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Science China Technological Sciences 2025年第1期 233-250页

作者： S.aravind KRISHNA N.RADHIKA Alokesh PRAMANIK N.JEYAPRAKASH Department of Mechanical Engineering Amrita School of EngineeringAmrita Vishwa Vidyapeetham School of Civil and Mechanical Engineering Curtin University School of Mechanical and Electrical Engineering China University of Mining and Technology

The ability to perform against extreme corrosion environments in stainless steel depreciates under challenging conditions in industrial applications. This can be resolved by employing surface modification techniques to modify the surface with the required characteristics. The present study investigates the outcomes of friction stir processing of SS304 with CoCrFeCuTi high entropy alloy(HEA) as reinforcement and the property enhancements post-annealing. The synthesized CoCrFeCuTi HEA exhibited irregular fragments with 17 μm mean particle size and body centred cubic(BCC) phase. The microstructure of the processed surface revealed ultra-refined grains with a uniform distribution of HEA filler. The microstructures of the samples annealed at 400℃, 550℃, 700℃ and 850℃ for 2 h also showed significant grain growth and grain refinements. The processed sample with HEA reinforcement annealed at 700℃ exhibited enhanced microhardness and tensile strength by 63% and 0.88 times than that of the processed sample with HEA pre-annealing. The subsequent electrochemical corrosion test displayed better corrosion resistance for the HEA-processed and annealed sample. Hot corrosion tests at 900℃ showcased excellent resistance for the HEA processed and annealed samples by 14.92%, 12.75%, and 14.83% against the samples pre-annealed under three different salt mixtures, and the corroded surface was analyzed.

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Fault Recognition of Multilevel Inverter Using Artificial Neural Network Approach

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Intelligent Automation & Soft Computing 2023年第5期36卷 1331-1347页

作者： aravind Athimoolam Karthik Balasubramanian Research Scholar Faculty of Electrical EngineeringAnna UniversityChennai600025India Associate Professor Department of EEESona College of TechnologySalem636005India

This paper focuses on the development of a diagnostic tool for detect-ing insulated gate bipolar transistor power electronic switchﬂaws caused by both open and short circuit faults in multi-level inverter time-frequency output voltage speciﬁ***-resolution laboratory virtual instrument engineering work-bench software testing tool with a sample rate data collection system,as well as specialized signal processing and soft computing technologies,are used in this proposed *** a single-phase cascaded H-bridge multilevel inverter,simu-lation and experimental investigations of both open and short issues of the insu-lated gate bipolar transistor components are performed *** all conceivable switch issues,the output voltage signals are evaluated for different modulation index *** fourier transform and discrete wavelet transform methods are used to investigate the frequency domain properties of output voltage *** the artiﬁcial neural network,the back propagation training technique was employed,and the generated neural parameter values were used in the laboratory Virtual Instrumentation Engineering Workbench real-time fault diagnosis model.

关键词： Back propagation learning DWT cascaded H-bridge MlI FFT sinusoidal PWM THD

Clinical utility of anti-p53 auto-antibody: Systematic review and focus on colorectal cancer

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World Journal of Gastroenterology 2013年第29期19卷 4651-4670页

作者： aravind Suppiah John Greenman Postgraduate Medical Institute Biomedical and Environmental Sciences University of Hull Cottingham HU6 7RX United Kingdom Castle Hill Hospital Cottingham HU16 5JQ United Kingdom School of Biological Biomedical and Environmental Sciences University of Hull Cottingham HU6 7RX United Kingdom

Mutation of the p53 gene is a key event in the carcinogenesis of many different types of tumours. These can occur throughout the length of the p53 gene. Anti-p53 auto-antibodies are commonly produced in response to these p53 mutations. This review firstly describes the various mechanisms of p53 dysfunction and their association with subsequent carcinogenesis. Following this, the mechanisms of induction of anti-p53 auto-antibody production are shown, with various hypotheses for the discrepancies between the presence of p53 mutation and the presence/absence of anti-p53 auto-antibodies. A systematic review was performed with a descriptive summary of key findings of each anti-p53 auto-antibody study in all cancers published in the last 30 years. Using this, the cumulative frequency of anti-p53 autoantibody in each cancer type is calculated and then compared with the incidence of p53 mutation in each cancer to provide the largest sample calculation and correlation between mutation and anti-p53 auto-antibody published to date. Finally, the review focuses onthe data of anti-p53 auto-antibody in colorectal cancer studies, and discusses future strategies including the potentially promising role using anti-p53 auto-antibody presence in screening and surveillance.

关键词： p53 gene p53 mutation Anti-p53 autoantibody Cancer Colorectal cancer

Split warhead simultaneous impact

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Defence Technology（防务技术） 2017年第6期13卷 434-438页

作者： Rahul Singh Dhari aravind Sekar Department of Mechanical Engineering Pandit Deendayal Petroleum UniversityGandhinagar382007India Department of Mechanical Engineering Dhanalakshmi College of EngineeringChennai601301India

A projectile system is proposed to improve efficiency and effectiveness of damage done by anti-tank weapon system on its target by designing a ballistic projectile that can split into multiple warheads and engage a target at the same time. This idea has been developed in interest of saving time consumed from the process of reloading and additional number of rounds wasted on target during an attack. The proposed system is achieved in three steps: Firstly, a mathematical model is prepared using the basic equations of motion. Second, An Ejection Mechanism of proposed warhead is explained with the help of schematics. Third, a part of numerical simulation which is done using the MATlAB software. The final result shows various ranges and times when split can be effectively achieved. With the new system,impact points are increased and hence it has a better probability of hitting a target.

关键词： Mathematical formulations Aerodynamics Military technology and weapons systems Projectile and target fragmentation Warhead Split warhead