ivarsen joshua B. Haislip Melissa C. Nysewander Aaron P. laCluyze Helen M. johnston Robert R. Shobbrook lászl l. Kiss Kinwah Wu Departments of Psychology and Physics University of Saskatchewan9 Campus DriveSaskatoonSaskatchewan S7N 5A5Canada Warsaw University observatory Al. Ujazdowskie 400-478 WarsawPoland Universidad de Concepcion Departamento de AstronomaCasilla 160-CConcepcionChile Department of Physics and Astronomy University of North Carolina-Chapel HillCB 3255Phillips HallChapel HillNC 27599-3255USA School of Physics A28 University of SydneyNew South Wales 2006Australia Konkoly observatory H-1525 BudapestP.O. Box 67Hungary Mullard Space Science laboratory University College LondonHolmbury St. MaryDorkingSurrey RH5 6NTUnited Kingdom

We searched for long period variation in V-band, It-band and RXTE X-ray light curves of the High Mass X-ray Binaries （HMXBs） lS 1698 / RX j1037.5-5647, HD 110432 / 1H 1249-637 and HD 161103 / RX j1744.7-2713 in an attempt to discover orbitally induced variation. Data were obtained primarily from the ASAS database and were supplemented by shorter term observations made with the 24- and 40-inch ANU telescopes and one of the robotic PRoMPT telescopes. Fourier periodograms suggested the existence of long period variation in the V-band light curves of all three HMXBs, however folding the data at those periods did not reveal convincing periodic variation. At this point we cannot rule out the existence of long term V-band variation for these three sources and hints of longer term variation may be seen in the higher precision PRoMPT data. long term V-band observations, on the order of several years, taken at a frequency of at least once per week and with a precision of 0.01 mag, therefore still have a chance of revealing long term variation in these three HMXBs.

关键词： accretion -- stars: Be stars -- stars: neutron stars -- stars: individual lS 1698 HD 110432 HD 161103 -- X-rays: binaries

Azimuthal correlation of hadrons in a partonic/hadronic transport model

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Azimuthal correlation of hadrons in a partonic/hadronic tran...

Studies of laser-plasma interaction physics with low-density targets for direct-drive inertial confinement fusion on the Shenguang III prototype

The 6th China-Nuclear Physics Symposium

作者： G. l. Ma, S. Zhang, Y. G. Ma, X. Z. Cai, j. H. Chen, Z. j. He, H. Z. Huang, j. l. long, W. Q. Shen, X. H. Shi, j. X. Zuo Shanghai Institute of Applied Physics, CAS

lattice QCD calculations have predicted a transition from quark-gluon plasma (QGP) to hadronic matter at a high temperature or density. The recent results form the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National laboratory (BNl) have demonstrated that a hot dense new matter with strong collective motion which can not be described with hadronic degrees of freedom was created at RHIC.

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Matter and Radiation at Extremes 2021年第2期6卷 54-66页

作者： V.T.Tikhonchuk T.Gong N.jourdain o.Renner F.P.Condamine K.Q.Pan W.Nazarov l.Hudec j.limpouch R.liska M.Krus F.Wang D.Yang S.W.li Z.C.li Z.Y.Guan Y.G.liu T.Xu X.S.Peng X.M.liu Y.l.li j.li T.M.Song j.M.Yang S.E.jiang B.H.Zhang W.Y.Huo G.Ren Y.H.Chen W.Zheng Y.K.Ding K.lan S.Weber ElI-Beamlines Institute of PhysicsCzech Academy of Sciences25241 Dolni BrezanyCzech Republic Centre lasers Intenses et Applications University of Bordeaux-CNRS-CEA33405 TalenceFrance laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Institute of Plasma Physics Czech Academy of Sciences18200 PragueCzech Republic Independent Foam Target Supplier CarnoustieDD76DPUnited Kingdom Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague11519 PragueCzech Republic Institute of Applied Physics and Computational Mathematics Beijing 100088China Center for Applied Physics and Technology Peking UniversityBeijing 100871China School of Science Xi’an Jiaotong UniversityXi’an 710049China

The physics of laser-plasma interaction is studied on the Shenguang III prototype laser facility under conditions relevant to inertial confinement fusion designs.A sub-millimeter-size underdense hot plasma is created by ionization of a low-density plastic foam by four high-energy(3.2 kj)laser *** interaction beam is fired with a delay permitting evaluation of the excitation of parametric instabilities at different stages of plasma *** diagnostics are used for plasma characterization,scattered radiation,and accelerated *** experimental results are analyzed with radiation hydrodynamic simulations that take account of foam ionization and *** measured level of stimulated Raman scattering is almost one order of magnitude larger than that measured in experiments with gasbags and hohlraums on the same installation,possibly because of a greater plasma *** amplification is achieved in high-intensity speckles,indicating the importance of implementing laser temporal smoothing techniques with a large bandwidth for controlling laser propagation and absorption.

关键词： density. interaction scattered

维普期刊数据库评论

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用于铁英岩铁矿石反浮选的胺类捕收剂

国外金属矿选矿 1978年第4期 6-14页

作者： R.Houot j.l.Polgaire 杨旭

一铁英岩型铁矿床一般呈接触变质构造,致使矿石在结构、铁品位和解离粒度方面都有很大变化,后者数量对选矿有相当大的影响(1975年***、***、***-smuth)。这类矿床由于蚀变作用使一些铁矿物氧化,并使之含有粘土和一些蚀变矿物(针铁矿、... 详细信息

一铁英岩型铁矿床一般呈接触变质构造,致使矿石在结构、铁品位和解离粒度方面都有很大变化,后者数量对选矿有相当大的影响(1975年***、***、***-smuth)。这类矿床由于蚀变作用使一些铁矿物氧化,并使之含有粘土和一些蚀变矿物(针铁矿、褐铁矿等)。

关键词：醚胺醋酸盐二氧化硅回收率乙酸盐实收率混合捕收剂脱泥浮选试验矿石淀粉浓度

用1兆週电路做成的1微秒幷行加法器的邏輯設計

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计算机研究与发展 1959年第1期 5-14页

作者： A.溫伯葛 j.l.斯密斯

本文討論一个並行加法器的邏輯設計,它可以將兩个53位數的加法在1微秒之内完成。設計中采用了已在國家标准局計算机SEAC和DYSEAC中@得良好效果的1兆週基本电路。根据进位數对加数和被加数之間函数关系的分析,可以証明,只要增加少量的元... 详细信息

本文討論一个並行加法器的邏輯設計,它可以將兩个53位數的加法在1微秒之内完成。設計中采用了已在國家标准局計算机SEAC和DYSEAC中@得良好效果的1兆週基本电路。根据进位數对加数和被加数之間函数关系的分析,可以証明,只要增加少量的元件,就能夠实現很多数位的同时进位。每一个进位数的布尔表示式,都可以由某一較低位的进位及適当的加數和被加数的@函数來表示。这些較复雜的公式,都用它們所包含的公共項及公因子來表示,使之簡化。这些公共項及公因子,称为輔助进位函数,可以簡單地來完成。所有函数表示式都可以由所采用的电路來实現。

关键词：加法器