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Radioisotope production using lasers:From basic science to applications

Matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： M.R.D.Rodrigues A.Bonasera M.scisciò j.A.Pérez-Hernández M.Ehret F.Filippi P.l.Andreoli M.Huault H.larreur D.singappuli D.Molloy D.Raffestin M.Alonzo G.G.Rapisarda D.lattuada G.l.Guardo C.Verona Fe.Consoli G.Petringa A.McNamee M.la Cognata s.Palmerini T.Carriere M.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.Margarone l.Giuffrida D.Batani P.Nicolai K.Batani R.lera l.Volpe D.Giulietti s.Agarwal M.Krupka s.singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA laboratori Nazionali del sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de láseres Pulsados(clpu) VillamayorSpain Universidad de salamanca SalamancaSpain Centre lasers Intenses et Applications(CElIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia school of Mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.Majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ElI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETsIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers.Protons with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary targets.Under such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical application.The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators.In this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other applications.At the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy production.The experiment was performed at the 1 PW laser facility at VegaⅢin salamanca,spain.Angular distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium detector.Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[Nucl.Instrum.Methods Phys.Res.,sect.A 637,164–170(2011)].

关键词： purity estimates backward

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COVID-19 vaccination produces exercise-responsive sARs-CoV-2 specific T-cells regardless of infection history

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journal of sport and Health science 2024年第1期13卷 99-107页

作者： Kyle A.smith Tiffany M.Zúñiga Forrest l.Baker Helena Batatinha Charles R.Pedlar shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard j.simpson school of Nutritional sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive sARs-CoV-2 T-cells and transiently alter nAb titers.Methods:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 vaccine.All major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to sARs-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and sARs-CoV-2 nAb serology.Results:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded exercise.However,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior sARs-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized sARs-CoV-2 specific T-cells to blood in an intensity-dependent manner.Both groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid antigens.nAbs increased significantly during exercise only in the hybrid immunity group.Conclusion:These data indicate that acute exercise mobilizes sARs-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology sARs-CoV-2 T-Cells Vaccine

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Effects of sterilization Treatments on the Compositions and Functions of Microflora on Duck Eggshell Inner and Outer surfaces

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Modern Food science and Technology 2024年第5期40卷 53-63页

作者： sun j. Peng X. Yang X. Yang H. lu l. Hu T. Xiang j. Zeng T. Pi j. Du j. Institute of Animal Husbandry and Veterinary Medicine Hubei Academy of Agricultural Sciences Wuhan 430064 China Zhejiang Academy of Agricultural sciences Hangzhou 310009 China Hubei Tianhu Egg Poultry Co. ltd. Jianli 433300 China Hubei shendan Healthy Food Co. ltd. Wuhan 430200 China

The effects of sterilization treatments on the microbial compositions on both the inner and outer surfaces of duck eggshells and the ratio of black to yellow salted egg yolks were investigated in this study. Duck eggs were fumigated and cleaned with different fumigants and cleaning agents, and then stored at different temperatures. Changes in the total number of bacteria on duck eggshell inner and outer surfaces before and after treatments were subsequently compared. The effects of sterilization on the microflora on duck eggshell outer surfaces were evaluated using 16s rRNA gene sequencing and PICRUst gene function prediction. salted duck eggs were prepared using the mud-packing method at 35 ℃, and the ratio of black to yellow salted egg yolks was calculated. The results show that fumigation significantly inhibits the migration of bacterial colonies from the outer to inner surfaces of the eggshells, effectively controlling the total number of bacteria inside the shell. Two fumigation treatments increase efficacy relative to one. Total bacteria on the outer surface can be reduced to below the detection limit by cleaning. low-temperature storage can limit bacterial proliferation on both inner and outer eggshell surfaces over 7 days. Total bacteria numbers on both inner and outer surfaces can be significantly reduced by combining fumigation, cleaning, and low-temperature storage. These processes also inhibit bacterial migration, tightly controlling the total bacteria inside the eggshell. 16s rRNA gene sequencing demonstrates a notable reduction in the proportion of Proteobacteria and Psychrobacter on the outer surface of the shell following sterilization treatments. Additionally, PICRUst gene function prediction indicates a significant decrease in microbial activity within pathways associated with lipid oxidation, amino acid transport, and metabolism after sterilization treatments. sterilization also significantly reduces the ratio of black to yellow salted egg yolks. These studies illustrate that sterilization trea

