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NONINVASIVE PROBING OF THE NEUROVASCUlAR SYSTEM IN HUMAN BONE/BONE MARROW USING NEAR-INFRARED lIGHT

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 183-189页

作者： TIZIANO BINZONI dimitri VAN DE VIllE Departement des Neurosciences Fondamentales University of Geneva Rue Michel-Servet 11211 Geneve 4Switzerland Departement de l'Imagerie et des Sciences de l'Information Medicale University Hospital Rue Gabrielle-Perret-Gentil 41211 Geneve 14Switzerland Institute of BioengineeringEcole Polytechnique Federale de lausanne(EPFl)STI-IBI BM4.128Station 171015 LausanneSwitzerland

Understanding the mechanisms of interaction between bone/bone marrow,circulatory system and nervous system is of great interest due to the potential clinical *** humans,the amount of knowledge in this domain remains relatively limited due to the extreme difficulty to monitor these tissues continuously,noninvasively and for long or repeated periods of time.A typical difficult task would be,for example,to continuously monitor bone/bone marrow blood perfusion,hemoglobin oxygen saturation or blood volume and study their dependence on the activity of the autonomic nervous *** this review article,we want to show that nearinfrared light might be utilized to solve these problems in *** hope that the present analysis will stimulate future studies in this domain,for which near-infrared light appears as the best available technology today.

关键词： Review laser-Dopplerflowmetry near-infrared spectroscopy photoplethysmography

Pointwise Convergence of a Nonparametric Estimator of Regression in a Measurable Space Used in Contingent Valuation Method

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Journal of Mathematics and System Science 2015年第5期5卷 188-195页

作者： Taibi-Hassani Salima dimitri laroutis S. l. Adigaw-E-Touck Esitpa 3 Rue du Tronquet CS 40118 76134 Mont Saint Aignan France. laboratoire de Mathematiques lMRS UMR 6085 CNRS-Universite de Rouen France.

The Contingent Valuation Method is used to evaluate individual preferences for a change concerning a public non-market resource or property. The objective is to build a nonparametric forecasting model of an individual＇s Willingness To Pay according to geographical location. Within this framework, an estimator （of type Nadaraya-Watson） is proposed for the regression of the variable related to geolocation. The specific characteristics of the location variable lead us to a more general regression model than the traditional models. Results are established for convergence of our estimator.

关键词： Regression nonparametric estimation mixing process almost complete convergence contingent valuation method.

Impact of type 2 diabetes on adenoma detection in screening colonoscopies performed in disparate populations

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World Journal of Clinical Cases 2021年第11期9卷 2433-2445页

作者： dimitri F Joseph Ellen li Samuel l Stanley III Yi-Cong Zhu Xiao-Ning li Jie Yang lorenzo F Ottaviano Juan Carlos Bucobo Jonathan M Buscaglia Joshua D Miller Rajesh Veluvolu Michele Follen Evan B Grossman Department of Medicine Renaissance School of Medicine at Stony Brook UniversityStony BrookNY 11794-8173United States Department of Medicine Division of GastroenterologyStony Brook UniversityStony BrookNY 11794-8173United States Department of Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794-3600United States Department of Biostatistics and Bioinformatics Shared Resource Stony Brook Cancer CenterStony Brook UniversityStony BrookNY 11794-3600United States Department of Family Populationand Preventative MedicineRenaissance School of Medicine at Stony Brook UniversityStony BrookNY 11794-8461United States Department of Medicine NYC Health and Hospitals/Kings CountyBrooklynNY 11203United States Department of Medicine SUNY Downstate Medical CenterBrooklynNY 11203United States Department of Obstetrics and Gynecology NYC Health and Hospitals/Kings CountyBrooklynNY 11203United States

