检索结果-南通市图书馆

ZmGns,a maize class I β-1,3-glucanase,is induced by biotic stresses and possesses strong antimicrobial activity

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2015年第3期57卷 271-283页

作者： Yu-Rong Xie Yenjit Raruang Zhi-Yuan Chen Robert l.brown Thomas E.Cleveland Department of Plant Pathology and Crop Physiology Louisiana State University Agricultural Center Biotechnology Research Institute the Chinese Academy of Agricultural Sciences Southern Regional Research Center USDA-ARS

Plant b-1,3-glucanases are members of the pathogenesis-related protein 2（PR-2） family,which is one of the 17 PR protein families and plays important roles in biotic and abiotic stress *** of the differentially expressed proteins（spot 842） identified in a recent proteomic comparison between five pairs of closely related maize（Zea mays l.） lines differing in aflatoxin resistance was further investigated in the present ***,the corresponding cDNA was cloned from maize and designated as *** encodes a protein of338 amino acids containing a potential signal *** expression of Zm Gns was detectible in all tissues studied with the highest level in *** was significantly induced by biotic stresses including three bacteria and the fungus Aspergillus *** was also induced by most abiotic stresses tested and growth hormones including salicylic *** vivo,ZmGns showed a significant inhibitory activity against thebacterial pathogen Pseudomonas syringae *** DC3000 and fungal pathogen Botrytis cinerea when it overexpressed in *** high level of expression in the silk tissue and its induced expression by phytohormone treatment,as well as by bacterial and fungal infections,suggest it plays a complex role in maize growth,development,and defense.

关键词： β-1 3-Glucanase biological activity expression profiles Zea mays ZmGns

The structure of colloidal polyethylenimine-silica nanocomposite microparticles

在线全文

学校读者我要写书评

暂无评论

Particuology 2023年第5期76卷 86-100页

作者： Alexandra Semenova luke W.Giles Mark louis P.Vidallon Bart Follink Paul l.brown Rico F.Tabor School of Chemistry Monash University19 Rainforest Walk.Clayton3800Australia Rio Tinto Bundoora Technical Development Centre1 Research AvenueBundoora3083Australia

Deposition of silica from an organosilane tetraethoxysilane(TEOS)onto parent polyethylenimine(PEI)microgel particles produces a novel PEI-silica nanocomposite,which possesses greater adsorption ca-pacity for copper ions than either parent *** study explores factors governing interactions of silica with the PEI matrix,along with structural features of resulting PEI-silica composite particles,to explain their properties and determine their application *** influence of initial TEOS/PEI mass ratio and the duration of silica deposition on the final silica content and distribution in the composite are studied.A comparative analysis of the structural architecture of chemically etched silica remnants,original PEI-silica composite particles and the parent PEI-microgel is carried out using X-ray photo-electron spectroscopy,small-angle X-ray scattering,and electron microscopy *** is found that silica sol nanoparticles are evenly distributed throughout the PEI-microgel framework and interlinked with it via electrostatic interactions,enabling a structural model of the PEI-silica nanocomposite to be *** chemical stability of resulting nanocomposite particles in parallel with the parent PEI-microgel is tested and shown to be robust for more than 100 days of storage in aqueous dispersions across a range of pH conditions,highlighting the application potential for these particles in copper capture.

关键词： Polyethylenimine Silica Organic-inorganic composite Nano-scale morphology Small angle X-ray scattering

Polymer graph neural networks for multitask property learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 1420-1429页

作者： Owen Queen Gavin A.McCarver Saitheeraj Thatigotla Brendan P.Abolins Cameron l.brown Vasileios Maroulas Konstantinos D.Vogiatzis Department of Mathematics University of TennesseeKnoxvilleTN 37996-1320USA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996-2250USA Department of Chemistry University of TennesseeKnoxvilleTN 37996-1600USA Eastman Chemical Company KingsportTN 37660USA

The prediction of a variety of polymer properties from their monomer composition has been a challenge for material informatics,and their development can lead to a more effective exploration of the material *** this work,POlYMERGNN,a multitask machine learning architecture that relies on polymeric features and graph neural networks has been developed towards this *** provides accurate estimates for polymer properties based on a database of complex and heterogeneous polyesters(linear/branched,homopolymers/copolymers)with experimentally refined *** POlYMERGNN,each polyester is represented as a set of monomer units,which are introduced as molecular graphs.A virtual screening of a large,computationally generated database with materials of variable composition was performed,a task that demonstrates the applicability of the POlYMERGNN on future studies that target the exploration of the polymer ***,a discussion on the explainability of the models is provided.