关键词： duck eggs function prediction high-throughput sequencing ratio of black to yellow salted egg yolks sterilization

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Highly divergent sympatric lineages of leptotila verreauxi(Aves:Columbidae)suggest a secondary contact area in the Isthmus of Tehuantepec,Mexico

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Avian Research 2024年第1期15卷 12-21页

作者： Orlando j.Espinosa-Chávez Adolfo G.Navarro-sigüenza Hernando Rodríguez-Correa luis A.sánchez-González Museo de Zoología“Alfonso l.Herrera” Depto.de Biología EvolutivaFacultad de CienciasUniversidad Nacional Autonoma de MexicoApdo.Postal 70-399CP 04510Ciudad de MexicoMexico Posgrado en Ciencias Biologicas Unidad de PosgradoEdificio D1◦PisoCircuito de PosgradosCiudad UniversitariaUniversidad Nacional Autonoma de MexicoCoyoacanCP 04510CDMXMexico Escuela Nacional de Estudios superiores Unidad Morelia Universidad Nacional Autonoma de Mexico.Antigua Carretera a Patzcuaro No.8701 Col.Ex Hacienda de San Jose de la HuertaC.P.58190MoreliaMichoacanMexico

Due to a complex geological and biotic history,the Isthmus of Tehuantepec(IT),has been long recognized as a driver for the evolutionary divergence of numerous lowland and highland taxa.Widely distributed in the lowlands of the American continent,the White-Tipped Dove(leptotila verreauxi)is a polytypic species with 13 recognized subspecies.Four of these have been recorded in Mexico,and the distribution of three abuts at the IT,suggesting a contact zone.To estimate phylogenetic patterns,divergence times and genetic differentiation,we examined two mt DNA(ND2 and COI)and one n DNA(β-fibint 7)markers.We also used correlative ecological niche models(ENM)to assess whether ecological differences across the IT may have acted as a biogeographical boundary.We estimated paleodistributions during the Middle Holocene,last Glacial Maximum and last Interglacial,to evaluate the influence of climate changes on the distribution and demographic changes.Our results showed genetically distinct lineages that diverged approximately 2.5 million years ago.Climatic and ecological factors may have played a dual role in promoting differentiation,but also in the formation of a secondary contact zone in the southern IT.Our ecological niche comparisons indicated that the ecological niche of sympatric lineages at the IT are not identical,suggesting niches divergence;in addition,environmental niche models across the region indicated no abrupt biogeographic barriers,but the presence of regions with low suitability.These results suggest that genetic differentiation originated by a vicariant event probably related to environmental factors,favored the evolution of different ecological niches.Also,the absence of a biogeographic barrier but the presence of less suitable areas in the contact regions,suggest that secondary contact zones may be also maintained by climatic factors for the eastern group,but also by biotic interactions for the western group.

关键词： Biogeographical boundary Humid and dry forests Isthmus of Tehuantepec Phylogeography secondary contact

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study on preparation and electromagnetic shielding properties of silver-coated ferrosilicochrome powder

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Chinese journal of ship Research 2024年第2期19卷 173-180页

作者： Wu j. Wang W. Yang X. Deng l. Chen Q. school of Materials science and Engineering Northwestern Polytechnical University Xi'an 710072 China China ship Development and Design Center Wuhan 430064 China

［Objective］This study focuses on the preparation and properties of high-performance electromagnetic shielding materials for electronic equipment in marine environments. ［Methods］The surface morphology, phase composition, electrical conductivity and ferromagnetic properties of the original ferrosilicochrome powder (FesiCr) and silver-coated powder (FesiCr@Ag) are analyzed with a scanning electron microscope, X-ray diffractometer, four probes and vibrating sample magnetometer, and a vector network analyzer is used to test the s parameters of the samples. A salt spray test chamber is used to simulate the corrosion behavi- or of the coating under marine environment conditions and observe its macro and micro morphology. Meanwhile, an electrochemical workstation is used to monitor the corrosion behavior of the coating in a mass fraction of 3.5% NaCl solution and study its corrosion mechanism. ［Results］The results show that the silver plating layer is compact and complete with the increase of the silver nitrate (AgNO3) addition. After electroless silver plating, the conductivity can reach 586.79 s/cm and the X-band shielding efficiency reaches 80 dB. After 96 h of accelerated corrosion in a humid heat and high salt spray environment, the surface of the resin coating prepared by FesiCr@Ag shows no corrosion phenomenon. The self-corrosion potential of the coating before and after electroless silver plating is −0.4 V and −0.09 V respectively, indicating that the penetration rate of the corrosive medium into the coating slows down after silver plating, and a good corrosion inhibition effect is achieved.［Conclusions］The modified FesiCr@Ag material has highly efficient electromagnetic shielding performance and good corrosion resistance properties. © 2024 Editorial Department of Chinese journal of ship Research. All rights reserved.

