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Cenozoic basin evolution of the Central Patagonian Andes:Evidence from geochronology, stratigraphy, and geochemistry

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Geoscience Frontiers 2019年第3期10卷 1139-1165页

作者： A.Encinas A.Folguera R.Riffo P.Molina l.fernández Paz V.D.litvak D.A.Colwyn V.A.Valencia M.Carrasco Departamento de Ciencias de la Tierra Facultad de Ciencias Químicas Universidad de Concepción Instituto de Estudios Andinos Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Departamento de Ciencias Geológicas CONICET-Universidad de Buenos Aires Instituto de Estudios Andinos Don Pablo Groeber (IDEAN) Department of Geology & Geophysics Yale University School of the Environment Washington State University

The Central Patagonian Andes is a particular segment of the Andean Cordillera that has been subjected to the subduction of two spreading ridges during Eocene and Neogene times. In order to understand the Cenozoic geologic evolution of the Central Patagonian Andes, we carried out geochronologic(U-Pb and^(40)Ar/^(39)Ar), provenance, stratigraphic, sedimentologic, and geochemical studies on the sedimentary and volcanic Cenozoic deposits that crop out in the Meseta Guadal and Chile Chico areas(～47°S). Our data indicate the presence of a nearly complete Cenozoic record, which refutes previous interpretations of a hiatus during the middle Eocene-late Oligocene in the Central Patagonian Andes. Our study suggests that the fluvial strata of the ligorio Marquez Formation and the flood basalts of the Basaltos Inferiores de la Meseta Chile Chico Formation were deposited in an extensional setting related to the subduction of the Aluk-Farallon spreading ridge during the late Paleocene-Eocene. Geochemical data on volcanic rocks interbedded with fluvial strata of the San Jose Formation suggest that this unit was deposited in an extensional setting during the middle Eocene to late Oligocene. Progressive crustal thinning allowed the transgression of marine waters of Atlantic origin and deposition of the upper Oligocene-lower Miocene Guadal Formation. The fluvial synorogenic strata of the Santa Cruz Formation were deposited as a consequence of an important phase of compressive deformation and Andean uplift during the early-middle Miocene. Finally, alkali flood basalts of the late middle to late Miocene Basaltos Superiores de la Meseta Chile Chico Formation were extruded in the area in response to the suduction of the Chile Ridge under an extensional regime. Our studies indicate that the tectonic evolution of the Central Patagonian Andes is similar to that of the North Patagonian Andes and appears to differ from that of the Southern Patagonian Andes, which is thought to have been the s

关键词： Central Patagonian Andes U-Pb geochronology Ar-Ar geochronology Geochemistry Stratigraphy Sedimentology

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混凝土路面砖配合比设计的改进

建筑砌块与砌块建筑 2017年第1期 34-37,46页

作者： J.Agnello l.fernández luco A.Benítez 崔玉忠（译）阿根廷国家工业技术研究院建筑施工中心混凝土技术部布宜诺斯艾利斯4724-6476 不详

建筑业要消耗大量原材料和能源。作为原材料选择方法之一,"可持续性"准则是人们在考虑社会和经济可持续发展需求后提出的。本文所介绍内容,涉及预制混凝土产品在传统原材料配合比不适用情况下,如何找到具有竞争力的替代性原材料。本文... 详细信息

建筑业要消耗大量原材料和能源。作为原材料选择方法之一,"可持续性"准则是人们在考虑社会和经济可持续发展需求后提出的。本文所介绍内容,涉及预制混凝土产品在传统原材料配合比不适用情况下,如何找到具有竞争力的替代性原材料。本文所提及方法,是将颗粒堆集"干扰"原理,用于混凝土路面砖的配合比设计中。以阿根廷一家混凝土路面砖工厂实际使用的骨料颗粒级配,作为参照,采用骨料破碎加工过程产生、粒径级配不符合要求的废料,替代部分细骨料生产混凝土路面砖,并对产品性能进行检测。测定采用这种固废骨料所配制砂浆试件的物理性能和力学性能。对配合比进行优化,直到获得具有同等力学性能、少水泥用量的配合比;对骨料破碎产生的细颗粒掺加物百分比,进行控制。用三个参数作为评价混凝土配合比"可持续性能"的指标。通过利废,降低路面砖生产对自然环境的影响;此外,还可获得更加经济的混凝土配合料。

关键词：混凝土路面砖尾矿可持续配合比设计间级级配干扰原理替代

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes lachén-Montes Elena Anaya-Cubero Joaquín fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