关键词： properties space polyester

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2019年第1期4卷 249-255页

作者： Emily G.long Merve Buluk Michelle B.Gallagher Jennifer M.Schneider Justin l.brown Department of Biomedical Engineering The Pennsylvania State University122 CBEB BuildingUniversity ParkPA16802USA Titan Spine Inc.Mequon Research Center6140 W.Executive DriveSuite AMequonWI53092USA

Orthopedic implants rely on facilitating a robust interaction between the implant material surface and the surrounding bone ***,the interface will encourage osseointegration with the host bone,resulting in strong fixation and implant ***,implant failure can occur due to the lack of integration with bone tissue or bacterial *** chosen material and surface topography of orthopedic implants are key factors that influence the early events following implantation and may ultimately define the success of a *** attachment,rapid migration and improved differentiation of stem cells to osteoblasts are necessary to populate the surface of biomedical implants,potentially preventing biofilm formation and implant-associated *** article explores these early stem cell specific events by seeding human mesenchymal stem cells(MSCs)on four clinically relevant materials:polyether ether ketone(PEEK),Ti6Al4V(smooth Ti),macro-micro rough Ti6Al4V(Endoskeleton®),and macro-micro-nano rough Ti6Al4V(nanolOCK®).The results demonstrate the incorporation of a hierarchical macro-micro-nano roughness on titanium produces a stellate morphology typical of mature osteoblasts/osteocytes,rapid and random migration,and improved osteogenic differentiation in seeded *** suggests rapid coverage of a surface by stem cells coupled with stimulation of bone differentiation minimizes the opportunity for biofilm formation while increasing the rate of device integration with the surrounding bone tissue.

关键词： titanium implantation roughness

Development and progression of cancer cachexia:Perspectives from bench to bedside

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2020年第4期2卷 177-185页

作者： Seongkyun lim Jacob l.brown Tyrone A.Washington Nicholas P.Greene Cachexia Research laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of Arkansas155 Stadium DrFayettevilleARUSA Aging and Metabolism Research Program Oklahoma Medical Research Foundation825 NE 13th StOklahoma CityOKUSA Exercise Muscle Biology laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of Arkansas155 Stadium DrFayettevilleARUSA

Cancer cachexia(CC)is a devastating syndrome characterized by weight loss,reduced fat mass and muscle mass that affects approximately 80%of cancer patients and is responsible for 22%-30%of cancer-associated *** underlying mechanisms for the development of CC are crucial to advance therapies to treat CC and improve cancer *** is a multi-organ syndrome that results in extensive skeletal muscle and adipose tissue wasting;however,CC can impair other organs such as the liver,heart,brain,and bone as well.A considerable amount of CC research focuses on changes that occur within the muscle,but cancer-related impairments in other organ systems are ***,metabolic changes in organ systems other than muscle may contribute to ***,the purpose of this review is to address degenerative mechanisms which occur during CC from a whole-body *** the information known about metabolic changes that occur in response to cancer is necessary to develop and enhance therapies to treat *** much of the current evidences in CC are from pre-clinical models we should note the majority of the data reviewed here are from preclinical models.

关键词： Muscle atrophy Tumor-bearing mouse lewis lung carcinoma Protein turnover Mitochondrial dysfunction

Creation of an optic nerve sheath diameter ultrasound model for Neuro ICU education

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2021年第1期8卷 116-120页

作者： Heidi M.Felix Kristin A.Rosenbush Amy M.lannen Robert A.Pooley Jason l.Siegel Benjamin l.brown Melissa l.Mc Mullan Christina I.Collins William D.Freeman J.Wayne and Delores Barr Weaver Simulation Center Mayo Clinic4500 San Pablo RoadJacksonvilleFL 32224USA Division of Medical Physics Mayo ClinicJacksonvilleFL 32224USA Department of Critical Care Medicine Mayo ClinicJacksonvilleFL 32224USA Department of Neurology Mayo ClinicJacksonvilleFL 32224USA Department of Neurologic Surgery Mayo ClinicJacksonvilleFL 32224USA Department of Radiology Mayo ClinicJacksonvilleFL 32224USA Department of Nursing Mayo ClinicJacksonvilleFL 32224USA

Background: Using ultrasound to measure optic nerve sheath diameter(ONSD) is an emerging bedside technique to noninvasively assess intracranial pressure(ICP) in patients with brain injury. This technique is unique among bedside ultrasonography and is often performed by providers who have no formal ultrasound training. We sought to create a low-cost, 3 D, reusable ONSD model to train neurology, neurosurgery, and critical care providers in measuring ***: We identified 253 articles, of which 15 were associated with models and 2 with simulation. One gelatin model was reported, upon which we based our initial design. We could not validate the visual findings of this model;however, after constructing multiple beta models, the design most representative of human eye anatomy was a globe made of ballistics gel and either a 3 mm, 5 mm, or 7 mm×50 mm 3 D-printed optic nerve inserted into a platform composed of ballistics gel, all of which sat inside a 3 D-printed skull. This model was used to teach ONSD measurements with ultrasound at a continuing medical education event prior to training on a live human ***: A simple 3 D ballistic ONSD model allows learners to practice proper hand placement and pressure, basic landmarks, and ONSD measurement prior to operating on a human eye. This model is replicable and sustainable given that the globe and platform are composed of ballistics gel.