关键词： coating modification corrosion resistance electromagnetic shielding ferrosilicochrome

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Physiological phenotypes differ among color morphs in introduced common wall lizards(Podarcis muralis)

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Integrative Zoology 2024年第3期19卷 505-523页

作者： Ali AMER sierra sPEARs Princeton l.VAUGHN Cece COlWEll Ethan H.lIVINGsTON Wyatt MCQUEEN Anna sCHIll Dustin G.REICHARD Eric j.GANGlOFF Kinsey M.BROCK Department of Biological sciences Ohio Wesleyan UniversityDelawareOhioUSA Department of Ecology and Evolutionary Biology Princeton UniversityPrincetonNew JerseyUSA Department of Biology Idaho State UniversityPocatelloIdahoUSA Department of Environmental science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA Museum of Vertebrate Zoology University of CaliforniaBerkeleyUSA

Many species exhibit color polymorphisms which have distinct physiological and behavioral characteristics.However,the consistency of morph trait covariation patterns across species,time,and ecological contexts remains unclear.This trait covariation is especially relevant in the context of invasion biology and urban adaptation.specifically,physiological traits pertaining to energy maintenance are crucial to fitness,given their immediate ties to individual reproduction,growth,and population establishment.We investigated the physiological traits of Podarcis muralis,a versatile color polymorphic species that thrives in urban environments(including invasive populations in Ohio,UsA).We measured five physiological traits(plasma corticosterone and triglycerides,hematocrit,body condition,and field body temperature),which compose an integrated multivariate phenotype.We then tested variation among co-occurring color morphs in the context of establishment in an urban environment.We found that the traits describing physiological status and strategy shifted across the active season in a morph-dependent manner—the white and yellow morphs exhibited clearly different multivariate physiological phenotypes,characterized primarily by differences in plasma corticosterone.This suggests that morphs have different strategies in physiological regulation,the flexibility of which is crucial to urban adaptation.The white-yellow morph exhibited an intermediate phenotype,suggesting an intermediary energy maintenance strategy.Orange morphs also exhibited distinct phenotypes,but the low prevalence of this morph in our study populations precludes clear interpretation.Our work provides insight into how differences among stable polymorphisms exist across axes of the phenotype and how this variation may aid in establishment within novel environments.

关键词： color polymorphism physiological status seasonal variation thermoregulation urban habitat

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Harnessing the power of complex light propagation in multimode fibers for spatially resolved sensing

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Photonics Research 2024年第3期12卷 411-422页

作者： DARCY l.sMITH lINH V.NGUYEN MOHAMMAD I.REjA ERIK P.sCHARTNER HEIKE EBENDORFF-HEIDEPRIEM DAVID j.OTTAWAY sTEPHEN C.WARREN-sMITH Institute for Photonics and Advanced sensing and school of Physics Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Research Council Centre of Excellence for Gravitational Wave Discovery(OzGrav) AdelaideSAAustralia Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia laser Physics and Photonics Devices laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of coherent light in multimode optical fibers results in a speckled output that is both complex and sensitive to environmental effects.These properties can be a powerful tool for sensing,as small perturbations lead to significant changes in the output of the fiber.However,the mechanism to encode spatially resolved sensing information into the speckle pattern and the ability to extract this information are thus far unclear.In this paper,we demonstrate that spatially dependent mode coupling is crucial to achieving spatially resolved measurements.We leverage machine learning to quantitatively extract the spatially resolved sensing information from three fiber types with dramatically different characteristics and demonstrate that the fiber with the highest degree of spatially dependent mode coupling provides the greatest accuracy.