利用土壤生物刺激素改善磷矿石类肥料在牧草上应用的短期效应

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腐植酸 2017年第1期 56-56页

作者： l.fernández R.Baigorri O.Urrutia 何一通河北农业大学资源与环境科学学院

在酸性土壤上使用活性磷矿石（RP）作为牧草和大田作物的磷源相对于可溶性磷酸盐而言具有明显的经济优势。然而，一些研究表明活性RP的短期效应（1年）比水溶性磷差，表现为不但对早期收获的作物产量和品质不利，而且对总产量也不利，... 详细信息

在酸性土壤上使用活性磷矿石（RP）作为牧草和大田作物的磷源相对于可溶性磷酸盐而言具有明显的经济优势。然而，一些研究表明活性RP的短期效应（1年）比水溶性磷差，表现为不但对早期收获的作物产量和品质不利，而且对总产量也不利，特别是当作物在施用初期受到生物或非生物胁迫的影响时。

关键词：短期效应土壤生物磷矿石牧草刺激素应用肥料石类

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(l-alanine,glycine,l-glutamine,and l-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores leonardo Aguilar-Hernández fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

A demand side management approach to increase self-consumption in buildings

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Building Simulation 2023年第2期16卷 317-335页

作者： Carlos fernández Bandera Gabriela Bastos Porsani María fernández-Vigil Iglesias School of Architecture University of Navarra31009 PamplonaSpain

There is a growing interest in increasing the presence of renewable energy in the electric *** production from grid-connected systems is leading this growth in terms of *** this development,concern about network security has emerged,because excesses of intermittent renewable energy on the grid could exceed voltage ***-consumption,understood as the capacity of the producer to consume his or her own production,can partially solve these *** controllable loads,such as heating and cooling,represent 50%of the total amount of energy consumed by buildings;the proper allocation of these loads could be a driving force for *** this study,a demand side management strategy is proposed based on a building energy model equipped with an inverter heat pump coupled with a photovoltaic *** goal is to maximize the use of local energy from the photovoltaic plant(self-consumption),reducing the export and import of energy to and from the *** goal is achieved by optimizing the set-points in each *** array of optimal set-points over six years is *** results show the capacity of the methodology to match similar values of self-consumption(70%in winter and 50%in summer)obtained by strategies based on chemical *** findings are shown in an energy matching chart at different levels of detail(yearly and monthly).Color bubbles are added to the matching chart to help visualize the unmatched energy of the system *** comparison with actual model predictive control technologies,this study’s strategy offers great simplicity and a large saving in computational time.

关键词： sensor data internal thermal mass energy simulation EnergyPlus inverse model

Determination of Soil Aggregate Porosity Using the Modified Water Saturation Method

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Pedosphere 2019年第6期29卷 794-800页

作者： David MORET-fernández María Victoria lóPEZ Departamento de Suelo y Agua Estación Experimental de Aula Dei Consejo Superior de Investigaciones Científicas (EEAD-CSIC)

The need to find a simple method for measuring soil aggregate porosity (φ) is justified by the growing interest of researchers in this important parameter of soil physical status. The aim of this study was to present a simple method (AM) for estimating the total 0 of a single soil aggregate. In this case, soil aggregate 0 was calculated as the quotient between the pore volume, estimated from the weight of the aggregate saturated with ethanol, and the total volume (V T ) of aggregate, calculated from the particle density and dry aggregate weight. The V T estimated with AM was compared with the corresponding volume measured with the photogrammetry (PHM) technique using soil aggregates of 8–16 mm in diameter and collected from three different tillage systems: conventional tillage (CT), reduced tillage (RT), and no tillage (NT). Next, the AM was used to study the effects of the tillage system on soil aggregate φ. Although a strong relationship ( R 2 = 0.99, P l evaporation during the first 10 s before the ethanol-saturated aggregate was weighed. The use of AM to determine the effects of different tillage systems on aggregate φ showed that this method was sensitive to detect significant differences among the tillage treatments. The results showed that AM could be an accurate, simple, and inexpensive alternative to estimate φ of a single soil aggregate.

关键词： Aggregate stability Bulk density Particle density Photogrammetry technique Tillage system

Tandem pore TWIK-related potassium channels and neuroprotection

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Neural Regeneration Research 2019年第8期14卷 1293-1308页

作者： J.Antonio lamas Diego fernández-fernández laboratory of Neuroscience Biomedical Research Center (CINBIO) University of Vigo

TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notw让hstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.

关键词： TREK channels TREK-1 TREK-2 TRAAK neuroprotection free fatty acids lysophospholipids riluzole