BACKGROUND The Black/African Ancestry(AA)population has a higher prevalence of type 2 diabetes mellitus(T2DM)and a higher incidence and mortality rate for colorectal cancer(CRC)than all other races in the United States.T2DM has been shown to increase adenoma risk in predominantly white/European ancestry(EA)populations,but the effect of T2DM on adenoma risk in Black/AA individuals is less *** hypothesize that T2DM has a significant effect on adenoma risk in a predominantly Black/AA *** To investigate the effect of T2DM and race on the adenoma detection rate(ADR)in screening colonoscopies in two disparate *** A retrospective cohort study was conducted on ADR during index screening colonoscopies(age 45-75)performed at an urban public hospital serving a predominantly Black/AA population(92%)(2017-2018,n=1606).Clinical metadata collected included basic demographics,insurance,body mass index(BMI),family history of CRC,smoking,diabetes diagnosis,and aspirin *** dataset was combined with a recently reported parallel retrospective cohort data set collected at a suburban university hospital serving a predominantly White/EA population(87%)(2012-2015,n=2882).RESUlTS The ADR was higher in T2DM patients than in patients without T2DM or prediabetes(35.2%vs 27.9%,P=0.0166,n=981)at the urban public *** analysis of the combined datasets showed that T2DM[odds ratio(OR)=1.29,95%confidence interval(CI):1.08-1.55,P=0.0049],smoking(current vs never OR=1.47,95%CI:1.18-1.82,current vs past OR=1.32,95%CI:1.02-1.70,P=0.0026),older age(OR=1.05 per year,95%CI:1.04-1.06,Ple sex(OR=1.87,95%CI:1.62-2.15,Ply associated with increased ADR on index screening colonoscopy while controlling for other factors.

关键词： Adenoma Diabetes mellitus,type 2 African continental ancestry group European continental ancestry group Colonoscopy Multivariate analysis

Simulation and Performance Analysis of Six Types of Sun Tracker Approaches:A Comparative Analysis for Solar Concentrating Technology Application at Burkina Faso

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Journal of Energy and Power Engineering 2024年第1期18卷 1-8页

作者： Stanislas Sanfo Serge dimitri Bazyomo Tizane Daho Abdoulaye Ouedraogo laboratoire de Physique et de Chimie de l’Environnement(lPCE) Departement de PhysiqueUnitéde Formation et de Recherche en Sciences Exactes et AppliquéesUniversitéJoseph KI-ZERBOOuagadougouBP 7021Burkina Faso laboratory of Thermal and Renewable Energies Department of Physics Unit of Training and Research on Exact and Applied SciencesUniversity Joseph KI-ZERBOOuagadougouBP 7021Burkina Faso laboratoire Recherche Développement(lARED) Universitéde OuahigouyaBurkina Faso

Modelization equations of six approaches for tracking the sun are recalled and used to evaluate the constraints and performances to which they lead *** geographical study case is taken for the specific latitude of 12 North that is a good matching with the location of the country of Burkina *** decisive periods were locally established in order to consider the different travels of the sun on sky during one *** work presents some technical data which facilitates the choice of sun tracking approaches with concern of a concentrator limits such as its angle of acceptance,its motion control card interpolation model,or its minimum irradiation level for energy conversion effectiveness.

关键词： Solar radiation sun tracker Burkina Faso experimental data

Molecular recognition of live methicillin-resistant staphylococcus aureus cells using DNA aptamers

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World Journal of Translational Medicine 2013年第3期2卷 67-74页

作者： Diane Turek dimitri Van Simaeys Judith Johnson Ismail Ocsoy Weihong Tan Shands Cancer and Genetic Research Center Department of Physiology and Functional Genomics University of Florida Gainesville FL 32611 United States Emerging Pathogens Institute University of Florida Gainesville FL 32611 United States Department of Chemistry Center for Research at Bio/Nano Interface University of Florida Gainesville FL 32611 United States

