检索结果-南通市图书馆

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

引用

Science China(Physics,Mechanics & Astronomy) 2014年第3期57卷 418-423页

作者： l Yan BAO JingDong School of Applied Science Taiyuan University of Science and Technology Department of Physics Beijing Normal University

The correlated levy flight is studied analytically in terms of the fractional Fokker-Planck equation and simulated numerically by using the langevin equation, where the usual white ltvy noise is generalized to an Ornstein-Uhlenbeck levy process （OAlP） with a correlation time τc. We analyze firstly the stable behavior of OUlP. The probability density function of ltvy flight particle driven by the OUlP in a harmonic potential is exactly obtained, which is also a ltvy-type one with Tc-dependence width; when the particle is bounded by a quartic potential, its stationary distribution has a bimodality shape and becomes noticeable with the increase of τc.

关键词： l3vy flight OUlP fractional Fokker-Planck equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Revision of the genus Inouenola lászló,Ronkay & Witt,2010(lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species

引用

Journal of Forestry Research 2015年第2期26卷 457-467页

作者： Gyula M.lászló Gábor Ronkay lászló Ronkay Fadrusz u.25 Budapest 1114Hungary Heterocera Press ltd. Szt.István krt.4Budapest 1137Hungary Department of Zoology Hungarian Natural History Museum

This paper contains the revision of the genus Inouenola la′szlo′,Ronkay ＆ Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species（Inouenola brunneolinea... 详细信息

关键词： Inouenola Nolini Nolidae Noctuoidea New species New status South East Asia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inertial lévy Flight with Nonlinear Friction

引用

Chinese Physics letters 2011年第11期28卷 1-3页

作者： lÜYan BAO Jing-Dong Department of Physics Beijing Normal UniversityBeijing 100875

lévy flight with nonlinear friction is *** to the occurrence of extremely long jumps lévy flights often possess infinite variance and are physically problematic if describing the dynamics of a particle of finite ***,by introducing nonlinear friction,we show that the stochastic process subject to lévy noise exhibits finite variance,leading to a well-defined kinetic *** the force-free field,normal diffusion behavior is observed and the diffusion coefficient decreases with lévy index𝜇.Furthermore,we find a kinetic resonance of the particle in the harmonic potential to the external oscillating field in the generally underdamped region and the value of the linear friction𝛾0 determines whether resonance occurs or not.

关键词： variance diffusion finite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flecainide in Cadaveric Blood and Tissues

引用

Journal of Pharmacy and Pharmacology 2017年第2期5卷 73-78页

作者： Vezzoli Sara conti Adelaide Bernini Marzia Department of legal Medicine University of Brescia Brescia 25123 ltaly

In this report, we described a death caused by a deliberate overdose of Flecainide acetate （Almarytm^（R））, an antiarrhythmic agent. The patient had taken a box of 20 Almarytm^（R） 100 mg tablets. The Flecainide concentration found in the post-mortem cardiac blood was 10.16 mg/l. This concentration could not have been determined by post-mortem diffusion of the drug from gastric residue because the patient was previously given activated carbon during the emergency procedure. In fact, in the peripheral blood, the Flecainide concentration was 8.64 mg/l, therefore, this concentration is overlapping with the concentration in the cardiac blood; the gastric content was negative at the screening of Flecainide, while the liver tissue concentration of Flecaiuide was 59.6 mg/l and the bile concentration was 128 mg/l. The brain tissue concentration of Flecainide was 4.19 mg/l. In this case, the cause of death, excluding that toxicity was depending on post-mortem gastric diffusion of the drug, because of the absorbing activity of the administered carbon at the recovery.

关键词： Flecainide antiarrhythmic cadaveric blood gastric content.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

引用

Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang Nan Qing li Xiufang li Zi-Xiu lu linzhe lü Jin liu luyao liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8l12（μ3-OH）24（X）]1clusters （l=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8l12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）l12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8l12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8l12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8l12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 ml

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Treatment of the ulnar nerve for overhead throwing athletes undergoing ulnar collateral ligament reconstruction

引用

World Journal of Orthopedics 2016年第10期7卷 650-656页

作者： Matthew S conti Christopher l Camp Neal S Elattrache David W Altchek Joshua S Dines Department of Orthopaedic Surgery Hospital for Special Surgery Shoulder and Sports Medicine Service Hospital for Special Surgery Kerlan-Jobe Orthopaedic Clinic

Ulnar nerve(UN) injuries are a common complaint amongst overhead athletes. The UN is strained during periods of extreme valgus stress at the elbow, especially in the late-cocking and early acceleration phases of throwing. Although early ulnar collateral ligament(UCl) reconstruction techniques frequently included routine submuscular UN transposition, this is becoming less common with more modern techniques. We review the recent literature on the sites of UN compression, techniques to evaluate the UN nerve, and treatment of UN pathology in the overhead athlete. We also discuss our preferred techniques for selective decompression and anterior transposition of the UN when indicated. More recent studies support the use of UN transpositions only when there are specific preoperative symptoms. Athletes with isolated ulnar neuropathy are increasingly being treated with subcutaneous anterior transposition of the nerve rather than submuscular transposition. When ulnar neuropathy occurs with UCl insufficiency, adoption of the muscle-splitting approach for UCl reconstructions, as well as using a subcutaneous UN transposition have led to fewer postoperative complications and improved outcomes. Prudent handling of the UN in addition to appropriate surgical technique can lead to a high percentage of athletes who return to competitive sports following surgery for ulnar neuropathy.