关键词： Intracranial pressure Simulation Task trainer Ultrasound

Regulation of P1-450 Gene Expression by Dimethylbenzanthracene in Human lung Tumor Cells in Culture

在线全文

学校读者我要写书评

暂无评论

Developmental and Reproductive Biology 1992年第1期1卷 7-15,T001-T003页

作者：费云标 Kirstin l.brown Debajit K.Biswas Institute of Developmental Biology Academia SinicaBeijing 100080 Harvard School of Dental Medicine and Harvard Medical School BostonMass 02115 U.S.A. laboratoory of Molecular Biology Harvard School of Dental Medicine and Harvard Medical SchoolBostonMass 02115 U.S.A.

Polycyclic aromatic hydrocarbons(PAHs),dimethyl beazanthracene(DMBA)and benzo-(a)-pyrene(BaP),stimulate the expression of the P1-450 gene in human lung tumor cells(ChaGo)in culture.A concentration-and time-dependent increase in the level of P1-450 specific mRNA sequences hasbeen observed in ChaGo cells treated with sublethal concentrations of *** presentedsuggest that the parent compound causes the induction of P1-450 gene *** methylationpattern of the internal“-C-” residues of the “-CCGG-” sequence has been studied in a stretch ofabout 8000 base pairs(bp)of DNA sequence in and around the P1-450 gene in the control andDMBA-treated ChaGo cells.A comparative Southern blot analysis of the Msp Ⅰ/Hpa Ⅱ digestedDNA of the control and DMBA-treated ChaGo cells followed by hybridization with ^(32)P-labelledregion-specific probes,revealed that i)the internal “-C-” residues of the “-CCGG-” sequences ofdifferent regions of P1-450 gene were methylated to different degrees;ii)DMBA treatment of thecells induced hypomethylation of only the 5' end “-CCGG-” sequences of the gene;and iii)themethylation patterns of “-CCGG-” sequences of most of the coding region and of the 3' end regionof P1-450 gene were not affected by such DMBA treatment.

关键词： P1-450 gene Dimethyl-benzanthracene(DMBA) Methylation Hypomethylation

Climate change impacts-the key issues and future research

在线全文

学校读者我要写书评

暂无评论

Climate change impacts-the key issues and future research

Effects of PGC-1αoverexpression on the myogenic response during skeletal muscle regeneration

23rd International Ornithological Congress

作者： Humphrey Q.P.Crick Jerram l.brown Mark M.Rehfisch British Trust for Ornithology The Nunnery Thetford Norfolk IP24 2PU UK Dept. Biological Sciences Stale University of New York Albany NY 72222 USA British Trust for Ornithology The Nunnery Thetford Norfolk IP24 2PU UK

＜正＞ Climate change is rapidly developing into one of the most important pressures that will affect bird populations and their conservation over the next 50-100 years. The impacts will be both direct （e.g. through changes in average weather patterns, the occurrence of extreme events and sea-level rise） and indirect （e.g. through changes in habitats, land-use, agriculture and the employment of sea-defenses）. The aim of this RTD is to review （a） the

关键词： climate change bird populations research review monitoring

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2022年第3期4卷 198-208页

作者： Tyrone A.Washington Wesley S.Haynie Eleanor R.Schrems Richard A.Perry Jr. lemuel A.brown Breanna M.Williams Megan E.Rosa-Caldwell David E.lee Jacob l.brown Exercise Muscle Biology laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA Cachexia Research laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA

The ability of skeletal muscle to regenerate from injury is crucial for locomotion,metabolic health,and quality of *** proliferator-activated receptor-γcoactivator-1α(PGC1A)is a transcriptional coactivator required for mitochondrial *** mitochondrial biogenesis is associated with improved muscle cell differentiation,however PGC1A's role in skeletal muscle regeneration following damage requires further *** purpose of this study was to investigate the role of skeletal muscle-specific PGC1A overexpression during regeneration following damage.22 C57Bl/6J(WT)and 26 PGC1A muscle transgenic(A1)mice were injected with either phosphate-buffered saline(PBS,uninjured control)or Bupivacaine(MAR,injured)into their tibialis anterior(TA)muscle to induce skeletal muscle *** muscles were extracted 3-or 28-days postinjury and analyzed for markers of regenerative myogenesis and protein ***1a mRNA was~10–20 fold greater in A1 *** of protein synthesis,AKT and 4EBP1,displayed decreases in A1 mice compared to WT at both timepoints indicating a decreased protein synthetic *** mRNA was~75%lower compared to WT 3 days *** mice exhibited decreased cross-sectional area of the TA muscle at 28 days post-injection with bupivacaine compared to all other ***1A overexpression modifies the myogenic response during regeneration.

关键词： PGC-1α Skeletal muscle Muscle regeneration Satellite cells Protein turnover p38 MAPK