AIM: To generate DNA-aptamers binding to Methicillinresistant Staphylococcus aureus(MRSA).METHODS: The Cell-Systematic Evolution of ligands by Exponential Enrichment(SElEX) technology was used to run the selection against MRSA bacteria and develop target-specific aptamers. MRSA bacteria were targeted while Enterococcus faecalis bacteria were used for counter selection during that process. Binding assays to determine the right aptamer candidates as well as binding assays on clinical samples were performed through flow cytometry and analyzed using the FlowJ o software. The characterization of the aptamers was done by determination of their Kd values and determined by analysis of flow data at different aptamer concentration using Sigma Plot. Finally, the recognitionof the complex Gold-nanoparticle-aptamer to the bacteria cells was observed using transmission electron microscopy(TEM).RESUlTS: During the cell-SElEX selection process, 17 rounds were necessary to generate enrichment of the pool. While the selection was run using fixed cells, it was shown that the binding of the pools with live cells was giving similar results. After sequencing and analysis of the two last pools, four sequences were identified to be aptamer candidates. The characterization of those aptamers showed that based on their Kd values, DTMRSA4 presented the best binding with a Kd value of 94.61 ± 18.82 nmol/l. A total of ten clinical samples of MRSA, S. aureus and Enterococcus faecalis were obtained to test those aptamers and determine their binding on a panel of samples. DTMRSA1 and DTMRSA3 showed the best results regarding their specificity to MRSA, DTMRSA1 being the most specific of all. Finally, those aptamers were coupled with gold-nanoparticle and their binding to MRSA cells was visualized through TEM showing that adduction of nanoparticles on the aptamers did not change their binding ***: A total of four aptamers that bind to MRSA were obtained with Kd values ranking from 94

关键词： Aptamer Methicillin-resistant Staphylococcus aureus Gram-positve bacteria Cell recognition

Detection and Serological Characterization of Rice Yellow Mottle Virus in Central African Republic

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Agricultural Sciences 2016年第12期7卷 911-919页

作者： Régis dimitri Sokpé longué Innocent Zinga Silla Semballa Nicolas Barro Oumar Traoré Crop Production Department Institute of Environment and Agricultural Research Ouagadougou Burkina Faso life Science Department University of Bangui Bangui Central African Republic Department of Biochemistry and Microbiology University of Ouagadougou I-Professor Joseph Ki-Zerbo Ouagadougou Burkina Faso

Serological and biological detection of Rice Yellow Mottle Virus (RYMV) in leaf samples belonging from cultivated rice species and wild grasses revealed 201 positive detections. All these isolates occurred exclusively on cultivated rice species (Oryza sativa l. and O. glaberrima Steud). A relationship was found between cultural practices and presence of RYMV in fields (X2 = 108.83, df = 1, P

关键词： RYMV Detection Serological Characterization Central African Republic

Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways

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Genes & Diseases 2023年第5期10卷 1759-1762页

作者： Colemonts-Vroninks Haaike Norman P.Brendan Van laere Sven Davison S.Andrew Marcélis lionel Casimir Georges Goyens Philippe Claes Paul De Bundel.dimitri Martens Geert Ranganath lakshminarayan Rao Vanhaecke Tamara Gallagher James A De Kock Joery Vrije Universiteit Brussel Liver Therapy&Evolution TeamIn Vitro Toxicology and Dermato-Cosmetology(IVTD)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium Vrije Universiteit Brussel Experimental Pharmacology(EFAR)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium University of liverpool Dept.of Musculoskeletal&Ageing ScienceInstitute of Life Course&Medical SciencesLiverpool L78TXUnited Kingdom Vrije Universiteit Brussel Interfaculty Center Data Processing and StatisticsFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium liverpool University Hospitals NHS Foundation Trust Clinical Biochemistry and Metabolic MedicineLiverpool L35PSUnited Kingdom Universitélibre de Bruxelles Laboratoire de PédiatrieBrussels B-1050Belgium Vrije Universiteit Brussel In Vitro Liver Disease Modelling TeamIn Vitro Toxicology and Dermato-Cosmetology(IVTD)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium AZ Delta General Hospital Department of Laboratory MedicineRoeselare 8800Belgium Ghent University Department of Biomolecular MedicineGhent 9052Belgium

