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大气污染与森林

大气污染与森林

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

作者： W.h.·史密斯(W.h. Smith)

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris l.Vos Charlotte l.Zuur Noel F.C.C.de Miranda heinz Jacobs Sjoerd h.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTl)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell.h.lp,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MhC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTl anticancer *** cooperation with CD40 ligand(l),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTl response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTls locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell.h.lp cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTl priming Tumor control

肾脏恶性肿瘤冷冻消融术后早期对比增强：影像表现与良性相关

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国际医学放射学杂志 2024年第1期 130-131页

作者： T.Grand C.Delavaud C.Dariane T.Ramtohul S.Guinebert O.hélénon 李江

摘要目的肾脏恶性肿瘤冷冻消融术后早期MRI对比增强可能提示肿瘤残留（RT）。但冷冻消融术后48 h内MRI上出现强化的病人在6周后没有对比度增强，研究旨在分析

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Recent Advances in Catalytic Carbonylation Reactions in Alternative Reaction Media

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Chinese Journal of Chemistry 2024年第4期42卷 406-429页

作者： Csaba Árvai lászló T.Mika Department of Chemical and Environmental Process Engineering Faculty of Chemical Technology and BiotechnologyBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111 BudapestHungary

Since the discovery of the hydroformylation(oxo-synthesis or Roelen reaction)and the Reppe-reaction,the transition metal-catalyzed carbonylation reactions,providing versatile,facile,and even atom-economic methods for the selective incorporation of C=O functionality to various skeletons,have gained tremendous importance in synthetic organic chemistry from laboratories to industrial *** carbonylation of carbon-carbon multiple bonds,aromatic halides,triflates,etc.,in the presence of various nucleophiles has led the way to produce aldehydes,carboxylic acids,esters,amides,etc.,in the fine chemical ***,these protocols usually proceed in conventional,fossil-based,and usually toxic reaction ***,several attempts have been directed to developing efficient carbonylation methods in alternative,less harmful,non-fossil-based and even in renewable reaction *** this review,we overview the recent applications of alternative solvents such as water,biomass-based alcohols,γ-valerolactone(GVl),2-methyltetrahydrofuran(2-MeThF),ionic liquids(Ils),deep eutectic solvents(DES),alkyl levulinates,limonene,α-pinene,and dimethyl carbonate as well as fluorous media to improve efficiency,safety and environmentally benign nature of carbonylation protocols.

关键词： Carbonylation Catalysis Solvents Green chemistry Carbon monoxide Transition metals homogeneous catalysis Palladium

Physiological phenotypes differ among color morphs in introduced common wall lizards(Podarcis muralis)

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Integrative Zoology 2024年第3期19卷 505-523页

作者： Ali AMER Sierra SPEARS Princeton l.VAUGhN Cece COlWEll Ethan h.lIVINGSTON Wyatt MCQUEEN Anna SChIll Dustin G.REIChARD Eric J.GANGlOFF Kinsey M.BROCK Department of Biological Sciences Ohio Wesleyan UniversityDelawareOhioUSA Department of Ecology and Evolutionary Biology Princeton UniversityPrincetonNew JerseyUSA Department of Biology Idaho State UniversityPocatelloIdahoUSA Department of Environmental Science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA Museum of Vertebrate Zoology University of CaliforniaBerkeleyUSA

Many species exhibit color polymorphisms which have distinct physiological and behavioral ***,the consistency of morph trait covariation patterns across species,time,and ecological contexts remains *** trait covariation is especially relevant in the context of invasion biology and urban ***,physiological traits pertaining to energy maintenance are crucial to fitness,given their immediate ties to individual reproduction,growth,and population *** investigated the physiological traits of Podarcis muralis,a versatile color polymorphic species that thrives in urban environments(including invasive populations in Ohio,USA).We measured five physiological traits(plasma corticosterone and triglycerides,hematocrit,body condition,and field body temperature),which compose an integrated multivariate *** then tested variation among co-occurring color morphs in the context of establishment in an urban *** found that the traits describing physiological status and strategy shifted across the active season in a morph-dependent manner—the white and yellow morphs exhibited clearly different multivariate physiological phenotypes,characterized primarily by differences in plasma *** suggests that morphs have different strategies in physiological regulation,the flexibility of which is crucial to urban *** white-yellow morph exhibited an intermediate phenotype,suggesting an intermediary energy maintenance *** morphs also exhibited distinct phenotypes,but the low prevalence of this morph in our study populations precludes clear *** work provides insight into how differences among stable polymorphisms exist across axes of the phenotype and how this variation may aid in establishment within novel environments.