关键词： Ulnar nerve Neuropathy Ulnar collateral ligament reconstruction Management Athletes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice spouted bed for manufacturing inclusion complexes of Endopleura uchi l extracts in β-cyclodextrin

引用

Particuology 2019年第1期17卷 208-215页

作者： l.V.D. Freitas A.C.R. Montes E.I.A. Campos E.C. Conceicao l.A. Tacon A.D. lanchote l.A.P.Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n14040-903Ribeirao PretoSPBrazil

Uxi (Endopleura uchi) is a plant from the Brazilian Amazon. It has many biological activities that are attributed to its main active component, bergenin (BG), which has low water solubility. The aim of this work was to obtain β-cyclodextrin (β-CD) inclusion complexes of uxi using lyophilized cooked rice as the solid substrate. The process was studied using a Box–Behnken design with the solution feed rate, molar ratio of β-CD to BG, and rice bed load as factors. These factors greatly affected the product bulk density, angle of repose, water content, and BG content, loss, and water solubility. The optimum process conditions determined using a desirability functions methodology were an extract feed rate of 1 ml/min, a ratio of β-CD to BG of 3:1, and a substrate load of 100 g. The predicted values under the optimum conditions were close to the experimental results of a water content of 5.8%± 0.2%, BG content of 985.7 ± 15.4 μg/g, BG water solubility of 2230.2 ± 21.1 μg/ml, and BG loss of 1.2%± 0.1%. These results confirm that spouted beds are an important tool for rapid, one-step preparation of pharmaceutical β-CD inclusion complexes in a solid form.

关键词： Bergenin Chromatography Yield Active loss Solubility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Towards an l^p Potential Theory for Sub-Markovian Semigroups:Kernels and Capacities

引用

Acta Mathematica Sinica,English Series 2006年第4期22卷 1227-1250页

作者： Niels JACOB Renél.SCHIllING Department of Mathematics University of Wales SwanseaSingleton ParkSwansea SA 2 8 PP.United Kinadom FB 12-Mathematik Philipps-Universitat MarburgD-35032 MarburgGermany

We study in fairly general measure spaces （X,μ） the （non-linear） potential theory of l^p sub-Markovian semigroups which are given by kernels having a density with respect to the underlying measure. In terms of mapping properties of the operators we provide sufficient conditions for the existence （and regularity） of such densities. We give various （dual） representations for several associated capacities and, in the corresponding abstract Bessel potential spaces, we study the role of the truncation property. Examples are discussed in the case of R^n where abstract Bessel potential spaces can be identified with concrete function spaces.

关键词： nonlinear potential theory (r,p)-capacity Bessel potential space gamma.transform sub-Markovian semigroup

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biophotonic rogue waves in red blood cell suspensions

引用

Photonics Research 2023年第11期11卷 1838-1846页

作者： YU-XUAN REN JOSHUA lAMSTEIN CHENSONG ZHANG ClAUDIO conti DEMETRIOS NCHRISTODOUlIDES ZHIGANG CHEN Institute for Translational Brain Research MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Department of Physics and Astronomy San Francisco State UniversitySan FranciscoCalifornia 94132USA Center for Systems and Therapeutics Gladstone InstitutesSan FranciscoCalifornia 94158USA Division of CryoEM and Bioimaging Stanford Synchrotron Radiation LightsourceSLAC National Accelerator LaboratoryMenlo ParkCalifornia 94025USA Department of Physics University SapienzaI-00185 RomaItaly Department of Electrical Engineering University of Southern CaliforniaLos AngelesCalifornia 90089USA TEDA Applied Physics Institute and School of Physics Nankai UniversityTianjin 300457China

Rogue waves are ubiquitous in nature,appearing in a variety of physical systems ranging from acoustics,microwave cavities,optical fibers,and resonators to plasmas,superfluids,and Bose–Einstein *** nonlinear solitary waves,rogue waves are extreme events that can occur even without nonlinearity by,for example,spontaneous synchronization of waves with different spatial frequencies in a linear ***,we report the observation of rogue-wave-like events in human red blood cell(RBC)suspensions under weak light illumination,characterized by an abnormal l-shaped probability *** biophotonic extreme events arise mostly due to the constructive interference of Mie-scattered waves from the suspended RBCs,whose biconcave shape and mutable orientation give rise to a time-dependent random phase modulation to an incident laser *** numerically simulate the beam propagation through the colloidal suspensions with added disorder in both spatial and temporal domains to mimic random scattering due to Brownian *** addition,at high power levels,nonlinear beam self-focusing is also observed,leading to a dual-exponential probability distribution associated with the formation of multiple soliton-like *** rogue wave events should also exist in environments with cells of other species such as swimming bacteria,and understanding of their underlying physics may lead to unexpected biophotonic applications.

关键词： suspensions extreme soliton

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：