Hereditary tyrosinemia type 1(HT1)is a life-threatening disease caused by the patient's inability to break down tyrosine due to loss-of-function mutations in the fumarylacetoacetate hydrolase(FAH)enzyme(Fig.S1).Currently,the only available life-saving treatment is nitisinone(NTBC).However,nitisinone therapy comes with debilitating side effects and requires a strict drug regime combined with a tyrosine-and phenylalanine-restricted ***,therapy adherence is often experienced as an additional *** this study,transcriptional profiling was conducted parallel to high-resolution metabolomics on,respectively,liver tissue and serum samples of Fah-deficient *** experimental workflow of our study is shown in Figure *** pathway analyses showed manifest activation of the NRF2-stress response,associated with hepatocellular damage and mainly driven by a markedly increased oxidative *** altered canonical pathways were primarily a downstream consequence of the ***,we observed an overall aminoacidemia and changes related to aminoacyl-tRNA biosynthesis,which postulates that short-term nitisinone discontinuation can already put the patient at risk for hepatocellular carcinoma ***,we did not only identify changes in numerous pathways,directly and indirectly,related to the metabolism of tyrosine and glutathione but also the presence of“side-chain”metabolites,such as y-glutamyl-and N-acetyl-coupled amino acids,indicating that non-directly related pathways like phase II biotransformation reactions are also affected.

关键词： continuation Figure hereditary

Peripheral Facial Paralysis in People living with Human Immunodeficiency Virus (HIV)

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第3期13卷 168-177页

作者： lekassa Pierrette Andjock Nkouo Yves Christian Mouinga Abayi Alex Davy Assoumou Ada Prudence BiyeNgoghe Prudence Ngoma Manfoumbi Albert Brice Manfoumbi Manfoumbi Kévin dimitri Miloundja Jerome Nzouba léon ENT and CFS Department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon Department of Surgery and Surgical Specialties University of Health Sciences Owendo Gabon ENT and CFS Department Yaound&#233 General Hospital Yaound&#233 Cameroon Ophthalmology Department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon Ophthalmology Department Owendo University Hospital Center Libreville Gabon Internal Medicine Department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon

Introduction: Peripheral facial palsy (PFP) is a frequent reason for ENT consultations. It is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to describe the diagnostic and therapeutic aspects and to establish the correlation between PFP and HIV in our context. Patients and Method: This was a retrospective descriptive study conducted in the ENT and CFS department of the HIAOBO, covering the medical records of patients hospitalized for taking a PFP on HIV terrain from January 1, 2016 to December 31, 2020. Results: The study involved 17 patients, 10 men (59%) and 7 women (41%), a sex ratio of 1.4. The average age was 39 years with the extremes of 11 and 69 years. Shopkeepers reported 9 cases (53%). The reason for consultation was facial asymmetry in 11 cases (100%). The delay in consultation during the first week was 82.4%. Clinical signs were unilateral facial asymmetry, the opening of the palpebral fissure and lacrimation. All patients received medical treatment for PFP and HIV. Evolution was favorable, with complete recovery and no sequelae in 82.4% of cases. Surgery was performed in one case. Conclusion: PFPs are common in HIV infection. Diagnosis is clinical and management is multidisciplinary. Progression depends on the length of time taken to treat the disease.

关键词： Peripheral Facial Paralysis HIV HIAOBO

Gallbladder Carcinoma of the Thyroid Revealed by an Acute Festered Thyroiditis: A literature Study about a Case

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第3期12卷 135-139页

作者： Aliou Faty Hady Tall Abdou Sy Fulgence Abdou Faye Birame loum Kevin dimitri Manfoumbi Manfoumbi ENT Department Diourbel Heinrich Lübke Regional Hospital Centre Diourbel Senegal ENT Department Saint-Louis Regional Hospital Centre Saint-Louis Senegal ENT Department Children’s Hospital of Diamniadio Dakar Senegal Department of Medecine Bambey Alioune Diop University’s Diourbel Senegal ENT Department H&#244pital Principal de Dakar Dakar Sénégal

The cutaneous extension of gallbladder thyroid carcinoma is uncommon and is among the aggressive forms of the disease. We are reporting the case of a woman of 54 that shows acute festered thyroiditis worsened by a necrotic ulcer wound on the skin lasting 3 weeks amid a big neglected hetero-multinodular goitre, evolving since 20 years. The anatomopathological test showed a gallbladder thyroid carcinoma of the thyroid with severe inflammation. The treatment consisted of a complete thyroidectomy with recurrent bilateral dredging. There was a favourable evolution. Gallbladder carcinoma, in its aggressive aspect, may be linked to the occurrence of acute festered thyroiditis. Therefore, the prognosis of our patient was favourable.

关键词： Thyroiditis Gallbladder Carcinoma Suppuration