关键词： color polymorphism physiological status seasonal variation thermoregulation urban habitat

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金属材料及习题

金属材料及习题

磷化镍修饰磷掺杂氧化镓可见光催化水分解产氢

作者： l.h.·范弗拉克(l.h. Vanvlack)

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无机化学学报 2024年第4期40卷 736-750页

作者：杨博吕功煊马建泰中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室兰州730000 中国科学院大学北京100049 兰州大学化学化工学院兰州730000

以Ga_(2)O_(3)半导体为前驱体,用浸渍加低温磷化法制备了P掺杂Ga_(2)O_(3)表面修饰Ni_(2)P光催化剂(x-Ni_(2)P/Ga_(2)O_(3)-P_(y),x代表Ni^(2+)和Ga_(2)O_(3)的物质的量之比,y代表Nah_(2)PO·h_(2)O与Ga_(2)O_(3)的物质的量之比)。5%-Ni_(2)P/Ga_(2)O_(3)-P_(6)催化剂展现出在纯水中光催化析氢的高活性,在430 nm光照下的光量子效率为0.22%。机理研究结果表明Ni_(2)P修饰和P掺杂扩展了催化剂的光响应范围,同时提升了载流子分离迁移效率,其长周期光催化反应稳定性明显优于未磷化催化剂。

关键词：氧化镓磷掺杂磷化镍光催化产氢

Photometric and Spectroscopic Study of Ten low Mass Ratio Contact Binary Systems:Orbital Stability,O'Connell Effect and Infrared Calcium line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： Surjit S.Wadhwa Adam Popowicz Raúl Michel Petar Kostić Oliver Vince Nick F.h.Tothill Ain Y.De horta Miroslav D.Filipović School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

青藏高原及其周边侏罗纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 1211-1243页

作者：李建国饶馨牟林崔肖辉李鑫罗辉刘培学中国科学院南京地质古生物研究所中国科学院生物演化与环境卓越创新中心南京210008 中国科学院大学南京学院南京211135

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗... 详细信息

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗系建立了一个新的多重地层划分对比和时代框架.该框架包括巴颜喀拉、羌塘、拉萨-冈底斯和藏南喜马拉雅四个分区.其中,综合生物地层框架得到了很大的补充和细化,包括了一系列在青藏高原侏罗系中常见并在国际侏罗系划分对比中具有重要作用的化石门类,如海相的菊石、双壳、腕足、放射虫、有孔虫和沟鞭藻以及陆相的孢子花粉和轮藻等.通过菊石标准分子或特征属种,建立了该生物地层框架与国际地层委员会2020年侏罗纪地质年表(GTS 2020)的标准分带的对比.以此为基础,建立了青藏高原主要区块间侏罗系的横向对比.生物群对比揭示,侏罗纪时拉萨-冈底斯区与羌塘区的关系比与藏南喜马拉雅更紧密,它们总体属于东特提斯洋北缘海区同一个特征相似的生物地理区系,不太支持雅鲁藏布江缝合带特提斯是弧后小盆地的观点.综合地层、生物和沉积特征,研究认为,班公湖-怒江特提斯在晚三叠世开始张裂,可能在早侏罗世晚期已有初始洋壳增生形成;中侏罗世晚期班公湖-怒江洋发展至顶峰,随后开始收缩,羌塘地块向南俯冲与拉萨-冈底斯地块发生碰撞和拼合.

关键词：生物地层年代地层特提斯雅鲁藏布缝合带班公湖-怒江缝合带