关键词： fiber spatially resolved

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Degradation and resynthesis of chlorophyll during increased oxidative stress and prolonged darkness differ between annual and perennial flax(linum l.)

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Oil Crop science 2024年第2期9卷 121-130页

作者： Kenyon j. Nisbett Abida Alokozai su Hyun Elizabeth Ko G. Adam Mott jason C.l. Browna Department of Biological sciences University of Toronto ScarboroughTorontoONCanada Department of Cell&systems Biology University of TorontoTorontoONCanada Centre for the Analysis of Genome Evolution&Function University of TorontoTorontoONCanada

Among plants,there is considerable variation in lifespan:annuals live less than one year,whereas perennials live for several years,with the longest-living perennial having survived 43,600 years.As proposed by the Disposable soma Theory,this lifespan variation among plants likely reflects differential investment of limited energy and nutrient resources,with perennials investing more energy and nutrients into biomolecular maintenance compared to annuals in order to ensure persistence over multiple seasons.such differential investment may be particularly important during periods of exogenous stress,which are known to accelerate biomolecular damage.The present study evaluated this hypothesis using annual and perennial flax(linum l.)subjected to two exogenous stressors—increased oxidative stress(i.e.,foliar H2O2spraying)and complete prolonged darkness.As chlorophyll has been shown to exhibit degradation in response to changes in environmental conditions,we utilized changes in chlorophyll levels during and after periods of exogenous stress to evaluate our hypotheses.We predicted that i)perennials would exhibit a slower rate of chlorophyll degradation during exposure to exogenous stressors compared to annuals,and ii)perennials would exhibit a faster rate of chlorophyll resynthesis following such exposure compared to annuals.Chlorophyll levels before,during,and after exposure to both exogenous stressors were measured in two separate trails,once using image colour analysis and once using spectrophotometry.While chlorophyll degradation rates in response to oxidative stress did not differ between annuals and perennials,contrary to our predictions,chlorophyll resynthesis rates following such exposure were significantly higher in perennials,as predicted.When plants were subjected to complete prolonged darkness,chlorophyll degradation rates were significantly lower in perennials than annuals,as predicted;however,when plants were subsequently reintroduced to natural photoperiod,chlorophyll resynthesis rates did not consistently

关键词： Ageing life history Maximum lifespan Oxidative stress somatic maintenance

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Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

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journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： lokesh Choudhary Parama Chakraborty Banerjee R.K.singh Raman Derrek E.lobo Christopher D.Easton Mainak Majumder Frank Witte jörg F.löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale science and Engineering laboratory(NsEl) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CsIRO Materials science and Engineering Bayview AvenueClaytonVIC 3168Australia julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body environment.This necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical integrity.In this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite coating.Detailed analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

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Effects of low molecular weight polysaccharide from sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-l1 adipocyte and HepG2 cells

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Food science and Human Wellness 2024年第4期13卷 2244-2252页

作者： Hyo-Geun lee D.P.Nagahawatta M.j.M.s.Kurera Kyung-Mo song Yun-sang Choi You-jin jeon Min-Cheol Kang Department of Marine life sciences Jeju National UniversityJeju 63243Republic of Korea Department of Biotechnology Faculty of Agriculture and Plantation ManagementWayamba University of Sri LankaMakanduraGonawila(NWP)60170Sri Lanka Research Group of Food Processing Korea Food Research Institute245Wanju 55365Republic of Korea

low molecular weight polysaccharides can be isolated from sargassum thunbergii(lMPsT)and in vitro experiments were conducted to evaluate the inhibitory effects on lipids.Two natures of lMPsT were attained from s.thunbergii and appraised their lMPsT on palmitic acid(PA)induced lipid accretion in Hep G2,and 3T3-l1 cells.lMPsT treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned cells.The mechanistic study publicized that lMPsT2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-l1 cells occupied in the lipolysis pathway.Furthermore,in PA-treated Hep G2 cells,the free fatty acid oxidation was significantly increased by lMPsT2.Given these constructive properties of lMPsT2 from s.thunbergii,is a potential candidate for diminishing the intracellular lipids,and for a therapeutic agent in those conditions.

关键词： sargassum thunbergii low molecular weight polysaccharide lipid accumulation Obesity liver steatosis

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